Cell mediated immunity to fungi: A reassessment

Medical Mycology

Volumn 46, Issue 6, 2008, Pages 515-529

  Romani, Luigina ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

Fungal infections; Immunity; Inflammation; Th Treg subsets

Indexed keywords

ANTIFUNGAL AGENT; CORTICOSTEROID; CYTOKINE; DECTIN 1; DECTIN 2; GALECTIN; GAMMA INTERFERON; INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 23; INTERLEUKIN 4; INTERLEUKIN 5; MANNOSE RECEPTOR; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TRYPTOPHAN;

ADAPTIVE IMMUNITY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL FUNCTION; CELLULAR IMMUNITY; CRYPTOCOCCUS NEOFORMANS; DENDRITIC CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; FUNGAL VIRULENCE; FUNGUS IMMUNITY; HOMEOSTASIS; HOST PATHOGEN INTERACTION; HUMAN; HUMORAL IMMUNITY; IMMUNOLOGICAL MEMORY; IMMUNOPATHOGENESIS; INNATE IMMUNITY; MYCOSIS; NONHUMAN; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; REVIEW; TISSUE INJURY;

ANIMALS; DENDRITIC CELLS; FUNGI; HUMANS; IMMUNITY, CELLULAR; MYCOSES; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, HELPER-INDUCER; T-LYMPHOCYTES, REGULATORY;

FUNGI;

EID: 51649093093     PISSN: 13693786     EISSN: 14602709     Source Type: Journal    
DOI: 10.1080/13693780801971450     Document Type: Review

References (130)

1. Romani, L. (2001) Overview of the fungal pathogens. Immunology of Infectious Diseases, pp. 25-37. ASM Press, Washington, DC
2. Simon-Nobbe, B., Denk, U., Poll, V., Rid, R. and Breitenbach, M. (2007) The spectrum of fungal allergy. Int Arch Allergy Immunol, 145, pp. 58-86.
3. Denning, DW, O'Driscoll, BR, Hogaboam, CM, Bowyer, P. and Niven, RM. (2006) The link between fungi and severe asthma: A summary of the evidence. Eur Respir J, 27, pp. 615-626.
4. Zeller, S., Glaser, AG, Vilhelmsson, M., Rhyner, C. and Crameri, R. (2007) Immunoglobulin-E-mediated reactivity to self antigens: A controversial issue. Int Arch Allergy Immunol, 145, pp. 87-93.
5. Ashbee, HR. (2006) Recent developments in the immunology and biology of Malassezia species. FEMS Immunol Med Microbiol, 47, pp. 14-23.
6. Lilic, D. (2002) New perspectives on the immunology of chronic mucocutaneous candidiasis. Curr Opin Infect Dis, 15, pp. 143-147.
7. Crameri, R., Faith, A. Hemmann, S. et al. (1996) Humoral and cell-mediated autoimmunity in allergy to Aspergillus fumigatus. J Exp Med, 184, pp. 265-270.
8. Mayer, C., Appenzeller, U. Seelbach, H. et al. (1999) Humoral and cell-mediated autoimmune reactions to human acidic ribosomal P2 protein in individuals sensitized to Aspergillus fumigatus P2 protein. J Exp Med, 189, pp. 1507-1512.
9. Schmid-Grendelmeier, P., Fluckiger, S. Disch, R. et al. (2005) IgE-mediated and T cell-mediated autoimmunity against manganese superoxide dismutase in atopic dermatitis. J Allergy Clin Immunol, 115, pp. 1068-1075.
10. Romani, L. and Puccetti, P. (2006) Protective tolerance to fungi: The role of IL-10 and tryptophan catabolism. Trends Microbiol, 14, pp. 183-189.
11. Romani, L. and Puccetti, P. (2007) Controlling pathogenic inflammation to fungi. Expert Rev Anti Infect Ther, 5, pp. 1007-1017.
12. Miceli, MH, Maertens, J. Buve, K. et al. (2007) Immune reconstitution inflammatory syndrome in cancer patients with pulmonary aspergillosis recovering from neutropenia: Proof of principle, description, and clinical and research implications. Cancer, 110, pp. 112-120.
