Biological models for phytochemical research: From cell to human organism

British Journal of Nutrition

Volumn 99, Issue E-SUPPL. 1, 2008, Pages

  Mortensen, Alicja ^a   Sorensen, Ilona K ^a   Wilde, Colin ^b   Dragoni, Stefania ^c   Mullerová, Dana ^d   Toussaint, Olivier ^e   Zloch, Zdeněk ^d   Sgaragli, Giampietro ^d   Ovesná, Jaroslava ^f  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b AvantiCell Science Ltd   (United Kingdom)

^c UNIVERSITY OF SIENA   (Italy)

^d CHARLES UNIVERSITY   (Czech Republic)

^e UNIVERSITY OF NAMUR   (Belgium)

^f CROP RESEARCH INSTITUTE   (Czech Republic)

Author keywords

Animal models; Human studies; In vitro models; Nutrigenomics

Indexed keywords

ALGINIC ACID; ANTIOXIDANT; BIOMATERIAL; CRANBERRY EXTRACT; CYTOCHROME P450; ESSENTIAL OIL; FLAVONOID; FOOD ADDITIVE; ISOFLAVONE DERIVATIVE; LIGNAN DERIVATIVE; NUTRACEUTICAL; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; OMEGA 9 FATTY ACID; PHYTOESTROGEN; PLANT MEDICINAL PRODUCT; POLYLACTIC ACID; POLYPHENOL DERIVATIVE; SOYBEAN OIL; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID; XENOBIOTIC AGENT;

ATHEROSCLEROSIS; BIOLOGICAL MODEL; CANCER RISK; CELL COMPARTMENTALIZATION; CELL DIFFERENTIATION; CELL ORGANELLE; CELL STIMULATION; CELL STRUCTURE; CHOLESTEROL METABOLISM; CLINICAL TRIAL; DIETARY INTAKE; DISEASE MODEL; DNA MICROARRAY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG RESEARCH; DRUG RESPONSE; DRUG UPTAKE; ENZYME ACTIVITY; ENZYME ANALYSIS; EXTRACELLULAR MATRIX; FOOD ANALYSIS; FOOD COMPOSITION; FOOD CONTAMINATION; FOOD SAFETY; FRUIT; GENE EXPRESSION; GENE INTERACTION; GENOMICS; GENOTOXICITY; HIGH THROUGHPUT SCREENING; HUMAN; HYPERCHOLESTEROLEMIA; IN VITRO STUDY; IN VIVO STUDY; MALIGNANT NEOPLASTIC DISEASE; METHODOLOGY; MOLECULAR BIOLOGY; NONHUMAN; NUTRIGENOMICS; NUTRITIONAL HEALTH; NUTRITIONAL REQUIREMENT; NUTRITIONAL VALUE; PREDICTION; PROTEOMICS; REVIEW; RISK ASSESSMENT; RISK FACTOR; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; TISSUE ENGINEERING; VEGETABLE;

ANIMALS; CELL LINE; DIET; DOSAGE COMPENSATION, GENETIC; HUMANS; MODELS, ANIMAL; MODELS, BIOLOGICAL; NUTRIGENOMICS; NUTRITIONAL PHYSIOLOGICAL PHENOMENA; SPECIES SPECIFICITY;

ANIMALIA;

EID: 52949137931     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114508965806     Document Type: Review

References (102)

