In vivo genotoxicity studies with 3-monochloropropan-1,2-diol

Mutagenesis

Volumn 18, Issue 5, 2003, Pages 401-404

  Robjohns, Stephen ^d   Marshall, Richard ^a   Fellows, Michael ^a,c   Kowalczyk, George ^b  

^a UK   (United Kingdom)

^b Health and Social Care North   (United Kingdom)

^c ASTRAZENECA   (United Kingdom)

^d Department of Health   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 MONOCHLOROPROPAN 1,2 DIOL; DNA; PROPANEDIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BONE MARROW CELL; CARCINOGENICITY; CHEMICAL CARCINOGENESIS; CLINICAL PROTOCOL; CONTROLLED STUDY; CYTOTOXICITY; ENDOCRINE DISEASE; GENOTOXICITY; IN VIVO STUDY; LIVER; MICRONUCLEUS TEST; MUTAGENICITY; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW; RODENT; UNSCHEDULED DNA SYNTHESIS;

ANIMALS; ANIMALS, OUTBRED STRAINS; BONE MARROW CELLS; DNA; ERYTHROCYTES; GLYCEROL; LIVER; MICRONUCLEUS TESTS; MUTAGENICITY TESTS; RATS;

ANIMALIA; RODENTIA;

EID: 0042880882     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/geg017     Document Type: Review

References (29)

1. Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment (2000) Statement on Carcinogencity of 3-Monochloropropane-1,2-diol (3-MCPD), COC/00/S5. Available at www.doh.gov.uk/mcpd1.htm
2. Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment (2001) Statement on Carcinogenicity of 1,3-Dichloropropan-1-ol (1,3-DCP) and 2,3-Dichloropropan-1ol (2,3-DCP), COC/01/Sl. Available at www.doh.gov.uk/cocdcp.htm
3. Committee on Mutagenicity of Chemicals in Food, Consumer Products and the Environment (2000) Statement on Carcinogencity of 3-Monochloropropane-1,2-diol (3-MCPD), COM/00/S4. Available at www.doh.gov.uk/mcpd2.htm
4. Drinking Water Inspectorate (1999) Polyamine Flocculants - Review of Conditions of Approval, Regulation 25, Letter 4/99 dated 12 November 1999. Committee on Chemicals and Materials of Construction for use in Public Water Supply and Swimming Pools. DWI, London, UK.
5. European Commission (1998) Directive on the Quality of Water Intended for Human Consumption, Council Directive 98/83/EC, 3 November 1998. European Commission, Brussels, Belgium.
6. European Commission (2001) Setting Maximum Levels for Certain Contaminants in Foodstuffs, Commission Regulation no. 466/2001, 8 March 2001. European Commission, Brussels, Belgium.
7. Epstein,S.S., Arnold,E., Andrea,J., Bass,W. and Bishop,Y. (1972) Detection of chemical mutagens by the dominant lethal assay in the mouse. Toxicol. Appl. Pharmacol., 23, 288-325.
8. Food Standards Agency (2001) Survey of 3-Monochloropropane-1,2-Diol (3-MCPD) in Soy Sauce and Related Products, no. 14/01. Food Standards Agency. Available at www.foodstandards.gov.uk/science/surveillance/fsis-2001/3
9. Jones,A.R., Davies,P., Edwards,K. and Jackson,H. (1969) Antifertility effects and metabolism of α- and epi-chlorohydrins in the rat. Nature, 224, 83.
10. Jones,A.R. (1975) The metabolism of 3-chloro, 3-bromo and 3-iodopropan-1,2-diol in rats and mice. Xenobiotica, 5, 155-165.
11. Jones,A.R., Milton,D.H. and Murcott,C. (1978) The oxidative metabolism of alpha-chlorohydrin in the male rat and the formation of spermatoceles. Xenobiotica, 8, 573-582.
12. Jones,A.R., Gadiel,P. and Murcott,C. (1979) The renal oxidative toxicity of the rodenticide alpha-chlorohydrin in the rat. Naturwissenschaften, 66, 425.
13. Jones,P. and Jackson,H. (1976) Antifertility and dominant lethal mutation studies in male rats with dl-alpha-chlorohydrin and an amino-analogue. Contraception, 13, 639-646.
14. Lovell,D.P., Anderson,D., Albanese,R., Amphlett,G.E., Clare,G., Ferguson,R., Richold,M., Papworth,D.G. and Savage,J.R.K. (1989) Statistical analysis of in vivo cytogenetic assays. In Kirkland,D.J. (ed.), Statistical Evaluation of Mutagenicity Test Data, UKEMS Sub-committee on Guidelines for Mutagenicity Testing Report, Part III. Cambridge University Press, Cambridge, UK, pp. 184-232.
15. Kennelly,J.C., Waters,R., Ashby,J., Lefevre,P.A., Burlinson,B., Benford,D.J., Dean,S.W. and Mitchell,I.deG. (1993) In vivo rat liver UDS assay. In Kirkland,D.J. and Fox,M. (eds), Supplementary Mutagenicity Tests UKEMS Recommended Procedures. Cambridge University Press, Cambridge, UK, pp. 52-77.
16. Lynch,B.S., Bryant,D.W., Hook,G.J., Nestmann,E.R. and Munro,I.C. (1998) Carcinogenicity of monochloro-1,2-propanediol (alpha-chlorohydrin, 3-MCPD). Int. J. Toxicol., 17, 47-76.
17. Majeska,J.B. and Matheson,D.W. (1983) Quantitative estimate of mutagenicity of tris-[1,3-dichloro-2-propyl]-phosphate (TCPP) and its possible metabolites in Salmonella. Environ. Mutagen., 5, 478. (Abstract)
18. Morris,I.D. and Jackson,C.M. (1978) Gonadotrophin changes in male rats following a sterilising dose of alpha-chlorohydrin. Int. J. Androl., 1, 85-95.
19. OECD (1997) Genetic toxicology: micronucleus test. In OECD Guidelines for the Testing of Chemicals, Test Guideline 474. OECD, Paris, France.
20. OECD (1997) Genetic toxicology: unscheduled DNA synthesis (UDS) test with mammalian liver cells in vivo. In OECD Guidelines for the Testing of Chemicals, Test Guideline 486. OECD, Paris, France.
21. Ohkubo,T., Hayashi,T., Watanabe,E., Endo,H., Goto,S., Endo,O., Mizoguchi,T. and Mori,Y. (1995) Mutagenicity of chlorohydrins. Nippon Suisan Gakkai Shi, 61, 596-601. (In Japanese)
22. Olsen,P. (1993) Chloropropanols. In Joint FAO/WHO Expert Committee on Food Additives. Toxicological Evaluation of Certain Food Additives and Contaminants, WHO Food Additives Series no. 32. World Health Organization, Geneva, Switzerland, pp. 267-285.
23. Piasecki,A., Ruge,A. and Marquardt,H. (1990) Malignant transformation of mouse M2-fibroblasts by glycerol chlorohydrins contained in protein hydrolysates and commercial food. Arzneim.-Forsch/Drug Res., 40, 1054-1055.
24. Rossi,A.M., Migliore,L., Lascialfari,D., Sbrana,I., Loprieno,N., Tortoreto,M., Bidoli,F. and Pantarotto,C. (1983) Genotoxicity, metabolism and blood kinetics of epichlorohydrin in mice. Mutat. Res., 118, 213-226.
25. Silhankova,L., Smid,F., Cerna,M., Davidek,J. and Velisek,J. (1982) Mutagenicity of glycerol chlorohydrins and of their esters with higher fatty acids present in protein hydrolysates. Mutat. Res., 103, 77-81.
26. Stolzenberg,S.J. and Hine,C.H. (1979) Mutagenicity of halogenated and oxygenated three-carbon compounds. J. Toxicol. Environ. Health, 5, 1149-1158.
27. Stolzenberg,S.J. and Hine,C.H. (1980) Mutagenicity of 2- and 3-carbon halogenated compounds in the Salmonella/mammalian-microsome test. Environ. Mutagen., 2, 5946.
28. Sunahara,G., Perrin,I. and Marchessini,M. (1993) Carcinogenicity Study on 3-Monochloro propane 1,2,-diol (3-MCPD) Administered in Drinking Water to Fischer 344 Rats, Report no. RE-SR93003. Nestec Ltd, Vevey, Switzerland.
29. Zeiger,E., Anderson,B., Haworth,S., Lawlor,T. and Mortelmans,K. (1988) Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals. Environ. Mol. Mutagen., 11 (suppl. 12), 1-158.