13. Shelburne 3rd, SA, Darcourt, J. White Jr, AC et al. (2005) The role of immune reconstitution inflammatory syndrome in AIDS-related Cryptococcus neoformans disease in the era of highly active antiretroviral therapy. Clin Infect Dis, 40, pp. 1049-1052.
14. Singh, N. and Perfect, JR. (2007) Immune reconstitution syndrome associated with opportunistic mycoses. Lancet Infect Dis, 7, pp. 395-401.
15. Thompson, GR 3rd, LaValle, CE 3rd and Everett, ED. (2004) Unusual manifestations of histoplasmosis. Diagn Microbiol Infect Dis, 50, pp. 33-41.
16. Haas-Stapleton, EJ, Lu, Y. Hong, S. et al. (2007) Candida albicans modulates host defense by biosynthesizing the pro-resolving mediator resolvin E1. PLoS ONE, 2, p. e1316.
17. Wheeler, RT and Fink, GR. (2006) A drug-sensitive genetic network masks fungi from the immune system. PLoS Pathog, 2, p. e35.
18. Dupont, B. (2007) Hepatosplenic candidiasis: A new immune recostitution inflammatory syndrome?. J Med Mycol, 17, pp. 155-156.
19. Wisplinghoff, H., Seifert, H., Wenzel, RP and Edmond, MB. (2006) Inflammatory response and clinical course of adult patients with nosocomial bloodstream infections caused by Candida spp. Clin Microbiol Infect, 12, pp. 170-177.
20. Ortega, M., Rovira, M. Filella, X. et al. (2006) Prospective evaluation of procalcitonin in adults with non-neutropenic fever after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant, 37, pp. 499-502.
21. Schubert, MS. (2006) Allergic fungal sinusitis. Clin Rev Allergy Immunol, 30, pp. 205-216.
22. Assari, T. (2006) Chronic granulomatous disease; fundamental stages in our understanding of CGD. Med Immunol, 5, p. 4.
23. Segal, BH, Leto, TL, Gallin, JI, Malech, HL and Holland, SM. (2000) Genetic, biochemical, and clinical features of chronic granulomatous disease. Medicine (Baltimore), 79, pp. 170-200.
24. Rempe, S., Sachdev, MS Bhakta, R. et al. (2007) Coccidioides immitis fungemia: Clinical features and survival in 33 adult patients. Heart Lung, 36, pp. 64-71.
25. Corvino, CL, Mamoni, RL, Fagundes, GZ and Blotta, MH. (2007) Serum interleukin-18 and soluble tumour necrosis factor receptor 2 are associated with disease severity in patients with paracoccidioidomycosis. Clin Exp Immunol, 147, pp. 483-490.
26. Romani, L. (2004) Immunity to fungal infections. Nat Rev Immunol, 4, pp. 1-23.
27. Akira, S., Uematsu, S. and Takeuchi, O. (2006) Pathogen recognition and innate immunity. Cell, 124, pp. 783-801.
28. Brown, GD. (2006) Dectin-1: A signalling non-TLR pattern-recognition receptor. Nat Rev Immunol, 6, pp. 33-43.
29. Filler, SG. (2006) Candida-host cell receptor-ligand interactions. Curr Opin Microbiol, 9, pp. 333-339.
30. Hohl, TM, Rivera, A. and Pamer, EG. (2006) Immunity to fungi. Curr Opin Immunol, 18, pp. 465-472.
31. Netea, MG, Ferwerda, G., van der Graaf, CA, Van der Meer, JW and Kullberg, BJ. (2006) Recognition of fungal pathogens by toll-like receptors. Curr Pharm Des, 12, pp. 4195-4201.
32. Dong Kim, K, Zhao, J. Auh, S. et al. (2007) Adaptive immune cells temper initial innate responses. Nat Med, 13, pp. 1248-1252.
33. Fidel, PLJr and Sobel, JD. (1994) The role of cell-mediated immunity in candidiasis. Trends Microbiol, 2, pp. 202-206.
