Differences in the frequency of micronucleated erythrocytes in humans in relation to consumption of fried carbohydrate-rich food

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 653, Issue 1-2, 2008, Pages 50-56

  Abramsson Zetterberg, Lilianne ^a   Vikström, Anna C ^b   Törnqvist, Margareta ^b   Hellenäs, Karl Erik ^a  

^a NATIONAL FOOD ADMINISTRATION   (Sweden)

^b STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Acrylamide; Carbohydrate rich food; Hemoglobin adducts; Human; Micronucleus; Transferrin positive reticulocytes

Indexed keywords

ACRYLAMIDE; CARBOHYDRATE; HEMOGLOBIN; TRANSFERRIN; WATER;

ADULT; ARTICLE; BLOOD SAMPLING; CALCULATION; CHROMOSOMAL INSTABILITY; COMPARATIVE STUDY; CONTROLLED STUDY; EATING; ERYTHROCYTE; FEMALE; FOOD; FOOD INTAKE; HEATING; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL; RETICULOCYTE; ANIMAL; CARBOHYDRATE DIET; COOKING; CYTOLOGY; ERYTHROBLAST; ERYTHROCYTE COUNT; FOOD ANALYSIS; HEAT; METHODOLOGY; MIDDLE AGED; MOUSE;

MUS;

ACRYLAMIDE; ADULT; ANIMALS; COOKERY; DIETARY CARBOHYDRATES; ERYTHROBLASTS; ERYTHROCYTE COUNT; FEMALE; FOOD ANALYSIS; HEAT; HUMANS; MALE; MICE; MIDDLE AGED; RETICULOCYTES;

EID: 49649121296     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2008.03.007     Document Type: Article

References (66)

