-
1
-
-
0021019927
-
Phosphorylation pattern of a 25 Kdalton stress protein from rat myoblasts
-
Kim, Y. J., J. Shuman, M. Sette & A. Przybyla: Phosphorylation pattern of a 25 Kdalton stress protein from rat myoblasts. Biochem Biophys Res Commun, 117, 682-7 (1983) (Pubitemid 14185028)
-
(1983)
Biochemical and Biophysical Research Communications
, vol.117
, Issue.3
, pp. 682-687
-
-
Kim, Y.J.1
Shuman, J.2
Sette, M.3
Przybyla, A.4
-
2
-
-
0021908896
-
Phorbol ester, calcium ionophore, or serum added to quiescent rat embryo fibroblast cells all result in the elevated phosphorylation of two 28,000-dalton mammalian stress proteins
-
Welch, W. J.: Phorbol ester, calcium ionophore, or serum added to quiescent rat embryo fibroblast cells all result in the elevated phosphorylation of two 28, 000-dalton mammalian stress proteins. J Biol Chem, 260, 3058-62 (1985) (Pubitemid 15139344)
-
(1985)
Journal of Biological Chemistry
, vol.260
, Issue.5
, pp. 3058-3062
-
-
Welch, W.J.1
-
3
-
-
0026342759
-
Identification of the phosphorylation sites of the murine small heat shock protein hsp25
-
Gaestel, M., W. Schroder, R. Benndorf, C. Lippmann, K. Buchner, F. Hucho, V. A. Erdmann & H. Bielka: Identification of the phosphorylation sites of the murine small heat shock protein hsp25. J Biol Chem, 266, 14721-4. (1991) (Pubitemid 21907563)
-
(1991)
Journal of Biological Chemistry
, vol.266
, Issue.22
, pp. 14721-14724
-
-
Gaestel, M.1
Schroder, W.2
Benndorf, R.3
Lippmann, C.4
Buchner, K.5
Hucho, F.6
Erdmann, V.A.7
Bielka, H.8
-
4
-
-
0027118212
-
Cell-free phosphorylation of the murine small heat-shock protein hsp25 by an endogenous kinase from Ehrlich ascites tumor cells
-
Benndorf, R., K. Hayess, J. Stahl & H. Bielka: Cell-free phosphorylation of the murine small heat-shock protein hsp25 by an endogenous kinase from Ehrlich ascites tumor cells. Biochim Biophys Acta, 1136, 203-7 (1992)
-
(1992)
Biochim Biophys Acta
, vol.1136
, pp. 203-207
-
-
Benndorf, R.1
Hayess, K.2
Stahl, J.3
Bielka, H.4
-
5
-
-
0027400129
-
Transient activation of a distinct serine protein kinase is responsible for 27-kDa heat shock protein phosphorylation in mitogen-stimulated and heat- shocked cells
-
Zhou, M., H. Lambert & J. Landry: Transient activation of a distinct serine protein kinase is responsible for 27-kDa heat shock protein phosphorylation in mitogen-stimulated and heat-shocked cells. J Biol Chem, 268, 35-43 (1993) (Pubitemid 23021282)
-
(1993)
Journal of Biological Chemistry
, vol.268
, Issue.1
, pp. 35-43
-
-
Zhou, M.1
Lambert, H.2
Landry, J.3
-
6
-
-
0024516567
-
Molecular cloning, sequencing and expression of Escherichia coli of the 25-kDa growth-related protein of Ehrlich ascites tumor and its homology to mammalian stress proteins
-
DOI 10.1111/j.1432-1033.1989.tb14542.x
-
Gaestel, M., B. Gross, R. Benndorf, M. Strauss, W. H. Schunk, R. Kraft, A. Otto, H. Bohm, J. Stahl, H. Drabsch & et al.: Molecular cloning, sequencing and expression in Escherichia coli of the 25-kDa growth-related protein of Ehrlich ascites tumor and its homology to mammalian stress proteins. Eur J Biochem, 179, 209-13. (1989) (Pubitemid 19097678)
-
(1989)
European Journal of Biochemistry
, vol.179
, Issue.1
, pp. 209-213
-
-
Gaestel, M.1
Gross, B.2
Benndorf, R.3
Strauss, M.4
Schunk, W.-H.5
Kraft, R.6
Otto, A.7
Bohm, H.8
Stahl, J.9
Drabsch, H.10
Bielka, H.11
-
7
-
-
0026733636
-
MAPKAP kinase-2; A novel protein kinase activated by mitogen-activated protein kinase
-
Stokoe, D., D. G. Campbell, S. Nakielny, H. Hidaka, S. J. Leevers, C. Marshall & P. Cohen: MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase. Embo J, 11, 3985-94. (1992)
-
(1992)
Embo J
, vol.11
, pp. 3985-3994
-
-
Stokoe, D.1
Campbell, D.G.2
Nakielny, S.3
Hidaka, H.4
Leevers, S.J.5
Marshall, C.6
Cohen, P.7
-
8
-
-
0026457201
-
Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins
-
Stokoe, D., K. Engel, D. G. Campbell, P. Cohen & M. Gaestel: Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins. FEBS Lett, 313, 307-13. (1992)
-
(1992)
FEBS Lett
, vol.313
, pp. 307-313
-
-
Stokoe, D.1
Engel, K.2
Campbell, D.G.3
Cohen, P.4
Gaestel, M.5
-
9
-
-
0027454318
-
The MAP kinase-activated protein kinase 2 contains a proline-rich SH3-binding domain
-
DOI 10.1016/0014-5793(93)81628-D
-
Engel, K., K. Plath & M. Gaestel: The MAP kinaseactivated protein kinase 2 contains a proline-rich SH3-binding domain. FEBS Lett, 336, 143-7. (1993) (Pubitemid 23362022)
-
(1993)
FEBS Letters
, vol.336
, Issue.1
, pp. 143-147
-
-
Engel, K.1
Plath, K.2
Gaestel, M.3
-
10
-
-
0027739284
-
The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2
-
Stokoe, D., B. Caudwell, P. T. Cohen & P. Cohen: The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2. Biochem J, 296, 843-9. (1993) (Pubitemid 24008205)
-
(1993)
Biochemical Journal
, vol.296
, Issue.3
, pp. 843-849
-
-
Stokoe, D.1
Caudwell, B.2
Cohen, P.T.W.3
Cohen, P.4
-
11
-
-
0028015872
-
Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27
-
DOI 10.1016/0092-8674(94)90278-X
-
Freshney, N. W., L. Rawlinson, F. Guesdon, E. Jones, S. Cowley, J. Hsuan & J. Saklatvala: Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell, 78, 1039-49. (1994) (Pubitemid 24292331)
-
(1994)
Cell
, vol.78
, Issue.6
, pp. 1039-1049
-
-
Freshney, N.W.1
Rawlinson, L.2
Guesdon, F.3
Jones, E.4
Cowley, S.5
Hsuan, J.6
Saklatvala, J.7
-
12
-
-
0028022750
-
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
-
DOI 10.1016/0092-8674(94)90277-1
-
Rouse, J., P. Cohen, S. Trigon, M. Morange, A. Alonso-Llamazares, D. Zamanillo, T. Hunt & A. R. Nebreda: A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell, 78, 1027-37. (1994) (Pubitemid 24292330)
-
(1994)
Cell
, vol.78
, Issue.6
, pp. 1027-1037
-
-
Rouse, J.1
Cohen, P.2
Trigon, S.3
Morange, M.4
Alonso-Llamazares, A.5
Zamanillo, D.6
Hunt, T.7
Nebreda, A.R.8
-
13
-
-
0027936755
-
A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
-
Han, J., J. D. Lee, L. Bibbs & R. J. Ulevitch: A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science, 265, 808-11. (1994) (Pubitemid 24266145)
-
(1994)
Science
, vol.265
, Issue.5173
, pp. 808-811
-
-
Man, J.1
Lee, J.-D.2
Bibbs, L.3
Ulevitch, R.J.4
-
14
-
-
0029923193
-
Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase
-
DOI 10.1074/jbc.271.14.8488
-
McLaughlin, M. M., S. Kumar, P. C. McDonnell, S. Van Horn, J. C. Lee, G. P. Livi & P. R. Young: Identification of mitogen-activated protein (MAP) kinaseactivated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. J Biol Chem, 271, 8488-92. (1996) (Pubitemid 26108688)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.14
, pp. 8488-8492
-
-
McLaughlin, M.M.1
Kumar, S.2
McDonnell, P.C.3
Van Horn, S.4
Lee, J.C.5
Livi, G.P.6
Young, P.R.7
-
15
-
-
9044220225
-
3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region
-
Sithanandam, G., F. Latif, F. M. Duh, R. Bernal, U. Smola, H. Li, I. Kuzmin, V. Wixler, L. Geil & S. Shrestha: 3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region. Mol Cell Biol, 16, 868-76. (1996) (Pubitemid 26061656)
-
(1996)
Molecular and Cellular Biology
, vol.16
, Issue.3
, pp. 868-876
-
-
Sithanandam, G.1
Latif, F.2
Duh, F.-M.3
Bernal, R.4
Smola, U.5
Li, H.6
Kuzmin, I.7
Wixler, V.8
Geil, L.9
Shrestha, S.10
Lloyd, P.A.11
Bader, S.12
Sekido, Y.13
Tartof, K.D.14
Kashuba, V.I.15
Zabarovsky, E.R.16
Dean, M.17
Klein, G.18
Lerman, M.I.19
Minna, J.D.20
Rapp, U.R.21
Allikmets, R.22
more..