34. Puccetti, P., Romani, L. and Bistoni, F. (1995) A TH1-TH2-like switch in candidiasis: New perspectives for therapy. Trends Microbiol, 3, pp. 237-240.
35. Filipe-Santos, O., Bustamante, J. Chapgier, A. et al. (2006) Inborn errors of IL-12/23- and IFN-gamma-mediated immunity: Molecular, cellular, and clinical features. Semin Immunol, 18, pp. 347-361.
36. Moraes-Vasconcelos, D., Grumach, AS Yamaguti, A. et al. (2005) Paracoccidioides brasiliensis disseminated disease in a patient with inherited deficiency in the beta1 subunit of the interleukin (IL)-12/ IL-23 receptor. Clin Infect Dis, 41, p. e31.
37. Zerbe, CS and Holland, SM. (2005) Disseminated histoplasmosis in persons with interferon-gamma receptor 1 deficiency. Clin Infect Dis, 41, p. e38.
38. De Luca, A., Montagnoli, C. Zelante, T. et al. (2007) Functional yet balanced reactivity to Candida albicans requires TRIF, MyD88, and IDO-dependent inhibition of Rorc. J Immunol, 179, pp. 5999-6008.
39. Zelante, T., De Luca, A. Bonifazi, P. et al. (2007) IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Eur J Immunol, 37, pp. 2695-2706.
40. Bellocchio, S., Montagnoli, C. Bozza, S. et al. (2004) The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo. J Immunol, 172, pp. 3059-3069.
41. Bellocchio, S., Moretti, S. Perruccio, K. et al. (2004) TLRs govern neutrophil activity in aspergillosis. J Immunol, 173, pp. 7406-7415.
42. Netea, MG, Gow, NA Munro, CA et al. (2006) Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors. J Clin Invest, 116, pp. 1642-1650.
43. Sato, K., Yang, XL Yudate, T. et al. (2006) Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responses. J Biol Chem, 281, pp. 3854-3866.
44. Behnsen, J., Narang, P. Hasenberg, M. et al. (2007) Environmental dimensionality controls the interaction of phagocytes with the pathogenic fungi Aspergillus fumigatus and Candida albicans. PLoS Pathoge, 3, p. e13.
45. Trinchieri, G. and Sher, A. (2007) Cooperation of Toll-like receptor signals in innate immune defence. Nat Rev Immunol, 7, pp. 179-190.
46. Netea, MG, Van der Meer, JW and Kullberg, BJ. (2004) Toll-like receptors as an escape mechanism from the host defense. Trends Microbiol, 12, pp. 484-488.
47. Bellocchio, S., Gaziano, R. Bozza, S. et al. (2005) Liposomal amphotericin B activates antifungal resistance with reduced toxicity by diverting Toll-like receptor signalling from TLR-2 to TLR-4. J Antimicrob Chemother, 55, pp. 214-222.
48. Biondo, C., Midiri, A. Messina, L. et al. (2005) MyD88 and TLR2, but not TLR4, are required for host defense against Cryptococcus neoformans. Eur J Immunol, 35, pp. 870-878.
49. Bozza, S., Gaziano, R. Lipford, GB et al. (2002) Vaccination of mice against invasive aspergillosis with recombinant Aspergillus proteins and CpG oligodeoxynucleotides as adjuvants. Microbes Infect, 4, pp. 1281-1290.
50. Braedel, S., Radsak, M. Einsele, H. et al. (2004) Aspergillus fumigatus antigens activate innate immune cells via toll-like receptors 2 and 4. Br J Haematol, 125, pp. 392-399.
51. Edwards, L., Williams, AE Krieg, AM et al. (2004) Stimulation via Toll-like receptor 9 reduces Cryptococcus neoformans-induced pulmonary inflammation in an IL-12-dependent manner. Eur J Immunol, 35, pp. 273-281.
52. Ferreira, KS, Bastos, KR, Russo, M. and Almeida, SR. (2007) Interaction between Paracoccidioides brasiliensis and pulmonary dendritic cells induces interleukin-10 production and toll-like receptor-2 expression: possible mechanisms of susceptibility. J Infect Dis, 196, pp. 1108-1115.