1. Larsson B.K. Polycyclic aromatic hydrocarbons in smoked fish. Z. Lebensm. Unters. Forsch. 174 (1982) 101-107
2. Jägerstad M., Laser Reuterswärd A., Olsson R., Grivas S., Nyhammar T., Olsson K., and Dahlqvist A. Creatin(in)e and Maillard reaction products as precursors of mutagenic compounds: effects of various amino acids. Food Chem. 12 (1983) 239-244
3. Becalski A., and Seaman S. Furan precursors in food: a model study and development of a simple headspace method for determination of furan. J. AOAC 88 (2005) 102-106
4. Hasnip S., Crews C., and Castle L. Some factors affecting the formation of furan in heated foods. Food Addit. Contam. 23 (2006) 219-227
5. U.K. Food Standards Agency (FSA), Ethyl carbamate in bread, toast and similar products (C 03020), London, 2002.
6. Hamlet C.G., and Sadd P.A. Effects of yeast stress and pH on 3-monochloropropanediol (3-MCPD)-producing reactions in model dough systems. Food Addit. Contam. 22 (2005) 616-623
7. Stadler R.H. Acrylamide formation in different foods and potential strategies for reduction. Adv. Exp. Med. Biol. 561 (2005) 157-169
8. Tareke E., Rydberg P., Karlsson P., and Törnqvist M. Acrylamide: a cooking carcinogen?. Chem. Res. Toxicol. 13 (2000) 517-522
9. Tareke E., Rydberg P., Karlsson P., Erikssons S., and Tornqvist M. Analysis of acrylamide, a carcinogen formed in heated foodstuffs. J. Agric. Food Chem. 50 (2002) 4998-5006
10. Rosén J., and Hellenäs K.E. Analysis of acrylamide in cooked foods by liquid chromatography tandem mass spectrometry. Analyst 127 (2002) 880-882
11. Institute for Reference Materials and Measurements (IRMM): Http://www.irmm.jrc.be/html/activities/acrylamide/EUacrylamidelevelmonitoringdatabase__statusJune2006.xls.
12. U.S. Food and Drug Administration (FDA), http://www.cfsan.fda.gov/∼dms/acrydata.html.
13. Monographs on the Evaluation of Carcinogenic Risks to Human: Some Industrial Chemicals vol. 60 (1994), International Agency for Research on Cancer (IARC), Lyon pp. 389-433
14. Nursten H.E. The Maillard Reaction (2005), Royal Society of Chemistry, Cambridge
15. Mottram D.S., Low M.Y., and Elmore J.S. The Maillard reaction and its role in the formation of acrylamide and other potentially hazardous compounds in foods. In: Skog K., and Alexander J. (Eds). Acrylamide and Other Hazardous Compounds in Heat-Treated Foods (2006), Woodhead Publishing Limited, Cambridge
16. Kamal-Eldin A. Lipid Oxidation Pathways (Ed.) (2003), AOCS Press, Illinois
17. Mucci L.A., Dickman P.W., Steinbeck G., Adami H.O., and Augustsson K. Dietary acrylamide and cancer of the large bowel, kidney, and bladder: absence of an association in a population-based study in Sweden. Br. J. Cancer 88 (2003) 84-89
18. Mucci L.A., Lindbland P., Steinbeck G., and Adami H.O. Dietary acrylamide and risk of renal cell cancer. Int. J. Cancer 109 (2004) 774-776
19. Mucci L.A., Sandin S., Balter K., Adami H.O., Magnusson C., and Weiderpass E. Acrylamide intake and breast cancer risk in Swedish women. JAMA 293 (2005) 1326-1327
20. Mucci L.A., Adami H.O., and Wolk A. Prospective study of dietary acrylamide and risk of colorectal cancer among women. Int. J. Cancer 118 (2006) 169-173
21. Pelucchi C., Franceschi S., Levi F., Trichopoulos D., Bosetti C., Negri E., and La Vecchia C. Fried potatoes and human cancer. Int. J. Cancer 105 (2003) 558-560
22. Hogervorst J.G., Schouten L.J., Konings E.J., Goldbohm R.A., and van den Brandt1 P.A. A prospective study of dietary acrylamide intake and the risk of endometrial, Ovarian, and Breast Cancer. Cancer Epidemiol. Biomarkers Prev. 16 (2007) 2304-2313
23. Hagmar L., and Törnqvist M. Inconclusive results from an epidemiological study on dietary acrylamide and cancer. Br. J. Cancer 89 (2003) 774-775
24. Hagmar L., Wirfält E., Paulsson B., and Törnqvist M. Differences in hemoglobin adduct levels of acrylamide in the general population with respect to dietary intake, smoking habits and gender. Mut. Res. 580 (2005) 157-165
25. Kütting B., Schettgen T., Beckmann M.W., Angerer J., and Drexler H. Influence of diet on exposure to acrylamide--reflections on the validity of a questionnaire. Ann. Nutr. Metab. 49 (2005) 173-177
26. Urban M., Kavvadias D., Riedel K., Scherer G., and Tricker A.R. Urinary mercapturic acids and a hemoglobin adduct for the dosimetry of acrylamide exposure in smokers and nonsmokers. Inhal. Toxicol. 18 (2006) 831-839