-
16
-
-
0032526694
-
PRAK, a novel protein kinase regulated by the p38 MAP kinase
-
DOI 10.1093/emboj/17.12.3372
-
New, L., Y. Jiang, M. Zhao, K. Liu, W. Zhu, L. J. Flood, Y. Kato, G. C. Parry & J. Han: PRAK, a novel protein kinase regulated by the p38 MAP kinase. Embo J, 17, 3372-84. (1998) (Pubitemid 28279511)
-
(1998)
EMBO Journal
, vol.17
, Issue.12
, pp. 3372-3384
-
-
New, L.1
Jiang, Y.2
Zhao, M.3
Liu, K.4
Zhu, W.5
Flood, L.J.6
Kato, Y.7
Parry, G.C.N.8
Han, J.9
-
17
-
-
0032512546
-
MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extracellular-regulated kinase (ERK) and p38 kinase
-
DOI 10.1006/bbrc.1998.8135
-
Ni, H., X. S. Wang, K. Diener & Z. Yao: MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extracellularregulated kinase (ERK) and p38 kinase. Biochem Biophys Res Commun, 243, 492-6. (1998) (Pubitemid 28414052)
-
(1998)
Biochemical and Biophysical Research Communications
, vol.243
, Issue.2
, pp. 492-496
-
-
Ni, H.1
Wang, X.S.2
Diener, K.3
Yao, Z.4
-
18
-
-
10744224857
-
Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination
-
DOI 10.1128/MCB.23.21.7732-7741.2003
-
Shi, Y., A. Kotlyarov, K. Laaß, A. D. Gruber, E. Butt, K. Marcus, H. E. Meyer, A. Friedrich, H. D. Volk & M. Gaestel: Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination. Mol Cell Biol, 23, 7732-41. (2003) (Pubitemid 37271471)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.21
, pp. 7732-7741
-
-
Shi, Y.1
Kotlyarov, A.2
Laass, K.3
Gruber, A.D.4
Butt, E.5
Marcus, K.6
Meyer, H.E.7
Friedrich, A.8
Volk, H.-D.9
Gaestel, M.10
-
19
-
-
11244276988
-
Scaffolding by ERK3 regulates MK5 in development
-
Epub 2004 Nov 11
-
Schumacher, S., K. Laass, S. Kant, Y. Shi, A. Visel, A. D. Gruber, A. Kotlyarov & M. Gaestel: Scaffolding by ERK3 regulates MK5 in development. Embo J, 23, 4770-4779. Epub 2004 Nov 11. (2004)
-
(2004)
Embo J
, vol.23
, pp. 4770-4770
-
-
Schumacher, S.1
Laass, K.2
Kant, S.3
Shi, Y.4
Visel, A.5
Gruber, A.D.6
Kotlyarov, A.7
Gaestel, M.8
-
20
-
-
19944429022
-
Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway
-
Epub 2004 Dec 2
-
Seternes, O. M., T. Mikalsen, B. Johansen, E. Michaelsen, C. G. Armstrong, N. A. Morrice, B. Turgeon, S. Meloche, U. Moens & S. M. Keyse: Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway. Embo J, 23, 4780-91. Epub 2004 Dec 2. (2004)
-
(2004)
Embo J
, vol.23
, pp. 4780-4780
-
-
Seternes, O.M.1
Mikalsen, T.2
Johansen, B.3
Michaelsen, E.4
Armstrong, C.G.5
Morrice, N.A.6
Turgeon, B.7
Meloche, S.8
Moens, U.9
Keyse, S.M.10
-
21
-
-
0031195041
-
Identification of MAPKAPK homolog (MAPKAPK-4) as a myosin II regulatory light-chain kinase in sea urchin egg extracts
-
DOI 10.1006/abbi.1997.9966
-
Komatsu, S., N. Murai, G. Totsukawa, M. Abe, K. Akasaka, H. Shimada & H. Hosoya: Identification of MAPKAPK homolog (MAPKAPK-4) as a myosin II regulatory light-chain kinase in sea urchin egg extracts. Arch Biochem Biophys, 343, 55-62. (1997) (Pubitemid 27274342)
-
(1997)
Archives of Biochemistry and Biophysics
, vol.343
, Issue.1
, pp. 55-62
-
-
Komatsu, S.1
Murai, N.2
Totsukawa, G.3
Mari, A.4
Akasaka, K.5
Shimada, H.6
Hosoya, H.7
-
22
-
-
33244471768
-
MAPKAP kinases - MKs - Two's company, three's a crowd
-
DOI 10.1038/nrm1834, PII NRM1834
-
Gaestel, M.: MAPKAP kinases-MKs-two's company, three's a crowd. Nat Rev Mol Cell Biol., 7, 120-30. (2006) (Pubitemid 43278295)
-
(2006)
Nature Reviews Molecular Cell Biology
, vol.7
, Issue.2
, pp. 120-130
-
-
Gaestel, M.1
-
23
-
-
33845807361
-
The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK
-
DOI 10.1128/MCB.01456-06
-
Ronkina, N., A. Kotlyarov, O. Dittrich-Breiholz, M. Kracht, E. Hitti, K. Milarski, R. Askew, S. Marusic, L. L. Lin, M. Gaestel & J. B. Telliez: The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK. Mol Cell Biol, 27, 170-81 (2007) (Pubitemid 46013242)
-
(2007)
Molecular and Cellular Biology
, vol.27
, Issue.1
, pp. 170-181
-
-
Ronkina, N.1
Kotlyarov, A.2
Dittrich-Breiholz, O.3
Kracht, M.4
Hitti, E.5
Milarski, K.6
Askew, R.7
Marusic, S.8
Lin, L.-L.9
Gaestel, M.10
Telliez, J.-B.11
-
24
-
-
0030045453
-
Identification of anisomycin-activated kinases p45 and p55 in murine cells as MAPKAP kinase-2
-
Cano, E., Y. N. Doza, R. Ben-Levy, P. Cohen & L. C. Mahadevan: Identification of anisomycin-activated kinases p45 and p55 in murine cells as MAPKAP kinase-2. Oncogene, 12, 805-12. (1996) (Pubitemid 26072267)
-
(1996)
Oncogene
, vol.12
, Issue.4
, pp. 805-812
-
-
Cano, E.1
Doza, Y.N.2
Ben-Levy, R.3
Cohen, P.4
Mahadevan, L.C.5
-
25
-
-
0034705080
-
Two distinct forms of MAPKAP kinase-2 in adult cardiac ventricular myocytes
-
DOI 10.1021/bi9928389
-
Chevalier, D. & B. G. Allen: Two distinct forms of MAPKAP kinase-2 in adult cardiac ventricular myocytes. Biochemistry, 39, 6145-56. (2000) (Pubitemid 30327090)
-
(2000)
Biochemistry
, vol.39
, Issue.20
, pp. 6145-6156
-
-
Chevalier, D.1
Allen, B.G.2
-
26
-
-
0033145354
-
MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis
-
Kotlyarov, A., A. Neininger, C. Schubert, R. Eckert, C. Birchmeier, H. D. Volk & M. Gaestel: MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis. Nat Cell Biol, 1, 94-7. (1999) (Pubitemid 129501950)
-
(1999)
Nature Cell Biology
