Involvement of non-neuronal cells in entorhinal-hippocampal reorganization following lesions

Annals of the New York Academy of Sciences

Volumn 911, Issue , 2000, Pages 192-206

  Bechmann, Ingo ^a   Nitsch, Robert ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; FAS LIGAND; GROWTH FACTOR;

ANTIGEN PRESENTING CELL; APOPTOSIS; ASTROCYTE; BRAIN INJURY; CELL ACTIVATION; CELL INTERACTION; CELL MIGRATION; CELL PROLIFERATION; CELL STRUCTURE; CENTRAL NERVOUS SYSTEM; CONFERENCE PAPER; DENDRITE; DENERVATION; ENTORHINAL CORTEX; GLIA CELL; HIPPOCAMPUS; IMMUNOPHENOTYPING; LYMPHOCYTE; MICROGLIA; MYELIN SHEATH; NERVE CELL PLASTICITY; NERVE DEGENERATION; NERVE FIBER; NERVE SPROUTING; NONHUMAN; PHAGOCYTOSIS; SYNAPSE;

EID: 0033913587     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb06727.x     Document Type: Conference Paper

References (77)

1. 1. LYNCH, G., D.A. MATTHEWS, S. MOSKO, T. PARKS & W. COTMAN. 1972. Induced acctylcholine-rich layer in rat dentate gyrus following entorhinal lesion. Brain Res. 42: 311-318.
2. 2. LYNCH, G., S.A. DLADWYLER & G. COTMAN. 1973. Postlesion axonal growth produces permanent functional connections. Science 180: 1364-1368.
3. 3. MATTHEWS, D.A., C.W. COTMAN & G. LYNCH. 1976. An electron microscopical study of lesion-induced synaptogenesis in the dentate gyrus of the adult rat. I. Magnitude and time course of degeneration. Brain Res. 115: 1-21.
4. 4. MATTHEWS, D.A., C.W. COTMAN & G. LYNCH. 1976. An electron microscopical study of lesion induced synaptogenesis in the dentate gyrus of the adult rat. II. Reappearance of morphologically normal synaptic contacts. Brain Res. 115: 23-41.
5. 5. STEWARD, O. & J.A. MESSENHEIMER. 1978. Histochemical evidence for a postlesion reorganization of cholinergic afferents in the hippocampal formation of the mature cat. J. Comp. Neurol. 178: 697-709.
6. 6. FROTSCHER, M. 1991. Target cell specificity of synaptic connections in the hippocampus. Hippocampus 1: 123-130.
7. 7. DELLER, T., M. FROTSCHER & R. NITSCH. 1995. Morphological evidence for the sprouting of inhibitory commissural fibers in response to the lesion of excitatory entorhinal input to the rat dentate gyrus. J. Neurosci. 15: 6868-6878.
8. 8. DELLER, T., M. FROTSCHER & R. NITSCH. 1996. Sprouting of crossed entorhinodentate fibers after unilateral entorhinal lesion: anterograde tracing of fiber reorganization with Phaseolus vulgaris-leucoagglutinin (PHAL). J. Comp. Neurol. 365: 42-55.
9. 9. MYHRER, T. 1975. Maze performance in rats with hippocampal perforant path lesion: some aspects of functional recovery. Physiol. Behav. 15: 433-437.
10. 10. LOESCHE, J. & O. STEWARD. 1977. Behavioral correlates of the denervation and reinnervation of the hippocampal formation of the rat: recovery of alteration performance following unilateral entorhinal lesion. Brain Res. Bull. 2: 31-39.
11. 11. STEWARD, O., J. LOESCHE & W.C. HORTON. 1977. Behavioral correlates of denervation and reinnervation of the hippocampal formation of the rat: open field activity and cue utilization following bilateral entorhinal cortex lesions. Brain Res. Bull. 2: 41-48.
12. 12. COTMAN, C.W. & M. NIETO-SAMPEDRO. 1985. Progress in facilitating the recovery of function after central nervous system trauma. Ann. N.Y. Acad. Sci. 457: 83-104.
13. 13. ADAMS, I. & D.G. JONES. 1982. Synaptic remodeling and astrocytic hypertrophy in rat cerebral cortex from early to late adulthood. Neurobiol. Aging 3: 179-186.
