메뉴 건너뛰기




Volumn 172, Issue , 2008, Pages 407-420

PTEN-5-HT2C coupling: a new target for treating drug addiction

Author keywords

5 HT2C receptor; cannabinoids; coupled receptors; drug addiction; G protein; PTEN; Tat 3L4F; ventral tegmental area

Indexed keywords

2 (6 CHLORO 5 FLUORO 1 INDOLYL) 1 METHYLETHYLAMINE; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; DEXANABINOL; DRONABINOL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PEPTIDE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; SEROTONIN 2C RECEPTOR; SMALL INTERFERING RNA; TAT 3L4F PEPTIDE; UNCLASSIFIED DRUG;

EID: 50349100359     PISSN: 00796123     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0079-6123(08)00920-5     Document Type: Review
Times cited : (12)

References (62)
  • 1
    • 0032585889 scopus 로고    scopus 로고
    • Agonist induced GTPγ35S binding mediated by human 5-HT2c receptors expressed in human embryonic kidney 293 cells
    • Alberts G.L., Pregenzer J.F., Im W.B., Zaworski P.G., and Gill G.S. Agonist induced GTPγ35S binding mediated by human 5-HT2c receptors expressed in human embryonic kidney 293 cells. Eur. J. Pharmacol. 383 3 (1999) 311-319
    • (1999) Eur. J. Pharmacol. , vol.383 , Issue.3 , pp. 311-319
    • Alberts, G.L.1    Pregenzer, J.F.2    Im, W.B.3    Zaworski, P.G.4    Gill, G.S.5
  • 2
    • 1242317116 scopus 로고    scopus 로고
    • Anxiogenic effects in the rat elevated plus-maze of 5-HT(2C) agonists into ventral but no dorsal hippocampus
    • Alves S.H., Pinheiro G., Motta V., landeira-Fernandez J., and Cruz A.P. Anxiogenic effects in the rat elevated plus-maze of 5-HT(2C) agonists into ventral but no dorsal hippocampus. Behav. Pharmacol. 15 1 (2004) 37-43
    • (2004) Behav. Pharmacol. , vol.15 , Issue.1 , pp. 37-43
    • Alves, S.H.1    Pinheiro, G.2    Motta, V.3    landeira-Fernandez, J.4    Cruz, A.P.5
  • 3
    • 0034604706 scopus 로고    scopus 로고
    • Deletion of the serotonin 5-HT2c receptor PDZ recognition motif prevents receptor phosphorylation and delays resensitization of receptor responses
    • Backstrom J.R., Price R.D., Reasoner D.T., and Sanders-Bush E. Deletion of the serotonin 5-HT2c receptor PDZ recognition motif prevents receptor phosphorylation and delays resensitization of receptor responses. J. Biol. Chem. 275 31 (2000) 23620-23626
    • (2000) J. Biol. Chem. , vol.275 , Issue.31 , pp. 23620-23626
    • Backstrom, J.R.1    Price, R.D.2    Reasoner, D.T.3    Sanders-Bush, E.4
  • 4
  • 5
    • 34247469816 scopus 로고    scopus 로고
    • Distribution of serotonin 5-HT2c receptors in the ventral tegmental area
    • Bubar M.J., and Cunningham K.A. Distribution of serotonin 5-HT2c receptors in the ventral tegmental area. Neuroscience 146 4 (2007) 286-297
    • (2007) Neuroscience , vol.146 , Issue.4 , pp. 286-297
    • Bubar, M.J.1    Cunningham, K.A.2
  • 6
    • 0027939237 scopus 로고
    • Cocaine inhibits GABA release in the VTA through endogenous 5-HT
    • Cameron D.L., and Williams J.T. Cocaine inhibits GABA release in the VTA through endogenous 5-HT. J. Neurosci. 14 11 (1994) 6763-6767
    • (1994) J. Neurosci. , vol.14 , Issue.11 , pp. 6763-6767
    • Cameron, D.L.1    Williams, J.T.2
  • 7
