Mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 deficiency protects brain from ischemic injury in mice

Journal of Biological Chemistry

Volumn 277, Issue 46, 2002, Pages 43968-43972

  Wang, Xinkang ^a   Xu, Lin ^a   Wang, Hugh ^a   Young, Peter R ^a   Gaestel, Matthias ^b   Feuerstein, Giora Z ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ASSAYS; BRAIN; ENZYMES; NEUROLOGY; TUMORS;

IMMUNOSORBENT ASSAYS;

BIOCHEMISTRY;

CASPASE 3; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE ACTIVATED PROTEIN KINASE 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN PROTECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME DEFICIENCY; FEMALE; HEMODYNAMICS; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BRAIN; BRAIN ISCHEMIA; CASPASE 3; CASPASES; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; INTERLEUKIN-1; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 0037113928     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M206837200     Document Type: Article

References (29)

1. Cano, E., and Mahadevan, L. C. (1995) Trends Biochem. Sci. 20, 117-122
2. Kotlyarov, A., Neininger, A., Schubert, C., Eckert, R., Birchmeier, C., Volk, H. D., and Gaestel, M. (1999) Nat. Cell Biol. 1, 94-97
3. Wang, X. K., and Feuerstein, G. Z. (2000) Drug News Perspect. 13, 133-140
4. Sugino, T., Nozaki, K., Takagi, Y., Hattori, I., Hashimoto, N., Moriguchi, T., and Nishida, E. (2000) J. Neurosci. 20, 4506-4514
5. Irving, E. A., Barone, F. C., Reith, A. D., Hadingham, S. J., and Parsons, A. A. (2000) Mol. Brain Res. 77, 65-75
6. Alessandrini, A., Namura, S., Moskowitz, M. A., and Bonventre, J. V. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 12866-12869
7. Wang, H., Xu, L., Venkatachalam, S., Trzaskos, J. M., Friedman, S. M., Feuerstein, G. Z., and Wang, X. (2001a) Biochem. Biophys. Res. Commun. 286, 869-874
8. Barone, F. C., Irving, E. A., Ray, A. M., Lee, J. C., Kassis, S., Kumar, S., Badger, A. M., White, R. F., McVey, M. J., Legos, J. J., Erhardt, J. A., Nelson, A. H., Ohlstein, E. H., Hunter, A. J., Ward, K., Smith, B. R., Adams, J. L., and Parsons, A. A. (2001) J. Pharmacol. Exp. Ther. 296, 312-321
9. Zhang, R. L., Chopp, M., Zhang, Z. G., Jiang, Q., and Ewing, J. R. (1997) Brain Res. 766, 83-92
10. Wang, X., Li, X., Currie, R. W., Willette, R. N., Barone, F. C., Feuerstein, G. Z. (2000) J. Neurosci. Res. 59, 238-246
11. Wang, H., Zhan, Y., Xu, L., Feuerstein, G. Z., and Wang, X. (2001b) Stroke 32, 1020-1027
12. Floyd, R. A., and Carney, J. M. (1992) Ann. Neurol. 32, S22-S27
13. Bederson, J. B., Pitts, L. H., Germano, S. M., Nishimura, M. C., Davis, R. L., and Bartkowski, H. M. (1986) Stroke 17, 1304-1308
14. Barone, F. C., Clark, R. K., Feuerstein, G., Lenkinski, R. E., and Sarkar, S. K. (1991) Brain Res. Bull. 26, 285-291
15. Minematsu, K., Li, L., Fisher, M., Sotak, C. H., Davis, M. A., and Fiandaca, M. S. (1992) Neurology 42, 235-240
16. Lin, S. P., Song, S. K., Miller, J. P., Ackerman, J. J., and Neil, J. J. (2001) Stroke 32, 925-932
17. del Zoppo, G., Ginis, I., Hallenbeck, J. M., Iadecola, C., Wang, X., and Feuerstein, G. Z. (2000) Brain Pathol. 10, 95-112
18. Lee, J. C., Laydon, J. T., McDonnell, P. C., Gallagher, T. F., Kumar, S., Green, D., McNulty, D., Blumenthal, M. J., Heys, J. R., Landvatter, S. W., and Young, P. R. (1994) Nature 372, 739-746
19. Young, P. R., McLaughlin, M. M., Kumar, S., Kassis, S., Doyle, M. L., McNulty, D., Gallagher, T. F., Fisher, S., McDonnell, P. C., Carr, S. A., Huddleston, M. J., Seibel, G., Porter, T. G., Livi, G. P., Adams, J. L., and Lee, J. C. (1997) J. Biol. Chem. 272, 12116-12121
20. Rothwell, N. J., and Luheshi, G. N. (2000) Trends Neurosci. 23, 618-625
21. Loddick, S. A., and Rothwell, N. J. (1996) J. Cereb. Blood Flow Metab. 16, 932-940
22. Basu, A., Krady, J. K., O'Malley, M., Styren, S. D., DeKosky, S. T., Levison, S. W. (2002) J. Neurosci. 22, 6071-6082
23. Graham, S. H., and Chen, J. (2001) J. Cereb. Blood Flow Metab. 21, 99-109
24. Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., and Greenberg, M. E. (1995) Science 270, 1326-1331
25. Rouse, J., Cohen, P., Trigon, S., Morange, M., Alonso-Llamazares, A., Zamanillo, D., Hunt, T., and Nebreda, A. R. (1994) Cell 78, 1027-1037
26. Huang, C. K., Zhan, L., Ai, Y., and Jongstra, J. (1997) J. Biol. Chem. 272, 17-19
27. Thomas, G., Haavik, J., and Cohen, P. (1997) Eur. J. Biochem. 247, 1180-1189
28. Werz, O., Szellas, D., Steinhilber, D., and Radmark, O. (2002) J. Biol. Chem. 277, 14793-14800
29. Department of Health and Human Services (1996) Guide for the Care and Use of Laboratory Animals (DHEW (DHHS) Publication No. (NIH) 85-23), Office of Science and Health Reports, DRR/NIH, Bethesda, MD