Genetics and neurobiology of circadian clocks in mammals

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 72, Issue , 2007, Pages 251-259

  Siepka, S M ^a   Yoo, S H ^a   Park, J ^a   Lee, C ^b   Takahashi, J S ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b FLORIDA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CRYPTOCHROME; F BOX PROTEIN; FLAVOPROTEIN; PROTEIN BMAL1; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR CLOCK; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CARRIER PROTEIN; CRYPTOCHROME 1; CRYPTOCHROME 2; CYCLOHEXIMIDE; ETHYLNITROSOUREA; FBXL3 PROTEIN; ISOLEUCINE; MUTANT PROTEIN; OVTM PROTEIN; PART TIME PROTEIN; PER1 PROTEIN; PER2 PROTEIN; THREONINE; TRANSCRIPTION FACTOR ARNTL; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL; BIOLOGICAL MODEL; CIRCADIAN RHYTHM; FEEDBACK SYSTEM; FEMALE; GENETICS; HOMEOSTASIS; MALE; MAMMAL; MOLECULAR CLONING; MOLECULAR GENETICS; MOUSE; MUTAGENESIS; NEUROBIOLOGY; PHENOTYPE; PHYSIOLOGY; REVIEW; SEQUENCE HOMOLOGY; AMINO ACID SUBSTITUTION; CLONING; FIBROBLAST; GENE EXPRESSION; GENE REGULATORY NETWORK; GENE REPRESSION; GENETIC COMPLEMENTATION; GENETIC TRANSFECTION; LOSS OF FUNCTION MUTATION; NEGATIVE FEEDBACK; NERVOUS SYSTEM; NONHUMAN; OSCILLATION; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN SYNTHESIS; UBIQUITINATION;

AMINO ACID SEQUENCE; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CIRCADIAN RHYTHM; CLONING, MOLECULAR; F-BOX PROTEINS; FEEDBACK, BIOCHEMICAL; FEMALE; FLAVOPROTEINS; HOMEOSTASIS; MALE; MAMMALS; MICE; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS; NEUROBIOLOGY; PHENOTYPE; SEQUENCE HOMOLOGY, AMINO ACID; TRANS-ACTIVATORS;

EID: 48249087247     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2007.72.052     Document Type: Conference Paper

References (43)