27. Wirfält E., Paulsson B., Törnqvist M., Axmon A., and Hagmar L. Associations between estimated acrylamide intakes, and hemoglobin AA adducts in a sample from the Malmö Diet and Cancer cohort. Eur. J. Clin. Nutr. 62 (2008) 314-323
28. Bjellaas T., Olesen P.T., Frandsen H., Haugen M., Stølen L.H., Paulsen J.E., Alexander J., Lundanes E., and Becher G. Comparison of estimated dietary intake of acrylamide with hemoglobin adducts of acrylamide and glycidamide. Toxicol. Sci. 98 (2007) 110-117
29. Bonassi S., Znaor A., Ceppi M., Lando C., Chang W.P., Holland N., Kirsch-Volders M., Zeiger E., Ban S., Barale R., Bigatti M.P., Bolognesi C., Cebulska-Wasilewska A., Fabianova E., Fucic A., Hagmar L., Joksic G., Martelli A., Migliore L., Mirkova E., Scarfi M.R., Zijno A., Norppa H., and Fenech M. An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans. Carcinogenesis 28 (2007) 625-631
30. Abramsson-Zetterberg L., Zetterberg G., Bergqvist M., and Grawe J. Human cytogenetic biomonitoring using flow-cytometric analysis of micronuclei in transferrin-positive immature peripheral blood reticulocytes. Environ. Mol. Mutagen. 36 (2000) 22-31
31. Törnqvist M., and Landin H.H. Hemoglobin adducts for in vivo dose monitoring and cancer risk estimation. J. Occup. Environ. Med. 37 (1995) 1077-1085
32. Abramsson-Zetterberg L., Durling L.J.K., Yang-Wallentin F., Rytter E., and Vessby B. The impact of folate status and folic acid supplementation on the micronucleus frequency in human erythrocytes. Mut. Res. 603 (2006) 33-40
33. Törnqvist M., Mowrer J., Jensen S., and Ehrenberg L. Monitoring of environmental cancer initiators through hemoglobin adducts by a modified Edman degradation method. Anal. Biochem. 154 (1986) 255-266
34. Bergmark E. Hemoglobin adducts of acrylamide and acrylonitrile in laboratory workers, smokers and nonsmokers. Chem. Res. Toxicol. 10 (1997) 78-84
35. Rosén J., Nyman A., and Hellenäs K.E. Retention studies of acrylamide for the design of a robust liquid chromatography-tandem mass spectrometry method for food analysis. J. Chromatogr. A 1172 (2007) 19-24
36. Wenzl T., Karasek L., Rosen J., Hellenaes K.E., Crews C., Castle L., and Anklam E.J. Collaborative trial validation study of two methods, one based on high performance liquid chromatography-tandem mass spectrometry and on gas chromatography-mass spectrometry for the determination of acrylamide in bakery and potato products. Chromatogr. A 1132 (2006) 211-218
37. Grimmer G., and Böhnke H. Polycyclic aromatic hydrocarbon profile analysis of high-protein foods, oils, and fats by gas chromatography. J. Assoc. Off. Anal. Chem. 58 (1975) 725-733
38. The European Union legislation on PAH in Food: Commission Regulation (EC) No 208/2005 and Commission Directive 2005/10/EC.
39. Abramsson-Zetterberg L. The dose-response relationship at very low doses of acrylamide is linear in the flow cytometer-based mouse micronucleus assay. Mut. Res. 535 (2003) 215-222
40. Paulsson B., Grawé J., and Törnqvist M. Hemoglobin adducts and micronucleus frequencies in mouse and rat after acrylamide or N-methylolacrylamide treatment. Mut. Res. 26 (2002) 101-111
41. Tareke E., Twaddle N.C., McDaniel L.P., Churchwell M.I., Young J.F., and Doerge D.R. Relationships between biomarkers of exposure and toxicokinetics in Fischer 344 rats and B6C3F1 mice administered single doses of acrylamide and glycidamide and multiple doses of acrylamide. Toxicol. Appl. Pharmacol. 217 (2006) 63-75
42. A. Vikström, S. Eriksson, B. Paulsson, P. Karlsson, I. Athanassiadis, M. Törnqvist, Internal doses of acrylamide and glycidamide in mice fed diets with low acrylamide contents, Mol. Nut. Food Res., (2008), in press.
43. Vesper H.W., Licea-Perez H., Meyers T., Ospina M., and Myers G.L. Pilot study on the impact of potato chips consumption on biomarkers of acrylamide exposure. Adv. Exp. Med. Biol. 561 (2005) 89-96
44. Springarn N.E., Slocum L.A., and Weisburger J.H. Formation of mutagens in cooked foods. II. Foods with high starch content. Cancer Lett. 9 (1980) 7-12
45. Osman A., Wootton M., Baker R.S., Arlauskas A., and Bonin T.M. Mutagenic activity of heated potato/oil systems. Nut. Cancer 5 (1983) 146-152
46. Lijinsky W., and Andrews A.W. Mutagenicity of vinyl compounds in Salmonella typhimurium. Teratogenesis, Carcinogenesis, Mutagenesis 1 (1980) 259-267
