Double-strand break repair mediated by DNA end-joining

Genes to Cells

Volumn 3, Issue 3, 1998, Pages 135-144

  Tsukamoto, Yasumasa ^a   Ikeda, Hideo ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DOUBLE STRANDED DNA; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; RIBOSOME DNA;

DNA DAMAGE; DNA STRAND BREAKAGE; GENE LOCUS; GENE MUTATION; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW; SACCHAROMYCES CEREVISIAE; YEAST;

ANIMALS; BASE SEQUENCE; DNA; DNA REPAIR; HUMANS; MODELS, BIOLOGICAL; RECOMBINATION, GENETIC;

MAMMALIA; SACCHAROMYCES CEREVISIAE;

EID: 0031878710     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2443.1998.00180.x     Document Type: Review

References (88)

1. Ajimura, M., Leem, S.H. & Ogawa, H. (1993) Identification of new genes required for meiotic recombination in Saccharomyces cerevisiae. Genetics 133, 51-66.
2. Alani, E., Padmore, R. & Kleckner, N. (1990) Analysis of wild-type and rad 50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination. Cell 61, 419-436.
3. Bardwell, A.J., Bardwell, L., Tomkinson, A.E. & Friedberg, E.C. (1994) Specific cleavage of model recombination and repair intermediates by the yeast Rad1-Rad10 DNA endonuclease. Science 265, 2082-2085.
4. Barker, D.G., White, J.H. & Johnston, L.H. (1985) The nucleotide sequence of the DNA ligase gene (CDC9) from Saccharomyces cerevisiae: a gene which is cell-cycle regulated and induced in response to DNA damage. Nucl. Acids Res. 13, 8323-8337.
5. Bliss, T.M. & Lane, D.P. (1997) Ku selectively transfers between DNA molecules with homologous ends. J. Biol. Chem. 272, 5765-5773.
6. Blunt, T., Finnie, N.J., Taccioli, G.E., et al. (1995) Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 80, 813-823.
7. Boubnov, N.V., Hall, K.T., Wills, Z., et al. (1995) Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen. Proc. Natl. Acad. Sci. USA 92, 890-894.
8. Boulton, S.J. & Jackson, S.P. (1996a) Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance. Nucl. Acids Res. 24, 4639-4648.
9. Boulton, S.J. & Jackson, S.P. (1996b) Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways. EMBO J. 15, 5093-5103.
10. Brachmann, C.B., Sherman, J.M., Devine, S.E., et al. (1995) The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev. 9, 2888-2902.
11. Braunstein, M., Rose, A.B., Holmes, S.G., Allis, C.D. & Broach, J.R. (1993) Transcriptional silencing in yeast is associated with reduced nucleosome acetylation. Genes Dev. 7, 592-604.
12. Braunstein, M., Sobel, R.E., Allis, C.D, Turner, B.M. & Broach, J.R. (1996) Efficient transcriptional silencing in Saccharomyces cerevisiae requires a heterochromatin histone acetylation pattern. Mol. Cell. Biol. 16, 4349-4356.
13. Cary, R.B., Peterson, S.R., Wang, J., et al. (1997) DNA looping by Ku and the DNA-dependent protein kinase. Proc. Natl. Acad. Sci. USA 94, 4267-4272.
14. Critchlow, S.E., Bowater, R.P. & Jackson, S.P. (1997) Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV. Curr. Biol. 7, 588-598.
15. Dolganov, G.M., Maser, R.S., Novikov, A., et al. (1996) Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair. Mol. Cell. Biol. 16, 4832-4841.
16. Dvir, A., Peterson, S.R., Knuth, M.W., Lu, H. & Dynan, W.S. (1992) Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II. Proc. Natl. Acad. Sci. USA 89, 11920-11924.
17. Feldmann, H., Driller, L., Meier, B., et al. (1996) HDF2, the second subunit of the Ku homologue from Saccharomyces cerevisiae. J. Biol. Chem. 271, 27765-27769.
18. Feldmann, H. & Winnacker, E.L. (1993) A putative homologue of the human autoantigen Ku from Saccharomyces cerevisiae. J. Biol. Chem. 268, 12895-12900.
19. Fishman-Lobell, J. & Haber, J.E. (1992) Removal of nonhomologous DNA ends in double-strand break recombination: the role of the yeast ultraviolet repair gene RAD1. Science 258, 480-484.
