Evaluation of the genotoxic potential of 3-monochloropropane-1,2-diol (3-MCPD) and its metabolites, glycidol and β-chlorolactic acid, using the single cell gel/comet assay

Food and Chemical Toxicology

Volumn 45, Issue 1, 2007, Pages 41-48

  El Ramy, R ^a   Ould Elhkim, M ^a   Lezmi, S ^b   Poul, J M ^a  

^a Healthy Pigs Production and Experimentation Section   (France)

^b SANOFI   (France)

Author keywords

Chlorolactic acid; 3 Monochloropropane 1,2 diol; Genotoxicity; Glycidol; In vivo and in vitro comet assay; Rat

Indexed keywords

3 MONOCHLOROPROPANE 1,2 DIOL; CHLOROLACTIC ACID; GLYCIDOL; LACTIC ACID DERIVATIVE; PROPANEDIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOASSAY; BONE MARROW; CARCINOGENICITY; CHO CELL; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; FEMALE; GENOTOXICITY; IN VITRO STUDY; IN VIVO STUDY; KIDNEY; LEUKOCYTE; LIVER; MALE; MAMMAL CELL; METABOLISM; NONHUMAN; RAT; TESTIS;

ADMINISTRATION, ORAL; ANIMALS; BONE MARROW CELLS; CARCINOGENS; CHO CELLS; COMET ASSAY; CRICETINAE; CRICETULUS; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPOXY COMPOUNDS; GLYCEROL; KIDNEY; LACTIC ACID; LEUKOCYTES; LIVER; MALE; MUTAGENS; PROPANOLS; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY; TESTIS;

MAMMALIA;

EID: 33751358979     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2006.07.014     Document Type: Article

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