Dual Neuroprotective Signaling Mediated by Downregulating Two Distinct Phosphatase Activities of PTEN

Journal of Neuroscience

Volumn 24, Issue 16, 2004, Pages 4052-4060

  Ning, Ke ^a,b   Pei, Lin ^c,d   Liao, Mingxia ^a,b   Liu, Baosong ^a,b   Zhang, Yunzhou ^e   Jiang, Wen ^e   Mielke, John G ^a   Li, Lei ^a,b   Chen, Yonghong ^a,b   El Hayek, Youssef H ^a,b   Fehlings, Michael G ^a,b   Zhang, Xia ^e   Liu, Fang ^c,d   Eubanks, James ^a,b   Wan, Qi ^a,b  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^e UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Cerebral ischemia; Neuroprotection; NMDA receptor; Phosphatase; Stroke; Synapse

Indexed keywords

DIZOCILPINE; GLUTATHIONE TRANSFERASE; GLYCINE; GREEN FLUORESCENT PROTEIN; IFENPRODIL; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN BAD; PROTEIN KINASE B; SMALL INTERFERING RNA; SULFUR 35;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; HIPPOCAMPUS; MALE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; STROKE; SYNAPSE;

ANIMALS; BCL-ASSOCIATED DEATH PROTEIN; CARRIER PROTEINS; CELL DEATH; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ENZYME ACTIVATION; HIPPOCAMPUS; ISCHEMIC ATTACK, TRANSIENT; MACROMOLECULAR SUBSTANCES; MALE; NEURONS; PATCH-CLAMP TECHNIQUES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 11144356390     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5449-03.2004     Document Type: Article

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