, vol.1
, Issue.2
, pp. 94-97
-
-
Kotlyarov, A.1
Neininger, A.2
Schubert, C.3
Eckert, R.4
Birchmeier, C.5
Volk, H.-D.6
Gaestel, M.7
-
27
-
-
0028297257
-
The primary structure of a human MAP kinase activated protein kinase 2
-
DOI 10.1006/bbrc.1994.1566
-
Zu, Y. L., F. Wu, A. Gilchrist, Y. Ai, M. E. Labadia & C. K. Huang: The primary structure of a human MAP kinase activated protein kinase 2. Biochem Biophys Res Commun, 200, 1118-24. (1994) (Pubitemid 24146078)
-
(1994)
Biochemical and Biophysical Research Communications
, vol.200
, Issue.2
, pp. 1118-1124
-
-
Zu, Y.L.1
Wu, F.Y.2
Gilchrist, A.3
Ai, Y.X.4
Labadia, M.E.5
Huang, C.K.6
-
28
-
-
0028129125
-
Characterization of the proline-rich region of mouse MAPKAP kinase 2: Influence on catalytic properties and binding to the c-abl SH3 domain in vitro
-
Plath, K., K. Engel, G. Schwedersky & M. Gaestel: Characterization of the proline-rich region of mouse MAPKAP kinase 2: influence on catalytic properties and binding to the c-abl SH3 domain in vitro. Biochem Biophys Res Commun, 203, 1188-94. (1994)
-
(1994)
Biochem Biophys Res Commun
, vol.203
, pp. 1188-1194
-
-
Plath, K.1
Engel, K.2
Schwedersky, G.3
Gaestel, M.4
-
29
-
-
0028875318
-
Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif
-
Engel, K., H. Schultz, F. Martin, A. Kotlyarov, K. Plath, M. Hahn, U. Heinemann & M. Gaestel: Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif. J Biol Chem, 270, 27213-21. (1995)
-
(1995)
J Biol Chem
, vol.270
, pp. 27213-27221
-
-
Engel, K.1
Schultz, H.2
Martin, F.3
Kotlyarov, A.4
Plath, K.5
Hahn, M.6
Heinemann, U.7
Gaestel, M.8
-
30
-
-
0032526988
-
Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation
-
DOI 10.1093/emboj/17.12.3363
-
Engel, K., A. Kotlyarov & M. Gaestel: Leptomycin Bsensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation. Embo J, 17, 3363-71 (1998) (Pubitemid 28279510)
-
(1998)
EMBO Journal
, vol.17
, Issue.12
, pp. 3363-3371
-
-
Engel, K.1
Kotlyarov, A.2
Gaestel, M.3
-
31
-
-
0032563807
-
Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2
-
Ben-Levy, R., S. Hooper, R. Wilson, H. F. Paterson & C. J. Marshall: Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2. Curr Biol, 8, 1049-57 (1998) (Pubitemid 28451029)
-
(1998)
Current Biology
, vol.8
, Issue.19
, pp. 1049-1057
-
-
Ben-Levy, R.1
Hooper, S.2
Wilson, R.3
Paterson, H.F.4
Marshall, C.J.5
-
32
-
-
0037020266
-
Structure of mitogen-activated protein kinaseactivated protein (MAPKAP) kinase 2 suggests a bifunctional switch that couples kinase activation with nuclear export
-
Meng, W., L. L. Swenson, M. J. Fitzgibbon, K. Hayakawa, E. Ter Haar, A. E. Behrens, J. R. Fulghum & J. A. Lippke: Structure of mitogen-activated protein kinaseactivated protein (MAPKAP) kinase 2 suggests a bifunctional switch that couples kinase activation with nuclear export. J Biol Chem, 277, 37401-5. (2002)
-
(2002)
J Biol Chem
, vol.277
, pp. 37401-37405
-
-
Meng, W.1
Swenson, L.L.2
Fitzgibbon, M.J.3
Hayakawa, K.4
Ter Haar, E.5
Behrens, A.E.6
Fulghum, J.R.7
Lippke, J.A.8
-
33
-
-
10744225800
-
Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme
-
DOI 10.1016/S0969-2126(03)00092-3
-
Underwood, K. W., K. D. Parris, E. Federico, L. Mosyak, R. M. Czerwinski, T. Shane, M. Taylor, K. Svenson, Y. Liu, C. L. Hsiao, S. Wolfrom, M. Maguire, K. Malakian, J. B. Telliez, L. L. Lin, R. W. Kriz, J. Seehra, W. S. Somers & M. L. Stahl: Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme. Structure, 11, 627-36 (2003) (Pubitemid 37281179)
-
(2003)
Structure
, vol.11
, Issue.6
, pp. 627-636
-
-
Underwood, K.W.1
Parris, K.D.2
Federico, E.3
Mosyak, L.4
Czerwinski, R.M.5
Shane, T.6
Taylor, M.7
Svenson, K.8
Liu, Y.9
Hsiao, C.-L.10
Wolfrom, S.11
Maguire, M.12
Malakian, K.13
Telliez, J.-B.14
Lin, L.-L.15
Kriz, R.W.16
Seehra, J.17
Somers, W.S.18
Stahl, M.L.19
-
34
-
-
34447339643
-
The discovery of carboline analogs as potent MAPKAP-K2 inhibitors
-
DOI 10.1016/j.bmcl.2007.05.101, PII S0960894X07006385
-
Wu, J. P., J. Wang, A. Abeywardane, D. Andersen, M. Emmanuel, E. Gautschi, D. R. Goldberg, M. A. Kashem, S. Lukas, W. Mao, L. Martin, T. Morwick, N. Moss, C. Pargellis, U. R. Patel, L. Patnaude, G. W. Peet, D. Skow, R. J. Snow, Y. Ward, B. Werneburg & A. White: The discovery of carboline analogs as potent MAPKAP-K2 inhibitors. Bioorg Med Chem Lett, 17, 4664-9 (2007) (Pubitemid 47058930)
-
(2007)
Bioorganic and Medicinal Chemistry Letters
, vol.17
, Issue.16
, pp. 4664-4669
-
-
Wu, J.-P.1
Wang, J.2
Abeywardane, A.3
Andersen, D.4
Emmanuel, M.5
Gautschi, E.6
Goldberg, D.R.7
Kashem, M.A.8
Lukas, S.9
Mao, W.10
Martin, L.11
Morwick, T.12
Moss, N.13
Pargellis, C.14
Patel, U.R.15
Patnaude, L.16
Peet, G.W.17
Skow, D.18
Snow, R.J.19
Ward, Y.20
Werneburg, B.21
White, A.22
more..
-
35
-
-
34250181285
-
Pyrrolopyridine Inhibitors of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK-2)
-
Epub 2007 May 5
-
Anderson, D. R., M. J. Meyers, W. F. Vernier, M. W. Mahoney, R. G. Kurumbail, N. Caspers, G. I. Poda, J. F. Schindler, D. B. Reitz & R. J. Mourey: Pyrrolopyridine Inhibitors of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK-2). J Med Chem., 50, 2647-54. Epub 2007 May 5. (2007)
-
(2007)
J Med Chem.