1. Allada R., Emery P., Takahashi J.S., and Rosbash M. 2001. Stopping time: The genetics of fly and mouse circadian clocks. Annu. Rev. Neurosci. 24: 1091.
2. Antoch M.P., Song E.J., Chang A.M., Vitaterna M.H., Zhao Y., Wilsbacher L.D., Sangoram A.M., King D.P., Pinto L.H., and Takahashi J.S. 1997. Functional identification of the mouse circadian Clock gene by transgenic BAC rescue. Cell 89: 655.
3. Bunger M.K., Wilsbacher L.D., Moran S.M., Clendenin C., Radcliffe L.A., Hogenesch J.B., Simon M.C., Takahashi J.S., and Bradfield C.A. 2000. Mop3 is an essential component of the master circadian pacemaker in mammals. Cell 103: 1009.
4. Busino L., Bassermann F., Maiolica A., Lee C., Nolan P.M., Godinho S.I., Draetta G.F., and Pagano M. 2007. SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. Science 316: 900.
5. Cardozo T. and Pagano M. 2004. The SCF ubiquitin ligase: Insights into a molecular machine. Nat. Rev. Mol. Cell Biol. 5: 739.
6. DeBruyne J.P., Weaver D.R., and Reppert S.M. 2007. CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock. Nat. Neurosci. 10: 543.
7. Eide E.J., Woolf M.F., Kang H., Woolf P., Hurst W., Camacho F., Vielhaber E.L., Giovanni A., and Virshup D.M. 2005. Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation. Mol. Cell. Biol. 25: 2795.
8. Gallego M. and Virshup D.M. 2007. Post-translational modifications regulate the ticking of the circadian clock. Nat. Rev. Mol. Cell Biol. 8: 139.
9. Gekakis N., Staknis D., Nguyen H.B., Davis F.C., Wilsbacher L.D., King D.P., Takahashi J.S., and Weitz C.J. 1998. Role of the CLOCK protein in the mammalian circadian mechanism. Science 280: 1564.
10. Godinho S.I., Maywood E.S., Shaw L., Tucci V., Barnard A.R., Busino L., Pagano M., Kendall R., Quwailid M.M., Romero M.R., O'Neill J., Chesham J.E., Brooker D., Lalanne Z., Hastings M.H., and Nolan P.M. 2007. The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period. Science 316: 897.
11. Griffin E.A., Jr., Staknis D., and Weitz C.J. 1999. Light-independent role of CRY1 and CRY2 in the mammalian circadian clock. Science 286: 768.
12. Grima B., Lamouroux A., Chelot E., Papin C., Limbourg-Bouchon B., and Rouyer F. 2002. The F-box protein slimb controls the levels of clock proteins Period and Timeless. Nature 420: 178.
13. Hao B., Zheng N., Schulman B.A., Wu G., Miller J.J., Pagano M., and Pavletich N.P. 2005. Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. Mol. Cell 20: 9.
14. Harmon F.G. and Kay S.A. 2003. The F box protein AFR is a positive regulator of phytochrome A-mediated light signaling. Curr. Biol. 13: 2091.
15. He Q., Cheng P., Yang Y., Yu H., and Liu Y. 2003. FWD1-mediated degradation of FREQUENCY in Neurospora establishes a conserved mechanism for circadian clock regulation. EMBO J. 22: 4421.
16. Imaizumi T., Schultz T.F., Harmon F.G., Ho L.A., and Kay S.A. 2005. FKF1 F-box protein mediates cyclic degradation of a repressor of CONSTANS in Arabidopsis. Science 309: 293.
17. Jin J., Cardozo T., Lovering R.C., Elledge S.J., Pagano M., and Harper J.W. 2004. Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev. 18: 2573.
18. King D.P., Zhao Y., Sangoram A.M., Wilsbacher L.D., Tanaka M., Antoch M.P., Steeves T.D., Vitaterna M.H., Kornhauser J.M., Lowrey P.L., Turek F.W., and Takahashi J.S. 1997. Positional cloning of the mouse circadian Clock gene. Cell 89: 641.
19. Ko C.H. and Takahashi J.S. 2006. Molecular components of the mammalian circadian clock. Hum. Mol. Genet. (suppl. 2) 15: R271.
20. Ko H.W., Jiang J., and Edery I. 2002. Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime. Nature 420: 673.
21. Koh K., Zheng X., and Sehgal A. 2006. JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS. Science 312: 1809.
22. Kume K., Zylka M.J., Sriram S., Shearman L.P., Weaver D.R., Jin X., Maywood E.S., Hastings M.H., and Reppert S.M. 1999. mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell 98: 193.
23. Lee C., Etchegaray J.P., Cagampang F.R., Loudon A.S., and Reppert S.M. 2001. Posttranslational mechanisms regulate the mammalian circadian clock. Cell 107: 855.
24. Lowrey P.L. and Takahashi J.S. 2004. Mammalian circadian biology: Elucidating genome-wide levels of temporal organization. Annu. Rev. Genomics Hum. Genet. 5: 407.
25. Lowrey P.L., Shimomura K., Antoch M.P., Yamazaki S., Zemenides P.D., Ralph M.R., Menaker M., and Takahashi J.S. 2000. Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau. Science 288: 483.
26. Mas P., Kim W.Y., Somers D.E., and Kay S.A. 2003. Targeted degradation of TOC1 by ZTL modulates circadian function in Arabidopsis thaliana. Nature 426: 567.
27. Preitner N., Damiola F., Lopez-Molina L., Zakany J., Duboule D., Albrecht U., and Schibler U. 2002. The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 110: 251.
28. Reppert S.M. and Weaver D.R. 2002. Coordination of circadian timing in mammals. Nature 418: 935.
29. Ripperger J.A. and Schibler U. 2006. Rhythmic CLOCKBMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions. Nat. Genet. 38: 369.
30. Rost B., Yachdav G., and Liu J. 2004. The PredictProtein server. Nucleic Acids Res. 32: W321.
31. Sato T.K., Panda S., Miraglia L.J., Reyes T.M., Rudic R.D., McNamara P., Naik K.A., FitzGerald G.A., Kay S.A., and Hogenesch J.B. 2004. A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron 43: 527.
32. Shimomura K., Low-Zeddies S.S., King D.P., Steeves T.D., Whiteley A., Kushla J., Zemenides P.D., Lin A., Vitaterna M.H., Churchill G.A., and Takahashi J.S. 2001. Genomewide epistatic interaction analysis reveals complex genetic determinants of circadian behavior in mice. Genome Res. 11: 959.
33. Shirogane T., Jin J., Ang X.L. and Harper J.W. 2005. SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein. J. Biol. Chem. 280: 26863.
34. Siepka S.M. and Takahashi J.S. 2005. Forward genetic screens to identify circadian rhythm mutants in mice. Methods Enzymol. 393: 219.
35. Siepka S.M., Yoo S.H., Park J., Song W., Kumar V., Hu Y., Lee C., and Takahashi J.S. 2007. Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression. Cell 129: 1011.
36. Somers D.E., Schultz T.F., Milnamow M., and Kay S.A. 2000. ZEITLUPE encodes a novel clock-associated PAS protein from Arabidopsis. Cell 101: 319.
37. Takahashi J.S. 2004. Finding new clock components: Past and future. J. Biol. Rhythms 19: 339.
38. Takahashi J.S., Pinto L.H., and Vitaterna M.H. 1994. Forward and reverse genetic approaches to behavior in the mouse. Science 264: 1724.
39. Vitaterna M.H., Pinto L.H., and Takahashi J.S. 2006. Largescale mutagenesis and phenotypic screens for the nervous system and behavior in mice. Trends Neurosci. 29: 233.
40. Vitaterna M.H., King D.P., Chang A.M., Kornhauser J.M., Lowrey P.L., McDonald J.D., Dove W.F., Pinto L.H., Turek F.W., and Takahashi J.S. 1994. Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science 264: 719.
41. Vitaterna M.H., Selby C.P., Todo T., Niwa H., Thompson C., Fruechte E.M., Hitomi K., Thresher R.J., Ishikawa T., Miyazaki J., Takahashi J.S., and Sancar A. 1999. Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2. Proc. Natl. Acad. Sci. 96: 12114.
42. Yoo S.H., Ko C.H., Lowrey P.L., Buhr E.D., Song E.J., Chang S., Yoo O.J., Yamazaki S., Lee C., and Takahashi J.S. 2005. A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo. Proc. Natl. Acad. Sci. 102: 2608.
43. Young M.W. and Kay S.A. 2001. Time zones: A comparative genetics of circadian clocks. Nat. Rev. Genet. 2: 702.