1. Donaldson MS (2004) Nutrition and cancer: A review of the evidence for anti-cancer diet. Nutr J 3, 19, Published online 2004 October 20. doi: 10.1186/1475-2891-3-19. Available from http://www.nutritionj.com/content/3/1/19.
2. Alonso A & Martínez-González MA (2004) Olive oil consumption and reduced incidence of hypertension: The SUN study. Lipids 39, 1233-1238.
3. Goh SSC, Woodman OL, Pepe S, Cao AH, Quin C & Ritchie RH (2007) The red wine antioxidant resveratrol prevents cardiomyocyte injury following ischemia-reperfusion via multiple sites and mechanisms. Antioxid Redox Signal 9, 101-113.
4. Afman L & Müller M (2006) Nutrigenomics: From molecular nutrition to prevention of disease. J Am Diet Assoc 106, 569-576.
5. van den Veyver IB (2002) Genetic effects of methylation diets. Annu Rev Nutr 22, 255-282.
6. de Boom MJ, Rennie AE, Buchanan-Smith HM & Hendriksen CFM (2005) The interplay between replacement, reduction and refinement: Considerations where the three Rs interact. Anim Welf 14, 327-332.
7. Ordovacs JM & Corella1 D (2004) Nutritional genomics. Annu Rev Genomics Hum Genet 5, 71-118.
8. Buttriss JL, Hughes J, Colette NMK & Stanner S (2002) Anti-oxidants in food: A summary of the review conducted for the Food Standards Agency 2002, British Nutrition Foundation. Nutr Bull 27, 227-236.
9. Breinholt V & Larsen JC (1998) Detection of weak estrogenic flavonoids using a recombinant yeast strain and a modified MCF7 cell proliferation assay. Chem Res Toxicol 11, 622-629.
10. Pinto M, Robine-Leon S, Appay M-D, Kedinger M, Triadou N, Dussaulx E, Lacroix B, Simon-Assmann P, Haffen K, Fogh J, Zweibaum A, et al. (1983) Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture. Biol Cell 47, 323-330.
11. Brandsch M, Miyamoto Y, Ganapathy V & Leibach FH (2004) Expression and protein kinase C-dependent regulation of peptide/H + co-transport system in the Caco-2 human colon carcinoma cell line. Biochem J 299 253-260.
12. Hidalgo IJ & Borchardt RT (1990) Transport of bile acids in a human intestinal epithelial cell line, Caco-2. Biochim Biophys Acta 1035, 97-103.
13. Yamamoto T, Seino Y, Fukumoto H, Koh G, Yano H, Inagaki N, Yamada Y, Inoue K, Manabe T & Imura H (1990) Over-expression of facilitative glucose transporter genes in human cancer. Biochem Biophys Res Commun 170, 223-230.
14. Hochman JH, Fix JA & LeCluyse EL (1994) In vitro and in vivo analysis of the mechanism of absorption enhancement by palmitoylcarnitine. J Pharmacol Exp Ther 269, 813-822.
15. Grasset E, Pinto M, Dussaulx E, Zweibaum A & Desjeux JF (1984) Epithelial properties of human colonic carcinoma cell line Caco-2: electrical parameters. Am J Physiol Cell Physiol 247, C260-C267.
16. Pinto M, Appay MD, Simonassmann P, Chevalier G, Dracopoli N, Fogh J & Zweibaum A (1982) Enterocytic differentiation of cultured human-colon cancer-cells by replacement of glucose by galactose in the medium. Biol Cell 44, 193-196.
17. Chantret I, Barbat A, Dussaulx E, Brattain MG & Zweibaum A (1988) Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells: A survey of twenty cell lines. Cancer Res 48, 1936-1942.
18. Jumarie C & Malo C (1991) Caco-2 cells cultured in serum-free medium as a model for the study of enterocytic differentiation in vitro. J Cell Physiol 149, 24-33.
19. Artrusson P (1990) Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells. J Pharm Sci 79, 476-482.
