Asian plantain (Plantago asiatica) essential oils suppress 3-hydroxy-3-methylglutaryl-co-enzyme A reductase expression in vitro and in vivo and show hypocholesterolaemic properties in mice

British Journal of Nutrition

Volumn 99, Issue 1, 2008, Pages 67-75

  Chung, Mi Ja ^a   Woo Park, Kuen ^a   Heon Kim, Kyoung ^a   Kim, Cheong Tae ^b   Pill Baek, Jun ^a   Bang, Kyong Hwan ^c   Choi, Young Mi ^a   Lee, Sung Joon ^a  

^a Korea University   (South Korea)

^b Nong Shim Co   (South Korea)

^c National Institute of Crop Science   (South Korea)

Author keywords

3 Hydroxy 3 methyl glutaryl co enzyme A reductase; Cholesterol; Essential oils; Low density lipoprotein receptor; Plantago asiatica; Triacylglycerols

Indexed keywords

ALPHA PHELLANDRENE; ANETHOLE; BENZYL ALCOHOL; BETA PINENE; BICYCLOGERMACRENE; BORNEOL; CARVACROL; CARVEOL; CARYOPHYLLENE; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; CITRAL; CITRONELLAL; DODECANE; EPOXYLINALOOL; ESSENTIAL OIL; EUGENOL; GERANYL ACETATE; GERMACRENE D; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; JASMONE; LIMONENE; LINALOOL; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; SABINENE; TERPENE DERIVATIVE; TERPINEOL; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; ASIAN; C57BL 6 MOUSE; CELL STRAIN HEPG2; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENZYME INHIBITION; FOOD COMPOSITION; GAS CHROMATOGRAPHY; HEART PROTECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; LIPID OXIDATION; LIVER; MASS SPECTROMETRY; MOUSE; NONHUMAN; PLANTAGO; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CHOLESTEROL; CHOLESTEROL 7-ALPHA-HYDROXYLASE; DEPRESSION, CHEMICAL; GENE EXPRESSION; HYDROXYMETHYLGLUTARYL COA REDUCTASES; LIPID METABOLISM; LIVER; MICE; MICE, INBRED C57BL; OILS, VOLATILE; PLANT EXTRACTS; PLANTAGO; RECEPTORS, LDL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

MUS; PLANTAGO ASIATICA;

EID: 37349057813     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114507798926     Document Type: Article

References (32)