20. Fishman-Lobell, J., Rudin, N. & Haber, J.E. (1992) Two alternative pathways of double-strand break repair that are kinetically separable and independently modulated. Mol. Cell. Biol. 12, 1292-1303.
21. Gotta, M., Laroche, T., Formenton, A., et al. (1996) The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae. J. Cell Biol. 134, 1349-1363.
22. Gottlieb, TM. & Jackson, S.P. (1993) The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell 72, 131-142.
23. Grawunder, U., Wilm, M., Wu, X., et al. (1997) Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature 388, 492-495.
24. Greenwell, P.W., Kronmal, S.L., Porter, S.E., et al. (1995) TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene. Cell 82, 823-829.
25. Hays, S.L., Firmenich, A.A. & Berg, P. (1995) Complex formation in yeast double-strand break repair: participation of Rad51, Rad52, Rad55, and Rad57 proteins. Proc. Natl. Acad. Sci. USA 92, 6925-6929.
26. Hecht, A., Laroche, T., Strahl-Bolsinger, S., Gasser, S.M. & Grunstein, M. (1995) Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast. Cell 80, 583-592.
27. Iijima, S., Teraoka, H., Date, T. & Tsukada, K. (1992) DNA-activated protein kinase in Raji Burkitt's lymphoma cells. Phosphorylation of c-Myc oncoprotein. Eur. J. Biochem. 206, 595-603.
28. Ivanov, E.L., Korolev, V.G. & Fabre, F. (1992) XRS2, a DNA repair gene of Saccharomyces cerevisiae, is needed for meiotic recombination. Genetics 132, 651-664.
29. Ivanov, E.L., Sugawara, N., White, C.I., Fabre, F. & Haber, J.E. (1994) Mutations in XRS2 and RAD50 delay but do not prevent mating-type switching in Saccharomyces cerevisiae. Mol. Cell. Biol. 14, 3414-3425.
30. Johzuka, K. & Ogawa, H. (1995) Interaction of Mre11 and Rad50: two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae. Genetics 139, 1521-1532.
31. Kato, R. & Ogawa, H. (1994) An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae. Nucl. Acids Res. 22, 3104-3112.
32. Kim, D., Ouyang, H., Yang, S.H., et al. (1995) A constitutive heat shock element-binding factor is immunologically identical to the Ku autoantigen. J. Biol. Chem. 270, 15277-15284.
33. Kirchgessner, C.U, Patil, C.K., Evans, J.W., et al. (1995) DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect. Science 267, 1178-1183.
34. Kironmai, K.M. & Muniyappa, K. (1997) Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae. Genes Cells 2, 443-455.
35. Kowalczykowski, S.C., Dixon, DA., Eggleston, A.K., Lauder, S.D. & Rehrauer, W.M. (1994) Biochemistry of homologons recombination in Escherichia coli. Microbiol. Rev. 58, 401-465.
36. Kramer, K.M., Brock, J.A., Bloom, K., Moore, J.K. & Haber, J.E. (1994) Two different types of double-strand breaks in Saccharomyces cerevisiae are repaired by similar RAD52-independent, nonhomologous recombination events. Mol. Cell. Biol. 14, 1293-1301.
37. Laurenson, P. & Rine, J. (1992) Silencers, silencing, and heritable transcriptional states. Microbiol. Rev. 56, 543-560.
38. Lees-Miller, S.P., Chen, Y.R. & Anderson, C.W. (1990) Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen. Mol. Cell. Biol. 10, 6472-6481.
39. Liang, F., Romanienko, P.J., Weaver, D.T., Jeggo, P.A. & Jasin, M. (1996) Chromosomal double-strand break repair in Ku80-deficient cells. Proc. Natl. Acad. Sci. USA 93, 8929-8933.
40. Lieber, M.R., Hesse, J.E., Lewis, S., et al. (1988) The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination. Cell 55, 7-16.
41. Malone, R.E., Ward, T., Lin, S. & Waring, J. (1990) The RAD50 gene, a member of the double strand break repair epistasis group, is not required for spontaneous mitotic recombination in yeast. Curr. Genet. 18, 111-116.
42. Milne, G.T., Jin, S., Shannon, K.B. & Weaver, D.T. (1996) Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae. Mol. Cell. Biol. 16, 4189-4198.
