MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity: Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease

Journal of Biological Chemistry

Volumn 281, Issue 33, 2006, Pages 23658-23667

  Culbert, Ainsley A ^a   Skaper, Stephen D ^a   Howlett, David R ^a   Evans, Nicholas A ^a   Facci, Laura ^a   Soden, Peter E ^a   Seymour, Zoe M ^a   Guillot, Florence ^a   Gaestel, Matthias ^b   Richardson, Jill C ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CHEMICAL ACTIVATION; DISEASE CONTROL; NEUROLOGY; TOXICITY;

ALZHEIMER DISEASE; CHEMOKINES; NEURODEGENERATIVE PATHOLOGY; TUMOR NECROSIS;

ENZYME KINETICS;

AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; CHEMOKINE; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PRESENILIN 1; TUMOR NECROSIS FACTOR ALPHA;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CORTEX; BRAIN REGION; CELL ACTIVATION; COCULTURE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE RELEASE; ENZYME ACTIVATION; EX VIVO STUDY; FETUS; GENE EXPRESSION; GENE OVEREXPRESSION; INFLAMMATION; MICROGLIA; MOUSE; MUTATION; NERVE CELL; NERVE CELL CULTURE; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; TRANSGENIC MOUSE; UPREGULATION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; ASTROCYTES; CELL LINE; CEREBRAL CORTEX; CHEMOKINES; COCULTURE TECHNIQUES; CYTOKINES; DISEASE MODELS, ANIMAL; DOWN-REGULATION; HUMANS; INFLAMMATION MEDIATORS; INTERFERON TYPE II; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROGLIA; NEURONS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN KINASES; RATS;

MUS MUSCULUS;

EID: 33747632142     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M513646200     Document Type: Article

References (55)

