Cellular signaling in macrophage migration and chemotaxis

Journal of Leukocyte Biology

Volumn 68, Issue 5, 2000, Pages 593-602

  Jones, G E ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Actin cytoskeleton; Cell locomotion; Cell polarity; GTPases; Phosphoinositide 3 kinases; Review; Signal transduction

Indexed keywords

ACTIN; CELL PROTEIN; G PROTEIN COUPLED RECEPTOR; GUANOSINE TRIPHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN ARP2 3 COMPLEX; RHO FACTOR; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG; WISKOTT ALDRICH SYNDROME PROTEIN;

ACTIN FILAMENT; ARTICLE; BLOOD VESSEL; CELL MIGRATION; CELL MOTILITY; CELL POLARITY; CELL SHAPE; CHEMOTAXIS; CYTOSKELETON; LEUKOCYTE; MACROPHAGE MIGRATION; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN BINDING; SIGNAL TRANSDUCTION; WISKOTT ALDRICH SYNDROME;

ANIMALS; CELL MOVEMENT; CHEMOTAXIS; HUMANS; MACROPHAGES; SIGNAL TRANSDUCTION;

EID: 0033755860     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (108)

1. Cell migration: A physically integrated molecular process
2. Actin-based cell motility and cell locomotion
3. The modular structure of actin-regulatory proteins
4. Integrin-mediated cell adhesion: The cyloskeletal connection
5. Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages
6. Cytoskeletal and adhesive structural polarizations accompany IL,-13-induced human macrophage fusion
7. Integrating the actin and vimentin cytoskeletons, adhesion-dependent formation of fimbrin-vimentin complexes in macrophages
8. A role for Cdc42 in macrophage chemotaxis
9. Cell migration as a five-step cycle
10. Multistep navigation and the combinatorial control of leukocyte chemotaxis
11. Integrating conflicting chemotactic signals. The role of memory in leukocyte navigation
12. Hypoxia inhibits macrophage migration
13. Phagocyte chemoattractant receptors
14. G protein signaling events are activated at the leading edge of chemotactic cells
15. Roles of PLC-β2 and -β3 and PI3Kγ in chemoattractant-mediated signal transduction
16. Function of PI3Kg in thymocyte development, T cell activation, and neutrophil migration
17. Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation
18. Polarization of chemoattractant receptor signaling during neutrophil chemotaxis
19. Localization of the G protein bg complex in living cells during chemotaxis
20. Signaling by distinct classes of phosphoinositide 3-kinase
21. Specific interactions of chemoattractant factor receptors with G-proteins
22. New roles for G-protein beta gammadimers in transmembrane signaling
23. Activation of Akt/protein kinase B by G protein-coupled receptors. A role for alpha and beta gamma subunits of heterotrimeric G proteins acting through phosphatidylinositol-3-OH kinasegamma
24. Receptors induce chemotaxis by releasing the betagamma subunit of Gi, not by activating Gq or Gs
25. A cell's sense of direction
26. Novel mechanisms of RTK signal generation
27. CSF-1 signal transduction
28. Biology and action of colony-stimulating factor-1
29. Isolation and characterization of a cloned growth factor dependent macrophage cell line, BAC1.2F5
30. Colony-stimulating factor-1 induces rapid behavioural responses in the mouse macrophage cell line, BAC1.2FS
31. Direct observation and quantification of macrophage chemoattraction to the growth factor CSF-1
32. CSF-1 and its receptor in breast carcinomas and neoplasms of the female reproductive tract
33. Association between phosphatidylinositol-3 kinase, Cbl and other tyrosine phosphorylated proteins in colony-stimulating factor-1-stimulated macrophages
34. Why cytoplasmic signaling proteins should be recruited to cell membranes
35. Monocyte colony-stimulating factor stimulates binding of phosphatidylinositol 3-kinase to Grb2.Sos complexes in human monocytes
36. Distinct PI(3)Ks mediate mitogenic signaling and cell migration in macrophages
37. The pleckstrin homology domain: An intriguing multifunctional protein module
38. Phospholipid-binding protein domains
39. Role of actin polymerization and adhesion to extracellular matrix in Rac- and Rho-induced cytoskeletal reorganization
40. Effectors for the Rho GTPases
41. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
42. Rac and Bcr regulate phagocytic phoxes
43. Focal adhesions, contractility, and signaling
44. Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
45. The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling
46. The DH protein family, exchange factors for Rho-like GTPases
47. Role of substrates and products of PI3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav
48. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product
49. Small GTP-binding proteins and the regulation of the actin cytoskeleton
