The antifungal drug amphotericin B promotes inflammatory cytokine release by a toll-like receptor- and CD14-dependent mechanism

Journal of Biological Chemistry

Volumn 278, Issue 39, 2003, Pages 37561-37568

  Sau, Keya ^a   Mambula, Salamatu S ^a   Latz, Eicke ^b   Henneke, Philipp ^b,c   Golenbock, Douglas T ^b   Levitz, Stuart M ^a,d  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF FREIBURG   (Germany)

^d Section of Infectious Diseases   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASE CONTROL; FUNGI; IMMUNOLOGY; MUTAGENESIS; TOXIC MATERIALS;

MACROPHAGES;

DRUG THERAPY;

ADAPTOR PROTEIN; AMPHOTERICIN B; AMPHOTERICIN B DEOXYCHOLATE; AMPHOTERICIN B LIPID COMPLEX; ANTIFUNGAL AGENT; CD14 ANTIGEN; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANOREXIA; ARTICLE; CELL STIMULATION; CHILL; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFICACY; DRUG FORMULATION; DRUG INFUSION; FEMALE; FEVER; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; INFLAMMATION; MACROPHAGE; MALE; MOUSE; MUTATION; MYCOSIS; NAUSEA; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; SIGNAL TRANSDUCTION; TACHYPNEA;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMPHOTERICIN B; ANTIBIOTICS, ANTIFUNGAL; ANTIGENS, CD14; ANTIGENS, DIFFERENTIATION; CELL LINE; CELL SURVIVAL; HUMANS; INTERLEUKIN-1; MEMBRANE GLYCOPROTEINS; MYELOID DIFFERENTIATION FACTOR 88; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; FUNGI; MURINAE;

EID: 0141844541     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M306137200     Document Type: Article

References (56)