1. Hu FB & Willett WC (2002) Optimal diets for prevention of coronary heart disease. JAMA 288, 2569-2578.
2. Sprecher DL (1998) Triglycerides as a risk factor for coronary artery disease. Am J Cardiol 82, 49U-56U, discussion; 85U-86U.
3. Werner RM & Pearson TA (1998) LDL-cholesterol: A risk factor for coronary artery disease - from epidemiology to clinical trials. Can J Cardiol 14, Suppl. B, 3B-10B.
4. Cullen P (2000) Evidence that triglycerides are an independent coronary heart disease risk factor. Am J Cardiol 86, 943-949.
5. Regnstrom J, Nilsson J, Tornvall P, Landou C & Hamsten A (1992) Susceptibility to low-density lipoprotein oxidation and coronary atherosclerosis in man. Lancet 339, 1183-1186.
6. Reaven PD (1994) Mechanisms of atherosclerosis: Role of LDL oxidation. Adv Exp Med Biol 366, 113-128.
7. Wilt TJ, Bloomfield HE, MacDonald R, Nelson D, Rutks I, Ho M, Larsen G, McCall A, Pineros S & Sales A (2004) Effectiveness of statin therapy in adults with coronary heart disease. Arch Intern Med 164, 1427-1436.
8. Tucker KL (2004) Dietary intake and coronary heart disease: A variety of nutrients and phytochemicals are important. Curr Treat Options Cardiovasc Med 6, 291-302.
9. Vasu VT, Hiren M, Thaikoottathil JV & Gupta S (2005) Hypolipideamic and antioxidant effect of Enicostemma littorale Blume aqueous extract in cholesterol fed rats. J Ethnopharmacol 101, 277-282.
10. Chu YF & Liu RH (2005) Cranberries inhibit LDL oxidation and induce LDL receptor expression in hepatocytes. Life Sci 77, 1892-1901.
11. Foresti R, Hoque M, Monti D, Green CJ & Motterlini R (2005) Differential activation of heme oxygenase-1 by chalcones and rosolic acid in endothelial cells. J Pharmacol Exp Ther 312, 686-693.
12. Alcaraz MJ, Fernandez P & Guillen MI (2003) Anti-inflammatory actions of the heme oxygenase-1 pathway. Curr Pharm Des 9, 2541-2551.
13. Fang J, Akaike T & Maeda H (2004) Antiapoptotic role of heme oxygenase (HO) and the potential of HO as a target in anticancer treatment. Apoptosis 9, 27-35.
14. Balla J, Vercellotti GM, Jeney V, Yachie A, Varga Z, Eaton JW & Balla G (2005) Heme, heme oxygenase and ferritin in vascular endothelial cell injury. Mol Nutr Food Res 49, 1030-1043.
15. Chiang LC, Chiang W, Chang MY & Lin CC (2003) In vitro cytotoxic, antiviral and immunomodulatory effects of Plantago major and Plantago asiatica. Am J Chin Med 31, 225-234.
16. Berrougui H, Cloutier M, Isabelle M & Khalil A (2006) Phenolic-extract from argan oil (Argania spinosa L.) inhibits human low-density lipoprotein. (LDL) oxidation and enhances cholesterol efflux from human THP-1 macrophages. Atherosclerosis 184, 389-396.
17. Clegg RJ, Middleton B, Bell GD & White DA (1982) The mechanism of cyclic monoterpene inhibition of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase in vivo in the rat. J Biol Chem 257, 2294-2299.
18. von Bergmann K, Beck A, Engel C & Leiss O (1987) Administration of a terpene mixture inhibits cholesterol nucleation in bile from patients with cholesterol gallstones. Klin Wochenschr 65, 458-462.
19. Lee S, Moye L, Campos H, Williams G & Sacks F (2003) Hypertriglyceridemia but not diabetes status is associated with VLDL containing apolipoprotein CIII in patients with coronary heart disease. Atherosclerosis 167, 293-302.
20. Andreou E & Prokipcak R (1998) Analysis of human CYP7A1 mRNA decay in HepG2 cells by reverse transcription-polymerase chain reaction. Arch Biochem Biophys 357, 137-146.
21. Hasumi M, Suzuki K, Matsui H, Koike H, Ito K & Yamanaka H (2003) Regulation of metallothionein and zinc transporter expression in human prostate cancer cells and tissues. Cancer Lett 200, 187-195.
22. Hanaka S, Abe T, Itakura H & Matsumoto A (2000) Gene expression related to cholesterol metabolism in mouse brain during development. Brain Dev 22, 321-326.
23. Han SH, Chung MJ, Lee SJ & Rhee C (2006) Digestion-resistant fraction from soybean Glycine max (L.) Merrill] induces hepatic LDL recepto r and CYP7A1 expression in apolipoprotein E-deficient mice. J Nutr Biochem 17, 682-688.
24. Wood I, Hunter H & Trayhurn P (2003) Expression of class III facilitative glucose transporter genes (GLUT-10 and GLUT-12) in mouse and human adipose tissues. Biochem Biophys Res Commun 308, 43-49.
25. Witztum JL (1994) The oxidation hypothesis of atherosclerosis. Lancet 344, 793-795.
26. Naderi G, Asgary S, Ani M, Sarraf-Zadegan N & Safari M (2004) Effect of some volatile oils on the affinity of intact and oxidized low-density lipoproteins for adrenal cell surface receptors. Mol Cell Biochem 267, 59-66.
27. Brown MS & Goldstein JL (1985) Scavenger cell receptor shared. Nature 316, 680-681.
28. Cooper AD (1997) Bile salt biosynthesis: An alternate synthetic pathway joins the mainstream. Gastroenterology 113, 2005-2008.
29. Smith J, Osborne T, Brown M, Goldstein J & Gil G (1988) Multiple sterol regulatory elements in promoter for hamster 3-hydroxy-3-methylglutaryl-coenzyme A synthase. J Biol Chem 263 18480-18487.
30. Smith J, Osborne T, Goldstein J & Brown M (1990) Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene. J Biol Chem 265, 2306-2310.
31. Clarke CF, Fogelman AM & Edwards PA (1985) Transcriptional regulation of the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene in rat liver. J Biol Chem 260, 14363-14367.
32. Molowa DT & Cimis GM (1989) Co-ordinate regulation of low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-CoA reductase and synthase gene expression in HepG2 cells. Biochem J 260, 731-736.