Hemoglobin adducts of acrylamide and acrylonitrile in laboratory workers, smokers and nonsmokers

Chemical Research in Toxicology

Volumn 10, Issue 1, 1997, Pages 78-84

  Bergmark, Emma ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACRYLAMIDE; ACRYLONITRILE; ETHYLENE OXIDE; HEMOGLOBIN;

ADULT; ARTICLE; CIGARETTE SMOKING; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; LABORATORY PERSONNEL; MALE; OCCUPATIONAL EXPOSURE; POLYACRYLAMIDE GEL ELECTROPHORESIS; SMOKING; TOBACCO;

ACRYLAMIDE; ACRYLAMIDES; ACRYLONITRILE; ADULT; ETHYLENE OXIDE; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEMOGLOBINS; HUMANS; LABORATORIES; MALE; MIDDLE AGED; OCCUPATIONAL EXPOSURE; SMOKING;

EID: 0031023980     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx960113p     Document Type: Article

References (25)

1. Smith, E. A., and Oehme, F. W. (1991) Acrylamide and polyacrylamide: a review of production, use, environmental fate and neurotoxicity. Rev. Environ. Health 9, 215-228.
2. United States Environmental Protection Agency (1990) Assessment of health risks from exposure to acrylamide. Office of Toxic Substances, U.S. Environmental Protection Agency, Washington, DC.
3. Dement, J. H., and Cromer, J. R. (1992) Cancer and reproductive risks among chemists and laboratory workers: a review. Appl. Occup. Environ. Hyg. 7, 120-126.
4. Schumacher, J. N., Green, C. R., Best, F. W., and Newell, M. P. (1977) Smoke composition. An extensive investigation of the water-soluble portion of cigarette smoke. J. Agric. Food Chem. 25, 310-320.
5. IARC (International Agency for Research on Cancer) (1994) IARC monographs on the evaluation of the carcinogenic risk to humans. Vol. 60, pp 389-433, IARC, Lyon.
6. Dearfield, K. L., Douglas, G. R., Ehling, U. H., Moore, M. M., Sega, G. A., and Brusick D. J. (1995) Acrylamide: a review of its genotoxicity and an assessment of heritable genetic risk. Mutat. Res. 330, 71-99.
7. Bergmark, E., Calleman, C. J., He, F., and Costa, L. G. (1993) Hemoglobin adducts in humans occupationally exposed to acrylamide. Toxicol. Appl. Pharmacol. 120, 45-54.
8. Törnqvist, M., and Hindsø Landin, H. (1995) Hemoglobin adducts for in vivo dose monitoring and cancer risk estimation. J. Occup. Environ. Med. 37, 1077-1085.
9. Törnqvist, M. (1993) Current research on hemoglobin adducts and cancer risks: an overview. In: Use of Biomarkers in Assessing Health and Environmental Impacts of Chemical Pollutants (Travis, C. C., Ed.) pp 17-30, Plenum Press, New York.
10. Törnqvist, M., and Ehrenberg, L. (1994) On cancer risk estimation of urban air pollution. Environ. Health Perspect. 102 (Suppl. 4), 173-182.
11. Calleman, C., J., Wu, Y., He, F., Tian, G., Bergmark, E., Zhang, S., Deng, H., Wang, Y., Crofton, K. M., Fennell, T., and Costa, L. G. (1994) Relationships between biomarkers of exposure and neurological effects in a group of workers exposed to acrylamide. Toxicol. Appl. Pharmacol. 126, 361-371.
12. Osterman-Golkar, S., MacNeela, J. P., Turner, M. J., Walker, V., Swenberg, J. A., Sumner, S. J., Youtsey, N., and Fennell, T. R. (1994) Monitoring of exposure to acrylonitrile using adducts with N-terminal valine in hemoglobin. Carcinogenesis 15, 2701-2707.
13. Törnqvist, M., Osterman-Golkar, S., Kautiainen, A., Jensen, S., Farmer, P. B., and Ehrenberg, L. (1986) Tissue doses of ethylene oxide in cigarette smokers determined from adduct levels in hemoglobin. Carcinogenesis 7, 1519-1521.
14. Farmer, P. B., Bailey, E., Gorf, S. M., Törnqvist, M., Osterman-Golkar, S., Kautiainen A., and Lewis-Enright, D. P. (1986) Monitoring human exposure to ethylene oxide by the determination of haemoglobin adducts using gas chromatography-mass spectrometry. Carcinogenesis 7, 637-640.
15. Mowrer, J., Törnqvist, M., Jensen, S., and Ehrenberg, L. (1986) Modified Edman degradation applied to hemoglobin for monitoring occupational exposure to alkylating agents. Toxicol. Environ. Chem. 11, 215-231.
16. Törnqvist, M. (1994) Epoxide adducts to N-terminal valine of hemoglobin. In Methods in Enzymology (Everse, J., Winslow, R. M., and Vandegriff, K. D., Eds.) Vol. 231, Part B, pp 650-657, Academic Press, San Diego.
17. Bergmark, E., Calleman, C. J., and Costa, L. G. (1991) Formation of hemoglobin adducts of acrylamide and its epoxide metabolite glycidamide in the rat. Toxicol. Appl. Pharmacol. 111, 352-363.
18. Törnqvist, M., Kautiainen, A., Gatz, R. N., and Ehrenberg, L. (1988) Hemoglobin adducts in animals exposed to gasoline and diesel exhausts. 1. Alkenes. J. Appl. Toxicol. 8, 159-170.
19. Rydberg, P., Lüning, B., Wachtmeister C. A., and Törnqvist, M. (1993) Synthesis and characterization of N-substituted valines and their phenyl- and pentafluorophenyl-thiohydantoins. Acta Chem. Scand. 47, 813-817.
20. Ehrenberg, L., and Osterman-Golkar, S. (1980) Alkylation of macromolecules for detecting mutagenic agents. Teratog., Carcinog., Mutagen. 1, 105-127.
21. Calleman, C. J., Stern, L. G., Bergmark, E., and Costa, L. G. (1992) Linear versus nonlinear models for hemoglobin adduct formation by acrylamide and its metabolite glycidamide: implications for risk estimation. Cancer Epidemiol. Biomarkers Prev. 1, 361-368.
22. Rohwein, C. E. (1991) Occupational exposure assesssment of laboratory workers to acrylamide monomer, MSc Thesis, University of Washington.
23. Calleman, C. J., Bergmark, E., and Costa, L. G. (1990) Acrylamide is metabolized to glycidamide in the rat: Evidence from hemoglobin adduct formation. Chem. Res. Toxicol. 3, 406-412.
24. 14C] acrylamide. Carcinogenesis 16, 1161-1165.
25. Törnqvist, M., Gustafsson, B., Kautiainen, A., Harms-Ringdahl, M., Granath, F., and Ehrenberg, L. (1989) Unsaturated lipids and intestinal bacteria as sources of endogenous production of ethene and ethylene oxide. Carcinogenesis 10, 39-41.