Abnormal migration phenotype of mitogen-activated protein kinase-activated protein kinase 2-/- neutrophils in zigmond chambers containing formyl-methionyl-leucyl-phenylalanine gradients

Journal of Immunology

Volumn 167, Issue 7, 2001, Pages 3953-3961

  Hannigan, M O ^a   Zhan, L ^a   Ai, Y ^a   Kotlyarov, A ^a   Gaestel, M ^a   Huang, C K ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FORMYLMETHIONYLLEUCYLPHENYLALANINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE;

ANIMAL CELL; ARTICLE; CELL ISOLATION; IMMUNOBLOTTING; LEUKOCYTE MIGRATION; MOUSE; NEUTROPHIL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0035478006     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.7.3953     Document Type: Article

References (77)

1. Organization and regulation of mitogen-activated protein kinase signaling pathways
2. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
3. Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27
4. Common and distinct intracellular signaling pathways in human neurophils utilized by platelet activating factor and FMLP
5. Chemotactic peptide N-formyl-Met-Leu-Phe activation of p38 mitogen-activated protein kinase (MAPK) and MAP-activated protein kinase-2 in human neutrophils
6. p38 Mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-α or FMLP stimulation
7. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
8. A protein kinase involved in the regulation of inflammatory cytokine hiosynthesis
9. The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase activated prorein kinase 2 and an AU-rich region targeted mechanism
10. Activation of the protein kinase p38 in the spindle assembly checkpoint and mitotic arrest
11. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
12. T 92,000 type IV collagenase secretion and in vitro invasion
13. p38 MAP kinases: Beyond the stress response
14. Sounding the alarm: Protein kinase cascades activated by stress and inflammation
15. Dissection of protein kinase cascades that mediate cellular response to cytokines and cell stress
16. From receptors to stress-activated MAP kinases
17. The JNK and p38 MAP kinase signaling pathways in T cell-mediated immune responses
18. Sequential protein kinase reactions controlling cell growth and differentiation
19. MKK3-and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway
20. Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP kinase
21. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation
22. ERKs and p38 kinase phosphorylate p53 protein al serine 15 in response to UV radiation
23. MAPKAP kinase-2: A novel protein kinase activated by mitogen-activated protein kinase
24. 3pK. A new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region
25. Mitogen-activated protein kinases activate the serine/threunine kinases MNK1 and MNK2
26. PRAK, a novel protein kinase regulated by p38 MAP kinase
27. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediated activation of CREB
28. The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2
29. Constitutive activation of mitogen-activated protein kinase 2 by mutation of phosphorylation sites and a A-helix motif
30. Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2
31. A conserved docking motif in MAP kinases common to substrates, activators and regulators
32. Identification of two distinct regions of p38 MAPK required for substrate binding and phosphorylation
33. Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2
34. Characterization of the proline-rich region of mouse MAPKAP kinase 2: Influence on catalytic properties and binding to the c-abl-SH3 domain in vitro
35. Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation
36. Regulation of HSP27 oligomerization, chaperone function and protective activity against oxidative stress/tumor necrosis factor a hy phosphorylation
37. HSP27 multimerization mediated by phosphorylation-sensitive intermolecular interactions at the amino terminus
38. MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo
39. Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity
40. CREB is activated by UVC through a p38/HOG-1-dependent protein kinase
41. 5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases
42. Identification of mitogen-activated protein kinase-activated protein kinase-2 as a vimentin kinase activated by okadaic acid in 9L rat brain tumor cells
43. 2+-ATPase activity of myosin II
44. LSP1 is the major substrate for mitogen-activated protein kinase activated protein kinase 2 in human neutrophils
45. Inflammation
46. Phagocytosis
47. 2-integrin-dependent neutrophil adhesion and the adhesion-dependent oxidative burst
48. Activation of the neutrophil NADPH oxidase is inhibited by SB 203580, a specific inhibitor of SAPK2/p38
49. p38 mitogen-activated protein kinase-dependent and -independent intracellular signal transduction pathways leading to apoptosis in human neutrophils
50. SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airway eosinophil inflammation, and persistence
51. Inhibition of p38 mitogen activated kinase attenuates the severity of prancreatitis-induced adult respiratory distress syndrome
52. MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis
53. Deficiency of Src kinase p59/61 hck and p58c-fgr results in defective adhesion-dependent neutrophil functions
54. The distribution of actin during chemolaxis in rabbit neutrophils
55. Introduction to confocal microscopy and three-dimensional reconstruction
56. The role of p38 MAP kinase in TGF-β1-induced signal transduction in human neutrophils
57. Kinase pathways in chemoauractant-induced degranulation of neutrophils: The role of p-38 mitogen-activated protein kinase activated by src family kinases
58. Polarization of chemoattractant receptor signaling during neutrophil chemotaxis
59. Localization of the G protein βγ complex in living cells during chemotaxis
60. Characterization of an autoinhibitory domain in human mitogen activated protein kinase-activated protein kinase 2
61. A new visual assay of leukocyte chemotaxis
62. A cell's sense of direction
63. Cell migration: Movin' on
64. Leukocytes navigate by compass: Roles of P13Kγ and its lipid products
65. A role for Cdc42 in macrophage chemotaxis
66. Inhibition of cell migration by Abl-family tyrosine kinases through uncoupling of Crk/CAS complexes
67. LSP1 modulates the locomotion of monocyte-differentiated U937 cells
68. Leukocyte specific genel protein (LSP1) is involved in chemokine KC activated cytoskeletal reorganization in murine neutrophils in vitro
69. p38 Kinase-dependent MAPKAPK-2 activation functions as PDK2 for AKT in human neutrophils
70. Ras and Rho GTPases: A family reunion
71. Chemolactic peptide-induced activation of MEK-2, the predominant isoform in human neutrophils
72. Differential effects of a mitogen-activated protein kinase kinase inhibitor on human neutrophil responses to chemotactic factors
73. Importance of MEK in neutrophil microbicidal responsiveness
74. Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSB p38 MAP kinase
75. Protrusive activity quantitatively determines the rate and direction of cell locomotion
76. Gelsolin is a downstream effector of RAC for fibroblast motility
77. Intracellular calcium levels correlate with speed and persistent forward motion in migrating neutrophils