1. Han, J., Lee, J. D., Bibbs, L., and Ulevitch, R. J. (1994) Science 265, 808-811
2. Lee, J. C., Laydon, J. T., McDonnell, P. C., Gallagher, T. F., Kumar, S., Green, D., McNulty, D., Blumenthal, M. J., Heys, J. R., Landvatter, S. W., Strickler, J. E., McLaughlin, M. M., Siemens, I. R., Fisher, S. M., Livi, G. P., White, J. R., Adams, J. L., and Young, P. R. (1994) Nature 372, 739-746
3. Kotlyarov, A., Neininger, A., Schubert, C., Eckert, R., Birchmeier, C., Volk, H. D., and Gaestel, M. (1999) Nat. Cell Biol. 1, 94-97
4. Kotlyarov, A., and Gaestel, M. (2002) Biochem. Soc. Trans. 30, 959-963
5. McGeer, P. L., and McGeer, E. G. (2003) Prog. Neuropsychopharmacol. Biol. Psychiatry 5, 741-749
6. McGeer, P. L., and McGeer, E. G. (2001) Neurobiol. Aging 22, 799-809
7. Akiyama, H., Barger, S., Barnum, S., Bradt, B., Bauer, J., Cole, G. M., Cooper, N. R., Eikelenboom, P., Emmerling, M., Fiebich, B., Finch, C. E., Frautschy, S., Griffin, W. S. T., Hampel, H., Hull, M., Landreth, G., Lue, L. F., Mrak, R., Mackenzie, I. R., McGeer, P. L., O'Banion, M. K., Pachter, J., Pasinetti, G., Plata-Salaman, C., Rogers, J., Rydel, R., Shen, Y., Streit, W., Strohmeyer, R., Tooyama, I., Van Muiswinkel, F. L., Veerhuis, R., Walker, D., Webster, S., Wegrzyniak, B., Wenk, G., and Wyss-Coray, T. (2000) Neurobiol. Aging 21, 383-421
8. Eikelenboom, P., Bate, C., Van Gool, W. A., Hoozemans, J. J., Rozemuller, J. M., Veerhuis, R., and Williams, A. (2002) Glia 40, 232-239
9. Rogers, J., Strohmeyer, R., Kovelowski, C. J., and Li, R. (2002) Glia 40, 260-269
10. Chao, C. C., Hu, S., Molitor, T. W., Shaskan, E. G., and Peterson, P. K. (1992) J. Immunol. 149, 2736-2741
11. Flavin, M. P., Zhao, G., and Ho, L. T. (2000) Glia 29, 347-354
12. Golde, S., Chandran, S., Brown, G. C., and Compston, A. (2002) J. Neurochem. 82, 269-282
13. Parvathenani, L. K., Tertyshnikova, S., Greco, C. R., Roberts, S. B., Robertson, B., and Posmantur, R. (2003) J. Biol. Chem. 278, 13309-13317
14. Diemel, L. T., Copelman, C. A., and Cuznre, M. L. (1998) Neurochem. Res. 23, 341-347
15. Giulian, D. (1999) Am. J. Hum. Genet. 65, 13-18
16. Kaul, M., Garden, G. A., and Lipson, S. A. (2001) Nature 401, 988-994
17. McGeer, P. L., Schulzer, M., and McGeer, E. G. (1996) Neurology 47, 425-432
18. Stewart, W. F., Kawas, C., Corrada, M., and Metter, E. J. (1997) Neurology 48, 626-632
19. Zandi, P. P., Anthony, J. C., Hayden, K. M., Mehta, K., Mayer, L., and Breitner, J. C. S. (2002) Neurology 59, 880-886
20. Hensley, K., Floyd, R. A., Zheng, N.-Y., Nael, R., Robinson, X. N., Pye, Q. N., Stewart, C. A., Geddes, J., Markesbery, W. R., Patel, E., Johnson, G. V. W., and Bing, G. (1999) J. Neurochem. 72, 2053-2058
21. Giovannini, M. G., Scali, C., Prosperi, C., Bellucci, A., Vannucchi, M. G., Rosi, S., Pepeu, G., and Casamenti, F. (2002) Neurobiol. Dis. 11, 257-274
22. Koistinaho, M., Kettunen, M. I., Goldsteins, G., Keinanen, R., Salminen, A., Ort, M., Bures, J., Liu, D., Kauppinen, R. A., Higgins, L. S., and Koistinaho, J. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 1610-1615
23. Hwang, D. Y., Cho, J. S., Lee, S. H., Chae, K. R., Lim, H. J., Min, S. H., Seo, S. J., Song, Y. S., Song, C. W., Paik, S. G., Sheen, Y. Y., and Kim, Y. K. (2004) Exp. Neurol. 186, 20-32
24. Atzori, C., Ghetti, B., Piva, R., Srinivasan, A. N., Zolo, P., Delisle, M. B., Mirra, S. S., and Migheli, A. (2001) J. Neuropathol. Exp. Neurol. 60, 1190-1197
