Acrylamide: A cooking carcinogen?

Chemical Research in Toxicology

Volumn 13, Issue 6, 2000, Pages 517-522

  Tareke, E ^a   Rydberg, P ^a   Karlsson, P ^b   Eriksson, S ^b   Tornqvist M ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b AnalyCen Nordic AB   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACRYLAMIDE;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER RISK; CARCINOGEN TESTING; CARCINOGENICITY; CONTROLLED STUDY; COOKING; HEMOGLOBIN DETERMINATION; NONHUMAN; RAT;

ACRYLAMIDE; ACRYLAMIDES; ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; DIET; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEAT; HEMOGLOBINS; MALE; RATS; RATS, SPRAGUE-DAWLEY; VALINE;

ANIMALIA;

EID: 0034043150     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx9901938     Document Type: Article

References (25)

1. Törnqvist, M., Mowrer, J., Jensen, S., and Ehrenberg, L. (1986) Monitoring of environmental cancer initiators through hemoglobin adducts by a modified Edman method. Anal. Biochem. 154, 255-266.
2. Törnqvist, M. (1994) Epoxide adducts to N-terminal valine of hemoglobin. Methods Enzymol. 231, 650-657.
3. Bergmark, E., Calleman, C. J., He, F., and Costa, L. G. (1993) Determination of hemoglobin adducts in humans occupationally exposed to acrylamide. Toxicol. Appl. Pharmacol. 120, 45-54.
4. 14C]acrylamide. Carcinogenesis 16, 1161-1165.
5. Calleman, C. J. (1996) The metabolism and pharmacokinetics of acrylamide: Implications for mechanisms of toxicity and human risk estimation. Drug Metab. Rev. 28, 527-590.
6. Dearfield, K. L., Douglas, G. R., Ehling, U. H., Moore, M. M., Sega, G. A., and Brusick, D. J. (1995) Acrylamide: a review of its genotoxicity and an assessment of heritable genetic risk. Mutat. Res. 330, 71-99.
7. Bergmark, E. (1997) Hemoglobin adducts of acrylamide and acrylonitrile in laboratory workers, smokers, and nonsmokers. Chem. Res. Toxicol. 10, 78-84.
8. Törnqvist, M., Bergmark, E., Ehrenberg, L., and Granath, F. (1998) Risk Estimation of Acrylamide (in Swedish). Technical Report 7/98, pp 28, Swedish Chemicals Inspectorate, Solna, Sweden.
9. Kautiainen, A., Osterman-Golkar, S., and Ehrenberg, L. (1986) Misincorporation of alkylated amino acids into hemoglobin: a possible source of background alkylations. Acta Chem. Scand. B40, 453-456.
10. SLV, Livsmedelsverket (1998) GPC column packing instruction, SLV K1-i10-4, GPC, The Swedish National Food Administration, Uppsala, Sweden.
11. Mowrer, J., Törnqvist, M., Jensen, S., and Ehrenberg, L. (1986) Modified Edman degradation applied to hemoglobin for monitoring occupational exposure to alkylating agents. Toxicol. Environ. Chem. 11, 215-231.
12. Castle, L., Campos, M. J., and Gilbert, J. (1993) Determination of acrylamide monomer in hydroponically grown tomato fruits by capillary gas chromatography mass spectrometry. J. Sci. Food Agric. 54, 549-555.
13. United States Environmental Protection Agency (1996) SW 846, Test methods for evaluating solid waste. Acrylamide by gas chromatography. Method 8032A, Washington, DC.
14. Granath, F., Ehrenberg, L., and Törnqvist, M. (1992) Degree of alkylation of macromolecules in vivo from variable exposure. Mutat. Res. 284, 297-360.
15. Kautiainen, A., Midtvedt, T., and Törnqvist, M. (1993) Intestinal bacteria and endogenous production of malonaldehyde and alkylators in mice. Carcinogenesis 14, 2633-2636.
16. Törnqvist, M. (1996) Ethylene oxide as a biological reactive intermediate of endogenous origin. In Biological Reactive Intermediates V (Snyder, R., et al., Eds.) pp 275-283, Plenum Press, New York.
17. Gold, L. S., et al. (1984) A carcinogenic potency data base of the standardized results of animal bioassays. Environ. Health Perspect. 58, 9-319.
18. Johnson, K. A., Gorzinski, S. J., Bondner, K. M., Campbell, R. A., Wolf, C. H., Friedman, M. A., and Mast, R. W. (1986) Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats. Toxicol. Appl. Pharmacol. 85, 154-168.
19. Friedman, M., Dulak, H. L., and Stedham, A. M. (1995) A life time oncogenicity study in rats with acrylamide. Fundam. Appl. Toxicol. 27, 95-105.
20. United States Environmental Protection Agency (1990) Assessment of Health Risks from Exposure to Acrylamide. Office of Toxic Substances, Washington, DC.
21. Granath, F. N., Vaca, C. E., Ehrenberg, L. G., and Törnqvist, M. Å. (1999) Cancer risk estimation of genotoxic chemicals based on target dose and a multiplicative model. Risk Anal. 19, 309-320.
22. Törnqvist, M., and Kautiainen, A. (1993) Adducted proteins for identification of endogenous electrophiles. Environ. Health Prespect. 99, 39-44.
23. Törnqvist, M. (1993) Current research on hemoglobin adducts and cancer risks: an overview. In Use of Biomarkers in Assessing Health and Environmental Impacts of Chemical Pollutants (Travis, C., Ed.) pp 17-30, Plenum Press, New York.
24. Gupta, R. C., and Lutz, W. K., Eds. (1999) Special Issue: Background DNA damage. Mutat. Res. 424 (1 and 2).
25. Rydberg, P., Lüning, B., Wachtmeister, C. A., and Törnqvist, M. (1993) Synthesis and characterization of N-substituted valines and their phenyl-and pentafluorophenyl-thiohydantoins. Acta Chem. Scand. 47, 813-817.