, vol.50
, pp. 2647-2647
-
-
Anderson, D.R.1
Meyers, M.J.2
Vernier, W.F.3
Mahoney, M.W.4
Kurumbail, R.G.5
Caspers, N.6
Poda, G.I.7
Schindler, J.F.8
Reitz, D.B.9
Mourey, R.J.10
-
36
-
-
0030565457
-
A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress
-
DOI 10.1016/0014-5793(96)00816-2
-
Clifton, A. D., P. R. Young & P. Cohen: A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress. FEBS Lett, 392, 209-14 (1996) (Pubitemid 26289115)
-
(1996)
FEBS Letters
, vol.392
, Issue.3
, pp. 209-214
-
-
Clifton, A.D.1
Young, P.R.2
Cohen, P.3
-
37
-
-
0033622470
-
Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development
-
Adams, R. H., A. Porras, G. Alonso, M. Jones, K. Vintersten, S. Panelli, A. Valladares, L. Perez, R. Klein & A. R. Nebreda: Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development. Mol Cell, 6, 109-16 (2000)
-
(2000)
Mol Cell
, vol.6
, pp. 109-116
-
-
Adams, R.H.1
Porras, A.2
Alonso, G.3
Jones, M.4
Vintersten, K.5
Panelli, S.6
Valladares, A.7
Perez, L.8
Klein, R.9
Nebreda, A.R.10
-
38
-
-
0028806565
-
Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2
-
Ben-Levy, R., I. A. Leighton, Y. N. Doza, P. Attwood, N. Morrice, C. J. Marshall & P. Cohen: Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2. Embo J, 14, 5920-30. (1995)
-
(1995)
Embo J
, vol.14
, pp. 5920-5930
-
-
Ben-Levy, R.1
Leighton, I.A.2
Doza, Y.N.3
Attwood, P.4
Morrice, N.5
Marshall, C.J.6
Cohen, P.7
-
39
-
-
3543060538
-
Catalysis and function of the p38α·MK2a signaling complex
-
DOI 10.1021/bi049508v
-
Lukas, S. M., R. R. Kroe, J. Wildeson, G. W. Peet, L. Frego, W. Davidson, R. H. Ingraham, C. A. Pargellis, M. E. Labadia & B. G. Werneburg: Catalysis and function of the p38 alpha.MK2a signaling complex. Biochemistry, 43, 9950-60 (2004) (Pubitemid 39030885)
-
(2004)
Biochemistry
, vol.43
, Issue.31
, pp. 9950-9960
-
-
Lukas, S.M.1
Kroe, R.R.2
Wildeson, J.3
Peet, G.W.4
Frego, L.5
Davidson, W.6
Ingraham, R.H.7
Pargellis, C.A.8
Labadia, M.E.9
Werneburg, B.G.10
-
40
-
-
0036273201
-
Distinct cellular functions of MK2
-
DOI 10.1128/MCB.22.13.4827-4835.2002
-
Kotlyarov, A., Y. Yannoni, S. Fritz, K. Laass, J. B. Telliez, D. Pitman, L. L. Lin & M. Gaestel: Distinct cellular functions of MK2. Mol Cell Biol, 22, 4827-35. (2002) (Pubitemid 34620417)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.13
, pp. 4827-4835
-
-
Kotlyarov, A.1
Yannoni, Y.2
Fritz, S.3
Laass, K.4
Telliez, J.-B.5
Pitman, D.6
Lin, L.-L.7
Gaestel, M.8
-
41
-
-
26444578205
-
p38 mitogen-activated protein kinase plays a key role in regulating MAPKAPK2 expression
-
DOI 10.1016/j.bbrc.2005.09.063, PII S0006291X05020589
-
Sudo, T., K. Kawai, H. Matsuzaki & H. Osada: p38 mitogen-activated protein kinase plays a key role in regulating MAPKAPK2 expression. Biochem Biophys Res Commun, 337, 415-21 (2005) (Pubitemid 41429300)
-
(2005)
Biochemical and Biophysical Research Communications
, vol.337
, Issue.2
, pp. 415-421
-
-
Sudo, T.1
Kawai, K.2
Matsuzaki, H.3
Osada, H.4
-
42
-
-
22144498878
-
Time-resolved Forster resonance energy transfer assays for the binding of nucleotide and protein substrates to p38α protein kinase
-
DOI 10.1016/j.ab.2005.05.011, PII S0003269705003726
-
Zhang, W. X., R. Wang, D. Wisniewski, A. I. Marcy, P. LoGrasso, J. M. Lisnock, R. T. Cummings & J. E. Thompson: Time-resolved Forster resonance energy transfer assays for the binding of nucleotide and protein substrates to p38alpha protein kinase. Anal Biochem, 343, 76-83 (2005) (Pubitemid 40978611)
-
(2005)
Analytical Biochemistry
, vol.343
, Issue.1
, pp. 76-83
-
-
Wen, X.Z.1
Wang, R.2
Wisniewski, D.3
Marcy, A.I.4
LoGrasso, P.5
Lisnock, J.-M.6
Cummings, R.T.7
Thompson, J.E.8
-
43
-
-
34248200476
-
Crystal structure of the P38α-MAPKAP kinase 2 heterodimer
-
DOI 10.1074/jbc.M611165200
-
ter Haar, E., P. Prabhakar, X. Liu & C. Lepre: Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer. J Biol Chem, 282, 9733-9 (2007) (Pubitemid 47104583)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.13
, pp. 9733-9739
-
-
Ter Haar, E.1
Prabakhar, P.2
Liu, X.3
Lepre, C.4
-
44
-
-
34447295963
-
Molecular basis of MAPK-activated protein kinase 2:p38 assembly
-
DOI 10.1073/pnas.0701679104
-
White, A., C. A. Pargellis, J. M. Studts, B. G. Werneburg & B. T. Farmer, 2nd: Molecular basis of MAPK-activated protein kinase 2:p38 assembly. Proc Natl Acad Sci U S A, 104, 6353-8 (2007) (Pubitemid 47186098)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.15
, pp. 6353-6358
-
-
White, A.1
Pargellis, C.A.2
Studts, J.M.3
Werneburg, B.G.4
Farmer II, B.T.5
-
45
-
-
1842850620
-
ShcA interacts with MAPKAP kinase 2 and regulates its activity
-
DOI 10.1016/S0014-5793(04)00351-5, PII S0014579304003515
-
Yannoni, Y. M., M. Gaestel & L. L. Lin: P66 (ShcA) interacts with MAPKAP kinase 2 and regulates its activity. FEBS Lett, 564, 205-11 (2004) (Pubitemid 38490725)
-
(2004)
FEBS Letters
, vol.564
, Issue.1-2
, pp. 205-211
-
-
Yannoni, Y.M.1
Gaestel, M.2
Lin, L.-L.3
-
46
-
-
14044263532
-
MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1
-
DOI 10.1074/jbc.M407155200
-
Voncken, J. W., H. Niessen, B. Neufeld, U. Rennefahrt, V. Dahlmans, N. Kubben, B. Holzer, S. Ludwig & U. R. Rapp: MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1. J Biol Chem, 280, 5178-87 (2005) (Pubitemid 40279988)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.7
, pp. 5178-5187
-
-
Voncken, J.W.1
Niessen, H.2
Neufeld, B.3
Rennefahrt, U.4
Dahlmans, V.5
Kubben, N.6
Holzer, B.7
Ludwig, S.8
Rapp, U.R.9
-
47
-
-
35548930283
-
The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways
-
DOI 10.1038/ni1517, PII NI1517
-
Zaru, R., N. Ronkina, M. Gaestel, J. S. Arthur & C. Watts: The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways. Nat Immunol, 8, 1227-35 (2007) (Pubitemid 350011762)
-
(2007)
Nature Immunology
, vol.8
, Issue.11
, pp. 1227-1235
-
-
Zaru, R.1
Ronkina, N.2
Gaestel, M.3
Arthur, J.S.C.4
Watts, C.5
-
48
-
-
0031056783
-
Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27
-
Guay, J., H. Lambert, G. Gingras-Breton, J. N. Lavoie, J. Huot & J. Landry: Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27. J Cell Sci, 110, 357-68. (1997) (Pubitemid 27095655)
