Endogenous interleukin 4 is required for development of protective CD4+ T helper type 1 cell responses to Candida albicans

Journal of Experimental Medicine

Volumn 187, Issue 3, 1998, Pages 307-317

  Mencacci, Antonella ^a   Del Sero, Giuseppe ^a   Cenci, Elio ^a   D'Ostiani, Cristiana Fè ^a   Bacci, Angela ^a   Montagnoli, Claudia ^a   Kopf, Manfred ^b   Romani, Luigina ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CANDIDIASIS; CELL DIFFERENTIATION; HELPER CELL; IMMUNE SYSTEM; IMMUNITY; IMMUNIZATION; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CANDIDA ALBICANS; CANDIDIASIS; CD4-POSITIVE T-LYMPHOCYTES; INFECTION; INTERFERON TYPE II; INTERLEUKIN-4; INTERLEUKINS; MACROPHAGES; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; NEUTROPHILS; NITRITES; RNA, MESSENGER; SPLEEN; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 0032472840     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.187.3.307     Document Type: Article

References (58)

1. Romani, L., P. Puccetti, and F. Bistoni. 1996. Biological role of Th cell subsets in candidiasis. Chem. Immunol. 63:115-137.
2. Puccetti, P., L. Romani, and F. Bistoni. 1995. A TH1-TH2-like switch in candidiasis: new perspectives for therapy. Trends Microbiol. 3:237-240.
3. + subset expression in murine candidiasis. Th responses correlate directly with genetically determined susceptibility or vaccine-induced resistance. J. Immunol. 150:925-931.
4. Romani, L., A. Mencacci, U. Grohmann, S. Mocci, P. Mosci, P. Puccetti, and F. Bistoni. 1992. Neutralizing antibody to interleukin 4 induces systemic protection and T helper type 1-associated immunity in murine candidiasis. J. Exp. Med. 176:19-25.
5. Puccetti, P., A. Mencacci, E. Cenci, R. Spaccapelo, P. Mosci, K.-H. Enssle, L. Romani, and F. Bistoni. 1994. Cure of murine candidiasis by recombinant soluble interleukin-4 receptor. J. Infect. Dis. 169:1325-1331.
6. + subset expression in murine candidiasis. Infect. Immun. 60:4950-4952.
7. Spaccapelo, R., L. Romani, L. Tonnetti, E. Cenci, A. Mencacci, R. Tognellini, S.G. Reed, P. Puccetti, and F. Bistoni. 1995. TGF-β is important in determining the in vivo of susceptibility or resistance in mice infected with Candida albicans. J. Immunol. 155:1349-1360.
8. Romani, L., P. Puccetti, A. Mencacci, E. Cenci, R. Spaccapelo, L. Tonnetti, U. Grohmann, and F. Bistoni. 1994. Neutralization of IL-10 up-regulates nitric oxide production and protects susceptible mice from challenge with Candida albicans. J. Immunol. 152:3514-3521.
9. Romani, L., A. Mencacci, L. Tonnetti, R. Spaccapelo, E. Cenci, P. Puccetti, S.F. Wolf, and F. Bistoni. 1994. Interleukin-12 is both required and prognostic in vivo for T helper type 1 differentiation in murine candidiasis. J. Immunol. 153: 5167-5175.
10. Romani, L., A. Mencacci, L. Tonnetti, R. Spaccapelo, E. Cenci, S. Wolf, P. Puccetti, and F. Bistoni. 1994. Interleukin-12 but not interferon-γ production correlates with induction of T helper type-1 phenotype in murine candidiasis. Eur. J. Immunol. 22:909-915.
11. Romani, L., F. Bistoni, A. Mencacci, E. Cenci, R. Spaccapelo, and P. Puccetti. 1996. IL12 in Candida albicans infections. Res. Immunol. 146:532-538.
12. Tonnetti, L., R. Spaccapelo, E. Cenci, A. Mencacci, P. Puccetti, R.L. Coffman, F. Bistoni, and L. Romani. 1995. Interleukin-4 and -10 exacerbate candidiasis in mice. Eur. J. Immunol. 25:1559-1565.
13. + T-helper-cell responses in mice with low-level Candida albicans infection. Infect. Immun. 64:4907-4914.
14. Kopf, M., F. Brombacher, G. Kohler, G. Kienzle, K.-H. Widmann, K. Lefrang, C. Humborg, B. Lederman, and W. Solbach. 1996. IL-4-deficient BALB/c mice resist infection with Leishmania major. J. Exp. Med. 184:1127-1136.
15. Suzuki, Y., Q. Yang, S. Yang, N. Nguyen, S. Lim, O. Liesenfeld, T. Kojima, and J.S. Remington. 1996. IL-4 is protective against development of toxoplasmic encephalitis. J. Immunol. 157:2564-2569.