43. Mimori, T. & Hardin, J.A. (1986) Mechanism of interaction between Ku protein and DNA. J. Biol. Chem. 261, 10375-10379.
44. Moore, J.K. & Haber, J.E. (1996a) Capture of retrotransposon DNA at the sites of chromosomal double-strand breaks. Nature 383, 644-646.
45. Moore, J.K. & Haber, J.E. (1996b) Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae. Mol Cell. Biol. 16, 2164-2173.
46. Morrow, D.M., Tagle, D.A., Shiloh, Y., Collins, F.S. & Hieter, P. (1995) TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell 82, 831-840.
47. Mortensen, U.H., Bendixen, C., Sunjevaric, I. & Rothstein, R. (1996) DNA strand annealing is promoted by the yeast Rad52 protein. Proc. Natl. Acad. Sci. USA 93, 10729-10734.
48. Nash, R. & Lindahl, T. (1996) DNA ligases. In: DNA Replication in Eukaryotic Cells (ed. M.L. DePamphilis), pp. 575-586. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
49. North, P., Ganesh, A. & Thacker, J. (1990) The rejoining of double-strand breaks in DNA by human cell extracts. Nucl. Acids Res. 18, 6205-6210.
50. Palladino, F., Laroche, T., Gilson, E., et al. (1993) SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres. Cell 75, 543-555.
51. Peterson, S.R., Dvir, A., Anderson, C.W. & Dynan, W.S. (1992) DNA binding provides a signal for phosphorylation of the RNA polymerase II heptapeptide repeats. Genes Dev. 6, 426-438.
52. Petes, T.D., Malone, R.E. & Symington, L.S. (1992) Recombination in yeast. In: The Molecular and Cellular Biology of the Yeast Saccharomyces: Genome Dynamics, Protein Synthesis, and Energetics (eds J.R. Broach, J.R. Pringle & E.W. Jones), Volume I, pp. 407-521. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
53. Petrini, J.H., Walsh, M.E., DiMare, C., et al. (1995) Isolation and characterization of the human MRE11 homologue. Genomics 29, 80-86.
54. Pfeiffer, P. & Vielmetter, W. (1988) Joining of nonhomologous DNA double strand breaks in vitro. Nucl. Acids Res. 16, 907-924.
55. Plessis, A., Perrin, A., Haber, J.E. & Dujon, B. (1992) Site-specific recombination determined by I-SceI, a mitochondrial group I intron-encoded endonuclease expressed in the yeast nucleus. Genetics 130, 451-460.
56. Porter, S.E., Greenwell, P.W., Ritchie, K.B. & Petes, T.D. (1996) The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae. Nucl. Acids Res. 24, 582-585.
57. Ramsden, D.A. & Gellert, M. (1998) Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double-strand breaks. EMBO J. 17, 609-614.
58. Rathmell, W.K. & Chu, G. (1994) Involvement of the Ku autoantigen in the cellular response to DNA double-strand breaks. Proc. Natl. Acad. Sci. USA 91, 7623-7627.
59. Reeves, W.H. (1985) Use of monoclonal antibodies for the characterization of novel DNA-binding proteins recognized by human autoimmune sera. J. Exp. Med. 161, 18-39.
60. Roth, D.B., Lindahl, T. & Gellert, M. (1995) Repair and recombination. How to make ends meet. Curr. Biol. 5, 496-499.
61. Roth, D.B., Porter, T.N. & Wilson, J.H. (1985) Mechanisms of nonhomologous recombination in mammalian cells. Mol. Cell. Biol. 5, 2599-2607.
62. Roth, DB. & Wilson, J.H. (1986) Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction. Mol. Cell. Biol. 6, 4295-4304.
63. Rouet, P., Smih, F. & Jasin, M. (1994) Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease. Mol. Cell. Biol. 14, 8096-8106.
64. Sargent, R.G., Brenneman, M.A. & Wilson, J.H. (1997) Repair of site-specific double-strand breaks in a mammalian chromosome by homologous and illegitimate recombination. Mol. Cell. Biol. 17, 267-277.
65. Schar, P., Herrmann, G., Daly, G. & Lindahl, T. (1997) A newly identified DNA ligase of Saccharomyces cerevisiae involved in RAD52-independent repair of DNA double-strand breaks. Genes Dev. 11, 1912-1924.