-
(1997)
Journal of Cell Science
, vol.110
, Issue.3
, pp. 357-368
-
-
Guay, J.1
Lambert, H.2
Gingras-Breton, G.3
Lavoie, J.N.4
Huot, J.5
Landry, J.6
-
49
-
-
0035478006
-
Abnormal migration phenotype of mitogen-activated protein kinase-activated protein kinase 2-/-neutrophils in Zigmond
-
chambers containing formylmethionyl-leucyl-phenylalanine gradients
-
Hannigan, M. O., L. Zhan, Y. Ai, A. Kotlyarov, M. Gaestel & C. K. Huang: Abnormal migration phenotype of mitogen-activated protein kinase-activated protein kinase 2-/-neutrophils in Zigmond chambers containing formylmethionyl-leucyl-phenylalanine gradients. J Immunol, 167, 3953-61 (2001)
-
(2001)
J Immunol
, vol.167
, pp. 3953-3961
-
-
Hannigan, M.O.1
Zhan, L.2
Ai, Y.3
Kotlyarov, A.4
Gaestel, M.5
Huang, C.K.6
-
50
-
-
1642276942
-
A requirement of MAPKAPK2 in the uropod localization of PTEN during FMLP-induced neutrophil chemotaxis
-
DOI 10.1016/j.bbrc.2004.02.107, PII S0006291X04003328
-
Wu, Y., M. O. Hannigan, A. Kotlyarov, M. Gaestel, D. Wu & C. K. Huang: A requirement of MAPKAPK2 in the uropod localization of PTEN during FMLP-induced neutrophil chemotaxis. Biochem Biophys Res Commun, 316, 666-72 (2004) (Pubitemid 38368004)
-
(2004)
Biochemical and Biophysical Research Communications
, vol.316
, Issue.3
, pp. 666-672
-
-
Wu, Y.1
Hannigan, M.O.2
Kotlyarov, A.3
Gaestel, M.4
Wu, D.5
Huang, C.-K.6
-
51
-
-
33749257848
-
CXCL12 and C5a trigger cell migration via a PAK1/2-p38α MAPK-MAPKAP-K2-HSP27 pathway
-
DOI 10.1016/j.cellsig.2006.02.006, PII S0898656806000428
-
Rousseau, S., I. Dolado, V. Beardmore, N. Shpiro, R. Marquez, A. R. Nebreda, J. S. Arthur, L. M. Case, M. Tessier-Lavigne, M. Gaestel, A. Cuenda & P. Cohen: CXCL12 and C5a trigger cell migration via a PAK1/2-p38alpha MAPK-MAPKAP-K2-HSP27 pathway. Cell Signal, 18, 1897-905 (2006) (Pubitemid 44485980)
-
(2006)
Cellular Signalling
, vol.18
, Issue.11
, pp. 1897-1905
-
-
Rousseau, S.1
Dolado, I.2
Beardmore, V.3
Shpiro, N.4
Marquez, R.5
Nebreda, A.R.6
Arthur, J.S.C.7
Case, L.M.8
Tessier-Lavigne, M.9
Gaestel, M.10
Cuenda, A.11
Cohen, P.12
-
52
-
-
11344286593
-
2/M transition and S phase progression in response to UV irradiation
-
DOI 10.1016/j.molcel.2004.11.021, PII S1097276504007129
-
Manke, I. A., A. Nguyen, D. Lim, M. Q. Stewart, A. E. Elia & M. B. Yaffe: MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. Mol Cell., 17, 37-48. (2005) (Pubitemid 40075363)
-
(2005)
Molecular Cell
, vol.17
, Issue.1
, pp. 37-48
-
-
Manke, I.A.1
Nguyen, A.2
Lim, D.3
Stewart, M.Q.4
Elia, A.E.H.5
Yaffe, M.B.6
-
53
-
-
0030565457
-
A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress
-
DOI 10.1016/0014-5793(96)00816-2
-
Clifton, A. D., P. R. Young & P. Cohen: A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress. FEBS Lett, 392, 209-14. (1996) (Pubitemid 26289115)
-
(1996)
FEBS Letters
, vol.392
, Issue.3
, pp. 209-214
-
-
Clifton, A.D.1
Young, P.R.2
Cohen, P.3
-
54
-
-
0036273201
-
Distinct cellular functions of MK2
-
DOI 10.1128/MCB.22.13.4827-4835.2002
-
Kotlyarov, A., Y. Yannoni, S. Fritz, K. Laass, J. B. Telliez, D. Pitman, L. L. Lin & M. Gaestel: Distinct cellular functions of MK2. Mol Cell Biol, 22, 4827-35 (2002) (Pubitemid 34620417)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.13
, pp. 4827-4835
-
-
Kotlyarov, A.1
Yannoni, Y.2
Fritz, S.3
Laass, K.4
Telliez, J.-B.5
Pitman, D.6
Lin, L.-L.7
Gaestel, M.8
-
55
-
-
0033516660
-
Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation
-
Rogalla, T., M. Ehrnsperger, X. Preville, A. Kotlyarov, G. Lutsch, C. Ducasse, C. Paul, M. Wieske, A. P. Arrigo, J. Buchner & M. Gaestel: Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation. J Biol Chem, 274, 18947-56 (1999)
-
(1999)
J Biol Chem
, vol.274
, pp. 18947-18956
-
-
Rogalla, T.1
Ehrnsperger, M.2
Preville, X.3
Kotlyarov, A.4
Lutsch, G.5
Ducasse, C.6
Paul, C.7
Wieske, M.8
Arrigo, A.P.9
Buchner, J.10
Gaestel, M.11
-
56
-
-
0027391629
-
Small heat shock proteins are molecular chaperones
-
Jakob, U., M. Gaestel, K. Engel & J. Buchner: Small heat shock proteins are molecular chaperones. J Biol Chem, 268, 1517-20. (1993) (Pubitemid 23033534)
-
(1993)
Journal of Biological Chemistry
, vol.268
, Issue.3
, pp. 1517-1520
-
-
Jakob, U.1
Gaestel, M.2
Engel, K.3
Buchner, J.4
-
57
-
-
35348844114
-
Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption
-
DOI 10.1002/dvg.20319
-
Huang, L., J. N. Min, S. Masters, N. F. Mivechi & D. Moskophidis: Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption. Genesis, 45, 487-501 (2007) (Pubitemid 47584207)
-
(2007)
Genesis
, vol.45
, Issue.8
, pp. 487-501
-
-
Huang, L.1
Min, J.-N.2
Masters, S.3
Mivechi, N.F.4
Moskophidis, D.5
-
58
-
-
0036569435
-
Mitogen-activated protein kinase-activated protein kinase 2-deficient mice show increased susceptibility to Listeria monocytogenes infection
-
Lehner, M. D., F. Schwoebel, A. Kotlyarov, M. Leist, M. Gaestel & T. Hartung: Mitogen-activated protein kinase-activated protein kinase 2-deficient mice show increased susceptibility to Listeria monocytogenes infection. J Immunol, 168, 4667-73. (2002) (Pubitemid 34441374)
-
(2002)
Journal of Immunology
, vol.168
, Issue.9
, pp. 4667-4673
-
-
Lehner, M.D.1
Schwoebel, F.2
Kotlyarov, A.3
Leist, M.4
Gaestel, M.5
Hartung, T.6
-
59
-
-
0036479125
-
MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels
-
DOI 10.1074/jbc.C100685200
-
Neininger, A., D. Kontoyiannis, A. Kotlyarov, R. Winzen, R. Eckert, H. D. Volk, H. Holtmann, G. Kollias & M. Gaestel: MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels. J Biol Chem, 277, 3065-8. (2002) (Pubitemid 34953164)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.5
, pp. 3065-3068
-
-
Neininger, A.1
Kontoyiannis, D.2
Kotlyarov, A.3
Winzen, R.4
Eckert, R.5
Volk, H.-D.6
Holtmann, H.7
Kollias, G.8
Gaestel, M.9
-
60
-
-
0033568608
-
The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism
-
DOI 10.1093/emboj/18.18.4969
-