16. Roberts, C.W., D.J.P. Ferguson, H. Jebbari, A. Satoskar, H. Bluethmann, and J. Alexander. 1996. Differential roles for interleukin-4 during the course of Toxoplasma gondii infection. Infect. Immun. 64:897-904.
17. Noble, A., and D.M. Kemeny. 1995. Interleukin-4 enhances interferon-γ synthesis but inhibits development of interferon-γ-producing cells. Immunology. 85:357-363.
18. Platzer, C., G. Ricther, W. Muller, H. Blocker, T. Diamantstein, and T. Blackenstein. 1992. Analysis of cytokine mRNA levels in interleukin-4-transgenic mice by quantitative polymerase chain reaction. Eur. J. Immunol. 22:1179-1184.
19. + T cells. Annu. Rev. Immunol. 12:635-673.
20. Kamogawa, Y., L.E. Minasi, S.R. Carding, K. Bottomly, and R.A. Flavell. 1993. The relationship of IL-4-and IFN-γ-producing T cells studied by lineage ablation of IL-4-producing cells. Cell. 75:985-995.
21. + T cells. J. Immunol. 158:1085-1094.
22. Nakamura, T., R.K. Lee, S.Y. Nam, E.R. Podack, K. Bottomly, and R.A. Flavell. 1997. Roles of IL-4 and IFN-γ in stabilizing the T helper cell type 1 and 2 phenotype. J. Immunol. 158:2648-2653.
23. Kopf, M., G. Le Gros, M. Bachmann, M.C. Lamers, H. Bluethmann, and G. Kohler. 1993. Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature. 362:245-248.
24. Cenci, E., A. Mencacci, R. Spaccapelo, L. Tonnetti, P. Mosci, K.-H. Enssle, P. Puccetti, L. Romani, and F. Bistoni. 1995. T helper cell type 1 (Th1)-and Th2-like responses are present in mice with gastric candidiasis but protective immunity is associated with Th1 development. J. Infect. Dis. 171: 1279-1288.
25. + T helper subset selection in mice with candidiasis. J. Immunol. 158:2356-2362.
26. Romani, L., A. Mencacci, E. Cenci, R. Spaccapelo, G. Del Sero, I. Nicoletti, G. Trinchieri, F. Bistoni, and P. Puccetti. 1997. Neutrophil production of IL-12 and IL-10 in candidiasis and efficacy of IL-12 therapy in neutropenic mice. J. Immunol. 158:5349-5356.
27. Cenci, E., L. Romani, A. Mencacci, R. Spaccapelo, E. Schiaffella, P. Puccetti, and F. Bistoni. 1993. Interleukin-4 and interleukin-10 inhibit nitric oxide-dependent macrophage killing of Candida albicans. Eur. J. Immunol. 23:1034-1038.
28. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
29. Saiki, R.K., S. Scharf, F. Faloona, K.B. Mullis, G.T. Horn, H.A. Erlich, and N. Arnheim. 1985. Enzymatic amplification of β-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science. 230:1350-1354.
30. Reiner, S.L., S. Zheng, D.B. Corry, and R.M. Locksley. 1993. Constructing polycompetitor cDNA for quantitative PCR. J. Immunol. Methods. 165:37-46.
31. Djeu, J.Y. 1993. Modulators of immune responses to fungi. In Fungal Infections and Immune Responses. J.W. Murphy, H. Friedman, and M. Bendinelli, editors. Plenum Press, New York. 521-532.
32. Kullberg, B.J., J.W. van't Want, C. Hoogstraten, and R. van Furth. 1993. Recombinant interferon-γ enhances resistance to acute disseminated C. albicans infection in mice. J. Infect. Dis. 168:436-443.
33. + subset differentiation in Candida albicans-infected mice. Infect. Immun. 61: 3769-3774.
34. Szabo, S.J., A.S. Dighe, U. Gubler, and K.M. Murphy. 1997. Regulation of the interleukin (IL)-12Rβ2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185:817-824.
35. Rogge, L., L. Barberis-Maino, M. Biffi, N. Passini, D.H. Presky, U. Gubler, and F. Sinigaglia. 1997. Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J. Exp. Med. 185:825-831.
36. Hilton, D.J., J.G. Zhang, D. Metcalf, W.S. Alexander, N.A. Nicola, and T.A. Wilson. 1996. Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. Proc. Natl. Acad. Sci. USA. 81:7189-7193.
37. von-der-Weid, T., M. Kopf, G. Kohler, and J. Langhorne. 1994. The immune response to Plasmodium chabaudi malaria in interleukin-4-deficient mice. Eur. J. Immunol. 24:2285-2293.