14. 14. GALL, C., G. ROSE & G. LYNCH. 1979. Proliferative and migratory activity of glial cells in the partially deafferentated hippocampus. J. Comp. Neurol. 183: 539-550.
15. 15. GEHRMANN, J., S.W. SCHOEN & G.W. KREUTZBERG. 1991. Lesion of the rat entorhinal cortex leads to a rapid microglial reaction in the dentate gyrus. Acta Neuropathol. 82: 442-455.
16. 16. FAGAN, A.M. & F.H. GAGE. 1994. Mechanism of sprouting in the adult nervous system: cellular responses in areas of terminal degeneration and reinnervation of the hippocampus. Neuroscience 58: 705-725.
17. 17. JENSEN, M.B., B. GONZALEZ, B. CASTELLANO & J. ZIMMER. 1994. Microglial and astroglial reactions to anterograde axonal degeneration: a histochemical and immunocytochemical study of the adult rat fascia dentata after entorhinal perforant path lesion. Exp. Brain Res. 98: 245-260.
18. 18. BECHMANN, I. & R. NITSCH. 1997. Astrocytes and microglial cells incorporate degenerating fibers following entorhinal lesion: a light, confocal, and electron microscopical study using a phagocytosis-dependent labeling technique. Glia 20(2): 145-154.
19. 19. BECHMANN, I. & R. NITSCH. 1997. Identification of phagocytic glial cells after lesion-induced anterograde degeneration using double-fluorescence labeling: combination of axonal tracing and lectin or immunostaining. Histochem. Cell Biol. 107(5): 391-397.
20. 20. SCHOEN, S.W. & G.W. KRLUTZBERG. 1994. Synaptic 5′-nucleotidase activity reflects lesion-induced sprouting within the adult rat dentate gyrus. Exp. Neurol. 127(1): 106-118.
21. 21. HAILER, N.P., I. BECHMANN, S. HEIZMANN & R. NITSCH. 1997. Adhesion molecule expression on phagocytic microglial cells following anterograde degeneration of perforant path axons. Hippocampus 7: 341-349.
22. 22. JENSEN, M.B., B. FINSEN & J. ZIMMER. 1997. Morphological and immunophenotypic microglial changes in the denervated fascia dentata of adult rats: correlation with blood-brain barrier damage and astroglial reactions. Exp. Neurol. 143: 103-116.
23. 23. JENSEN, M.B., B. GONZALEZ, B. CASTELLANO & J. ZIMMER. 1994. Microglial and astroglial reactions to anterograde axonal degeneration: a histochemical and immunocytochemical study of the adult rat fascia dentata after entorhinal perforant path lesion. Exp. Brain Res. 98: 245-260.
24. 24. STEWARD, O., M.S. KLLLEY & E.R. TORRE. 1993. The process of reinnervation in the denate gyrus of adult rats: temporal relationsship between changes in the level of glial fibrillary acidic protein (GFAP) and GFAP mRNA in reactive astrocytes. Exp. Neurol. 124: 167-183.
25. 25. SCHNELL, L. & M.E. SCHWAB. 1990. Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors. Nature 343: 269-272.
26. 26. RINAMAN, L., C.E. MILLIGAN & P. LEVITT. 1991. Persistence of fluoro-gold following degeneration of labeled motoneurons is due to phagocytosis by microglia and macrophages. Neuroscience 44(3): 765-776.
27. 27. THANOS, S. 1991. Specific transcellular carbocyanine-labeling of rat retinal microglia during injury-induced neuronal degeneration. Neurosci. Lett. 127: 108-112.
28. 28. THANOS, S. 1992. Sick photoreceptors attract activated microglia from the ganglion cell layer: a model to study the inflammatory cascades in rats with inherited retinal dystrophy. Brain Res. 588: 21-28.
29. 29. THANOS, S., J. MEY & M. WILD. 1993. Treatment of adult retina with microglia-suppressing factor retards axotomy induced neuronal degradation and enhances axonal regeneration in vivo and in vitro. J. Neurosci. 13: 455-466.
30. 30. THANOS, S., J. KASCA, J. SEEGER & J. MEY. 1994. Old dyes for new scopes: phagocytosis-dependent long-term fluorescence labeling of microglial cells in vivo. TINS 17: 1994.