53. Gil, ML and Gozalbo, D. (2006) TLR2, but not TLR4, triggers cytokine production by murine cells in response to Candida albicans yeasts and hyphae. Microbes Infect, 8, pp. 2299-2304.
54. Kesh, S., Mensah, NY Peterlongo, P. et al. (2005) TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation. Ann N Y Acad Sci, 1062, pp. 95-103.
55. Mambula, SS, Sau, K., Henneke, P., Golenbock, DT and Levitz, SM. (2002) Toll-like receptor (TLR) signaling in response to Aspergillus fumigatus. J Biol Chem, 277, pp. 39320-39326.
56. Murciano, C., Villamon, E. Gozalbo, D. et al. (2006) Toll-like receptor 4 defective mice carrying point or null mutations do not show increased susceptibility to Candida albicans in a model of hematogenously disseminated infection. Med Mycol, 44, pp. 149-157.
57. Netea, MG, Sutmuller, R. Hermann, C. et al. (2004) Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells. J Immunol, 172, pp. 3712-3718.
58. Netea, MG, Warris, A. Van der Meer, JW et al. (2003) Aspergillus fumigatus evades immune recognition during germination through loss of toll-like receptor-4-mediated signal transduction. J Infect Dis, 188, pp. 320-326.
59. Rivera, A., Ro, G. Van Epps, HL et al. (2006) Innate immune activation and CD4+ T cell priming during respiratory fungal infection. Immunity, 25, pp. 665-675.
60. Sau, K., Mambula, SS Latz, E. et al. (2003) The antifungal drug amphotericin B promotes inflammatory cytokine release by a Toll-like receptor- and CD14-dependent mechanism. J Biol Chem, 278, pp. 37561-37568.
61. van der Graaf, CA, Netea, MG, Verschueren, I., van der Meer, JW and Kullberg, BJ. (2005) Differential cytokine production and Toll-like receptor signaling pathways by Candida albicans blastoconidia and hyphae. Infect Immun, 73, pp. 7458-7464.
62. Villamon, E., Gozalbo, D. Roig, P. et al. (2004) Myeloid differentiation factor 88 (MyD88) is required for murine resistance to Candida albicans and is critically involved in Candida-induced production of cytokines. Eur Cytokine Netw, 15, pp. 263-271.
63. Carvalho, A., Pasqualotto, AC Pitzurra, L. et al. (2008) Polymorphisms in Toll-like receptor genes and susceptibility to pulmonary aspergillosis. J Infrect Dis, 197, pp. 618-631.
64. Specht, CA, Nong, S., Dan, JM, Lee, CK and Levitz, SM. (2007) Contribution of glycosylation to T cell responses stimulated by recombinant Cryptococcus neoformans mannoprotein. J Infect Dis, 196, pp. 796-800.
65. Gantner, BN, Simmons, RM, Canavera, SJ, Akira, S. and Underhill, DM. (2003) Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med, 197, pp. 1107-1117.
66. Gantner, BN, Simmons, RM and Underhill, DM. (2005) Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments. Embo J, 24, pp. 1277-1286.
67. Gersuk, GM, Underhill, DM, Zhu, L. and Marr, KA. (2006) Dectin-1 and TLRs permit macrophages to distinguish between different Aspergillus fumigatus cellular states. J Immunol, 176, pp. 3717-3724.
68. Hohl, TM, Van Epps, HL Rivera, A. et al. (2005) Aspergillus fumigatus triggers inflammatory responses by stage-specific beta-glucan display. PLoS Pathog, 1, p. e30.
69. Rappleye, CA, Eissenberg, LG and Goldman, WE. (2007) Histoplasma capsulatum alpha-(1,3)-glucan blocks innate immune recognition by the beta-glucan receptor. Proc Natl Acad Sci USA, 104, pp. 1366-1370.
70. Saijo, S., Fujikado, N. Furuta, T. et al. (2007) Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans. Nat Immunol, 8, pp. 39-46.
