Fluorescence imaging with near-infrared light: New technological advances that enable in vivo molecular imaging

European Radiology

Volumn 13, Issue 1, 2003, Pages 195-208

  Ntziachristos, Vasilis ^a   Bremer, Christoph ^a   Weissleder, Ralph ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Fluorescence; In vivo; Molecular imaging; Near infrared

Indexed keywords

BIOMATERIAL; CARBOCYANINE; FLUORESCENT DYE; FLUOROCHROME; HEMOGLOBIN; PROTEIN; WATER; DIAGNOSTIC AGENT;

ANIMAL EXPERIMENT; BIOCOMPATIBILITY; CONTROLLED STUDY; FEASIBILITY STUDY; FLUORESCENCE ANALYSIS; FLUORESCENCE MOLECULAR TOMOGRAPHY; GENE EXPRESSION; IMAGING SYSTEM; IN VIVO STUDY; INFRARED PHOTOGRAPHY; LIGHT ABSORPTION; MEDICAL TECHNOLOGY; MOLECULAR DYNAMICS; MOUSE; NEAR INFRARED SPECTROSCOPY; NON INVASIVE MEASUREMENT; NONHUMAN; PHOTON; PRIORITY JOURNAL; REVIEW; SENSITIVITY ANALYSIS; THREE DIMENSIONAL IMAGING; WATER ABSORPTION; ANIMAL; DIAGNOSTIC IMAGING; FLUORESCENCE; HUMAN; INFRARED RADIATION; TOMOGRAPHY;

ANIMALS; DIAGNOSTIC IMAGING; FLUORESCENCE; FLUORESCENT DYES; HUMANS; INFRARED RAYS; MICE; SPECTROSCOPY, NEAR-INFRARED; TOMOGRAPHY;

EID: 0037983399     PISSN: 09387994     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00330-002-1524-x     Document Type: Review

References (66)