31. 31. STREIT, W.J. & M.B. GRAEBER. 1993. Heterogeneity of microglial and perivascular cell populations: insights gained from the facila nucleus paradigm. Glia 7: 68-74.
32. 32. ANGELOV, D.N., W.F. NEISS, M. STREPPEL, M. WALTHER, O. GUNTINAS-LICHIUS & E. STENNERT. 1996. ED2-positive perivascular cells act as neuronophages during delayed neuronal loss in the facial nucleus of the rat. Glia 16: 129-139.
33. 33. FRITZSCH, B. 1993. Fast axonal diffusion of 3000 molecular weight dextran amines. J. Neurosci. Methods 50: 95-103.
34. 34. FRITZSCH, B. & C. WILM. 1990. Dextran amines in neuronal tracing. TINS 13: 14 (letter).
35. 35. BOULTON, C.L., D. VON HAEBLER & U. HEINEMANN. 1992. Tracing of axonal connections by rhodamine-dextranamine in the rat hippocampal-entorhinal cortex slice preparation. Hippocampus 2: 99-106.
36. 36. OHM, T.G. & S. DIEKMANN. 1994. The use of lucifer yellow and mini ruby for intracellular staining in fixed brain tissue. Methodological considerations evaluated in rat and human autopsy brains. J. Neurosci. Methods 55: 105-110.
37. 37. CADELLI, D.S., C.E. BANDTLOW & M.E. SCHWAB. 1992. Oligodendrocyte-and myelin-associated inhibitors of neurite outgrowth: their involvement in the lack of CNS regeneration. Exp. Neurol. 115: 189-92.
38. 38. LAZAROV-SPIEGLER, O., A.S. SOLOMON, S. BENN ZEEV-BRANN, M. BELKIN, S. RUMELT & M. SCHWARTZ. 1996. Transplantation of activated macrophages overcomes central nervous system regrowth failure. FASEB J. 10: 1296-1302.
39. 39. ZEEV-BRANN, A.B., O. LAZAROV-SPIEGLER, T. BRENNER & M. SCHWARTZ. 1998. Differential effects of central and peripheral nerves on macrophages and microglia. Glia 23: 181-190.
40. 40. SAVASKAN, N.E., M. PLASCHKE, O. NINNEMANN, A.A. SPILLMANN, M.E. SCHWAB, R. NITSCH & T. SKUTELLA. 1999. Myelin does not influence the choice behaviour of entorhinal axons but strongly inhibits their outgrowth length in vitro. Eur. J. Neurosci. 11(1): 316-326.
41. 41. HICKEY, W.F., B.L. HSU & H. KIMURA. 1991. T-lymphocyte entry into the central nervous system. J. Neurosci. Res. 28: 254-260.
42. 42. WEKERLE, H. 1993. Lymphocyte traffic to the brain. In The Blood-Brain Barrier. W.M. Pardridg, Ed.: 67-85. Raven Press. New York.
43. 43. RAIVICH, G., L.L. JONES, C.U. KLOSS, A. WERNER, H. NEUMANN & G.W. KREUTZBERG. 1998. Immune surveillance in the injured nervous system: T-lymphocytes invade the axotomized mouse facial motor nucleus and aggregate around sites of neuronal degeneration. J. Neurosci. 18(15): 5804-5816.
44. 44. LASSMANN, H., F. ZIMPRICH, K. VASS & W.F. HICKEY. 1991. Microglial cells are components of the perivascular glia limitans. J. Neurosci. Res. 28: 236-243.
45. 45. RAPALINO, O., O. LAZAROV-SPIEGLER, E. AGRANOV, G.J. VELAN, E. YOLES, M. FRAIDAKIS, A. SOLOMON, R. GEPSTEIN, A. KATZ, M. BELKIN, M. HADANI & M. SCHWARTZ. 1998. Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats. Nature Med. 4(7): 814-821.
46. 46. MOALEM, G., R. LEIBOWITZ-AMIT, E. YOLES, F. MOR, I.R. COHEN & M. SCHWARTZ. 1999. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nature Med. 5(1): 49-55.