25. Richardson, J. C., Kendal, C. E., Anderson, R., Priest, F., Gower, E., Soden, P., Gray, R., Topps, S., Howlett, D. R., Lavendar, D., Clarke, N. J., Barnes, J. C., Haworth, R., Stewart, M. G., and Rupniak, H. T. R. (2003) Neurosci. 122, 213-228
26. Howlett, D. R., Richardson, J. C., Austin, A., Parsons, A. A., Bate, S. T., Davies, D. C., and Gonzalez, M. I. (2004) Brain Res. 1017, 130-136.
27. Chessell, I. P., Michel, A. D., and Humphrey, P. P. A. (1997) Br. J. Pharmacol. 121, 1429-1437
28. Cross, D. A. E. (2001) Methods Mol. Biol. 124, 147-159
29. Ginham, R., Harrison, D. C., Facci, L., Skaper, S. D., and Philpott, K. L. (2001) Neurosci. Lett. 302, 113-116
30. Rosin, C., Bates, T. E., and Skaper, S. D. (2004) J. Neurochem. 90, 1173-1185
31. Skaper, S. D., Facci, L., Milani, D., Leon, A., and Toffano, G. (1990) in Methods in Neurosciences (Conn, P. M., ed) Vol. 2, pp. 17-33, Academic Press, San Diego
32. Karp, H. L., Tillotson, M. L., Soria, J., Reich, C., and Wood, J. G. (1994) Glia 11, 284-290
33. Sudo, T., Kawai, K., Matsuzaki, H., and Osada, H. (2005) Biochem. Biophys. Res. Commun. 337, 415-421
34. Vician, L. J., Xu, G., Liu, W., Feldman, J. D., Machado, H. B., and Herschman, H. R. (2004) J. Neurosci. Res. 78, 315-328
35. Reynolds, L. J., and Richards, R. J. (2001) Toxicology 165, 145-152
36. Puig, B., Gomez-Isla, T., Ribe, E., Cuadrado, M., Torrejon-Escribano, B., Dalfo, E., and Ferrer, I. (2004) Neuropath. Appl. Neurobiol. 30, 491-502
37. Stoecklin, G., Stubbs, T., Kedersha, N., Wax, S., Rigby, W. F. C., Blackwell, T. K., and Anderson, P. (2004) EMBO J. 23, 1313-1324
38. Mahtani, K. R., Brook, M., Dean, J. L. E., Sully, G., Saklatvala, J., and Clark, A. R. (2001) Mol. Cell. Biol. 21, 6461-6469
39. Rousseau, S., Morrice, N., Peggie, M., Campbell, D. G., Gaestel, M., and Cohen, P. (2002) EMBO J. 21, 6505-6514
40. Lasa, M., Mahtani, K. R., Finch, A., Brewer, G., Saklatvala, J., and Clark, A. R. (2000) Mol. Cell. Biol. 20, 4265-4274
41. Wang, X., Xu, L., Wang, H., Young, P. R., Gaestel, M., and Feuerstein, G. Z. (2002) J. Biol. Chem. 277, 43968-43972
42. Winzen, R., Kracht, M., Ritter, B., Wilhelm, A., Chen, C.-Y. A., Shyu, A.-B., Muller, M., Gaestel, M., Resch, K., and Holtmann, H. (1999) EMBO J. 18, 4969-4980
43. Neininger, A., Kontoyiannis, D., Kotylarov, A., Winzen, R., Eckert, R., Volk, H.-D., Holtmann, H., Kollias, G., and Gaestel, M. (2002) J. Biol. Chem. 277, 3065-3068
44. Bajetto, A., Bonavia, R., Barbero, S., and Schettini, G. (2002) J. Neurochem. 82, 1311-1329
45. Streit, W. J., Conde, J. R., and Harrison, J. K. (2001) Neurobiol. Aging 22, 909-913
46. Xie, Z., Smith, C. J., and Van Eldik, L. J. (2004) Glia 45, 170-179
47. Stein, T. D., and Johnson, J. A. (2002) J. Neurosci. 22, 7380-7388
48. Wang, C. X., and Shuaib, A. (2002) Prog. Neurobiol. 67, 161-172
49. Probert, L., Akassoglou, K., Kassiotis, M., Pasparakis, M., Alexopoulou, G., and Kollias, G. (1997) J. Neuroimmunol. 72, 137-141
50. Aloe, L., Fiore, M., Probert, L., Turrini, P., and Tirassa, P. (1999) Cytokine 11, 45-54
51. Pickering, M., Cumiskey, D., and O'Connor, J. J. (2005) Exp. Physiol. 90, 663-670
52. Aloe, L., Properzi, F., Probert, L., Akassoglou, K., Kassiotis, G., Micera, A., and Fiore, M. (1999) Brain Res. 840, 125-137
53. Wu, Y.-P., and Proia, R. L. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 8425-8430
54. Kitazawa, M., Oddo, S., Yamasaki, T. R., Green, K. N., and LaFerla, F. M. (2005) J. Neurosci. 25, 8843-8853
55. Xia, M., and Hyman, B. (2002) J. Neuroimmunol. 122, 55-64