71. Steele, C., Marrero, L. Swain, S. et al. (2003) Alveolar macrophage-mediated killing of Pneumocystis carinii f. sp. muris involves molecular recognition by the Dectin-1 beta-glucan receptor. J Exp Med, 198, pp. 1677-1688.
72. Steele, C., Rapaka, RR Metz, A. et al. (2005) The beta-glucan receptor dectin-1 recognizes specific morphologies of Aspergillus fumigatus. PLoS Pathog, 1, p. e42.
73. Taylor, PR, Tsoni, SV Willment, JA et al. (2007) Dectin-1 is required for beta-glucan recognition and control of fungal infection. Nat Immunol, 8, pp. 31-38.
74. Viriyakosol, S., Fierer, J., Brown, GD and Kirkland, TN. (2005) Innate immunity to the pathogenic fungus Coccidioides posadasii is dependent on Toll-like receptor 2 and Dectin-1. Infect Immun, 73, pp. 1553-1560.
75. Heinsbroek, SE, Brown, GD and Gordon, S. (2005) Dectin-1 escape by fungal dimorphism. Trends Immunol, 26, pp. 352-354.
76. Gross, O., Gewies, A. Finger, K. et al. (2006) Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature, 442:7103, pp. 651-656.
77. Leibundgut-Landmann, S., Gross, O. Robinson, MJ et al. (2007) Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat Immunol, 8, pp. 630-638.
78. Romani, L., Bistoni, F. and Puccetti, P. (2002) Fungi, dendritic cells and receptors: A host perspective of fungal virulence. Trends Microbiol, 10, pp. 508-514.
79. Romani, L. and Puccetti, P. (2006) Dendritic Cells. Biology, Diseases and Therapies, pp. 915-930. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany
80. Montagnoli, C., Perruccio, K. Bozza, S. et al. (2008) Provision of antifungal immunity and concomitant alloantigen tolerization by conditioned dendritic cells in experimental hematopoietic transplantation. Blood Cells Mol Dis, 40, pp. 55-62.
81. Awasthi, S. (2007) Dendritic cell-based vaccine against Coccidioides infection. Ann NY Acad Sci, 1111, pp. 269-274.
82. Romani, L., Bistoni, F. and Puccetti, P. (2003) Adaptation of Candida albicans to the host environment: The role of morphogenesis in virulence and survival in mammalian hosts. Curr Opin Microbiol, 6, pp. 338-343.
83. Lindell, DM, Ballinger, MN, McDonald, RA, Toews, GB and Huffnagle, GB. (2006) Immunologic homeostasis during infection: Coexistence of strong pulmonary cell-mediated immunity to secondary Cryptococcus neoformans infection while the primary infection still persists at low levels in the lungs. J Immunol, 177, pp. 4652-4661.
84. Lindell, DM, Moore, TA, McDonald, RA, Toews, GB and Huffnagle, GB. (2006) Distinct compartmentalization of CD4+ T-cell effector function versus proliferative capacity during pulmonary cryptococcosis. Am J Pathol, 168, pp. 847-855.
85. Yauch, LE, Lam, JS and Levitz, SM. (2006) Direct inhibition of T-cell responses by the Cryptococcus capsular polysaccharide glucuronoxylomannan. PLoS Pathog, 2, p. e120.
86. Allen, HL and Deepe Jr, GS (2005) Apoptosis modulates protective immunity to the pathogenic fungus Histoplasma capsulatum. J Clin Invest, 115, pp. 2875-2885.
87. Deepe Jr, GS (2000) Immune response to early and late Histoplasma capsulatum infections. Curr Opin Microbiol, 3, pp. 359-362.
88. Gomez, FJ, Woodward, EO, Pilcher-Roberts, R., Gibbons, RS and Deepe Jr, GS (2001) V beta 6+ and V beta 4+ T cells exert cooperative activity in clearance of secondary infection with Histoplasma capsulatum. J Immunol, 166, pp. 2855-2862.
89. Levitz, SM, Mathews, HL and Murphy, JW. (1995) Direct antimicrobial activity of T cells. Immunol Today, 16, pp. 387-391.
