Inhibition of monoamine oxidase B by analogues of the adenosine A2A receptor antagonist (E)-8-(3-chlorostyryl)caffeine (CSC)

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 10, 2006, Pages 3512-3521

  Vlok, Nevil ^a   Malan, Sarel F ^a   Castagnoli Jr , Neal ^b   Bergh, Jacobus J ^a   Petzer, Jacobus P ^a  

^a NORTH WEST UNIVERSITY   (South Africa)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

Monoamine oxidase B; Reversible inhibitors; SAR; Structure activity relationship

Indexed keywords

8 (3 CHLOROSTYRYL)CAFFEINE; 8 (3 METHYLSTYRYL)CAFFEINE; 8 (3 TRIFLUOROMETHYLSTYRYL)CAFFEINE; 8 (4 CHLOROSTYRYL)CAFFEINE; 8 (4 FLUOROSTYRYL)CAFFEINE; 8 (4 METHYLSTYRYL)CAFFEINE; 8 (4 TRIFLUOROMETHYLSTYRYL)CAFFEINE; ADENOSINE A2A RECEPTOR ANTAGONIST; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; FUNCTIONAL GROUP; PHENYL GROUP; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL REACTION; CONSTANTS AND COEFFICIENTS; DRUG BINDING; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; LIPOPHILICITY; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING, COMPETITIVE; CAFFEINE; LIVER; MOLECULAR STRUCTURE; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTOR, ADENOSINE A2A; STEREOISOMERISM;

ANIMALIA;

EID: 33645870453     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.01.011     Document Type: Article

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