1. Chance B (1991) Optical method. Annu Rev Biophys Biophys Chem 20:1-28
2. Weissleder R (2001) A clearer vision for in vivo imaging. Nat Biotechnol 19:316-317
3. Ntziachristos V, Chance B (2001) Probing physiology and molecular function using optical imaging: applications to breast cancer. Breast Cancer Res 3:41-46
4. Korlach J, Schwille P, Webb WW et al. (1999) Characterization of lipid bilayer phases by confocal microscopy and fluorescence correlation spectroscopy. Proc Natl Acad Sci 96:8461-8466
5. Rajadhyaksha M, Grossman M, Esterowitz D et al. (1995) In vivo confocal scanning laser microscopy of human skin: melanin provides strong contrast. J Invest Dermatol 104:946-952
6. Gonzalez S, Rajadhyaksha M, Rubinstein G et al. (1999) Characterization of psoriasis in vivo by reflectance confocal microscopy. J Med 30:337-536
7. Konig K (2000) Multiphoton microscopy in life sciences. J Microsc 200:83-104
8. Buehler C, Kim KH, Dong CY et al. (1999) Innovations in two-photon deep tissue microscopy. IEEE Eng Med Biol Mag 18:23-30
9. So PT, Dong CY, Masters BR et al. (2000) Two-photon excitation fluorescence microscopy. Annu Rev Biomed Eng 2:399-429
10. Masters BR, So PT, Gratton E (1997) Multiphoton excitation fluorescence microscopy and spectroscopy of in vivo human skin. Biophys J 72:2405-2412
11. Dellian M, Yuan F, Trubetskoy VS et al. (2000) Vascular permeability in a human tumour xenograft: molecular charge dependence. Br J Cancer 82:1513-1518
12. Monsky WL, Fukumura D, Gohongi T et al. (1999) Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor. Cancer Res 59:4129-4135
13. Toomre D, Manstein DJ (2001) Lighting up the cell surface with evanescent wave microscopy. Trends Cell Biol 11:298-303
14. Mahmood U, Tung CH, Bogdanov A et al. (1999) Near infrared optical imaging system to detect tumor protease activity. Radiology 213:866-870
15. Becker A, Hessenius C, Licha K et al. (2001) Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands. Nat Biotechnol 19:327-331
16. Yang M, Baranov E, Jiang P et al. (2000) Whole-body optical imaging of green fluorescent protein-expressing tumors and metastases, Proc Natl Acad Sci USA 97:1206-1211
17. Zaheer A, Lenkinski RE, Mahmood A et al. (2001) In vivo near-infrared fluorescence imaging of osteoblastic activity. Nat Biotechnol 19:1148-1154
18. Reynolds JS, Troy TL, Mayer RH et al. (1999) Imaging of spontaneous canine mammary tumors using fluorescent contrast agents. Photochem Photobiol 70:87-94
19. Ntziachristos V, Yodh AG, Schnall M et al. (2000) Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement. Proc Natl Acad Sci USA 97:2767-2772
20. Ntziachristos V, Tung C, Bremer C et al. (2002) Fluorescence-mediated tomography resolves protease activity in vivo. Nat Med 8:757-760
21. Chance B, Kang K, He L et al. (1993) Highly sensitive object location in tissue models with linear in-phase and anti-phase multi-element optical arrays in one and two dimensions. Proc Natl Acad Sci USA 90:3423-3427
22. Ntziachristos V, Ripoll J, Weissleder R (2002) Would near-infrared fluorescence signals propagate through large human organs for clinical studies. Opt Lett 27:527-529
23. Contag CH, Jenkins D, Contag PR et al. (2000) Use of reporter genes for optical measurements of neoplastic disease in vivo. Neoplasia 2:41-52
24. Ramanujam N, Chen J, Gossage K et al. (2001) Fast and noninvasive fluorescence imaging of biological tissues in vivo using a flying-spot scanner. IEEE Trans Biomed Eng 48:1034-1041
25. Weissleder R, Tung CH, Mahmood U et al. (1999) In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nat Biotech 17:375-378
26. Tung CH, Mahmood U, Bredow S et al. (2000) In vivo imaging of proteolytic enzyme activity using a novel molecular reporter. Cancer Res 60:4953-4958
27. Bremer C, Tung C, Weissleder R (2001) Imaging of metalloproteinase2 inhibition in vivo. Nat Med 7:743-748
28. Bremer C, Bredow S, Mahmood U et al. (2001) Optical imaging of matrix metalloproteinase-2 activity in tumors: feasibility study in a mouse model. Radiology 221:523-529
29. Achilefu S, Dorshow RB, Bugaj JE et al. (2000) Novel receptor-targeted fluorescent contrast agents for in vivo tumor imaging [in process citation]. Invest Radiol 35:479-485
30. Bugaj JE, Achilefu S, Dorshow RB et al. (2001) Novel fluorescent contrast agents for optical imaging of in vivo tumors based on a receptor-targeted dye-peptide conjugate platform. J Biomed Opt 6:122-133
31. Wouters FS, Verveer PJ, Bastiaens PI (2001) Imaging biochemistry inside cells. Trends Cell Biol 11:203-211
32. Contag CH, Spilman SD, Contag PR et al. (1997) Visualizing gene expression in living mammals using a bioluminescent reporter. Photochem Photobiol 66:523-531
33. Sweeney TJ, Mailander V, Tucker AA et al. (1999) Visualizing the kinetics of tumor-cell clearance in living animals. Proc Natl Acad Sci 96:12044-12049
34. Mahmood U, Tung CH, Tang Y et al. (in press) Feasibility of in-vivo multi-channel optical imaging of gene expression: an experimental study in mice. Radiology