    • 0034706069 scopus 로고    scopus 로고
    • Lack of response suppression follows repeated ventral tegmental cannabinoid administration: an in vitro electrophysiological study
    • Cheer J.F., Marsden C.A., Kendall D.A., and Mason R. Lack of response suppression follows repeated ventral tegmental cannabinoid administration: an in vitro electrophysiological study. Neuroscience 99 4 (2000) 661-667
    • (2000) Neuroscience , vol.99 , Issue.4 , pp. 661-667
    • Cheer, J.F.1    Marsden, C.A.2    Kendall, D.A.3    Mason, R.4
  • 8
    • 0033778106 scopus 로고    scopus 로고
    • Similarities in the action of Ro 60-0175, a 5-HT2C receptor agonist, and d-fenfluramine on feeding patterns in the rat
    • Clifton P.G., Lee M.D., and Dourish C.T. Similarities in the action of Ro 60-0175, a 5-HT2C receptor agonist, and d-fenfluramine on feeding patterns in the rat. Psychopharmacology 152 3 (2000) 256-267
    • (2000) Psychopharmacology , vol.152 , Issue.3 , pp. 256-267
    • Clifton, P.G.1    Lee, M.D.2    Dourish, C.T.3
  • 9
    • 0036765561 scopus 로고    scopus 로고
    • Differential activation of Gq/11 and Gi3 proteins at 5-hydroxytryptamine2c receptors revealed by antibody capture assays: influence of receptor reserve and relationship to agonist-directed trafficking
    • Cussac D., Newman-Tancredi A., Duqueyroix D., Pasteau V., and Millan M.J. Differential activation of Gq/11 and Gi3 proteins at 5-hydroxytryptamine2c receptors revealed by antibody capture assays: influence of receptor reserve and relationship to agonist-directed trafficking. Mol. Pharmacol. 62 3 (2002) 578-589
    • (2002) Mol. Pharmacol. , vol.62 , Issue.3 , pp. 578-589
    • Cussac, D.1    Newman-Tancredi, A.2    Duqueyroix, D.3    Pasteau, V.4    Millan, M.J.5
  • 10
    • 1842610940 scopus 로고    scopus 로고
    • Constitutive activity of the serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens
    • De Deurwaerdère P., Navailles S., Berg K.A., Clarke WilliamP., and Spampinato U. Constitutive activity of the serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens. J. Neurosci. 24 13 (2004) 3235-3241
    • (2004) J. Neurosci. , vol.24 , Issue.13 , pp. 3235-3241
    • De Deurwaerdère, P.1    Navailles, S.2    Berg, K.A.3    Clarke, WilliamP.4    Spampinato, U.5
  • 11
    • 0032940954 scopus 로고    scopus 로고
    • Selective blockade of serotonin2c/2b receptors enhances mesolimbic and mesostriatal dopaminergic function: a combined in vivo electrophysiological and microdialysis study
    • Di Giovanni G., De Deurwaerdère P., Di Mascio M., Di Matteo V., Esposito E., and Spampinato U. Selective blockade of serotonin2c/2b receptors enhances mesolimbic and mesostriatal dopaminergic function: a combined in vivo electrophysiological and microdialysis study. Neuroscience 91 2 (1999) 587-597
    • (1999) Neuroscience , vol.91 , Issue.2 , pp. 587-597
    • Di Giovanni, G.1    De Deurwaerdère, P.2    Di Mascio, M.3    Di Matteo, V.4    Esposito, E.5    Spampinato, U.6
  • 12
    • 0036125178 scopus 로고    scopus 로고
    • Role of serotonin(2C) receptors in the control of brain dopaminergic function
