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Volumn 15, Issue 4, 2000, Pages 239-251

Animal models of Huntington's disease: From basic research on neuronal death to assessment of new therapeutic strategies

(1)  Brouillet, E a  

a DIF   (France)

Author keywords

Animal models; Apoptosis; Excitotoxicity; Huntington's disease; Mitochondria; Therapy

Indexed keywords

3 NITROPROPIONIC ACID; CILIARY NEUROTROPHIC FACTOR; CREATINE; GLUTAMATE RECEPTOR ANTAGONIST; HUNTINGTIN; NITRIC OXIDE SYNTHASE INHIBITOR; RILUZOLE; SCAVENGER; SUCCINATE DEHYDROGENASE;

EID: 0034490994     PISSN: 03935264     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (3)

References (50)
  • 11
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • (1993) Cell , vol.72 , pp. 971-983
  • 17
    • 0017090806 scopus 로고
    • Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acid
    • (1976) Nature , vol.263 , pp. 517-519
    • McGeer, E.G.1    McGeer, P.L.2
  • 18
    • 0017167057 scopus 로고
    • Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea
    • (1976) Nature , vol.263 , pp. 244-246
    • Coyle, J.T.1    Schwarcz, R.2
  • 22
    • 0026584524 scopus 로고
    • Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?
    • (1992) Ann Neurol , vol.31 , pp. 119-130
    • Beal, M.F.1
  • 24
    • 0026782947 scopus 로고
    • Evidence that the loss of the voltage-dependent Mg++ block at the N-methyl-D-aspartate receptor underlies receptor activation during inhibition of neuronal metabolism
    • (1992) J Neurochem , vol.59 , pp. 1211-1220
    • Zeevalk, G.D.1    Nicklas, W.J.2
  • 25
    • 0032851595 scopus 로고    scopus 로고
    • Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization
    • (1999) Nat Med , vol.5 , pp. 1194-1198
    • Sawa, A.1    Wiegand, G.W.2    Cooper, J.3
  • 29
  • 32
    • 18544410106 scopus 로고    scopus 로고
    • Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation
    • (1997) Cell , vol.90 , pp. 537-548
    • Davies, S.W.1    Turmaine, M.2    Cozens, B.3
  • 34
    • 0034006477 scopus 로고    scopus 로고
    • Non linear decrease over time in N-acetyl aspartate levels in the absence of neuronal loss and decreases in glutamine and glucose in transgenic Huntington's disease mice
    • (2000) J Neurochem , vol.74 , pp. 2108-2119
    • Jenkins, B.G.1    Klivenyi, P.2    Kustermann, E.3
  • 35
  • 36
  • 41
    • 0027433553 scopus 로고
    • Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid
    • (1993) J Neurosci , vol.13 , pp. 1481-1492
    • Beal, M.F.1    Brouillet, E.2    Jenkins, B.3
  • 42
    • 0034127284 scopus 로고    scopus 로고
    • Major strain differences in response to chronic systemic administration of the mitochondrial toxin 3-nitropropionate in rats: Implications for neuroprotection studies
    • (2000) Neuroscience , vol.97 , pp. 521-530
    • Ouary, S.1    Bizat, N.2    Altérac, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.