20. Trotter PJ & Storch J (1991) Fatty acid uptake and metabolism in a human intestinal cell line (Caco-2): Comparison of apical and basolateral incubation. J Lipid Res 32, 293-304.
21. Giovannini C, Straface E, Modesti D, Coni E, Cantafora A, de Vincenti M, Malorni W & Masella R (1999) Tyrosol, the major olive oil biophenol, protects against oxidized-LDL induced injury in Caco-2 Cells. J Nutr 129, 1269-1276.
22. Anderberg EK & Artursson P (1993) Epithelial transport of drugs in cell culture. VIII: Effects of the pharmaceutical surfactant excipient sodium dodecyl sulphate on cell membrane and tight junction permeability in human intestinal epithelial (Caco-2) cells. J Pharm Sci 82, 392-398.
23. des Rieux A, Fievez V, Théate I, Mast J, Préat V & Schneider YJ (2007) An improved in vitro model of human intestinal follicle-associated epithelium to study nanoparticle transport by M cells. Eur J Pharm Sci 30, 380-391.
24. Aden DP, Fogel A, Plotkin S, Damjanov I & Knowles BB (1979) Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line. Nature 282, 615-616.
25. Cao J, Liu Y, Jia L, Zhou HM, Kong Y, Yang G, Jiang LP, Li QJ & Zhong LF (2007) Curcumin induces apoptosis through mitochondrial hyperpolarization and mtDNA damage in human hepatoma G2 cells. Free Radic Biol Med 43, 968-975.
26. Carter BA, Taylor OA, Prendergast DR, Zimmerman TL, Von Furstenberg RV, Moore DD & Karpen SJ (2007) Stigmasterol, a soy lipid-derived phytosterol, is an antagonist of the bile acid nuclear receptor FXR. Pediatr Res 62, 301-306.
27. Chung MJ, Woo Park K, Heon Kim K, Kim CT, Pill Baek J, Bang KH, Choi YM & Lee SJ (2008) Asian plaintain (Plantago asiatica) essential oils suppress 3-hydroxy-3- methyl-glutaryl-co-enzyme A reductase expression in vitro and in vivo and show hypocholesterolaemic properties in mice. Br J Nutr 99, 67-75.
28. Li LM, Weng ZY, Huang SX, Pu JX, Li SH, Huang H, Yang BB, Han Y, Xiao WL, Li ML, Han QB & Sun HD (2007) Cytotoxic ent-Kauranoids from the medicinal plant Isodon xerophilus. J Nat Prod 70, 1295-1301.
29. Gomes A, Giri B, Kole L, Saha A, Debnath A & Gomes A (2007) A crystalline compound (BM-ANF1) from the Indian toad (Bufo melanostictus, Schneider) skin extract, induced antiproliferation and apoptosis in leukemic and hepatoma cell line involving cell cycle proteins. Toxicon 50, 835-849.
30. Westerink WM & Schoonen WG (2007) Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HegG2 cells Toxicol In Vitro 21, 1581-1591.
31. Rimbach G, Saliou C, Canali R & Virgilli F (2001) Interaction between cultured endothelial cells and macrophages: in vitro model for studying flavonoids in redox-dependent gene expression. Methods Enzymol 335, 387-397.
32. Mashek DG & Grummer RR (2004) Effect of conjugated linoleic acid isomers on lipid metabolism and gluconeogenesis in monolayer cultures of bovine hepatocytes. J Dairy Sci 87, 67-72.
33. Papeleu P, Vanhaecke T, Henkens T, Elaut G, Vinken M, Snykers S & Rogiers V (2006) Isolation of rat hepatocytes. Methods Mol Biol 320, 229-237.
34. Rusu D, Loret S, Peulen O, Mainil J & Dandrifosse G (2005) Immunochemical, biomolecular and biochemical characterisation of bovine epithelial intestinal primocultures. BMC Cell Biol 6, 42-52.