    • Di Matteo V., Cacchio M., Di Giulio C., and Esposito E. Role of serotonin(2C) receptors in the control of brain dopaminergic function. Pharmacol. Biochem. Behav. 71 4 (2002) 727-734
    • (2002) Pharmacol. Biochem. Behav. , vol.71 , Issue.4 , pp. 727-734
    • Di Matteo, V.1    Cacchio, M.2    Di Giulio, C.3    Esposito, E.4
  • 13
    • 0034685842 scopus 로고    scopus 로고
    • Biochemical and electrophysiological evidence that Ro 60-0175 inhibits mesolimbic dopaminergic function through serotonin2c receptors
    • Di Matteo V., Di Giovanni G., Di Mascio M., and Esposito E. Biochemical and electrophysiological evidence that Ro 60-0175 inhibits mesolimbic dopaminergic function through serotonin2c receptors. Brain Res. 865 1 (2000) 85-90
    • (2000) Brain Res. , vol.865 , Issue.1 , pp. 85-90
    • Di Matteo, V.1    Di Giovanni, G.2    Di Mascio, M.3    Esposito, E.4
  • 14
    • 0030612624 scopus 로고    scopus 로고
    • Pattern expression of the serotonin 2C receptor messenger RNA in the basal ganglia of adult rats
    • Eberle-Wang K., Mikeladze Z., Uryu K., and Chesselet M.F. Pattern expression of the serotonin 2C receptor messenger RNA in the basal ganglia of adult rats. J. Comp. Neurol. 384 2 (1997) 233-247
    • (1997) J. Comp. Neurol. , vol.384 , Issue.2 , pp. 233-247
    • Eberle-Wang, K.1    Mikeladze, Z.2    Uryu, K.3    Chesselet, M.F.4
  • 15
    • 0032832155 scopus 로고    scopus 로고
    • Learning impairment produced in rats by the cannabinoid HU 210 in a water-maze task
    • Ferrari F., Ottani A., and Vivoli R. Learning impairment produced in rats by the cannabinoid HU 210 in a water-maze task. Pharmacol. Biochem. Behav. 64 (1999) 555-561
    • (1999) Pharmacol. Biochem. Behav. , vol.64 , pp. 555-561
    • Ferrari, F.1    Ottani, A.2    Vivoli, R.3
  • 16
    • 0842308153 scopus 로고    scopus 로고
    • Injection of the 5-HT2c receptor agonist Ro60-0175 into the ventral tegmental area reduces cocaine-induced locomotor activity and cocaine self-administration
    • Fletcher P.J., Chintoh A.R., Sinyard J., and Higgins G.A. Injection of the 5-HT2c receptor agonist Ro60-0175 into the ventral tegmental area reduces cocaine-induced locomotor activity and cocaine self-administration. Neuropsychopharmacology 29 2 (2004) 308-318
    • (2004) Neuropsychopharmacology , vol.29 , Issue.2 , pp. 308-318
    • Fletcher, P.J.1    Chintoh, A.R.2    Sinyard, J.3    Higgins, G.A.4
  • 17
    • 0030887785 scopus 로고    scopus 로고
    • Cannabinoids excite dopamine neurons in the ventral tegmentum and substantia nigra
    • French E.D., Dillon K., and Wu X. Cannabinoids excite dopamine neurons in the ventral tegmentum and substantia nigra. Neuroreport 8 3 (1997) 649-652
    • (1997) Neuroreport , vol.8 , Issue.3 , pp. 649-652
    • French, E.D.1    Dillon, K.2    Wu, X.3
  • 18
    • 0037661996 scopus 로고    scopus 로고
    • Role of endogenous cannabinoids in synaptic signaling
    • Freund T.F., Kayona I., and Piomelli D. Role of endogenous cannabinoids in synaptic signaling. Physiol. Rev. 83 3 (2003) 1017-1066
    • (2003) Physiol. Rev. , vol.83 , Issue.3 , pp. 1017-1066
    • Freund, T.F.1    Kayona, I.2    Piomelli, D.3
  • 19
    • 0030728479 scopus 로고    scopus 로고
    • Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain
    • Furnari F.B., Lin H., Huang H.S., and Cavenee W.K. Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain. Proc. Natl. Acad. Sci. U.S.A. 94 23 (1997) 12479-12484
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , Issue.23 , pp. 12479-12484
    • Furnari, F.B.1    Lin, H.2    Huang, H.S.3    Cavenee, W.K.4
  • 21
    • 20444398090 scopus 로고    scopus 로고
    • Endocannabinoid signaling system and brain reward: emphasis on dopamine
    • Gardner E.L. Endocannabinoid signaling system and brain reward: emphasis on dopamine. Pharmacol. Biochem. Behav. 81 (2005) 263-284
    • (2005) Pharmacol. Biochem. Behav. , vol.81 , pp. 263-284
    • Gardner, E.L.1
  • 22
    • 0033980706 scopus 로고    scopus 로고
    • Dorsal raphe stimulation differentially modulates dopaminergic neurons in the ventral tegmental area and substantia nigra
    • Gervais J., and Rouillard C. Dorsal raphe stimulation differentially modulates dopaminergic neurons in the ventral tegmental area and substantia nigra. Synapse 35 4 (2000) 281-291
    • (2000) Synapse , vol.35 , Issue.4 , pp. 281-291
    • Gervais, J.1    Rouillard, C.2
  • 23
    • 0032472382 scopus 로고    scopus 로고
    • Cannabinoids activate mesolimbic dopamine neurons by an action on cannabinoid CB1 receptors
    • Gessa G.L., Melis M., Muntoni A.L., and Diana M. Cannabinoids activate mesolimbic dopamine neurons by an action on cannabinoid CB1 receptors. Eur. J. Pharmacol. 341 1 (1998) 39-44
    • (1998) Eur. J. Pharmacol. , vol.341 , Issue.1 , pp. 39-44
    • Gessa, G.L.1    Melis, M.2    Muntoni, A.L.3    Diana, M.4
  • 24
    • 0034803239 scopus 로고    scopus 로고
    • Activation of 5-HT2c receptors reduces the locomotor and rewarding effects of nicotine
    • Grottick A.J., Corrigall W.A., and Higgins G.A. Activation of 5-HT2c receptors reduces the locomotor and rewarding effects of nicotine. Psychopharmacology 157 3 (2001) 292-298
    • (2001) Psychopharmacology , vol.157 , Issue.3 , pp. 292-298
    • Grottick, A.J.1    Corrigall, W.A.2    Higgins, G.A.3
  • 25
    • 0033680203 scopus 로고    scopus 로고
    • Studies to investigate the role of 5-HT(2C) receptors on cocaine- and food-maintained behavior
    • Grottick A.J., Fletcher P.J., and Higgins G.A. Studies to investigate the role of 5-HT(2C) receptors on cocaine- and food-maintained behavior. J. Pharmacol. Exp. Ther. 295 3 (2000) 1183-1191
    • (2000) J. Pharmacol. Exp. Ther. , vol.295 , Issue.3 , pp. 1183-1191
    • Grottick, A.J.1    Fletcher, P.J.2    Higgins, G.A.3
  • 26
    • 0025954862 scopus 로고
    • Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiography study
    • Herkenham M., Lynn A.B., Johnson M.R., Melvin L.S., de Costa B.R., and Rice K.C. Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiography study. J. Neurosci. 11 (1991) 563-583
    • (1991) J. Neurosci. , vol.11 , pp. 563-583
    • Herkenham, M.1    Lynn, A.B.2    Johnson, M.R.3    Melvin, L.S.4    de Costa, B.R.5    Rice, K.C.6
  • 27
    • 0242583841 scopus 로고    scopus 로고
    • Serotonin and drug reward: focus on 5-HT2C receptors
    • Higgins G.A., and Fletcher P.J. Serotonin and drug reward: focus on 5-HT2C receptors. Eur. J. Pharmacol. 480 1-3 (2003) 151-162