Winzen, R., M. Kracht, B. Ritter, A. Wilhelm, C. Y. Chen, A. B. Shyu, M. Muller, M. Gaestel, K. Resch & H. Holtmann: The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinaseactivated protein kinase 2 and an AU-rich region-targeted mechanism. Embo J, 18, 4969-80 (1999) (Pubitemid 29443799)
-
(1999)
EMBO Journal
, vol.18
, Issue.18
, pp. 4969-4980
-
-
Winzen, R.1
Kracht, M.2
Ritter, B.3
Wilhelm, A.4
Chen, C.-Y.A.5
Shyu, A.-B.6
Muller, M.7
Gaestel, M.8
Resch, K.9
Holtmann, H.10
-
61
-
-
0037436229
-
Affinity purification of ARE-binding proteins identifies poly(A)-binding protein 1 as a potential substrate in MK2-induced mRNA stabilization
-
DOI 10.1016/S0006-291X(03)00015-9
-
Bollig, F., R. Winzen, M. Gaestel, S. Kostka, K. Resch & H. Holtmann: Affinity purification of ARE-binding proteins identifies polyA-binding protein 1 as a potential substrate in MK2-induced mRNA stabilization. Biochem Biophys Res Commun, 301, 665-70. (2003) (Pubitemid 36268942)
-
(2003)
Biochemical and Biophysical Research Communications
, vol.301
, Issue.3
, pp. 665-670
-
-
Bollig, F.1
Winzen, R.2
Gaestel, M.3
Kostka, S.4
Resch, K.5
Holtmann, H.6
-
62
-
-
0037011121
-
Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs
-
DOI 10.1093/emboj/cdf639
-
Rousseau, S., N. Morrice, M. Peggie, D. G. Campbell, M. Gaestel & P. Cohen: Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs. Embo J, 21, 6505-14. (2002) (Pubitemid 35448428)
-
(2002)
EMBO Journal
, vol.21
, Issue.23
, pp. 6505-6514
-
-
Rousseau, S.1
Morrice, N.2
Peggie, M.3
Campbell, D.G.4
Gaestel, M.5
Cohen, P.6
-
63
-
-
1642332899
-
MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding
-
Epub 2003 Dec 19
-
Chrestensen, C. A., M. J. Schroeder, J. Shabanowitz, D. F. Hunt, J. W. Pelo, M. T. Worthington & T. W. Sturgill: MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding. J Biol Chem, 279, 10176-84. Epub 2003 Dec 19. (2004)
-
(2004)
J Biol Chem
, vol.279
, pp. 10176-10176
-
-
Chrestensen, C.A.1
Schroeder, M.J.2
Shabanowitz, J.3
Hunt, D.F.4
Pelo, J.W.5
Worthington, M.T.6
Sturgill, T.W.7
-
64
-
-
1942471656
-
MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay
-
Epub 2004 Mar 11
-
Stoecklin, G., T. Stubbs, N. Kedersha, S. Wax, W. F. Rigby, T. K. Blackwell & P. Anderson: MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. Embo J, 23, 1313-24. Epub 2004 Mar 11. (2004)
-
(2004)
Embo J
, vol.23
, pp. 1313-1313
-
-
Stoecklin, G.1
Stubbs, T.2
Kedersha, N.3
Wax, S.4
Rigby, W.F.5
Blackwell, T.K.6
Anderson, P.7
-
65
-
-
0141640857
-
Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2
-
DOI 10.1128/MCB.23.20.7177-7188.2003
-
Tran, H., F. Maurer & Y. Nagamine: Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2. Mol Cell Biol, 23, 7177-88 (2003) (Pubitemid 37211000)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.20
, pp. 7177-7188
-
-
Tran, H.1
Maurer, F.2
Nagamine, Y.3
-
66
-
-
18044371822
-
AU binding proteins recruit the exosome to degrade ARE-containing mRNAs
-
DOI 10.1016/S0092-8674(01)00578-5
-
Chen, C. Y., R. Gherzi, S. E. Ong, E. L. Chan, R. Raijmakers, G. J. Pruijn, G. Stoecklin, C. Moroni, M. Mann & M. Karin: AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Cell, 107, 451-64 (2001) (Pubitemid 33152781)
-
(2001)
Cell
, vol.107
, Issue.4
, pp. 451-464
-
-
Chen, C.-Y.1
Gherzi, R.2
Ong, S.-E.3
Chan, E.L.4
Raijmakers, R.5
Pruijn, G.J.M.6
Stoecklin, G.7
Moroni, C.8
Mann, M.9
Karin, M.10
-
67
-
-
34548241289
-
Tristetraprolin regulates TNF TNF-α mRNA stability via a proteasome dependent mechanism involving the combined action of the ERK and p38 pathways
-
DOI 10.1016/j.molimm.2007.05.017, PII S0161589007002271
-
Deleault, K. M., S. J. Skinner & S. A. Brooks: Tristetraprolin regulates TNF TNF-alpha mRNA stability via a proteasome dependent mechanism involving the combined action of the ERK and p38 pathways. Mol Immunol, 45, 13-24 (2008) (Pubitemid 47331659)
-
(2008)
Molecular Immunology
, vol.45
, Issue.1
, pp. 13-24
-
-
Deleault, K.M.1
Skinner, S.J.2
Brooks, S.A.3
-
68
-
-
33644767306
-
Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways
-
DOI 10.1128/MCB.26.6.2408-2418.2006
-
Brook, M., C. R. Tchen, T. Santalucia, J. McIlrath, J. S. Arthur, J. Saklatvala & A. R. Clark: Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways. Mol Cell Biol, 26, 2408-18 (2006) (Pubitemid 43346939)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.6
, pp. 2408-2418
-
-
Brook, M.1
Tchen, C.R.2
Santalucia, T.3
McIlrath, J.4
Arthur, J.S.C.5
Saklatvala, J.6
Clark, A.R.7
-
69
-
-
33644753147
-
Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element
-
DOI 10.1128/MCB.26.6.2399-2407.2006
-
Hitti, E., T. Iakovleva, M. Brook, S. Deppenmeier, A. D. Gruber, D. Radzioch, A. R. Clark, P. J. Blackshear, A. Kotlyarov & M. Gaestel: Mitogen-activated protein kinaseactivated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element. Mol Cell Biol, 26, 2399-407 (2006) (Pubitemid 43346938)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.6
, pp. 2399-2407
-
-
Hitti, E.1
Iakovleva, T.2
Brook, M.3
Deppenmeier, S.4
Gruber, A.D.5
Radzioch, D.6
Clark, A.R.7
Blackshear, P.J.8
Kotlyarov, A.9
Gaestel, M.10
-
70
-
-
38949115893
-
Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex
-
DOI 10.1042/BJ20071149
-
Mendoza, H., D. G. Campbell, K. Burness, J. Hastie, N. Ronkina, J. H. Shim, J. S. Arthur, R. J. Davis, M. Gaestel, G. L. Johnson, S. Ghosh & P. Cohen: Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex. Biochem J, 409, 711-22 (2008) (Pubitemid 351214197)
-
(2008)
Biochemical Journal
, vol.409
, Issue.3
, pp. 711-722
-
-
Mendoza, H.1
Campbell, D.G.2
Burness, K.3
Hastie, J.4
Ronkina, N.5
Shim, J.-H.6
Arthur, J.S.C.7
Davis, R.J.8
Gaestel, M.9
Johnson, G.L.10
Ghosh, S.11
Cohen, P.12
-
71
-
-
0346243941
-
Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling
-
DOI 10.1093/emboj/cdg605
-
Ishitani, T., G. Takaesu, J. Ninomiya-Tsuji, H. Shibuya, R. B. Gaynor & K. Matsumoto: Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. Embo J, 22, 6277-88 (2003) (Pubitemid 37522585)
-
(2003)
EMBO Journal
, vol.22
, Issue.23
, pp. 6277-6288
-
-
Ishitani, T.1
Takaesu, G.2
Ninomiya-Tsuji, J.3
Shibuya, H.4
Gaynor, R.B.5
Matsumoto, K.6
-
72
-
-
4344712350
-
TAB2 and TAB3 activate the NF-κB pathway through binding to polyubiquitin chains