47. 47. HAILER, N.P., A. GRAMP & R. NITSCH. 1999. Proliferation of microglia and astrocytes in the dentate gyrus following entorhinal lesion: a quantitative bromodeoxyuridine-labeling study. Eur. J. Neurosci. In press.
48. 48. GAGE, F.H., P. OLEJNICZAK & D.M. ARMSTRONG. 1988. Astrocytes are important for sprouting in the septohippocampal circuit. Exp. Neurol. 102: 2-13.
49. 49. FAGAN, A.M. & F.H. GAGE. 1990. Cholinergic sprouting in the hippocampus: a proposed role for IL-1. Exp. Neurol. 110(1): 105-120.
50. 50. GIULIAN, D. & L.B. LACHMANN. 1985. Interleukin-1 stimulation of astroglial proliferation after brain injury. Science 228: 497-498.
51. 51. LINDSAY, R.M. 1979. Adult rat brain astrocytes support survival of both NGF-dependent and NGF-insensitive neurons. Nature 282: 80-82.
52. 52. WUJEK, J.R. & R.A. AKESON. 1987. Extracellular matrix derived from astrocytes stimulates neuritic outgrowth from PCI2 cells in vitro. Brain Res. 431: 87-97.
53. 53. GAGE, F.H., G. KEMPERMANN, T.D. PALMER, D.A. PETERSON & J. RAY. 1998. Multipotent progenitor cells in the adult dentate gyrus. J. Neurobiol. 36(2): 249-266.
54. 54. MIYAWAKI, T., T. VEHARA, R. NIBU, T. TSUJI, A. YACHIE, S. YONEHARA & N. TAGUCHI. 1992. Differential expression of apoptosis-related Fas antigen on lymphocyte sub-populations in human peripheral blood. J. Immunol. 149: 3753-3758.
55. 55. OWEN-SCHAUB, L.B., S. YONEHARA, W.L. CRUMP III & E.A. GRIMM. 1992. DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement. Cell. Immunol. 140(1): 197-205.
56. 56. DHEIN, J., H. WALCZAK, C. BAUMLER, K.M. DEBATIN & P.H. KRAMMER. 1995. Autocrine T-cell suicide mediated by APO-1/(Fas/CD95). Nature 373(6513): 438-441.
57. 57. BECHMANN, I., G. MOR, J. NELSON, M. ELIZA, R. NITSCH & F. NAFTOLIN. 1999. FasL (CD95L, APO1L) is expressed in the normal rat and human brain: evidence for the existence of an immunological brain barrier. Glia 27: 62-74.
58. 58. D'SOUZA, S., B. BONETTI, V. BALASINGMAN, N. CASHMAN, P. BARKER, A. TROUTT, C. RAINE & J. ANTEL. 1996. Multiple sclerosis: Fas signaling in oligodendrocyte cell death. J. Exp. Med. 184: 2361-2370.
59. 59. SPANAUS, K.S., R. SCHLAPBACH & A. FONTANA. 1998. TNF-alpha and IFN-gamma render microglia sensitive to Fas ligand-induced apoptosis by induction of Fas expression and down-regulation of Bcl-2 and Bcl-xL. Eur. J. Immunol. 28(12): 4398-4408.
60. 60. NISHIMURA, T., H. AKIYAMA, S. YONEHARA, H. KONDO, K. IKEDA, M. KATO, E. ISEKI & K. KOSAKA. 1995. Fas antigen expression in brains of patients with Alzheimer-type dementia. Brain Res 695(2): 137-145.
61. 61. BECHER, B., S.D. D'SOUZA, A.B. TROUTT & J.P. ANTEL. 1998. Fas expression on human fetal astrocytes without susceptibility to Fas-mediated cytotoxicity. Neuroscience 4(2): 627-634.
62. 62. CHOI, C., J.Y. PARK, J. LEE, J.H. LIM, E.C. SHIN, Y.S. AHN, C.H. KIM, S.J. KIM, J.D. KIM, I.S. CHOI & I.H. CHOI. 1999. Fas ligand and Fas are expressed constitutively in human astrocytes and the expression increases with IL-1, IL-6, TNF-alpha, or IFN-gamma. J. Immunol. 162(4): 1889-1895.