35. Stevenson DJ, Morgan C, Goldie E, Connel G & Grant MH (2004) Cryopreservation of viable hepatocyte monolayers in cryoprotectant media with high serum content: Metabolism of testosterone and kaempherol post-cryopreservation. Cryobiology 49, 97-113.
36. Baten A, Sakamoto K & Shamsuddin AM (1992) Long term culture of normal human colonic epithelial cells in vitro. FASEB J 6, 2726-2734.
37. Richard L, Raulet E, Fabre G, Ferrini JB, Ourlin JC & Maurel P (2006) Human hepatocyte culture. Methods Mol Biol 320, 283-293.
38. Goldstein JL & Brown MS (1977) The low density lipoprotein pathway and its relation to atherosclerosis. Annu Rev Biochem 46, 897-930.
39. de Kanter R, Olinga P, de Jager MH, Merema MT, Meijer DKF & Groothius GMM (1999) Organ slices as an in vitro test system for drug metabolism in human liver, lung and kidney. Toxicol in Vitro 13 737-744.
40. Lerche-Langrand C & Toutain HJ (2000) Precsion-cut liver slices: characteristics and use for in vitro pharmaco-toxicology. Toxicology 153, 221-253.
41. Miller MG, Beyer J, Hall GL, De Graffenried IA & Adams PE (1993) Predictive value of liver slices for metabolism and toxicity in vivo use of acetaminophen as a model hepatotoxicant. Toxicol Appl Pharmacol 122, 108-116.
42. Prince RJ, Mistry H, Wield PT, Renwick AB, Beamand JA & Lake BG (1996) Comparison of the toxicity of allyl alcohol, coumarin and menadione in precision-cut rat, guinea-pig, cynomolgus monkey and human liver slices. Arch Toxicol 71, 107-111.
43. van de Bovenkamp M, Groothuis GMM, Draaisma AL, Merema MT, Bezuijen JI, Van Gils MJ, Meijer DKF, Friedman SL & Olinga P (2005) Precision-cut liver slices as a new model to study toxicity-induced hepatic stellate cell activation in a physiologic milieu. Toxicol Sci 85, 632-638.
44. Baumann P, Kerdar RS, Cramer P, Feser W, Blode H, Salomon A & Kuhnz W (1996) Use of rat and human liver slices for the detection of steroid hormone-induced DNA-adducts in vitro by means of the 32P-postlabelling technique. Pharmacol Toxicol 78, 214-223.
45. Lake BG, Beamand JA, Tredger JM, Barton PT, Renwick AB & Price RJ (1999) Inhibition of xenobiotic-induced genotoxicity in cultured precision-cut rat liver slices. Mutat Res 440 91-100.
46. Ekins S (1996) Past, present, and future applications of precision-cut liver slices for in vitro xenobiotic metabolism. Drug Metabol Rev 28, 591-623.
47. Meredith C, Scott MP, Renwick AB, Price RJ & Lake BG (2003) Studies on the induction of rat hepatic CYP1A, CYP2B, CYP3A and CYP4A subfamily form mRNAs in vivo and in vitro using precision-cut rat liver slices. Xenobiotica 33, 511-527.
48. Onderwater RC, Commandeur JN, Rooseboom M & Vermeulen NP (2005) Uptake-toxicity relationships of a series of N-substituted N'-(4-imidazole-ethyl)thiourea in precision-cut rat liver slices. Xenobiotica 35, 391-404.
49. Pfaff M, Powaga N, Akinci S, Schutz W, Banno Y, Wiegand S, Kummer W, Wess JJ & Haberberger RV (2005) Activation of the SPHK/SIP signalling pathway is coupled to muscarinic receptor-dependent regulation of peripheral airways. Respiratory Research 6, 48; available at http://respiratory-research.com/content/6/1/48.
50. Moronvalle-Halley V, Sacre-Salem B, Sallez V, Labbe G & Gautier JC (2005) Evaluation of cultured, precision-cut rat liver slices as a model. Toxicology 207, 203-214.