    • (2003) Eur. J. Pharmacol. , vol.480 , Issue.1-3 , pp. 151-162
    • Higgins, G.A.1    Fletcher, P.J.2
  • 28
    • 3843101699 scopus 로고    scopus 로고
    • Prolonged cannabinoid treatment results in spatial working memory deficits and impaired long-term potentiation in the CA1 region of the hippocampus in vivo
    • Hill M.N., Froc D.J., Fox C.J., Gorzalka B.B., and Christie B.R. Prolonged cannabinoid treatment results in spatial working memory deficits and impaired long-term potentiation in the CA1 region of the hippocampus in vivo. Eur. J. Neurosci. 20 (2004) 859-863
    • (2004) Eur. J. Neurosci. , vol.20 , pp. 859-863
    • Hill, M.N.1    Froc, D.J.2    Fox, C.J.3    Gorzalka, B.B.4    Christie, B.R.5
  • 29
    • 0034175606 scopus 로고    scopus 로고
    • Mechanisms of cannabinoid inhibition of GABA(A) synaptic transmission in the hippocampus
    • Hoffman A.F., and Lupica C.R. Mechanisms of cannabinoid inhibition of GABA(A) synaptic transmission in the hippocampus. J. Neurosci. 20 7 (2000) 2470-2479
    • (2000) J. Neurosci. , vol.20 , Issue.7 , pp. 2470-2479
    • Hoffman, A.F.1    Lupica, C.R.2
  • 30
    • 0035186226 scopus 로고    scopus 로고
    • Direct actions of cannabinoids on synaptic transmission in the nucleus accumbens: a comparison with opioids
    • Hoffman A.F., and Lupica C.R. Direct actions of cannabinoids on synaptic transmission in the nucleus accumbens: a comparison with opioids. J. Neurophysiol. 85 1 (2001) 72-83
    • (2001) J. Neurophysiol. , vol.85 , Issue.1 , pp. 72-83
    • Hoffman, A.F.1    Lupica, C.R.2
  • 31
    • 0041920807 scopus 로고    scopus 로고
    • Functional localization of cannabinoid receptors and endogenous cannabinoid production in distinct neuron populations of the hippocampus
    • Hoffman A.F., Riegel A.C., and Lupica C.R. Functional localization of cannabinoid receptors and endogenous cannabinoid production in distinct neuron populations of the hippocampus. Eur. J. Neurosci. 18 3 (2003) 524-534
    • (2003) Eur. J. Neurosci. , vol.18 , Issue.3 , pp. 524-534
    • Hoffman, A.F.1    Riegel, A.C.2    Lupica, C.R.3
  • 32
    • 33644817011 scopus 로고    scopus 로고
    • Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse
    • Ji S.P., Zhang Y., Van Cleemput J., Jiang W., Liao M., Li L., Wan Q., Backstrom J.R., and Zhang X. Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse. Nat. Med. 12 3 (2006) 324-329
    • (2006) Nat. Med. , vol.12 , Issue.3 , pp. 324-329
    • Ji, S.P.1    Zhang, Y.2    Van Cleemput, J.3    Jiang, W.4    Liao, M.5    Li, L.6    Wan, Q.7    Backstrom, J.R.8    Zhang, X.9
  • 33
    • 0026592638 scopus 로고
    • Opioids excite dopamine neurons by hyperpolarization of local interneurons
    • Johnson S.W., and North R.A. Opioids excite dopamine neurons by hyperpolarization of local interneurons. J. Neurosci. 12 2 (1992) 483-488
    • (1992) J. Neurosci. , vol.12 , Issue.2 , pp. 483-488
    • Johnson, S.W.1    North, R.A.2
  • 34
    • 0030756351 scopus 로고    scopus 로고
    • Drug abuse: hedonic homeostatic dysregulation
    • Koob G.F., and Le Moal M. Drug abuse: hedonic homeostatic dysregulation. Science 278 5335 (1997) 52-58
    • (1997) Science , vol.278 , Issue.5335 , pp. 52-58
