Inhibition of Rho-dependent pathways by Clostridium botulinum C3 protein induces a proinflammatory profile in microglia

GLIA

Volumn 56, Issue 11, 2008, Pages 1162-1175

  Hoffmann, Anja ^a,b,e   Hofmann, Fred ^c   Just, Ingo ^c   Lehnardt, Seija ^d   Hanisch, Uwe Karsten ^a   Brück, Wolfgang ^a   Kettenmann, Helmut ^b   Ahnert Hilger, Gudrun ^d   Höltje, Markus ^d  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e BAYER PHARMA AG   (Germany)

Author keywords

C3bot; GTPases; Inflammation

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; BACTERIUM LIPOPOLYSACCHARIDE; CHEMOKINE; CYTOKINE; EXOENZYME C3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CLOSTRIDIUM BOTULINUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVITY; ENZYME INHIBITION; INFLAMMATION; MICROGLIA; MOUSE; NERVE CELL CULTURE; NERVE REGENERATION; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SECRETION;

ADP RIBOSE TRANSFERASES; ANIMALS; BOTULINUM TOXINS; CELLS, CULTURED; CLOSTRIDIUM BOTULINUM; DOSE-RESPONSE RELATIONSHIP, DRUG; INFLAMMATION; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHENOTYPE; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

EID: 51349143226     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.20687     Document Type: Article

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