90. Wuthrich, M., Filutowicz, HI, Allen, HL, Deepe, GS and Klein, BS. (2007) V beta1+ J beta1.1+/V alpha2+ J alpha49+ CD4+ T cells mediate resistance against infection with Blastomyces dermatitidis. Infect Immun, 75, pp. 193-200.
91. Wuthrich, M., Filutowicz, HI, Warner, T., Deepe Jr, GS and Klein, BS. (2003) Vaccine immunity to pathogenic fungi overcomes the requirement for CD4 help in exogenous antigen presentation to CD8+ T cells: implications for vaccine development in immune-deficient hosts. J Exp Med, 197, pp. 1405-1416.
92. Mencacci, A., Del Sero, G Cenci, E. et al. (1998) Endogenous interleukin 4 is required for development of protective CD4+ T helper type 1 cell responses to Candida albicans. J Exp Med, 187, pp. 307-317.
93. Dong, C. (2006) Diversification of T-helper-cell lineages: Finding the family root of IL-17-producing cells. Nat Rev Immunol, 6, pp. 329-333.
94. Bettelli, E., Oukka, M. and Kuchroo, VK. (2007) T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol, 8, pp. 345-350.
95. Veldhoen, M., Hocking, RJ, Atkins, CJ, Locksley, RM and Stockinger, B. (2006) TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity, 24, pp. 179-189.
96. Trinchieri, G., Pflanz, S. and Kastelein, RA. (2003) The IL-12 family of heterodimeric cytokines: New players in the regulation of T cell responses. Immunity, 19, pp. 641-644.
97. Stockinger, B. and Veldhoen, M. (2007) Differentiation and function of Th17 T cells. Curr Opin Immunol, 19, pp. 281-286.
98. Bowman, EP, Chackerian, AA and Cua, DJ. (2006) Rationale and safety of anti-interleukin-23 and anti-interleukin-17A therapy. Curr Opin Infect Dis, 19, pp. 245-252.
99. Heninger, E., Hogan, LH Karman, J. et al. (2006) Characterization of the Histoplasma capsulatum-induced granuloma. J Immunol, 177, pp. 3303-3313.
100. Kleinschek, MA, Muller, U. Brodie, SJ et al. (2006) IL-23 enhances the inflammatory cell response in Cryptococcus neoformans infection and induces a cytokine pattern distinct from IL-12. J Immunol, 176, pp. 1098-1106.
101. Huang, W., Na, L., Fidel, PL and Schwarzenberger, P. (2004) Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J Infect Dis, 190, pp. 624-631.
102. Rudner, XL, Happel, KI, Young, EA and Shellito, JE. (2007) Interleukin-23 (IL-23)-IL-17 cytokine axis in murine Pneumocystis carinii infection. Infect Immun, 75, pp. 3055-3061.
103. Bozza, S., Fallarino, F. Pitzurra, L. et al. (2005) A crucial role for tryptophan catabolism at the host/Candida albicans interface. J Immunol, 174, pp. 2910-2918.
104. Montagnoli, C., Fallarino, F. Gaziano, R. et al. (2006) Immunity and tolerance to Aspergillus involve functionally distinct regulatory T cells and tryptophan catabolism. J Immunol, 176, pp. 1712-1723.
105. Andersson, A., Kokkola, R., Wefer, J., Erlandsson-Harris, H. and Harris, RA. (2004) Differential macrophage expression of IL-12 and IL-23 upon innate immune activation defines rat autoimmune susceptibility. J Leukoc Biol, 76, pp. 1118-1124.
106. Hung, CY, Xue, J. and Cole, GT. (2007) Virulence mechanisms of Coccidioides. Ann NY Acad Sci, 1111, pp. 225-235.
107. Yoshitomi, H., Sakaguchi, N. Kobayashi, K. et al. (2005) A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice. J Exp Med, 201, pp. 949-960.
108. Dillon, S., Agrawal, S. Banerjee, K. et al. (2006) Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance. J Clin Invest, 116, pp. 916-928.
109. Romani, L., Fallarino, F. De Luca, A. et al. (2008) Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous diseases. Nature, 451, pp. 211-216.