63. 63. SAAS, P., J. BOUCRAUT, A.L. QUIQUEREZ, V. SCHNURIGER, G. PERRIN, S. DESPLAT JEGO, D. BERNARD, P.R. WALKER & P.Y. DIETRICH. 1999. CD95 (Fas/Apo-1) as a receptor governing astrocyte apoptotic or inflammatory responses: a key role in brain inflammation? J. Immunol. 162(4): 2326-2333.
64. 64. BECHMANN, I., B. LOSSAU, B. STEINER, G. MOR, U. GIMSA & R. NITSCH. 1999. Reactive astrocytes upregulate Fas (CD95) and FasL (CD95L) expression, but do not undergo apoptosis in the course of anterograde degeneration. Submitted.
65. 65. SABELKO-DOWNES, K.A., A.H. CROSS & J.H. RUSSELL. 1999. Dual role for Fas ligand in the initiation of and recovery from experimental allergic encephalomyelitis. J. Exp. Med. 189(8): 1195-1205.
66. 66. DELLER, T., M. FROTSCHER & R. NITSCH. 1995. Morphological evidence for the sprouting of inhibitory commissural fibers in response to the lesion of the excitatory entorhinal input to the rat dentate gyrus. J. Neurosci. 15(10): 6868-6878.
67. 67. FROTSCHER, M., B. HEIMRICH & T. DELLER. 1997. Sprouting in the hippocampus is layer-specific. Trends Neurosci. 20(5): 218-222.
68. 68. DELLER, T. 1998. The anatomical organization of the rat fascia dentata: new aspects of laminar organization as revealed by anterograde tracing with Phaseolus vulgaris-leucoagglutinin (PHAL). Anat. Embryol. 197: 89-103.
69. 69. MILLER, P.D., S.D. STYREN, C.F. LAGENAUR & S.T. DEKOSKY. 1994. Embryonic neural cell adhesion molecule (N-CAM) is elevated in the denervated rat dentate gyrus. J. Neurosci. 14(7): 4217-4225.
70. 70. GUTHRIE, K.M., A.G. WOODS, T. NGUYEN & C.M. GALL. 1997. Astroglial ciliary neurotrophic factor mRNA expression is increased in fields of axonal sprouting in deafferented hippocampus. J. Comp. Neurol. 386(1): 137-148.
71. 71. LEE, M.Y., T. DELLER, M. KIRSCH, M. FROTSCHER & H.D. HOFMANN. 1997. Differential regulation of ciliary neurotrophic factor (CNTF) and CNTF receptor alpha expression in astrocytes and neurons of the fascia dentata after entorhinal cortex lesion. J. Neurosci. 17(3): 1137-1146.
72. 72. DELLER, T., C.A. HAAS, T. NAUMANN, A. JOESTER, A. FAISSNER & M. FROTSCHER. 1997. Up-regulation of astrocyte-derived tenascin-C correlates with neurite outgrowth in the rat dentate gyrus after unilateral entorhinal cortex lesion. Neuroscience 81(3): 829-846.
73. 73. DIEKMANN, S., R. NITSCH & T.G. OHM. 1994. The organotypic entorhinal-hippocampal complex slice culture of adolescent rats. A model to study transcellular changes in a circuit particularly vulnerable in neurodegenerative disorders. J. Neural Transm. Suppl. 44: 61-71.
74. 74. AMARAL, D.G. & M.P. WITTER. 1989. The three-dimensional organization of the hippocampal formation: a review of anatomical data. Neuroscience 31(3): 571-591.
75. 75. KLUGE, A., N.P. HAILER, T.L. HORVATH, I. BECHMANN & R. NITSCH. 1998. Tracing of the entorhinal-hippocampal pathway in vitro. Hippocampus 8: 57-68.
76. 76. HAILER, N.P., J. JARHULD & R. NITSCH. 1996. Resting microglial cells in vitro: analysis of morphology and adhesion molecule expression in organotypic hippocampal slice cultures. Glia 18: 319-331.
77. 77. HAILER, N.P., F.L. HEPPNER, D. HAAS & R. NITSCH. 1997. Fluorescent dye prelabeled microglial cells migrate into organotypic hippocampal slice cultures and ramify. Eur. J. Neurosci. 9: 863-866.