    • Koob, G.F.1    Le Moal, M.2
  • 36
    • 0346655318 scopus 로고    scopus 로고
    • The neurobiology of nicotine addiction: bridging the gap from molecule to behavior
    • Laviolette S.R., and van der Kooy D. The neurobiology of nicotine addiction: bridging the gap from molecule to behavior. Nat. Rev. Neurosci. 5 1 (2004) 55-65
    • (2004) Nat. Rev. Neurosci. , vol.5 , Issue.1 , pp. 55-65
    • Laviolette, S.R.1    van der Kooy, D.2
  • 37
    • 18644386370 scopus 로고    scopus 로고
    • Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor
    • Lee F.J., Xue S., Pei L., Vukusic B., Chery N., Wang Y., Wang Y.T., Niznik H.B., Yu X.M., and Liu F. Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor. Cell 111 2 (2002) 219-230
    • (2002) Cell , vol.111 , Issue.2 , pp. 219-230
    • Lee, F.J.1    Xue, S.2    Pei, L.3    Vukusic, B.4    Chery, N.5    Wang, Y.6    Wang, Y.T.7    Niznik, H.B.8    Yu, X.M.9    Liu, F.10
  • 38
    • 0242289624 scopus 로고    scopus 로고
    • Homo- and hetero-oligomerization of G protein-coupled receptors
    • Lee S.P., O'Dowd B.F., and George S.R. Homo- and hetero-oligomerization of G protein-coupled receptors. Life Sci. 74 2-3 (2003) 173-180
    • (2003) Life Sci. , vol.74 , Issue.2-3 , pp. 173-180
    • Lee, S.P.1    O'Dowd, B.F.2    George, S.R.3
  • 39
    • 4344684649 scopus 로고    scopus 로고
    • PTEN function: how normal cells control it and tumour cells lose it
    • Leslie N.R., and Downes C.P. PTEN function: how normal cells control it and tumour cells lose it. Biochem. J. 382 (2004) 1-11
    • (2004) Biochem. J. , vol.382 , pp. 1-11
    • Leslie, N.R.1    Downes, C.P.2
  • 40
    • 27144557271 scopus 로고    scopus 로고
    • Repeated cocaine exposure in vivo facilitates LTP induction in midbrain dopamine neurons
    • Liu Q.S., Pu L., and Poo M.M. Repeated cocaine exposure in vivo facilitates LTP induction in midbrain dopamine neurons. Nature 437 7061 (2005) 1027-1031
    • (2005) Nature , vol.437 , Issue.7061 , pp. 1027-1031
    • Liu, Q.S.1    Pu, L.2    Poo, M.M.3
  • 41
    • 0032577699 scopus 로고    scopus 로고
    • The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
    • Maehama T., and Dixon J.E. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 273 22 (1998) 13375-13378
    • (1998) J. Biol. Chem. , vol.273 , Issue.22 , pp. 13375-13378
    • Maehama, T.1    Dixon, J.E.2
  • 42
    • 33747180161 scopus 로고    scopus 로고
    • Intracellular 5-HT2c receptor dephosphorylation: a new target for treating drug addiction
    • Müller C.P., and Carey R.J. Intracellular 5-HT2c receptor dephosphorylation: a new target for treating drug addiction. Trends Pharmacol. Sci. 27 9 (2006) 455-458
    • (2006) Trends Pharmacol. Sci. , vol.27 , Issue.9 , pp. 455-458
    • Müller, C.P.1    Carey, R.J.2
  • 44
    • 1942517856 scopus 로고    scopus 로고
    • Historical review: molecular and cellular mechanisms of opiate and cocaine addiction
    • Nestler E.J. Historical review: molecular and cellular mechanisms of opiate and cocaine addiction. Trends Pharmacol. Sci. 25 4 (2004) 210-218
    • (2004) Trends Pharmacol. Sci. , vol.25 , Issue.4 , pp. 210-218
    • Nestler, E.J.1
  • 46
    • 1642281612 scopus 로고    scopus 로고