1. Mandell, G. L., Bennett, J. E., and Dolin, R. (2000) Principles and Practice of Infectious Diseases, 5th Ed., Vol. 1, pp. 448-459, Churchill Livingstone, Philadelphia
2. Cleary, J. D., Weisdorf, D., and Fletcher, C. V. (1988) Drug Intell. Clin. Pharm. 22, 769-772
3. Cleary, J. D., Chapman, S. W., and Nolan, R. L. (1992) Antimicrob. Agents Chemother. 36, 977-981
4. Arning, M., Kliche, K. O., Heer-Sonderhoff, A. H., and Wehmeier, A. (1995) Mycoses 38, 459-465
5. Beutler, B., and Poltorak, A. (2001) Crit. Care Med. 29, S2-S6; discussion S6-S7
6. Lien, E., and Ingalls, R. R. (2002) Crit. Care Med. 30, S1-S11
7. Kimbrell, D. A., and Beutler, B. (2001) Nat. Rev. Genet. 2, 256-267
8. Shoham, S., Huang, C., Chen, J. M., Golenbock, D. T., and Levitz, S. M. (2001) J. Immunol. 166, 4620-4626
9. Means, T. K., Golenbock, D. T., and Fenton, M. J. (2000) Cytokine Growth Factor Rev. 11, 219-232
10. Means, T. K., Golenbock, D. T., and Fenton, M. J. (2000) Life Sci. 68, 241-258
11. Wang, Q., Dziarski, R., Kirschning, C. J., Muzio, M., and Gupta, D. (2001) Infect. Immun. 69, 2270-2276
12. Horng, T., Barton, G. M., and Medzhitov, R. (2001) Nat. Immunol. 2, 835-841
13. Calandra, T. (2001) J. Chemother. 13, Spec. No. 1, 173-180
14. Alexander, C., and Rietschel, E. T. (2001) J. Endotoxin Res. 7, 167-202
15. Ma, Y., and Weis, J. J. (1993) Infect. Immun. 61, 3843-3853
16. Hirschfeld, M., Ma, Y., Weis, J. H., Vogel, S. N., and Weis, J. J. (2000) J. Immunol. 165, 618-622
17. Kawai, T., Adachi, O., Ogawa, T., Takeda, K., and Akira, S. (1999) Immunity 11, 115-122
18. Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K., and Akira, S. (1999) Immunity 11, 443-451
19. Moore, K. J., Andersson, L. P., Ingalls, R. R., Monks, B. G., Li, R., Arnaout, M. A., Golenbock, D. T., and Freeman, M. W. (2000) J. Immunol. 165, 4272-4280
20. Yang, Z., Breider, M. A., Carroll, R. C., Miller, M. S., and Bochsler, P. N. (1996) J. Leukocyte Biol. 59, 241-247
21. Pugin, J., Kravchenko, V. V., Lee, J. D., Kline, L., Ulevitch, R. J., and Tobias, P. S. (1998) Infect. Immun. 66, 1174-1180
22. Harrison, T. S., Nong, S., and Levitz, S. M. (1997) J. Infect. Dis. 176, 485-491
23. Chow, J. C., Young, D. W., Golenbock, D. T., Christ, W. J., and Gusovsky, F. (1999) J. Biol. Chem. 274, 10689-10692
24. Kirschning, C. J., Wesche, H., Merrill Ayres, T., and Rothe, M. (1998) J. Exp. Med. 188, 2091-2097
25. Yoshimura, A., Lien, E., Ingalls, R. R., Tuomanen, E., Dziarski, R., and Golenbock, D. (1999) J. Immunol. 163, 1-5
26. Golenbock, D. T., Liu, Y., Millham, F. H., Freeman, M. W., and Zoeller, R. A. (1993) J. Biol. Chem. 268, 22055-22059
27. Schromm, A. B., Lien, E., Henneke, P., Chow, J. C., Yoshimura, A., Heine, H., Latz, E., Monks, B. G., Schwartz, D. A., Miyake, K., and Golenbock, D. T. (2001) J. Exp. Med. 194, 79-88
28. Akira, S., Takeda, K., and Kaisho, T. (2001) Nat Immunol. 2, 675-680
29. Fitzgerald, K. A., Palsson-McDermott, E. M., Bowie, A. G., Jefferies, C. A., Mansell, A. S., Brady, G., Brint, E., Dunne, A., Gray, P., Harte, M. T., McMurray, D., Smith, D. E., Sims, J. E., Bird, T. A., and O'Neill, L. A. (2001) Nature 413, 78-83
30. Hirschfeld, M., Kirschning, C. J., Schwandner, R., Wesche, H., Weis, J. H., Wooten, R. M., and Weis, J. J. (1999) J. Immunol. 163, 2382-2386
31. Poltorak, A., He, X., Smirnova, I., Liu, M. Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., Freudenberg, M., Ricciardi-Castagnoli, P., Layton, B., and Beutler, B. (1998) Science 282, 2085-2088
