Synthesis and cytotoxic evaluation of substituted urea derivatives as inhibitors of human-leukemia K562 cells

Chemistry and Biodiversity

Volumn 4, Issue 5, 2007, Pages 881-886

  Cao, Ping ^a   Huang, Xian Feng ^a   Ding, Hui ^a   Ge, Hui Ming ^a   Li, Huan Qiu ^a   Ruan, Ban Feng ^a   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DIMETHYL 3 [(2 MORPHOLIN 4 YL)ETHYL]UREA; 2,4 DIHYDRO N.N DIMETHYLQUINOLINE 1(2H) CARBOXAMIDE; 3 (4 FLUOROBENZYL) 1,1 DIMETHYLUREA; 3 [(FURAN 2 YL)METHYL] 1,1 DIMETHYLUREA; 3 CYCLOHEXYL 1,1 DIMETHYLUREA; 3 CYCLOPENTANYL 1,1 DIMETHYLUREA; ANTINEOPLASTIC AGENT; FLUOROURACIL; IMATINIB; N,N DIMETHYL 10H PHENOTHIAZINE 10 CARBOXAMIDE; N,N DIMETHYL 1H INDOLE 1 CARBOXAMIDE; N,N DIMETHYL 9H CARBAZOLE 9 CARBOXAMIDE; N,N DIMETHYLMORPHOLINE 4 CARBOXAMIDE; N,N DIMETHYLPIPERIDINE 1 CARBOXAMIDE; N,N DIMETHYLPYRROLIDINE 1 CARBOXAMIDE; N,N''' PROPANE 1,3 DIYLBIS[1,1 DIMETHYLUREA]; N,N,N',N' TETRAMETHYLPIPERAZINE 1,4 DICARBOXAMIDE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL STRAIN K 562; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HUMANS; K562 CELLS; LEUKEMIA; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 34250644955     PISSN: 16121872     EISSN: 16121880     Source Type: Journal    
DOI: 10.1002/cbdv.200790075     Document Type: Article

References (28)

1. M. Gourley, J. S. Williamson, Curr. Pharm. Des. 2000, 6, 417.
2. S. Faderl, M. Talpaz, Z. Estrov, S. O'Brien, R. Kurzrock, H. M. Kantarjian, New Engl. J. Med. 1999, 341, 164.
3. S. Faderl, M. Talpaz, Z. Estrov, H. M. Kantarjian, Ann. Intern. Med. 1999, 131, 207;
4. M. Warmuth, S. Danhauser-Riedl, M. Hallek, Ann. Hematol. 1999, 78, 49.
5. J. M. Goldman, J. V. Melo, New Engl. J. Med. 2003, 349, 1451.
6. R. Bhatia, M. Holtz, N. Niu, R. Gray, D. S. Snyder, C. L. Sawyers, D. A. Arber, M. L. Slovak, S. J. Forman, Blood 2003, 101, 4701.
7. S. M. Graham, H. G. Jørgensen, E. Allan, C. Pearson, M. J. Alcorn, L. Richmond, T. L. Holyoake, Blood 2002, 99, 319.
8. J. R. Warr, A. Bamford, D. M. Quinn, Cancer Lett. 2002, 175, 39.
9. Y. Mizutania, H. Nakanishia, O. Yoshidab, M. Fukushimac, B. Bonavidad, T. Mikia, Eur. J. Cancer 2002, 38, 167.
10. F. T. Tyson, J. T. Shaw, J. Am. Chem. Soc. 1952, 74, 2273.
11. R. M. Silverstein, E. E. Ryskiewicz, C. Willard, R. C. Koehler, J. Org. Chem. 1955, 20, 668.
12. E. E. Ryskiewicz, R. M. Silverstein, J. Am. Chem. Soc. 1954, 76, 5802.
13. K. Tanji, T. Sasahara, J. Suzuki, T. Higashino, Heterocycles 1993, 35, 915.
14. J. Bergmen, B. Peleman, Tetrahedron 1988, 44, 521.
15. B.-F. Ruan, X.-F. Huang, H. Ding, C. Xu, H.-M. Ge, H.-L. Zhu, R.-X. Tan, Chem. Biodiv. 2006, 3, 975.
16. H.-Q. Li, H.-M. Ge, Y.-X. Chen, C. Xu, L. Shi, H. Ding, H.-L. Zhu, R.-X. Tan, Chem. Biodiv. 2006, 3, 463.
17. N. I. Burakov, A. L. Kanibolotskii, G. Y. Osichenko, V. A. Mikhailov, V. A. Savelova, V. V. Kosmynin, Russ. J. Org. Chem. 2001, 37, 1210.
18. A. I. Gurova, N. A. Drozhzhina, Gigiena Sanitariya 1989, 8, 15.
19. G. Katsoulos, M. Schlosser, Tetrahedron Lett. 1993, 34, 6263.
20. A. A. Aroyan, A. S. Azaryan, M. A. Iradyan, Izv. Akad. Nauk Armyanskoi SSSR, Khim. Nauki 1965, 18, 76.
21. N. Yamazaki, T. Tomioka, F. Higashi, Synthesis 1975, 6, 384.
22. T. Somlo, Ger. Offen. 1972, 23.
23. M. Mazza, L. Montanari, F. Pavanetto, Farmaco Ed. Sci. 1976, 31, 746.
24. A. R. Katritzky, G. W. Rewcastle, L. M. V. D. Miguel, J. Org. Chem. 1988, 53, 794.
25. W. J. Geary, N. J. Mason, I. W. Nowell, L. A. Nixon, J. Chem. Soc., Dalton Trans. 1982, 6, 1103.
26. H. Hintermaier, H. Michaud, M. Obinger, Ger. Offen. 1979, 17.
27. E. Ayman, C. Mohamed, A. Mohamed, Y. Ghassan, J. Heterocycl. Chem. 2006, 43, 599.
28. E. Ayman, K. Sherine, A. Mohamed, A. Fernando, Eur. J. Org. Chem. 2006, 6, 1563.