50. RhoGAPs and RhoGDIs, (His)stories of two families
51. Differential properties of D4/LyGDI versus RhoGDI: Phosphorylation and rho GTPase selectivity
52. Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: Possible involvement of phosphatidylinositol turnover and rho-dependent signaling pathway
53. Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl
54. Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases
55. PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase
56. Cytoskeletal reorganization by G protein-coupled receptors is dependent on phosphoinositide 3-kinase gamma, a Rac guanosine exchange factor, and Rac
57. A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains
58. Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GT-Pases
59. A tyrosine kinase signaling pathway accounts for the majority of phosphatidylinositol 3,4,5-trisphosphate formation in chemoattractant-stimulated human neutrophils
60. Differential involvement of Galpha12 and Galpha13 in receptor-mediated stress fiber formation
61. Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13
62. Signaling to Rho GTPases
63. Rho GTPases and the actin cytoskeleton
64. Rho family proteins and regulation of the actin cytoskeleton
65. Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton
66. The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases
67. Regulation of actin polymerization in cell-free systems by GTP-gammas and Cdc42
68. A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton
69. Regulation of cytoskeleton and cell adhesion by Rho targets
70. p21-activated kinase has substrate specificity similar to Acanthamoeba myosin 1 heavy chain kinase and activates Acanthamoeba myosin 1
71. PAK4 a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia
72. Roles of PAK family kinases
73. p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin
74. Understanding the molecular basis of Wiskott-Aldrich syndrome
75. Wiskott-Aldrich syndrome protein, WASP
76. Recent advances in our understanding of Wiskott-Aldrich syndrome
77. Two GTPases, cdc42 and rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome
78. Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42
79. Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization
80. Inducible recruitment of Cdc42 or WASP to a cell-surface receptor triggers actin polymerization and filopodium formation
81. The Wiskott-Aldrich syndrome protein (WASP): Roles in signaling and cytoskeletal organization
82. Structure of the enabled/VASP homology 1 domain-peptide complex: A key component in the spatial control of actin assembly
83. Waltzing with WASP
84. The essential role of profilin in the assembly of actin for microspike formation
85. Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex
86. The Arp2/3 complex is essential for the actin-based motility of Listeria monocytogenes
87. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins
88. The interaction of Arp2/3 complex with actin: Nucleation, high affinity pointed end capping, and formation of branching networks of filaments
89. Structure and function of the Arp2/3 complex
90. Multiple signal transduction pathways regulate TNF-induced actin reorganization in macrophages: Inhibition of Cdc42-mediated filopodium formation by TNF
91. Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness
92. A betal integrin signaling pathway involving Src-family kinases. Cbl and PI-3 kinase is required for macrophage spreading and migration
93. Integrin signal transduction in myeloid leukocytes
94. Chemokines and leukocyte traffic
95. Dendritic cells and the control of immunity
96. Is Wiskott-Aldrich syndrome a cell trafficking disorder?
97. Chemotaxis of macrophages is abolished in the Wiskott-Aldrich syndrome
98. Monocytes from Wiskott-Aldrich patients display reduced chemotaxis and lack of cell polarization in response to monocyte chemoattractant protein-1 and formyl-methionyl-leucyl-phenylalanine
99. Regulation of the polarization of T cells towards antigen-presenting cells by Ras-related GTPase Cdc42
100. Intrinsic dendritic cell abnormalities in Wiskott-Aldrich syndrome
101. Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span
102. Asymmetric distribution of the chemotactic peptide receptor on polymorphonuclear leukocytes
103. Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis
104. Molecular basis of localized responses during chemotaxis in amoebae and leukocytes
105. Role of dimerization and modification of the CSF-1 receptor in its activation and internalization during the CSF-1 response
106. Endosomes, receptor tyrosine kinase internalization and signal transduction
107. Spatial control of actin polymerization during neutrophil chemotaxis
108. Origins of cell polarity