    • Stimulation of serotonin 2C receptors blocks the hyperactivation of midbrain dopamine neurons induced by nicotine administration
    • Pierucci M., Di Matteo V., and Esposito E. Stimulation of serotonin 2C receptors blocks the hyperactivation of midbrain dopamine neurons induced by nicotine administration. J. Pharmacol. Exp. Ther. 309 1 (2004) 109-118
    • (2004) J. Pharmacol. Exp. Ther. , vol.309 , Issue.1 , pp. 109-118
    • Pierucci, M.1    Di Matteo, V.2    Esposito, E.3
  • 47
    • 0033561459 scopus 로고    scopus 로고
    • Drug addiction: bad habits add up
    • Robbins T.W., and Everitt B.J. Drug addiction: bad habits add up. Nature 398 6728 (1999) 567-570
    • (1999) Nature , vol.398 , Issue.6728 , pp. 567-570
    • Robbins, T.W.1    Everitt, B.J.2
  • 48
    • 0036881831 scopus 로고    scopus 로고
    • Limbic-striatal memory systems and drug addiction
    • Robbins T.W., and Everitt B.J. Limbic-striatal memory systems and drug addiction. Neurobiol. Learn. Mem. 78 3 (2002) 625-636
    • (2002) Neurobiol. Learn. Mem. , vol.78 , Issue.3 , pp. 625-636
    • Robbins, T.W.1    Everitt, B.J.2
  • 49
    • 0035499974 scopus 로고    scopus 로고
    • Modulation of transmitter release via presynaptic cannabinoid receptors
    • Schlicker E., and Kathmann M. Modulation of transmitter release via presynaptic cannabinoid receptors. Trends Pharmacol. Sci. 22 11 (2001) 565-572
    • (2001) Trends Pharmacol. Sci. , vol.22 , Issue.11 , pp. 565-572
    • Schlicker, E.1    Kathmann, M.2
  • 50
    • 0033520487 scopus 로고    scopus 로고
    • In vivo protein transduction: delivery of a biologically active protein into the mouse
    • Schwarze S.R., Ho A., Vocero-Akbani A., and Dowdy S.F. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 285 (1999) 1569-1572
    • (1999) Science , vol.285 , pp. 1569-1572
    • Schwarze, S.R.1    Ho, A.2    Vocero-Akbani, A.3    Dowdy, S.F.4
  • 51
    • 4644288937 scopus 로고    scopus 로고
    • Extinction training regulates neuroadaptive responses to withdrawal from chronic cocaine self-administration
    • Self D.W., Choi K.H., Simmons D., Walker J.R., and Smagula C.S. Extinction training regulates neuroadaptive responses to withdrawal from chronic cocaine self-administration. Learn. Mem. 11 5 (2004) 648-657
    • (2004) Learn. Mem. , vol.11 , Issue.5 , pp. 648-657
    • Self, D.W.1    Choi, K.H.2    Simmons, D.3    Walker, J.R.4    Smagula, C.S.5
  • 53
    • 27744596969 scopus 로고    scopus 로고
    • 5-hydroxytryptamine induced excitation and inhibition in the subthalamic nucleus: action at 5-HT2C, 5-HT4 and 5-HT1A receptors
    • Stanford I.M., Kantaria M.A., Chahal H.S., Loucif K.C., and Wilson C.L. 5-hydroxytryptamine induced excitation and inhibition in the subthalamic nucleus: action at 5-HT2C, 5-HT4 and 5-HT1A receptors. Neuropharmacology 49 8 (2005) 1228-1234
    • (2005) Neuropharmacology , vol.49 , Issue.8 , pp. 1228-1234
    • Stanford, I.M.1    Kantaria, M.A.2    Chahal, H.S.3    Loucif, K.C.4    Wilson, C.L.5
  • 54
    • 0036460445 scopus 로고    scopus 로고
    • Inhibition of GABAergic neurotransmission in the ventral tegmental area by cannabinoids
