Similarities in the action of Ro 60-0175, a 5-HT(2c) receptor agonist, and d-fenfluramine on feeding patterns in the rat

Psychopharmacology

Volumn 152, Issue 3, 2000, Pages 256-267

  Clifton, Peter G ^a   Lee, Michelle D ^a   Dourish, Colin T ^b  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

^b Vernalis PLC   (United Kingdom)

Author keywords

5 HT; 5 Hydroxytryptamine; d Fenfluramine; Feeding rate; Hypophagia; Meal size; Obesity; Ro 60 0175; SB 242084; Serotonin

Indexed keywords

2 CHLORO 5 FLUOROINDOL 1 YL 1 METHYLETHYLAMINE FUMARATE; FENFLURAMINE; SEROTONIN 2C AGONIST;

ANIMAL EXPERIMENT; ARTICLE; DRUG EFFECT; DRUG MECHANISM; DRUG USE; FEEDING BEHAVIOR; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT;

AMINOPYRIDINES; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYLAMINES; FEEDING BEHAVIOR; FENFLURAMINE; INDOLES; MALE; RATS; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS;

EID: 0033778106     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130000504     Document Type: Article

References (51)

1. Differential effects of serotonergic and catecholaminergic drugs on ingestive behavior
2. A review of central 5-HT receptors and their function
3. Fenfluramine-induced modification of palatability: Analysis by the taste reactivity test
4. Serotonin manipulations and the structure of feeding behaviour
5. Pharmacological manipulation of feeding behaviour: Possible influences of serotonin and dopamine on food intake
6. RS-102221: A novel high affinity and selective, 5-HT(2C) receptor antagonist
7. The effect of fenfluramine on the microstructure of feeding and drinking in the rat
8. Analysis of feeding and drinking patterns
9. Meal patterning in rodents: Psychopharmacological and neuroanatomical studies
10. A behavioural profile of fluoxetine-induced anorexia
11. Effects of food deprivation and mCPP treatment on the microstructure of ingestive behaviour of male and female rats
12. Valvular heart disease associated with fenfluramine-phentermine
13. Appetite suppression by commonly used drugs depends on 5-HT receptors but not on 5-HT availability
14. Analysis of the microstructure of the rhythmic tongue movements of rats ingesting maltose and sucrose solutions
15. Peripheral control of drinking: Gastrointestinal filling as a negative feedback signal, a theoretical and experimental analysis
16. Discriminative stimulus properties of the novel serotonin (5-HT) 2C receptor agonist, Ro 60-0175: A pharmacological analysis
17. Low doses of the putative serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicit feeding in the rat
18. The selective 5-HT(2C) receptor agonist Ro 60-0175 decreases meal size and accelerates the onset of the behavioural satiety sequence in the rat
19. Increased food intake in satiated rats induced by the 5-HT antagonists methysergide, metergoline and ritanserin
20. d-Fenfluramine-and d-norfenfluramine-induced hypophagia: Differential mechanisms and involvement of postsynaptic 5-HT receptors
21. The interaction of metergoline, a 5-HT receptor blocker, and dexfenfluramine inhuman feeding
22. Ritanserin attenuates anorectic, endocrine and thermic responses to d-fenfluramine in human volunteers
23. d-Fenfluramine's effects on normal ingestion assessed with taste reactivity measures
24. Role of serotonin receptors in the effect of d-fenfluramine on feeding patterns in the rat
25. Contribution of caudal brainstem to d-fenfluramine anorexia
26. The 5-HT(1B) receptor agonist CP-94,253 reduces food intake and preserves the behavioural satiety sequence
27. Evidence for the involvement of 5-HT(2B)/(2C) receptors in mediating fenfluramine-induced anorexia in rats
28. Neurochemical and behavioural evidence for mediation of the hyperphagic action of 8-OH-DPAT by 5-HT cell body autoreceptors
29. Evidence that hypophagia induced by mCPP and TFMPP requires 5-HT(1C) and 5-HT(1B) receptors; hypophagia induced by RU 24969 only requires 5-HT(1B) receptors
30. SB 242084, a selective and brain penetrant 5-HT(2C) receptor antagonist
31. BW 723C86, a 5-HT(2B) receptor agonist, causes hyperphagia and reduced grooming in rats
32. 2 re ceptor agonists using the post-prandial satiety sequence in rats
33. CP-94,253: A selective serotonin 1B (5-HT(1B)) agonist that promotes satiety
34. Infusion of the serotonin 1B (5-HT(1B)) agonist CP-93, 129 into the parabrachial nucleus potently and selectively reduces food intake in rats
35. Absence of fenfluramine-induced anorexia and reduced c-Fos induction in the hypothalamus and central amygdaloid complex of serotonin 1B receptor knock-out mice
36. 5-HT(2C) receptor agonists: Pharmacological characteristics and therapeutic potential
37. The effect of the 5-HT reuptake inhibitor fluoxetine on food intake and body weight in healthy male subjects
38. 5-HT(2C) receptors mediate penile erections in rats: Actions of novel and selective agonists and antagonists
39. 1 receptors
40. RU24969-induced behavioural syndrome requires activation of both 5-HT(1A) and 5-HT(1B) receptors
41. Functional characterization of agonists at recombinant human 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors in CHO-K1 cells
42. 5-HT(2C) receptor activation decreases appetite and body weight in obese subjects
43. 5-HT receptor subtypes influencing feeding and drinking: Focus on the periphery
44. Behavioral mechanisms for the anorectic action of the serotonin (5-HT) uptake inhibitor sertraline in rats: Comparison with directly acting 5-HT agonists
45. Analytical issues in the evaluation of food deprivation and sucrose concentration effects on the microstructure of licking behavior in the rat
46. Neural control of dieting
47. Eating disorder and epilepsy in mice lacking 5-HT(2C) serotonin receptors
48. Behavioural evidence that d-fenfluramine-induced anorexia in the rat is not mediated by the 5-HT(1A) receptor subtype
49. Reduced satiating effect of d-fenfluramine in serotonin 5-HT(2C) receptor mutant mice
50. Medial hypothalamic serotonin: Effects on deprivation and norepinephrine-induced eating