Insect peptides with improved protease-resistance protect mice against bacterial infection

Protein Science

Volumn 9, Issue 4, 2000, Pages 742-749

  Otvos Jr , Laszlo ^a   Bokonyi, Krisztina ^a   Varga, Istvan ^a   Otvos, Balint I ^a,b   Hoffmann, Ralf ^a,c   Ertl, Hildegund C J ^a   Wade, John D ^d   McManus, Ailsa M ^e   Craik, David J ^e   Bulet, Philippe ^b  

^a WISTAR INSTITUTE   (United States)

^b INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^e UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Antibacterial peptides; In vivo anti infection assay; Metabolite; Nuclear magnetic resonance spectroscopy; Serum stability; Stereospecific target protein

Indexed keywords

ANTIINFECTIVE AGENT; DROSOCIN; INSECT PROTEIN; PEPTIDE DERIVATIVE; PROTEINASE; PYRRHOCORICIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; ENTEROBACTER INFECTION; GRAM NEGATIVE INFECTION; HOST RESISTANCE; INSECT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ISOLATION; PROTEIN SECONDARY STRUCTURE;

ANIMALIA; BACTERIA (MICROORGANISMS); ENTEROBACTER; ESCHERICHIA COLI; HEXAPODA; INSECTA; MAMMALIA; NEGIBACTERIA;

EID: 0342264510     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.9.4.742     Document Type: Article

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