35. Schotland J-C (1997) Continuous wave diffusion imaging. J Opt Soc Am 14:275-279
36. Yodh AG, Chance B (1995) Spectroscopy and imaging with diffusing light. Phys Today 48:34-40
37. Hielscher AH, Klose AD, Hanson KM (1999) Gradient-based iterative image reconstruction scheme for time-resolved optical tomography. IEEE Trans Med Imaging 18:262-271
38. Barbour RL, Graber HL, Chang JW et al. (1995) MRI-guided optical tomography: prospects and computation for a new imaging method. IEEE Comput Sci Eng 2:63-77
39. Colak SB, van der Mark MB, Hooft GW et al. (1999) Clinical optical tomography and NIR spectroscopy for breast cancer detectio. IEEE J Selected Top Quantum Electron 5:1143-1158
40. Arridge SR (1999) Optical tomography in medical imaging. Inverse Prob 15:R41-R93
41. Oleary MA, Boas DA, Chance B et al. (1995) Experimental images of heterogeneous turbid media by frequency-domain diffusing-photon tomography. Opt Lett 20:426-428
42. Jiang HB, Paulsen KD, Osterberg UL et al. (1998) Improved continuous light diffusion imaging in single- and multi-target tissue-like phantoms. Phys Med Biol 43:675-693
43. Chang JW, Graber HL, Koo PC et al. (1997) Optical imaging of anatomical maps derived from magnetic resonance images using time-independent optical sources. IEEE Trans Med Imaging 16:68-77
44. Ntziachristos V, Ma XH, Chance B (1998) Time-correlated single photon counting imager for simultaneous magnetic resonance and near-infrared mammography. Rev Sci Instrum 69:4221-4233
45. Pogue BW, Testorf M, McBride T et al. (1997) Instrumentation and design of a frequency domain diffuse optical tomography imager for breast cancer detection. Opt Expr 1:391-403
46. Schmitz CH, Graber HL, Barbour RL (2000) A fast versatile instrument for dynamic optical tomography. In: Advances in optical imaging and photon migration, OSA. Technical Digest. Optical Society of America, Washington DC, pp 94-96
47. Chang JH, Graber HL, Barbour RL (1997) Imaging of fluorescence in highly scattering media. IEEE Trans Biomed Eng 44:810-822
48. Oleary MA, Boas DA, Li XD et al. (1996) Fluorescence lifetime imaging in turbid media. Opt Lett 21:158-160
49. Paithankar DY, Chen AU, Pogue BW et al. (1997) Imaging of fluorescent yield and lifetime from multiply scattered light reemitted from random media. Appl Opt 36:2260-2272
50. Chernomordik V, Hattery D, Gannot I et al. (1999) Inverse method 3-D reconstruction of localized in vivo fluorescence: application to Sjogren syndrome. IEEE J Selected Top Quantum Electron 5:930-935
51. Sevick-Muraca EM, Lopez G, Reynolds JS et al. (1997) Fluorescence and absorption contrast mechanisms for biomedical optical imaging using frequency-domain techniques. Photochem Photobiol 66:55-64
52. Ntziachristos V, Weissleder R (2001) Experimental three-dimensional fluorescence reconstruction of diffuse media using a normalized Born approximation. Opt Lett 26:893-895
53. Pogue BW, Poplack SP, McBride TO et al. (2000) Hemoglobin imaging of breast tumors with near-infrared tomography. Radiology 214:G05H
54. Hillman EMC, Hebden JC, Schweiger M et al. (2001) Time resolved optical tomography of the human forearm. Phys Med Biol 46:1117-1130
55. Benaron DA, Hintz SR, Villringer A et al. (2000) Noninvasive functional imaging of human brain using light. J Cereb Blood Flow Metab 20:469-477
56. Ntziachristos V (2000) Concurrent diffuse optical tomography, spectroscopy and magnetic resonance of breast cancer. University of Pennsylvania
57. Ntziachristos V, Weissleder R (2002) CCD-based scanner for three-dimensional fluorescence-mediated diffuse optical tomography of small animals. Med Phys 29:803-809
58. Demchik LL, Sameni M, Nelson K et al. (1999) Cathepsin B and glioma invasion. Int J Dev Neurosci 17:483-494
59. Yan S, Sameni M, Sloane BF (1998) Cathepsin B and human tumor progression. Biol Chem 379:113-123
60. Rempel SA, Rosenblum ML, Mikkelsen T et al. (1994) Cathepsin B expression and localization in glioma progression and invasion. Cancer Res 54:6027-6031
61. Koblinski JE, Ahram M, Sloane BF (2000) Uaveling the role of proteases in cancer. Clin Chim Acta 291:113-135
62. Culver J, Ntziachristos V, Holboke M et al. (2001) Optimization of optode arrangements for diffuse optical tomography: a singular value analysis. Opt Lett 26:701-703
63. Wu J, Perelman L, Dasari RR et al. (1997) Fluorescence tomographic imaging in turbid media using early-arriving photons and Laplace transforms. Proc Natl Acad Sci USA 94:8783-8788
64. Eppstein MJ, Dougherty DE, Troy TL et al. (1999) Biomedical optical tomography using dynamic parameterization and Bayesian conditioning on photon migration measurements. Appl Opt 38:2138-2150
65. Tyagi S, Kramer FR (1996) Molecular beacons: probes that fluoresce upon hybridization. Nat Biotechnol 14:303-308
66. Tyagi S, Marras SAE, Kramer FR (2000) Wavelength-shifting molecular beacons. Nat Biotechnol 18:1191-1196