    • Szabo B., Siemas S., and Wallmichrath I. Inhibition of GABAergic neurotransmission in the ventral tegmental area by cannabinoids. Eur. J. Neurosci. 15 12 (2002) 2057-2061
    • (2002) Eur. J. Neurosci. , vol.15 , Issue.12 , pp. 2057-2061
    • Szabo, B.1    Siemas, S.2    Wallmichrath, I.3
  • 55
    • 33846245536 scopus 로고    scopus 로고
    • Regulation of mitogen-activated protein kinases by glutamate receptors
    • Wang J.Q., Fibuch E.E., and Mao L. Regulation of mitogen-activated protein kinases by glutamate receptors. J. Neurochem. 100 1 (2007) 1-11
    • (2007) J. Neurochem. , vol.100 , Issue.1 , pp. 1-11
    • Wang, J.Q.1    Fibuch, E.E.2    Mao, L.3
  • 56
    • 33745255079 scopus 로고    scopus 로고
    • The PTEN phosphatase is essential for long-term depression of hippocampus synapses
    • Wang Y., Cheng A., and Mattson M.P. The PTEN phosphatase is essential for long-term depression of hippocampus synapses. Neuromolecular Med. 8 3 (2006) 329-336
    • (2006) Neuromolecular Med. , vol.8 , Issue.3 , pp. 329-336
    • Wang, Y.1    Cheng, A.2    Mattson, M.P.3
  • 57
    • 0035869212 scopus 로고    scopus 로고
    • PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model
    • Weng L.P., Brown J.L., and Eng C. PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model. Hum. Mol. Genet. 10 6 (2001) 599-604
    • (2001) Hum. Mol. Genet. , vol.10 , Issue.6 , pp. 599-604
    • Weng, L.P.1    Brown, J.L.2    Eng, C.3
  • 58
    • 0029117884 scopus 로고
    • Increase basal phosphorylation of the constitutively active serotonin 2C receptor accompanies agonist-mediated desensitization
    • Westphal R.S., Backstrom J.R., and Sanders-Bush E. Increase basal phosphorylation of the constitutively active serotonin 2C receptor accompanies agonist-mediated desensitization. Mol. Pharmacol. 48 2 (1995) 200-205
    • (1995) Mol. Pharmacol. , vol.48 , Issue.2 , pp. 200-205
    • Westphal, R.S.1    Backstrom, J.R.2    Sanders-Bush, E.3
  • 60
    • 1542395813 scopus 로고    scopus 로고
    • Therapeutic potential of 5-HT2C receptor antagonists in the treatment of anxiety disorders
    • Wood M.D. Therapeutic potential of 5-HT2C receptor antagonists in the treatment of anxiety disorders. Curr. Drug Targets CNS Neurol. Disord. 2 (2003) 383-387
    • (2003) Curr. Drug Targets CNS Neurol. Disord. , vol.2 , pp. 383-387
    • Wood, M.D.1
  • 61
    • 0033622131 scopus 로고    scopus 로고
    • Effects of chronic delta9-tetrahydrocannabinol on rat midbrain dopamine neurons: an electrophysiological assessment
    • Wu X., and French E.D. Effects of chronic delta9-tetrahydrocannabinol on rat midbrain dopamine neurons: an electrophysiological assessment. Neuropharmacology 39 3 (2000) 391-398
    • (2000) Neuropharmacology , vol.39 , Issue.3 , pp. 391-398
    • Wu, X.1    French, E.D.2
  • 62
    • 0030922666 scopus 로고    scopus 로고
    • Behavioural stress facilitates the induction of long-term depression in the hippocampus
    • Xu L., Anwyl R., and Rowan M.J. Behavioural stress facilitates the induction of long-term depression in the hippocampus. Nature 387 6632 (1997) 497-500
    • (1997) Nature , vol.387 , Issue.6632 , pp. 497-500
    • Xu, L.1    Anwyl, R.2    Rowan, M.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.