Substrate and Inhibitor Specificities for Human Monoamine Oxidase A and B are Influenced by a Single Amino Acid

Journal of Biological Chemistry

Volumn 276, Issue 13, 2001, Pages 9877-9882

  Geha, Rani Maurice ^a   Rebrin, Igor ^a   Chen, Kevin ^a   Shih, Jean Chen ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; AMINO ACIDS; CATALYST ACTIVITY; ENZYME INHIBITION; MUTAGENESIS; OXIDATION; SUBSTRATES;

MUTANTS;

ENZYMES;

AMINE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; AMINO ACID; BIOGENIC AMINE; CLORGYLINE; ISOLEUCINE; N (2 AMINOETHYL) 4 CHLOROBENZAMIDE; N (2 AMINOETHYL) 5 (3 FLUOROPHENYL) 4 THIAZOLECARBOXAMIDE; PHENETHYLAMINE; SELEGILINE; SEROTONIN; TYROSINE; AMINE OXIDASE (FLAVIN CONTAINING); ASPARTIC ACID; GLYCINE; ISOPROTEIN; MONOAMINE OXIDASE INHIBITOR; PHENETHYLAMINE DERIVATIVE; PSYCHOTROPIC AGENT; THREONINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CATALYSIS; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HUMAN; NONHUMAN; OXIDATION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; AMINO ACID SEQUENCE; ANIMAL; BACULOVIRUS; CHEMISTRY; GENE VECTOR; GENETICS; KINETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; SEQUENCE HOMOLOGY;

ANIMALIA; GYMNOMYZA SAMOENSIS;

AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; ASPARTIC ACID; BACULOVIRIDAE; CATALYSIS; CLORGYLINE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENETIC VECTORS; GLYCINE; HUMANS; ISOLEUCINE; KINETICS; MOLECULAR SEQUENCE DATA; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHENETHYLAMINES; PROTEIN ISOFORMS; PSYCHOTROPIC DRUGS; SELEGILINE; SEQUENCE HOMOLOGY, AMINO ACID; SEROTONIN; SUBSTRATE SPECIFICITY; THREONINE; TYROSINE;

EID: 0035971164     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M006972200     Document Type: Article

References (32)

1. Greenawalt, J. W., and Schnaitman, C. (1970) J. Cell Biol. 46, 173-179
2. Nara, S., Igaue, I., Gomes, B., and Yasunobu, K. T. (1966) Biochem. Biophys. Res. Commun. 23, 324-328
3. Shih, J. C., Chen, K., and Ridd, M. J. (1999) Annu. Rev. Neurosci. 22, 197-217
4. Johnston, J. P. (1968) Biochem. Pharmacol. 17, 1285-1297
5. Cesura, A. M., Bos, M., Galva, M. D., Imhof, R., and Da Prada, M. (1989) Mol. Pharmacol. 37, 358-366
6. Knoll, J., and Magyar, K. (1972) Adv. Biochem. Psychopharmacol. 5, 393-408
7. Cesura, A. M., Imhof, R., Galva, M. D., Kettler, R., and Da Prada, M. (1988) Pharmacol. Res. Comm. 20, 51-61
8. O'Carroll, A., Fowler, C. J., Phillips, J. P., Tobbia, I., and Tipton, K. F. (1983) Naunyn-Schmiedeberg's Arch. Pharmacol. 312, 51-55
9. Bach, A. W. J., Lan, N. C., Johnson, D. L., Abell, C. W., Bembenck, M. E., Kwan, S. W., Seeburg, P. H., and Shih, J. C. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 4934-4938
10. Lan, N. C., Heinzmann, C., Gal, A., Klisak, I., Orth, U., Lai, E., Grimsby, J., Sparkes, R. S., Mohandas, T., and Shih, J. C. (1989) Genomics 4, 552-559
11. Grimsby, J., Chen, K., Wang, L. J., Lan, N. C., and Shih, J. C. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 3637-3641
12. Brunner, H. G., Nelen, M., Breakfield, X. O., Ropers, H. H., and Van Oost, B. A. (1993) Science 262, 578-580
13. Cases, O., Seif, I., Grimsby, J., Gaspar, P., Chen, K., Pournin, S., Müller, U., Aguet, M., Babinet, C., Shih, J. C., and De Maeyer, E. (1995) Science 268, 1763-1766
14. Grimsby, J., Toth, M., Chen, K., Kumazawa, T., Klaidman, L., Adams, J. D., Karoum, F., Gal, J., and Shih, J. C. (1997) Nat. Genet. 17, 1-5
15. Cesura, A. M., Gottowik, J., Lahm, H.-W., Lang, G., Imhof, R., Malherbe, P., Röthlisberger, U., and Da Prada, M. (1996) Eur. J. Biochem. 286, 996-1002
16. Chen, K., Wu, H.-F., and Shih, J. C. (1996) J. Neurochem. 66, 797-803
17. Gottowik, J., Cesura, A. M., Malherbe, P., Lang, G., and Da Prada, M. (1993) FEBS Lett. 317, 152-156
18. Gottowik, J., Malherbe, P., Jang, G., Da Prada, M., and Cesura, A. M. (1995) Eur. J. Biochem. 230, 934-942
19. Tsugeno, Y., Hirashiki, I., Ogata, F., and Ito, A. (1995) J. Biochem. (Tokyo) 118, 974-980
20. Wu, H.-F., Chen, K., and Shih, J. C. (1993) Mol. Pharmacol. 43, 888-893
21. Geha, R. M., Chen, K., and Shih, J. C. (2000) J. Neurochem. 75, 1304-1309
22. Tsugeno, Y., and Ito, A. (1997) J. Biol. Chem. 272, 14033-14036
23. Chen, K., Wu, H.-F., Grimsby, J., and Shih, J. C. (1994) Mol. Pharmacol. 268, 1226-1233
24. Crossen, R., and Gruenwald, S. (1996) Baculovirus Expression Vector Manual, 3rd Ed., PharMingen, San Diego, CA
25. Schagger, H., and Jagow, G. (1987) Anal. Biochem. 166, 368-379
26. Grimsby, J., Zentner, M., and Shih, J. C. (1996) Life Sci. 58, 777-787
27. Glover, V., and Sandler, M. (1977) Nature 265, 80-81
28. Krueger, M. J., Mazouz, F., Ramsay, R. R., Milcent, R., and Singer, T. P. (1995) Biochem. Biophys. Res. Commun. 206, 556-562
29. Egashira, T., Takayama, F., and Yamanaka, Y. (1999) Jpn. J. Pharmacol. 81, 115-121
30. Inoue, H., Castagnoli, K., Van Der Schyf, C., Mabic, S., Igarashi, K., and Castagnoli, N. (1999) J. Pharmacol. Exp. Ther. 291, 856-864
31. Veselovsky, A. V., Ivanov, A. S., and Medvedev, A. E. (1998) Biochemistry (Mosc.) 63, 1441-1446
32. Binda, C., Coda, A., Angelini, R., Federico, R., Ascenzi, P., and Mattevi, A. (1999) Structure 7, 265-276