51. Kleinman HK, McGarvey ML, Hassall JR, Star VL, Cannon FB, Laurie GW & Martin GR (1986) Basement membrane complexes with biological activity. Biochemistry 25, 312-318.
52. VanHaecke T & Rogiers V (2006) Hepatocyte cultures in drug metabolism and toxicological research and testing. Methods Mol Biol 320 209-227.
53. Chua KN, Tang YN, Quej CH, Ramakrishna S, Leong KW & Mao HQA (2007) A dual-functional fibrous scaffold enhances P450 activity of cultured primary rat hepatocytes. Acta Biomater 3, 643-650.
54. Turner WS, Schmelzer E, McClelland R, Wauthier E, Chen W & Reid LM (2007) Human hepatoblast phenotype maintained by hyaluronan hydrogels. J Biomed Mater B 82, 1560-1168.
55. Huang H, Hanada S, Kojima N & Sakai Y (2006) Enhanced functional maturation of fetal porcine hepatocytes in three-dimensional polu-L-lactic acid scaffolds: A culture condition suitable for engineered Liver tissues in large-scale animal studies. Cell Transplant 15, 799-909.
56. Elkiyam T, Amitay-Shaprut S, Dvir-Ginsburg M, Harel T & Cohen, S (2006) Enhancing the drug metabolism of C3A - a human hepatocyte cell line - by tissue engineering within alginate scaffolds. Tissue Eng 12, 1357-1368.
57. Li J, Pan J, Zhang L, Guo X & Yu Y (2003) Culture of primary rat hepatocytes within porous chitosan scaffolds. J Biomed Mater Res A 67, 938-943.
58. Semino CE, Merok JR, Crane GG, Panagiotakos G & Zhang S (2003) Functional differentiation of hepatocyte-like spheroid structures from putative liver progenitor cells in three-dimensional peptide scaffolds. Differentiation 71, 262-270.
59. Beckstead BL, Santosa DM & Giachelli CM (2006) Mimicking cell-cell interactions at the biomaterial-cell interface for control of stem cell differentiation. J Biomed Mater Res A 79, 94-103.
60. Mei Y, Goldberg M & Anderson D (2007) The development of high-throughput screening approaches for stem cell engineering. Curr Opin Chem Biol Aug 14 (Epub ahead of print).
61. Öbrink KJ & Rehbinde C (1993) The defined animal. Scand J Lab Anim Sci 20, 5-9.
62. Meyer O & Svendsen O (2003) Animal models in pharmacology and toxicology. In Handbook of Laboratory Animal Science, (volume II), 2nd ed., pp. 11-39 [J Han and GL van HoosierJr, editors). CRC Press LLC.
63. Coffey DS & Isaacs JT (1980) Requirements for an idealized animal model in prostatic cancer. In Models for Prostate Cancer, pp. 379-391 [GP Murphy, editor]. New York: Alan R Liss.
64. Mutch DM, Wahli W & Williamson G (2005) Nutrigenomics and nutrigenetics: the emerging faces of nutrition. FASEB J 19, 1602-1616.
65. Wessler S (1976) Introduction: What is a Model? In: Animal Models of Thrombosis and Hemorrhagic Diseases, xi-xvi. Bethesda, Md: National Institutes of Health.
66. Moser AR, Pitot HC & Dove WF (1989) A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 247, 322-324.
67. Goldstein JL, Kita T & Brown MS (1983) Defective lipoprotein receptor and atherosclerosis. Lesson from an animal counterpart of familial hypercholesterolemia. N Engl J Med 309, 288-296.
68. Muller WJ, Sim E, Pattengale PK, Wallace R & Leder P (1988) Single-step induction of mammary adenocarcinoma in transgenic mice bearing activated c-neu oncogene. Cell 54, 105-115.
69. Grum-Schwesen B, Klingeholhofer J, Berg CH, El-Naaman C, Grigorian M, Lukanidin E & Ambartsumian N (2005) Suppression of tumour development and metastasis formation in mice lacking the S100A4(mts1) gene. Cancer Res 65, 3772-3780.