-
DOI 10.1016/j.molcel.2004.08.008, PII S1097276504004708
-
Kanayama, A., R. B. Seth, L. Sun, C. K. Ea, M. Hong, A. Shaito, Y. H. Chiu, L. Deng & Z. J. Chen: TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol Cell, 15, 535-48 (2004) (Pubitemid 39141781)
-
(2004)
Molecular Cell
, vol.15
, Issue.4
, pp. 535-548
-
-
Kanayama, A.1
Seth, R.B.2
Sun, L.3
Ea, C.-K.4
Hong, M.5
Shaito, A.6
Chiu, Y.-H.7
Deng, L.8
Chen, Z.J.9
-
73
-
-
0034045949
-
Inhibition of p38 MAP kinase as a therapeutic strategy
-
DOI 10.1016/S0162-3109(00)00206-X, PII S016231090000206X
-
Lee, J. C., S. Kumar, D. E. Griswold, D. C. Underwood, B. J. Votta & J. L. Adams: Inhibition of p38 MAP kinase as a therapeutic strategy. Immunopharmacology, 47, 185-201 (2000) (Pubitemid 30394538)
-
(2000)
Immunopharmacology
, vol.47
, Issue.2-3
, pp. 185-201
-
-
Lee, J.C.1
Kumar, S.2
Griswold, D.E.3
Underwood, D.C.4
Votta, B.J.5
Adams, J.L.6
-
74
-
-
33744956373
-
Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway
-
DOI 10.1074/jbc.M512953200
-
Wang, Y., R. Singh, J. H. Lefkowitch, R. M. Rigoli & M. J. Czaja: Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway. J Biol Chem, 281, 15258-67 (2006) (Pubitemid 43855115)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.22
, pp. 15258-15267
-
-
Wang, Y.1
Singh, R.2
Lefkowitch, J.H.3
Rigoli, R.M.4
Czaja, M.J.5
-
75
-
-
0000352873
-
Galactosamine-induced sensitization to the lethal effects of endotoxin
-
DOI 10.1073/pnas.76.11.5939
-
Galanos, C., M. A. Freudenberg & W. Reutter: Galactosamine-induced sensitization to the lethal effects of endotoxin. Proc Natl Acad Sci U S A, 76, 5939-43 (1979) (Pubitemid 10216692)
-
(1979)
Proceedings of the National Academy of Sciences of the United States of America
, vol.76
, Issue.11
, pp. 5939-5943
-
-
Galanos, C.1
Freudenberg, M.A.2
Reutter, W.3
-
76
-
-
33746214777
-
MAPKAP kinase 2-deficient mice are resistant to collagen-induced arthritis
-
Hegen, M., M. Gaestel, C. L. Nickerson-Nutter, L. L. Lin & J. B. Telliez: MAPKAP kinase 2-deficient mice are resistant to collagen-induced arthritis. J Immunol, 177, 1913-7 (2006) (Pubitemid 44092531)
-
(2006)
Journal of Immunology
, vol.177
, Issue.3
, pp. 1913-1917
-
-
Hegen, M.1
Gaestel, M.2
Nickerson-Nutter, C.L.3
Lin, L.-L.4
Telliez, J.-B.5
-
77
-
-
36348954401
-
Systemic deficiency of the MAP kinase-activated protein kinase 2 reduces atherosclerosis in hypercholesterolemic mice
-
DOI 10.1161/CIRCRESAHA.107.156075
-
Jagavelu, K., U. J. Tietge, M. Gaestel, H. Drexler, B. Schieffer & U. Bavendiek: Systemic deficiency of the MAP kinase-activated protein kinase 2 reduces atherosclerosis in hypercholesterolemic mice. Circ Res, 101, 1104-12 (2007) (Pubitemid 350146436)
-
(2007)
Circulation Research
, vol.101
, Issue.11
, pp. 1104-1112
-
-
Jagavelu, K.1
Tietge, U.J.F.2
Gaestel, M.3
Drexler, H.4
Schieffer, B.5
Bavendiek, U.6
-
78
-
-
34447258367
-
MK2 controls the level of negative feedback in the NF-κB pathway and is essential for vascular permeability and airway inflammation
-
DOI 10.1084/jem.20062621
-
Gorska, M. M., Q. Liang, S. J. Stafford, N. Goplen, N. Dharajiya, L. Guo, S. Sur, M. Gaestel & R. Alam: MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammation. J Exp Med, 204, 1637-52 (2007) (Pubitemid 47048030)
-
(2007)
Journal of Experimental Medicine
, vol.204
, Issue.7
, pp. 1637-1652
-
-
Gorska, M.M.1
Liang, Q.2
Stafford, S.J.3
Goplen, N.4
Dharajiya, N.5
Guo, L.6
Sur, S.7
Gaestel, M.8
Alam, R.9
-
79
-
-
35848937578
-
Lack of MK2 inhibits myofibroblast formation and exacerbates pulmonary fibrosis
-
DOI 10.1165/rcmb.2007-0077OC
-
Liu, T., R. R. Warburton, O. E. Guevara, N. S. Hill, B. L. Fanburg, M. Gaestel & U. S. Kayyali: Lack of MK2 inhibits myofibroblast formation and exacerbates pulmonary fibrosis. Am J Respir Cell Mol Biol, 37, 507-17 (2007) (Pubitemid 350058181)
-
(2007)
American Journal of Respiratory Cell and Molecular Biology
, vol.37
, Issue.5
, pp. 507-517
-
-
Liu, T.1
Warburton, R.R.2
Guevara, O.E.3
Hill, N.S.4
Fanburg, B.L.5
Gaestel, M.6
Kayyali, U.S.7
-
80
-
-
34047102327
-
Smooth muscle α-actin expression and myofibroblast differentiation by TGFβ are dependent upon MK2
-
DOI 10.1002/jcb.21154
-
Sousa, A. M., T. Liu, O. Guevara, J. Stevens, B. L. Fanburg, M. Gaestel, D. Toksoz & U. S. Kayyali: Smooth muscle alpha-actin expression and myofibroblast differentiation by TGFbeta are dependent upon MK2. J Cell Biochem, 100, 1581-92 (2007) (Pubitemid 46515589)
-
(2007)
Journal of Cellular Biochemistry
, vol.100
, Issue.6
, pp. 1581-1592
-
-
Sousa, A.M.1
Liu, T.2
Guevara, O.3
Stevens, J.4
Fanburg, B.L.5
Gaestel, M.6
Toksoz, D.7
Kayyali, U.S.8
-
81
-
-
44449177614
-
Deletion of MK2 signalling in vivo inhibits small Hsp phosphorylation but not diabetic nephropathy
-
Park, J. K., N. Ronkina, A. Hoft, C. Prohl, J. Menne, M. Gaestel, H. Haller & M. Meier: Deletion of MK2 signalling in vivo inhibits small Hsp phosphorylation but not diabetic nephropathy. Nephrol Dial Transplant (2008)
-
(2008)
Nephrol Dial Transplant
-
-
Park, J.K.1
Ronkina, N.2
Hoft, A.3
Prohl, C.4
Menne, J.5
Gaestel, M.6
Haller, H.7
Meier, M.8
-
82
-
-
0033930127
-
Small heat shock protein alteration provides a mechanism to reduce mesangial cell contractility in diabetes and oxidative stress
-
DOI 10.1046/j.1523-1755.2000.00866.x
-
Dunlop, M. E. & E. E. Muggli: Small heat shock protein alteration provides a mechanism to reduce mesangial cell contractility in diabetes and oxidative stress. Kidney Int, 57, 464-75 (2000) (Pubitemid 30430638)
-
(2000)
Kidney International
, vol.57
, Issue.2
, pp. 464-475
-
-
Dunlop, M.E.1
Muggli, E.E.2
-
83
-
-
11144252660
-
-/- gene knockout mouse hearts carry anti-apoptotic signal and are resistant to ischemia reperfusion injury
-
DOI 10.1016/j.yjmcc.2004.10.018, PII S0022282804003219
-
Shiroto, K., H. Otani, F. Yamamoto, C. K. Huang, N. Maulik & D. K. Das: MK2-/-gene knockout mouse hearts carry anti-apoptotic signal and are resistant to ischemia reperfusion injury. J Mol Cell Cardiol, 38, 93-7 (2005) (Pubitemid 40038655)
-
(2005)
Journal of Molecular and Cellular Cardiology
