Malonate and 3-nitropropionic acid neurotoxicity are reduced in transgenic mice expressing a caspase-1 dominant-negative mutant

Journal of Neurochemistry

Volumn 75, Issue 2, 2000, Pages 847-852

  Andreassen, Ole A ^a   Ferrante, Robert J ^b,d   Hughes, Duncan B ^a,e   Klivenyi, Peter ^a   Dedeoglu, Alpaslan ^a   Ona, Victor O ^c   Friedlander, Robert M ^c   Beal, M Flint ^a,e,f  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d DEPARTMENT OF VETERANS AFFAIRS   (United States)

^e Department of Obstetrics Gynecology   (United States)

^f WEILL CORNELL MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Caspases; Huntington's disease; Mitochondria

Indexed keywords

3 NITROPROPIONIC ACID; INTERLEUKIN 1BETA CONVERTING ENZYME; MALONIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; CORPUS STRIATUM; ENZYME ACTIVATION; HUNTINGTON CHOREA; MALE; MITOCHONDRION; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

ANIMALS; BRAIN; CASPASE 1; CROSSES, GENETIC; DISEASE MODELS, ANIMAL; FEMALE; HUNTINGTON DISEASE; MALE; MALONATES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEOSTRIATUM; NEUROTOXINS; NITRO COMPOUNDS; POINT MUTATION; PROPIONIC ACIDS;

ANIMALIA; MUS MUSCULUS;

EID: 0033914471     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0750847.x     Document Type: Article

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