70. Hau J, Andersen LLI, Rye Nielsen B & Poulsen OM (1989) Laboratory animal models. Scand J Lab Anim Sci 16, Suppl. 1, 7-9.
71. Thomsen AR, Almstrup K, Nielsen JE, Sørensen IK, Petersen OW, Leffers H & Breinholt VM (2006) Estrogenic effect of soy isoflavones on mammary gland morphogenesis and gene expression profile. Toxicol Sci 93 357-357.
72. Lund CO, Mortensen A, Nilas L, Breinholt VM, Larsen J-J & Ottesen B (2007) Estrogen and phytoestrogens: Effect on eNOS expression and in vivo vasodilation in cerebral arteries in ovariectomized Watanabe heritable hyperlipidemic rabbits. Eur J Obstet Gynecol Reprod Biol 130, 84-92.
73. Min mice. Nutr Cancer 45 203-210.
74. Min mice. Cancer Lett 130, 217-225.
75. Mukhopathyay S, Ballard BR, Mukherjee S, Kabir SM & Das SK (2006) Beneficial effects of soy protein in the initiation and progression against dimethylbenz [a] anthracene-induced breast tumors in female rats. Mol Cell Biochem 290, 169-176.
76. Day JK, Besch-Williford C, McMann TR, Hufford MG, Lubahn DB & MacDonald RS (2001) Dietary genistein increased DMBA-induced mammary adenocarcinoma in wild-type, but not ER alpha KO, mice. Nutr Res 39, 226-232.
77. Rowlands JC, HeL, Hakkak R, Ronis MJ & Badger TM (2001) Soy and whey proteins downregulate DMBA-induced liver and mammary gland CYP1 expression in female rats. J Nutr 131, 3281-3287.
78. Thomsen AR, Mortensen A, Breinholt VM, Lindecrona RH, Penalvo JL & Sorensen IK (2005) Influence of Prevastein, an isoflavone-rich soy product, on mammary gland development and tumorigenesis in Tg.NK (MMTV/ c-neu) mice. Nutr Cancer 52, 176-188.
79. Freircich EJ, Gehan EA, Rall DP, Schmidt LH & Skipper HE (1966) Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man. Cancer Chemother Rep 50, 219-244.
80. Hau I & Poulsen OM (1988) Doses of laboratory animals based on metabolic rate. Scand J Lab Anim Sci 15, 81-83.
81. Rao GN (1988) Rodent diets for carcinogenesis studies. J Nutr 118, 929-931.
82. Thigpen JE, Li L-A, Richter CB, Lebetkin EH & Jameson CW (1987) The mouse bioassay for detection of estrogenic activity in rodent diets: II.Comparative estrogenic activity of purified, certified and standard open and closed formula rodent diets. Lab Anim Sci 37, 602-605.
83. Degen GH, Janning P, Diel P & Bolt HM (2002) Estrogenic isoflavones in rodent diets. Tax Letters 128, 145-157.
84. Ritskes Hoitinga M (2001) The need for defined diets and refined feeding methods. Scand J Anim Sci 28, 51-54.
85. Hausner EA, Schlingmann KL, Chen WH, Gillies PG, Kieras CJ, Ross PE & van Pelt CS (1995) Hepaticand adrenal changes in rabbits associated with hyperlipidemia caused by a semi-synthetic diet. Lab Anim Sci 45 663-670.
86. Frederiksen H, Mortensen A, Schrøder M, Frandsen H, Bysted A, Knuthsen P & Rasmussen S (2067) Effects of red grape skin and seed extraxt supplementation on atherosclerosis in Watanabe heritable hyperlilidemic rabbits. Mol Nutr Food Res 51, 564-571.
87. Rao GN & Knapka JJ (1987) Contaminant and nutrient concentrations of natural ingredient rat and mouse diet used in chemical toxicology studies. Fund Appl Toxicol 9, 329-338,
88. Saarinen NM, Bingham C, Lorenzetti S, Mortensen A, et, al. (2006) Tools to evaluate estrogenic potency of dietary phytoestrogens: A consensus paper from the EU Thematic Network "Phyohealth" (QLKI-2002-2453). Genes Nutr 3/4, 143-158.