38. Lawrence, R.A., J.E. Allen, W.F. Gregory, M. Kopf, and R.M. Maizels. 1995. Infection of IL-4-deficient mice with the parasitic nematode Brugia malayi demonstrates that host resistance is not dependent on a T helper 2-dominated immune response. J. Immunol. 154:5995-6001.
39. Pearlman, E., J.H. Lass, D.S. Bardenstein, M. Kopf, F.E. Hazlett, E. Diaconu, and J.W. Kazura. 1995. IL-4 and Th2 cells are required for development of experimental onchocercal keratitis (river blindness). J. Exp. Med. 182:931-940.
40. Pearce, E.J., A. Cheever, S. Leonard, M. Covalesky, R. Fernandez-Botran, G. Kohler, and M. Kopf. 1996. Schistosoma mansoni in IL-4-deficient mice. Int. Immunol. 8:435-444.
41. Kopf, M., G. LeGros, A.J. Coyle, M. Kosco-Vilbois, and F. Brombacher. 1995. Immune responses of IL-4, IL-5, IL-6 deficient mice. Immunol. Rev. 148:45-69.
42. Metwali, A., D. Elliot, A.M. Blum, J. Li, M. Sandor, R.R. Lynch, N. Noben-Trauth, and J.V. Weinstock. 1996. The granulomatous response in murine Schistosomiasis mansoni does not switch to Th1 in IL-4-deficient C57BL/6 mice. J. Immunol. 157:4546-4553.
43. Vajdy, M., M.H. Kosko-Vilbois, M. Kopf, G. Kohler, and N. Lycke. 1995. Impaired mucosal immune responses in interleukin 4-targeted mice. J. Exp. Med. 181:41-53.
44. Mowat, A.M., and M.B. Widmer. 1995. A role for IL-4 in immunologically mediated enteropathy. Clin. Exp. Immunol. 99:65-69.
45. Stein, M., S. Keshav, N. Harris, and S. Gordon. 1992. Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J. Exp. Med. 176:287-292.
46. Redmond, H., L. Schuchter, J. Shou, L.K. Hofmann, P. Leon, L. Marodi, R. Johnston, and J. Daly. 1990. Interleukin 4 (IL-4) enhances macrophage microbicidal function. J. Leukocyte Biol. 48(Suppl.):24.
47. Bobert, L.A., T.A. Waters, C.C. Pugliese-Sivo, L.M. Sullivan, S.K. Narula, and M.J. Grace. 1995. IL-4 induces neutrophilic maturation of HL-60 cells and activation of human peripheral blood neutrophils. Clin. Exp. Immunol. 99:129-136.
48. Feldman, G.M., and D.S. Finbloom. 1990. Induction and regulation of IL-4 receptor expression on murine macrophage cell lines and bone marrow-derived macrophages by IFN-γ. J. Immunol. 145:854-859.
49. Park, L., D. Friend, H. Sassenfeld, and D. Urdal. 1987. Characterization of the human B cell stimulatory factor 1 receptor. J. Exp. Med. 166:476-488.
50. Lezama-Davila, C.M., D.M. Williams, G. Gallagher, and J. Alexander. 1992. Cytokine control of Leishmania infection in the BALB/c mouse: enhancement and inhibition of parasite growth by local administration of IL-2 or IL-4 is species and time dependent. Parasite Immunol. 14:37-18.
51. D'Andrea, A., X. Ma, M. Aste-Amegaza, C. Paganin, and G. Trinchieri. 1995. Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor α production. J. Exp. Med. 181: 537-546.
52. Takenaka, H., S. Maruo, N. Yamamoto, M. Wysocka, S. Ono, M. Kobayashi, H. Yagita, K. Okamura, T. Hamaoka, G. Trinchieri, and H. Fujiwara. 1997. Regulation of T cell-dependent and independent IL-12 production by the three Th2-type cytokines IL-10, IL-6, and IL-4. J. Leukocyte Biol. 61: 80-87.
53. Feldman, G.M., S. Ruhl, M. Bickel, D.S. Finbloom, and D.H. Pluznik. 1991. Regulation of interleukin-4 receptors on murine myeloid progenitor cells by interleukin-6. Blood. 78:1678-1684.
54. + T helper cell development in interleukin 6-deficient mice infected with Candida albicans. J. Exp. Med. 183:1345-1355.
55. Romani, L., P. Puccetti, A. Mencacci, R. Spaccapelo, E. Cenci, L. Tonnetti, and F. Bistoni. 1994. Tolerance to staphylococcal enterotoxin B initiates Th1 cell differentiation in mice infected with Candida albicans. Infect. Immun. 62:4047-4053.
56. Romani, L., and D.H. Howard. 1995. Mechanisms of resistance to fungal infections. Curr. Opin. Immunol. 7:517-523.
57. + T cells during initiation of infection. J. Exp. Med. 179:447-456.
58. -. Eur. J. Immunol. 25:3298-3307.