Pleiotropic behavior of 5-HT(2A) and 5-HT(2C) receptor agonists

Annals of the New York Academy of Sciences

Volumn 861, Issue , 1998, Pages 104-110

  Berg, K A ^a   Maayani, S ^b   Goldfarb, J ^b   Clarke, W P ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3 TRIFLUOROMETHYLPHENYL)PIPERAZINE; ARACHIDONIC ACID; CALCIUM ION; INOSITOL PHOSPHATE; LYSERGIDE; PHOSPHOLIPASE A2; PHOSPHOLIPASE C; RECEPTOR SUBTYPE; SEROTONIN 2A AGONIST; SEROTONIN 2C AGONIST;

CALCIUM MOBILIZATION; CONFERENCE PAPER; PLEIOTROPY; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

EID: 0032434460     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1998.tb10180.x     Document Type: Conference Paper

References (13)

1. 1. CLARK, A. J. 1937. General Pharmacology. In Heffner's Handbuch d-exp. Pharmacol. Erg. band 4 eds) Springer. Berlin.
2. 2. CLARKE, W. P. & R. A. BOND. 1998. The elusive nature of intrinsic efficacy. Trends Pharmacol. Sci. 19: 270-276.
3. 3. KENAKIN, T. 1997. Pharmacologic analysis of drug-receptor interaction. 3rd edition. Raven Press. New York.
4. 4. GUDERMAN, T., F. KALKBRENNER & G. SCHULTZ. 1996. Diversity and selectivity of receptor-G-protein interaction. Annu. Rev. Pharmacol. Toxicol. 36: 429-459.
5. 5. FURCHGOTT, R. F. 1966. The use of β-haloalkylamines in the differentiation of receptors and in the determination of dissociation constants of receptor-agonist complexes. In Advances in Drug Research. N.J. Harper & A. B. Simmonds, Eds. : 21-55. Academic Press. London.
6. 6. KENAKIN, T. 1995. Agonist-receptor efficacy II: Agonist trafficking of receptor signals. Trends Pharmacol. Sci. 16: 232-238.
7. 7. KENAKIN, T. 1996. The classification of seven transmembrane receptors in recombinant expressions systems. Pharmacol. Rev. 48: 413-463.
8. 8. RAYMOND, J. R. 1995. Multiple mechanisms of receptor-G protein signaling specificity. Am. J. Physiol. 269: F141-158.
9. 9. BERG, K. A., S. MAAYANI, J. GOLDFARB, C. SCARAMELLINI, P. LEFF & W. P. CLARKE. 1998. Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: Evidence for agonist-directed trafficking of receptor stimulus. Mol. Pharmacol. 54: 94-104.
10. 10. COSTA, T., Y. OGINO, P. J. MUNSON, H. O. ONARAN & D. RODBARD. 1992. Drug efficacy at guanine nucleotide-binding regulatory protein-linked receptors: Thermodynamic interpretation of negative antagonism and of receptor activity in the absence of ligand. Mol. Pharmacol. 41: 549-560.
11. 11. LEFF, P., C. SCARAMELLINI, C. LAW & K. MCKECHNIE. 1997. A three-state model of agonist action. Trends Pharmacol. Sci. 18: 355-362.
12. 12. BERG, K. A., W. P. CLARKE, C. SAILSTAD, A. SALTZMAN & S. MAAYANI. 1994. Signal transduction differences between 5-hydroxytryptamine type 2A and Type 2C receptor systems. Mol. Pharmacol. 46: 477-485.
13. 1B-like receptor function via arachidonic acid metabolism. Mol. Pharmacol. 50: 1017-1023.