66. Schiestl, R.H., Zhu, J. & Petes, T.D. (1994) Effect of mutations in genes affecting homologous recombination on restriction enzyme-mediated and illegitimate recombination in Saccharomyces cerevisiae. Mol. Cell. Biol. 14, 4493-4500.
67. Sharples, G.J. & Leach, D.R. (1995) Structural and functional similarities between the SbcCD proteins of Escherichia coli and the RAD50 and MRE11 (RAD32) recombination and repair proteins of yeast. Mol. Microbiol. 17, 1215-1217.
68. Shinohara, A. & Ogawa, T. (1995) Homologous recombination and the roles of double-strand breaks. Trends Biochem. Sci. 20, 387-391.
69. Shinohara, A., Shinohara, M., Ohta, T., Matsuda, S. & Ogawa, T. (1998) Rad52 forms ring structures and co-operates with RPA in single-strand DNA annealing. Genes Cells 3, 145-156.
70. Shore, D. (1995) Telomere position effects and transcriptional silencing in the yeast Saccharomyces cerevisiae. In: Telomeres (eds E.H. Blackburn & C.W. Greider), pp. 139-191. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
71. Siede, W., Friedl, A.A., Dianova, I., Eckardt-Schupp, F. & Friedberg, E.C. (1996) The Saccharomyces cerevisiae Ku autoantigen homologue affects radiosensitivity only in the absence of homologous recombination. Genetics 142, 91-102.
72. Smider, V., Rathmell, W.K., Lieber, M.R. & Chu, G. (1994) Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA. Science 266, 288-291.
73. Sugawara, N. & Haber, J.E. (1992) Characterization of double-strand break-induced recombination: homology requirements and single-stranded DNA formation. Mol. Cell. Biol. 12, 563-575.
74. Sugawara, N., Ivanov, E.L., Fishman-Lobell, J., et al. (1995) DNA structure-dependent requirements for yeast RAD genes in gene conversion. Nature 373, 84-86.
75. Taccioli, G.E., Gottlieb, T.M., Blunt, T., et al. (1994) Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science 265, 1442-1445.
76. Taccioli, G.E., Rathbun, G., Oltz, E., et al. (1993) Impairment of V(D)J recombination in double-strand break repair mutants. Science 260, 207-210.
77. Teng, S.C., Kim, B. & Gabriel, A. (1996) Retrotransposon reverse-transcriptase-mediated repair of chromosomal breaks. Nature 383, 641-644.
78. Teo, S.H. & Jackson, S.P. (1997) Identification of Saccharomyces cerevisiae DNA ligase IV: involvement in DNA double-strand break repair. EMBO J. 16, 4788-4795.
79. Thode, S., Schafer, A., Pfeiffer, P. & Vielmetter, W. (1990) A novel pathway of DNA end-to-end joining. Cell 60, 921-928.
80. Tomkinson, A.E. & Levin, D.S. (1997) Mammalian DNA ligases. Bioessays 19, 893-901.
81. Tsubouchi, H. & Ogawa, H. (1998) A novel mre11 mutation impairs processing of double-strand breaks of DNA during both mitosis and meiosis. Mol. Cell. Biol. 18, 260-268.
82. Tsukamoto, Y., Kato, J. & Ikeda, H. (1996a) Effects of mutations of RAD50, RAD51, RAD52, and related genes on illegitimate recombination in Saccharomyces cerevisiae. Genetics 142, 383-391.
83. Tsukamoto, Y, Kato, J. & Ikeda, H. (1996b) Hdf1, a yeast Ku-protein homologue, is involved in illegitimate recombination, but not in homologous recombination. Nucl. Acids Res. 24, 2067-2072.
84. Tsukamoto, Y, Kato, J. & Ikeda, H. (1997a) Budding yeast Rad50, Mre11, Xrs2, and Hdf1, but not Rad52, are involved in the formation of deletions on a dicentric plasmid. Mol. Gen. Genet. 255, 543-547.
85. Tsukamoto, Y, Kato, J. & Ikeda, H. (1997b) Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae. Nature 388, 900-903.
86. Tuteja, N., Tuteja, R., Ochem., A., et al. (1994) Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen. EMBO J. 13, 4991-5001.
87. Weaver, D.T. (1995) What to do at an end: DNA double-strand-break repair. Trends Genet. 11, 388-392.
88. Wilson, T.E., Grawunder, U. & Lieber, M.R. (1997) Yeast DNA ligase IV mediates non-homologous DNA end joining. Nature 388, 495-498.