110. Laurence, A. and O'Shea, JJ. (2007) T(H)-17 differentiation: Of mice and men. Nat Immunol, 8, pp. 903-905.
111. Xu, L., Kitani, A., Fuss, I. and Strober, W. (2007) Cutting edge: regulatory T cells induce CD4 + CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta. J Immunol, 178, pp. 6725-6729.
112. Jankovic, D. and Trinchieri, G. (2007) IL-10 or not IL-10: That is the question. Nat Immunol, 8, pp. 1281-1283.
113. O'Garra, A. and Vieira, P. (2004) Regulatory T cells and mechanisms of immune system control. Nat Med, 10, pp. 801-805.
114. Hori, S., Carvalho, TL and Demengeot, J. (2002) CD25 + CD4+ regulatory T cells suppress CD4+ T cell-mediated pulmonary hyperinflammation driven by Pneumocystis carinii in immunodeficient mice. Eur J Immunol, 32, pp. 1282-1291.
115. McKinley, L., Logar, AJ McAllister, F. et al. (2006) Regulatory T cells dampen pulmonary inflammation and lung injury in an animal model of Pneumocystis pneumonia. J Immunol, 177, pp. 6215-6226.
116. Montagnoli, C., Bacci, A. Bozza, S. et al. (2002) B7/CD28-dependent CD4+ CD25+ regulatory T cells are essential components of the memory-protective immunity to Candida albicans. J Immunol, 169, pp. 6298-6308.
117. Cavassani, KA, Campanelli, AP Moreira, AP et al. (2006) Systemic and local characterization of regulatory T cells in a chronic fungal infection in humans. J Immunol, 177, pp. 5811-5818.
118. Belkaid, Y. (2007) Regulatory T cells and infection: A dangerous necessity. Nat Rev Immunol, 7, pp. 875-888.
119. Deepe Jr, GS and Gibbons, RS. (2008) TNf-alpha antagonism generates a population of antigen specific CD4+CD2+T cells that inhibit protective immunity in munne histoplasmosis. J Immunol, 180, pp. 1088-1097.
120. Ryan, KR, Lawson, CA Lorenzi, AR et al. (2005) CD4+CD25+ T-regulatory cells are decreased in patients with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy. J Allergy Clin Immunol, 116, pp. 1158-1159.
121. Mellor, AL and Munn, DH. (2004) IDO expression by dendritic cells: tolerance and tryptophan catabolism. Nat Rev Immunol, 4, pp. 762-774.
122. Grohmann, U., Fallarino, F. and Puccetti, P. (2003) Tolerance, DCs and tryptophan: Much ado about IDO. Trends Immunol, 24, pp. 242-248.
123. Fallarino, F., Grohmann, U. You, S. et al. (2006) The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells. J Immunol, 176, pp. 6752-6761.
124. Puccetti, P. and Grohmann, U. (2007) IDO and regulatory T cells: A role for reverse signalling and non-canonical NF-kappaB activation. Nat Rev Immunol, 7, pp. 817-823.
125. Grohmann, U., Volpi, C. Fallarino, F. et al. (2007) Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy. Nat Med, 13, pp. 579-586.
126. Noverr, MC and Huffnagle, GB. (2004) Does the microbiota regulate immune responses outside the gut?. Trends Microbiol, 12, pp. 562-568.
127. Pirofski, LA and Casadevall, A. (2006) Immunomodulators as an antimicrobial tool. Curr Opin Microbiol, 9, pp. 489-495.
128. Roilides, E., Lyman, CA, Panagopoulou, P. and Chanock, S. (2003) Immunomodulation of invasive fungal infections. Infect Dis Clin North Am, 17, pp. 193-219.
129. Romani, L. (2001) Host immune reactivity and antifungal chemotherapy: the power of being together. J Chemother, 13, pp. 347-353.
130. Tilg, H., Moschen, A. and Kaser, A. (2007) Mode of function of biological anti-TNF agents in the treatment of inflammatory bowel diseases. Expert Opin Biol Ther, 7, pp. 1051-1059.