32. Ayestaran, A., Lopez, R. M., Montoro, J. B., Estibalez, A., Pou, L., Julia, A., Lopez, A., and Pascual, B. (1996) Antimicrob. Agents Chemother. 40, 609-612
33. Bekersky, I., Fielding, R. M., Dressler, D. E., Lee, J. W., Buell, D. N., and Walsh, T. J. (2002) Antimicrob. Agents Chemother. 46, 828-833
34. Hornung, V., Rothenfusser, S., Britsch, S., Krug, A., Jahrsdorfer, B., Giese, T., Endres, S., and Hartmann, G. (2002) J. Immunol. 168, 4531-4537
35. da Silva Correia, J., Soldau, K., Christen, U., Tobias, P. S., and Ulevitch, R. J. (2001) J. Biol. Chem. 276, 21129-21135
36. Schwandner, R., Dziarski, R., Wesche, H., Rothe, M., and Kirschning, C. J. (1999) J. Biol. Chem. 274, 17406-17409
37. Suschek, C. V., Bonmann, E., Kleinert, H., Wenzel, M., Mahotka, C., Kolb, H., Forstermann, U., Gerharz, C. D., and Kolb-Bachofen, V. (2000) Br. J. Pharmacol. 131, 473-481
38. McCarthy, D. O., Murray, S., Galagan, D., Gern, J. E., and Hutson, P. R. (1998) Nurs. Res. 47, 19-24
39. Heine, H., Kirschning, C. J., Lien, E., Monks, B. G., Rothe, M., and Golenbock, D. T. (1999) J. Immunol. 162, 6971-6975
40. Beutler, B., and Rehli, M. (2002) Curr. Top. Microbiol. Immunol. 270, 1-21
41. Rehli, M. (2002) Trends Immunol. 23, 375-378
42. Ozinsky, A., Underhill, D. M., Fontenot, J. D., Hajjar, A. M., Smith, K. D., Wilson, C. B., Schroeder, L., and Aderem, A. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 13766-13771
43. Wyllie, D. H., Kiss-Toth, E., Visintin, A., Smith, S. C., Boussouf, S., Segal, D. M., Duff, G. W., and Dower, S. K. (2000) J. Immunol. 165, 7125-7132
44. Bulut, Y., Faure, E., Thomas, L., Equils, O., and Arditi, M. (2001) J. Immunol. 167, 987-994
45. Ozinsky, A., Smith, K. D., Hume, D., and Underhill, D. M. (2000) J. Endotoxin Res. 6, 393-396
46. Flo, T. H., Ryan, L., Latz, E., Takeuchi, O., Monks, B. G., Lien, E., Halaas, O., Akira, S., Skjak-Braek, G., Golenbock, D. T., and Espevik, T. (2002) J. Biol. Chem. 277, 35489-35495
47. Vabulas, R. M., Ahmad-Nejad, P., da Costa, C., Miethke, T., Kirschning, C. J., Hacker, H., and Wagner, H. (2001) J. Biol. Chem. 276, 31332-31339
48. Hashimoto, M., Imamura, Y., Morichika, T., Arimoto, K., Takeuchi, O., Takeda, K., Akira, S., Aoyama, K., Tamura, T., Kotani, S., Suda, Y., and Kusumoto, S. (2000) Biochem. Biophys. Res. Commun. 273, 164-169
49. Abu-Salah, K. M. (1996) Br. J. Biomed. Sci. 53, 122-133
50. Bolard, J. (1986) Biochim. Biophys. Acta 864, 257-304
51. Heinemann, V., Kahny, B., Jehn, U., Muhlbayer, D., Debus, A., Wachholz, K., Bosse, D., Kolb, H. J., and Wilmanns, W. (1997) Antimicrob. Agents Chemother. 41, 728-732
52. Paquet, M., Fournier, I., Barwicz, J., Tancrede, P., and Auger, M. (2002) Chem. Phys. Lipids 119, 1-11
53. Carozzi, A. J., Ikonen, E., Lindsay, M. R., and Parton, R. G. (2000) Traffic 1, 326-341
54. Pfeiffer, A., Bottcher, A., Orso, E., Kapinsky, M., Nagy, P., Bodnar, A., Spreitzer, I., Liebisch, G., Drobnik, W., Gempel, K., Horn, M., Holmer, S., Hartung, T., Multhoff, G., Schutz, G., Schindler, H., Ulmer, A. J., Heine, H., Stelter, F., Schutt, C., Rothe, G., Szollosi, J., Damjanovich, S., and Schmitz, G. (2001) Eur. J. Immunol. 31, 3153-3164
55. Triantafilou, M., Miyake, K., Golenbock, D. T., and Triantafilou, K. (2002) J. Cell Sci. 115, 2603-2611
56. Simons, K., and Toomre, D. (2000) Nat. Rev. Mol. Cell Biol. 1, 31-39