47. Knaap A.G., Kramers P.G., Voogd C.E., Bergkamp W.G., Groot M.G., Langebroek P.G., Mout H.C., van der Stel J.J., and Verharen H.W. Mutagenic activity of acrylamide in eukaryotic systems but not in bacteria. Mutagenesis 3 (1988) 263-268
48. Chaudhry M.Q., Cotterill J., Watkins R., and Price N. The potential of molecular modelling for the prediction of toxicity of compounds generated during heat treatment of foods. In: Skog K., and Alexander J. (Eds). Acrylamide and Other Health Hazardous Compounds in Heat-Treated Foods (2006), Woodhead Publishing, Cambridge 132-160
49. Felton J.S., Jägerstad M., Knize M.G., Skog K., and Wakabayashi K.W. In: Nagao M., and Sugimura T. (Eds). Contents in Foods, beverages and tobacco. Heterocyclic amines: Food Borne Carcinogens (2000), John Wiley & Sons, New York 31-71
50. Ericson U., Wirfält E., Mattisson I., Gullberg B., and Skog K. Dietary intake of heterocyclic amines in relation to socioeconomic, lifestyle and other dietary factors: estimates in a Swedish population. Public Health Nut. 10 (2007) 616-627
51. Report of the Contam Panel on provisional findings on furan in food, EFSA J. 137 (2004) 1-20.
52. Durling L.J.K., Svensson K., and Abramsson-Zetterberg L. Furan is not genotoxic in the micronucleus assay in vivo or in vitro. Toxicol. Lett. 169 (2007) 43-50
53. Robjohns S., Marshall R., Fellows M., and Kowalczyk G. In vivo genotoxicity studies with 3-monochloropropan-1,2-diol. Mutagenesis 18 (2003) 401-404
54. El Ramy R., Ould Elhkim M., Lezmi S., and Poul J.M. Evaluation of the genotoxic potential of 3-monochloropropane-1,2-diol (3-MCPD) and its metabolites, glycidol and beta-chlorolactic acid, using the single cell gel/comet assay. Food Chem. Toxicol. 45 (2007) 41-48
55. Seefelder W., Varga N., Studer A., Williamsson G., Scanlan F.P., and Stadler R.H. Esters of 3-chloro-1,2-propanediol (3-MCPD) in vegetable oils: Significance in the formation of 3-MCPD. Food Addit. Contam. 25 (2008) 391-400
56. Grawé J., Biko J., Lorenz R., Reiners C., Stopper H., Vershenya S., Vukicevic V., and Hempel K. Evaluation of the reticulocyte micronucleus assay in patients treated with radioiodine for thyroid cancer. Mut. Res. 583 (2005) 12-25
57. Dertinger S.D., Miller R.K., Brewer K., Smudzin T., Torous D.K., Roberts D.J., Avlasevich S.L., Bryce S.M., Sugunan S., and Chen Y. Automated human blood micronucleated reticulocyte measurements for rapid assessment of chromosomal damage. Mut. Res. 626 (2007) 111-119
58. Törnqvist M., Fred C., Haglund J., Helleberg H., et al. Protein adducts: quantitative and qualitative aspects of their formation, analysis and applications. J. Chromatogr. B 778 (2002) 279-308
59. Törnqvist M., Paulsson B., and Osterman-Golkar S. Bio-monitoring of acrylamide. In: Skog K., and Alexander J. (Eds). Acrylamide and Their Hazardous Compounds in Heat-Treated Foods (2006) pp. 163-189
60. Schettgen T., Rossbach B., Kütting B., Letzel S., Drexler H., and Angerer J. Determination of haemoglobin adducts of acrylamide and glycidamide in smoking and non-smoking persons of the general population. Int. J. Hyg. Environ. Health 207 (2004) 531-539
61. Record I.R., Konstantinopoulos M., and Nestel P.J. A comparative study of micronucleus frequency in peripheral blood lymphocytes of human subjects given dietary cis, trans and saturated fat. Food Chem. Toxicol. 30 (1992) 585-588
62. Raj A.S., and Katz M. Corn oil and its minor constituents as inhibitors of DMBA-induced chromosomal breaks in vivo. Mut. Res. 136 (1984) 247-253
63. Kasamatsu T., Ogura R., Ikeda N., Morita O., Saigo K., Watabe H., Saito Y., and Suzuki H. Genotoxicity studies on dietary diacylglycerol (DAG) oil. Food Chem. Toxicol. 43 (2005) 253-260
64. Narasimhamurthy K., Muralidhara, and Raina P.L. Absence of in vivo mutagenic potency of heated and fried oils in mice. Ind. J. Exp. Biol. 37 (1999) 50-55
65. Ilbäck N.G., Nyblom M., Carlfors J., Fagerlund-Aspenström B., Tavelin S., and Glynn A.W. Do surface-active lipids in food increase the intestinal permeability to toxic substances and allergenic agents?. Med Hypotheses 63 (2004) 724-730
66. Aspenström-Fagerlund B., Ring L., Aspenström P., Tallkvist J., Ilbäck N.G., and Glynn A.W. Oleic acid and docosahexaenoic acid cause an increase in the paracellular absorption of hydrophilic compounds in an experimental model of human absorptive enterocytes. Toxicology 31 (2007) 12-23