1,3,4-Oxadiazole-3(2H)-carboxamide derivatives as potential novel class of monoamine oxidase (MAO) inhibitors: Synthesis, evaluation, and role of urea moiety

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 16, 2008, Pages 7565-7572

  Ke, Shaoyong ^a   Li, Zhong ^a   Qian, Xuhong ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

1,3,4 Oxadiazole 3(2H) carboxamide; Heterocycle; MAO inhibitor; Urea

Indexed keywords

2,2 DIBUTYL 3 ACETYL 5 (3,4,5 TRIMETHOXYPHENYL) 1,3,4 OXADIAZOLINE; 2,2 DIBUTYL 3 ACETYL 5 (3,5 DIMETHYLPHENYL) 1,3,4 OXADIAZOLINE; 2,2 DIBUTYL 3 ACETYL 5 (BENZO[D][1,3]DIOXOL 5 YL) 1,3,4 OXADIAZOLINE; 2,2 DIBUTYL 5 (2,4 DICHLOROPHENYL) N (2,3,5 TRIFLUORO 4 METHOXYBENZOYL) 1,3,4 OXADIAZOLE 3(2H) CARBOXAMIDE; 2,2 DIBUTYL 5 (2,4 DICHLOROPHENYL) N (2,6 DIFLUOROBENZOYL) 1,3,4 OXADIAZOLE 3(2H) CARBOXAMIDE; 2,2 DIBUTYL 5 (4 CHLOROPHENYL) N (2,6 DIFLUOROBENZOYL) 1,3,4 OXADIAZOLE 3(2H) CARBOXAMIDE; 2,2 DIBUTYL N (2 CHLOROBENZOYL) 5 (2,4 DICHLOROPHENYL) 1,3,4 OXADIAZOLE 3(2H) CARBOXAMIDE; 2,2 DIBUTYL N (2 CHLOROBENZOYL) 5 (3,5 DIMETHYLPHENYL) 1,3,4 OXADIAZOLE 3(2H) CARBOXAMIDE; 2,2 DIBUTYL N (2,3,5 TRIFLUORO 4 METHOXYBENZOYL) 5 (3,4,5 TRIMETHOXYPHENYL) 1,3,4 OXADIAZOLE 3(2H) CARBOXAMIDE; 2,2 DIBUTYL N (2,6 DIFLUOROBENZOYL) 5 (3,4,5 TRIMETHOXYPHENYL) 1,3,4 OXADIAZOLE 3(2H) CARBOXAMIDE; 2,2 DIBUTYL N (2,6 DIFLUOROBENZOYL) 5 (3,5 DIMETHYLPHENYL) 1,3,4 OXADIAZOLE 3(2H) CARBOXAMIDE; 2,2 DIBUTYL N (2,6 DIFLUOROBENZOYL) 5 (FURAN 2 YL) 1,3,4 OXADIAZOLE 3(2H) CARBOXAMIDE; 5 (BENZO[D][1,3] DIOXOL 5 YL) 2,2 DIBUTYL N (2 CHLOROBENZOYL) 1,3,4 OXADIAZOLE 3(2H) CARBOXAMIDE; 5 (BENZO[D][1,3]DIOXOL 5 YL) 2,2 DIBUTYL N (2,6 DIFLUOROBENZOYL) 1,3,4 OXADIAZOLE 3(2H) CARBOXAMIDE; MONOAMINE OXIDASE INHIBITOR; OXADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UREA;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CYCLIZATION; DRUG SYNTHESIS; ENZYME INHIBITION; FLUOROMETRY; INFRARED SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTUM YIELD;

ANIMALS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MITOCHONDRIA; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; OXADIAZOLES; RATS; SPECTROPHOTOMETRY, INFRARED; UREA;

EID: 49149125590     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.07.026     Document Type: Article

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