Biochemical and electrophysiological evidence that RO 60-0175 inhibits mesolimbic dopaminergic function through serotonin(2C) receptors

Brain Research

Volumn 865, Issue 1, 2000, Pages 85-90

  Di Matteo, Vincenzo ^a   Di Giovanni, Giuseppe ^b   Di Mascio, Michele ^a   Esposito, Ennio ^a  

^a Laboratorio di Neurofisiologia   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

Author keywords

5 HT2C receptors; Electrophysiology; Mesolimbic DA system; Microdialysis; RO 60 0175; Serotonin

Indexed keywords

2 CHLORO 5 FLUOROINDOL 1 YL 1 METHYLETHYLAMINE FUMARATE; SEROTONIN 2C AGONIST; SEROTONIN 2C RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; DOPAMINERGIC ACTIVITY; DRUG EFFECT; DRUG SCREENING; ELECTROPHYSIOLOGY; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; VENTRAL TEGMENTUM;

ANIMALS; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; ETHYLAMINES; INDOLES; LIMBIC SYSTEM; MALE; MICRODIALYSIS; NEURONS; NUCLEUS ACCUMBENS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTOR, SEROTONIN, 5-HT2B; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; VENTRAL TEGMENTAL AREA;

EID: 0034685842     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02246-0     Document Type: Article

References (22)

1. Azmitia E.C., Segal M. An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J. Comp. Neurol. 179:1978;641-668.
2. Cameron D.L., Wessendorf M.W., Williams J.T. A subset of ventral tegmental area neurons is inhibited by dopamine, 5-hydroxytryptamine and opioids. Neuroscience. 77:1997;155-166.
3. 2C/2B receptors enhances mesolimbic and mesostriatal dopaminergic function: a combined in vivo electrophysiological and microdialysis study. Neuroscience. 91:1999;587-597.
4. 2C/2B receptors enhances dopamine release in the rat nucleus accumbens. Neuropharmacology. 37:1998;265-272.
5. Duxon M.S., Flanigan T.P., Reavley A.C., Baxter G.S., Blackburn T.P., Fone K.C.F. Evidence for expression of the 5-hydroxytryptamine-2B receptor protein in the rat central nervous system. Neuroscience. 76:1997;323-329.
6. 2C receptor messenger RNA in the basal ganglia of adult rats. J. Comp. Neurol. 384:1997;233-247.
7. 2B receptor mRNA in rat brain. Br. J. Pharmacol. 114:1995;369P.
8. Grace A.A., Bunney B.S. The control of firing pattern in nigral dopamine neurons: burst firing. J. Neurosci. 4:1984;2877-2890.
9. Hoyer D., Clarke D.E., Fozard J.R., Hartig P.R., Martin G.R., Mylecharane E.J., Saxena P.R., Humphrey P.P.A. VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev. 46:1994;157-203.
10. 2B receptor agonist, causes hyperphagia and reduced grooming in rats. Neuropharmacology. 36:1997;233-239.
11. 2C receptor antagonist. Neuropharmacology. 36:1997;609-620.
12. 2C receptors inhibit the activity of mesocortical and mesolimbic dopaminergic pathways: a combined dialysis and electrophysiological analysis. Soc. Neurosci. Abstr. 23:1997;975.
13. 2C receptor agonists: Pharmacological characterisýtics and therapeutical potential. J. Pharmacol. Exp. Ther. 286:1998;913-924.
14. 1C receptor is a prominent serotonin receptor subtype in the central nervous system. Proc. Natl. Acad. Sci. USA. 86:1989;6793-6797.
15. 2C receptor agonists exhibit antidepressant-like properties in the anhedonia model of depression in rats. Eur. Neuropsychopharmacol. 6:1996;169-175.
16. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 1986;Academic Press, New York.
17. Pessia M., Jiang Z.-G., North R.A., Johnson S.W. Actions of 5-hydroxytryptamine on ventral tegmental area neurons of the rat in vitro. Brain Res. 654:1994;324-330.
18. Phillipson O.T. Afferent projections to ventral tegmental area of Tsai and interfascicular nucleus: a horseradish peroxidase study in the rat. J. Comp. Neurol. 187:1979;117-144.
19. 2C receptors. Mol. Brain Res. 23:1994;163-178.
20. Prisco S., Pagannone S., Esposito E. Serotonin-dopamine interaction in the rat ventral tegmental area: an electrophysiological study in vivo. J. Pharmacol. Exp. Ther. 271:1994;83-90.
21. 2A receptor blockade. J. Pharmacol. Exp. Ther. 277:1996;1541-1549.
22. Van Bockstaele E.J., Cestari D.M., Pickel V. Synaptic structure and connectivity of serotonin terminals in the ventral tegmental area: potential sites for modulation of mesolimbic dopamine neurons. Brain Res. 647:1994;307-322.