89. Luijten M, Thomsen AR, van den Berg JAH, Wester PW, Verhoef A, Nagelkerke NJD, Adlercreutz H, van Kranen HJ, Piersma AH, Sørensen IK, Rao GN & van Kreijl CF (2004) Effects of soy-derived isoflavones and a high-fat diet on spontaneous mammary tumor development in Tg.NK (MMTV/c-neu) mice. Nutr Cancer 50, 46-54.
90. Naumann E, van Rees AB, Önning G, Öste R, Wydra M & Mensink RP (2006) Beta-glucan incorporated into a fruit drink effectively lowers serum LDL-cholesterol concentrations. Am J Clin Nutr 83, 601-605.
91. Covas M-I, Nyyssönen K, Poulsen HE, EUROLIVE Study Group, et al (2006) The effect of polyphenols in olive oil on heart disease risk factors: A randomized trial. Ann Intern Med 145, 333-341.
92. Valentová K, Stejskal D, Bednár P, Vostálová J, Číhalík Č, Večerová R, Koukalová D, Kolár M, Reichenvach R, Škňourilová L, Ulrichová J & Šimánek V (2007) Biosafety, antioxidants status and metabolites in urine after consumption of dried cranberiy juice in healthy women: A, pilot double-blind placebo-controlled trial. J Agric Food Chem 55, 3217-3224.
93. John JH, Ziebland S, Yudkin P, Roe LS, Neil H & Oxford Fruit and Vegetable Study Group (2002) Effects of fruit and vegetable consumption on plasma antioxidant concentrations and blood pressure: A randomised controlled trial. Lancet 359, 1969-1974.
94. Watzl B, Girrbach S & Roller M (2005) Inulin, oligofructose and immunomodulation. Br J Nutr 93, Suppl. 1, S49-S55.
95. Estruch R, Martinez-Gonzales MA, Corella D, et al. (2006) PREDIMED study investigators. Effects of a Mediterranean- style diet on cardiovascular risk factors: A randomized trial Ann Intern Med 145, 1-111.
96. Beresford SAA, Johnson KC, Ritenbaugh C, et al. (2006) Low-fat dietary pattern and risk of colorectal cancer: The Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA 295, 643-654.
97. Baumann KH, Hessel F, Larass I, Müller T, Angerer P, Kielf R & von Schacky C (1999) Dietary omega-3, omega-6, and omega-9 unsaturated fatty acids and growth factor and cytokine gene expression in unstimulated and stimulated monocytes. A randomized volunteer study. Arterioscler Thromb Vasc Biol 19, 59-66.
98. Mullen A, Moloney F, Nugent AP, Doyle L, Cashman KD & Roche HM (2007) Conjugated linoleic acid supplementation reduces peripheral blood mononuclear cell interleukin-2 production in healthy middle-aged males. J Nutr Biochem, Mar 16; (Epub ahead of print).
99. Kovar J, Suchanek P, Hubacek JA & Poledne R (2004) The A-204C polymorphism in the cholesterol 7alpha-hydroxylase (CYP7A1) gene determines the cholesterolemia responsiveness to a high-fat diet. Physiol Res 53, 565-568.
100. Prynne CJ, Mishra GD, O'Connell MA, Muniz G, Laskey MA, Yan L, Prentice A & Ginty F (2006) Fruit and vegetable intakes and bone mineral status: a cross sectional study in 5 age and sca cohorts. Am J Clin Nutr 83, 1420-1428.
101. Coyne T, Ibiebele TI, Baade PD, Dobson A, McClintock C, Dunn S, Leonard D & Shaw J (2005) Diabetes mellitus and serum caroteroids: Findings of a population-based study in Queensland, Australia. Am J Clin Nutr 82, 685-693.
102. Pavia M, Pileggi C, Nobile CGA & Angelillo IF (2006) Association between fruit and vegetable consumption and oral cancer: A meta-analysis of observational studies. Am J Clin Nutr 83, 1126-1134.