, vol.38
, Issue.1
, pp. 93-97
-
-
Shiroto, K.1
Otani, H.2
Yamamoto, F.3
Huang, C.-K.4
Maulik, N.5
Das, D.K.6
-
84
-
-
34247586623
-
Ischemic preconditioning involves dual cardio-protective axes with p38MAPK as upstream target
-
DOI 10.1016/j.yjmcc.2007.02.010, PII S0022282807000491
-
Nagy, N., K. Shiroto, G. Malik, C. K. Huang, M. Gaestel, M. Abdellatif, A. Tosaki, N. Maulik & D. K. Das: Ischemic preconditioning involves dual cardio-protective axes with p38MAPK as upstream target. J Mol Cell Cardiol, 42, 981-90 (2007) (Pubitemid 46678032)
-
(2007)
Journal of Molecular and Cellular Cardiology
, vol.42
, Issue.5
, pp. 981-990
-
-
Nagy, N.1
Shiroto, K.2
Malik, G.3
Huang, C.-K.4
Gaestel, M.5
Abdellatif, M.6
Tosaki, A.7
Maulik, N.8
Das, D.K.9
-
85
-
-
0037113928
-
Mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 deficiency protects brain from ischemic injury in mice
-
DOI 10.1074/jbc.M206837200
-
Wang, X., L. Xu, H. Wang, P. R. Young, M. Gaestel & G. Z. Feuerstein: Mitogen-activated protein kinaseactivated protein (MAPKAP) kinase 2 deficiency protects brain from ischemic injury in mice. J Biol Chem, 277, 43968-72 (2002) (Pubitemid 36157821)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.46
, pp. 43968-43972
-
-
Wang, X.1
Xu, L.2
Wang, H.3
Young, P.R.4
Gaestel, M.5
Feuerstein, G.Z.6
-
86
-
-
33747632142
-
MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity: Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease
-
DOI 10.1074/jbc.M513646200
-
Culbert, A. A., S. D. Skaper, D. R. Howlett, N. A. Evans, L. Facci, P. E. Soden, Z. M. Seymour, F. Guillot, M. Gaestel & J. C. Richardson: MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease. J Biol Chem, 281, 23658-67 (2006) (Pubitemid 44274141)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.33
, pp. 23658-23667
-
-
Culbert, A.A.1
Skaper, S.D.2
Howlett, D.R.3
Evans, N.A.4
Facci, L.5
Soden, P.E.6
Seymour, Z.M.7
Guillot, F.8
Gaestel, M.9
Richardson, J.C.10
-
87
-
-
16444376420
-
HDM2 phosphorylation by MAPKAP kinase 2
-
DOI 10.1038/sj.onc.1208389
-
Weber, H. O., R. L. Ludwig, D. Morrison, A. Kotlyarov, M. Gaestel & K. H. Vousden: HDM2 phosphorylation by MAPKAP kinase 2. Oncogene, 24, 1965-72. (2005) (Pubitemid 40516191)
-
(2005)
Oncogene
, vol.24
, Issue.12
, pp. 1965-1972
-
-
Weber, H.O.1
Ludwig, R.L.2
Morrison, D.3
Kotlyarov, A.4
Gaestel, M.5
Vousden, K.H.6
-
88
-
-
0035799557
-
Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase
-
DOI 10.1038/35075107
-
Bulavin, D. V., Y. Higashimoto, I. J. Popoff, W. A. Gaarde, V. Basrur, O. Potapova, E. Appella & A. J. Fornace, Jr.: Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase. Nature, 411, 102-7 2001 (Pubitemid 32428198)
-
(2001)
Nature
, vol.411
, Issue.6833
, pp. 102-107
-
-
Bulavin, D.V.1
Higashimoto, Y.2
Popoff, I.J.3
Gaarde, W.A.4
Basrur, V.5
Potapova, O.6
Appella, E.7
Fornace, A.J.8
-
89
-
-
33846821915
-
p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage
-
DOI 10.1016/j.ccr.2006.11.024, PII S1535610806003825
-
Reinhardt, H. C., A. S. Aslanian, J. A. Lees & M. B. Yaffe: p53-deficient cells rely on ATM-and ATRmediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell, 11, 175-89 (2007) (Pubitemid 46209849)
-
(2007)
Cancer Cell
, vol.11
, Issue.2
, pp. 175-189
-
-
Reinhardt, H.C.1
Aslanian, A.S.2
Lees, J.A.3
Yaffe, M.B.4
-
90
-
-
0028605318
-
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
-
Lee, J. C., J. T. Laydon, P. C. McDonnell, T. F. Gallagher, S. Kumar, D. Green, D. McNulty, M. J. Blumenthal, J. R. Heys, S. W. Landvatter & et al.: A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature, 372, 739-46. (1994)
-
(1994)
Nature
, vol.372
, pp. 739-746
-
-
Lee, J.C.1
Laydon, J.T.2
McDonnell, P.C.3
Gallagher, T.F.4
Kumar, S.5
Green, D.6
McNulty, D.7
Blumenthal, M.J.8
Heys, J.R.9
Landvatter, S.W.10
-
91
-
-
35348907987
-
Protein kinases as small molecule inhibitor targets in inflammation
-
DOI 10.2174/092986707781696636
-
Gaestel, M., A. Mengel, U. Bothe & K. Asadullah: Protein kinases as small molecule inhibitor targets in inflammation. Curr Med Chem, 14, 2214-34 (2007) (Pubitemid 47570683)
-
(2007)
Current Medicinal Chemistry
, vol.14
, Issue.21
, pp. 2214-2234
-
-
Gaestel, M.1
Mengel, A.2
Bothe, U.3
Asadullah, K.4
-
92
-
-
21544434331
-
p38 MAP kinase inhibitors: Many are made, but few are chosen
-
Dominguez, C., D. A. Powers & N. Tamayo: p38 MAP kinase inhibitors: many are made, but few are chosen. Curr Opin Drug Discov Devel, 8, 421-30 (2005) (Pubitemid 40921741)
-
(2005)
Current Opinion in Drug Discovery and Development
, vol.8
, Issue.4
, pp. 421-430
-
-
Dominguez, C.1
Powers, D.A.2
Tamayo, N.3
-
93
-
-
0034610981
-
Deficiency of the stress kinase p38alpha results in embryonic lethality: Characterization of the kinase dependence of stress responses of enzymedeficient embryonic stem cells
-
Allen, M., L. Svensson, M. Roach, J. Hambor, J. McNeish & C. A. Gabel: Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzymedeficient embryonic stem cells. J Exp Med, 191, 859-70. (2000)
-
(2000)
J Exp Med
, vol.191
, pp. 859-870
-
-
Allen, M.1
Svensson, L.2
Roach, M.3
Hambor, J.4
McNeish, J.5
Gabel, C.A.6
-
94
-
-
0028883299
-
Characterization of an autoinhibitory domain in human mitogen-activated protein kinase-activated protein kinase 2
-
Zu, Y. L., Y. Ai & C. K. Huang: Characterization of an autoinhibitory domain in human mitogen-activated protein kinase-activated protein kinase 2. J Biol Chem, 270, 202-6. (1995)
-
(1995)
J Biol Chem
, vol.270
, pp. 202-206
-
-
Zu, Y.L.1
Ai, Y.2
Huang, C.K.3
-
95
-
-
20044384349
-
Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)
-
DOI 10.1016/j.bmcl.2005.01.067
-
Anderson, D. R., S. Hegde, E. Reinhard, L. Gomez, W. F. Vernier, L. Lee, S. Liu, A. Sambandam, P. A. Snider & L. Masih: Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem Lett, 15, 1587-90 (2005) (Pubitemid 40312534)
-
(2005)
Bioorganic and Medicinal Chemistry Letters
, vol.15
, Issue.6
, pp. 1587-1590
-
-
Anderson, D.R.1
Hegde, S.2
Reinhard, E.3
Gomez, L.4
Vernier, W.F.5
Lee, L.6
Liu, S.7
Sambandam, A.8
Snider, P.A.9
Masih, L.10
|