Novel series of substituted biphenylmethyl urea derivatives as MCH-R1 antagonists for the treatment of obesity

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 11, 2007, Pages 3896-3911

  Galiano, Silvia ^a   Ceras, Javier ^a   Cirauqui, Nuria ^a   Pérez, Silvia ^a   Juanenea, Laura ^a   Rivera, Gildardo ^a   Aldana, Ignacio ^a   Monge, Antonio ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Biphenylmethyl urea; MCH; MCH R1 antagonist; Obesity

Indexed keywords

1 (3' CYANO 4 BIPHENYLMETHYL) 3 (2 HYDROXY 1,1 DIMETHYLETHYL) 1 [2 [1 (4 METHYLBENZYL) 4 PIPERIDINYL]ETHYL]UREA; 1 (3' CYANO 4 BIPHENYLMETHYL) 3 [1,1 DI(HYDROXYMETHYL)PROPYL] 1 [2 [1 (4 METHYLBENZYL) 4 PIPERIDINYL]ETHYL]UREA; 1 (3' CYANO 4 BIPHENYLMETHYL) 3 ISOPROPYL 1 [2 [1 (4 METHYLBENZYL) 4 PIPERIDINYL]ETHYL]UREA; 1 (4 BIPHENYLMETHYL) 3 (2 HYDROXY 1,1 DIMETHYLETHYL) 1 [2 [1 (4 METHYLBENZYL) 4 PIPERIDINYL]ETHYL]UREA; 1 (4 BIPHENYLMETHYL) 3 [1,1 BIS(HYDROXYMETHYL)PROPYL] 1 [2 [1 (4 METHYLBENZYL) 4 PIPERIDINYL]ETHYL]UREA; 1 (4 BIPHENYLMETHYL) 3 ISOPROPYL 1 [2 [1 (4 METHYLBENZYL) 4 PIPERIDINYL]ETHYL]UREA; 1 (4' FLUORO 4 BIPHENYLMETHYL) 3 (1,1 DI(HYDROXYMETHYL)PROPYL) 1 [2 [1 (4 METHYLBENZYL) 4 PIPERIDIN]ETHYL]UREA; 1 (4' FLUORO 4 BIPHENYLMETHYL) 3 (2 HYDROXY 1,1 DIMETHYLETHYL) 1 [2 [1 (4 METHYLBENZYL) 4 PIPERIDINYL]ETHYL]UREA; 1 (4' FLUORO 4 BIPHENYLMETHYL) 3 ISOPROPYL 1 [2 [1 (4 METHYLBENZYL) 4 PIPERIDINYL]ETHYL]UREA; 3 (2 HYDROXY 1,1 DIMETHYLETHYL) 1 (2' METHOXY 4 BIPHENYLMETHYL) 1 [2 [1 (4 METHYLBENZYL) 4 PIPERIDINYL]ETHYL]UREA; 3 (2 HYDROXY 1,1 DIMETHYLETHYL) 1 (4' METHOXY 4 BIPHENYLMETHYL) 1 [2 [1 (4 METHYLBENZYL) 4 PIPERIDINYL]ETHYL]UREA; 3 [1 (ACETYLOXYMETHYL) 1 METHYLETHYL] 1 (2' METHOXY 4 BIPHENYLMETHYL) 1 [2 [1 (4 METHYLBENZYL) 4 PIPERIDINYL]ETHYL]UREA; 3 [1 (ACETYLOXYMETHYL) 1 METHYLETHYL] 1 (3' CYANO 4 BIPHENYLMETHYL) 1 [2 [1 (4 METHYLBENZYL) 4 PIPERIDINYL]ETHYL]UREA; 3 [1 (ACETYLOXYMETHYL) 1 METHYLETHYL] 1 (4 BIPHENYLMETHYL) 1 [2 [1 (4 METHYLBENZYL) 4 PIPERIDINYL]ETHYL]UREA; 3 [1 (ACETYLOXYMETHYL) 1 METHYLETHYL] 1 (4' FLUORO 4 BIPHENYLMETHYL) 1 [2 [1 (4 METHYLBENZYL) 4 PIPERIDINYL]ETHYL]UREA; 3 [1 (ACETYLOXYMETHYL) 1 METHYLETHYL] 1 (4' METHOXY 4 BIPHENYLMETHYL) 1 [2 [1 (4 METHYLBENZYL) 4 PIPERIDINYL]ETHYL]UREA; 3 [1,1 BIS(ACETYLOXYMETHYL)PROPYL] 1 (2' METHOXY 4 BIPHENYLMETHYL) 1 [2 [1 (4 METHYLBENZYL) 4 PIPERIDINYL]ETHYL]UREA; 3 [1,1 BIS(ACETYLOXYMETHYL)PROPYL] 1 (3' CYANO 4 BIPHENYLMETHYL) 1 [2 [1 (4 METHYLBENZYL) 4 PIPERIDINYL]ETHYL]UREA; 3 [1,1 BIS(ACETYLOXYMETHYL)PROPYL] 1 (4 BIPHENYLMETHYL) 1 [2 [1 (4 METHYLBENZYL) 4 PIPERIDINYL]ETHYL]UREA; 3 [1,1 BIS(ACETYLOXYMETHYL)PROPYL] 1 (4' FLUORO 4 BIPHENYLMETHYL) 1 [2 [1 (4 METHYLBENZYL) 4 PIPERIDINYL]ETHYL]UREA; 3 [1,1 BIS(ACETYLOXYMETHYL)PROPYL] 1 (4' METHOXY 4 BIPHENYLMETHYL) 1 [2 [1 (4 METHYLBENZYL) 4 PIPERIDINYL]ETHYL]UREA; 3 [1,1 BIS(HYDROXYMETHYL)PROPYL] 1 (2' METHOXY 4 BIPHENYLMETHYL) 1 [2 [1 (4 METHYLBENZYL) 4 PIPERIDINYL]ETHYL]UREA; 3 [1,1 BIS(HYDROXYMETHYL)PROPYL] 1 (4' METHOXY 4 BIPHENYLMETHYL) 1 [2 [1 (4 METHYLBENZYL) 4 PIPERIDINYL]ETHYL]UREA; 3 ISOPROPYL 1 (2' METHOXY 4 BIPHENYLMETHYL) 1 [2 [1 (4 METHYLBENZYL) 4 PIPERIDINYL]ETHYL]UREA; 3 ISOPROPYL 1 (4' METHOXY 4 BIPHENYLMETHYL) 1 [2 [1 (4 METHYLBENZYL) 4 PIPERIDINYL]ETHYL]UREA; HORMONE RECEPTOR BLOCKING AGENT; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; NONHUMAN; OBESITY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; ANTI-OBESITY AGENTS; BIPHENYL COMPOUNDS; CHO CELLS; CRICETINAE; CRICETULUS; DRUG DESIGN; HUMANS; PIPERIDINES; RECEPTORS, SOMATOSTATIN; UREA;

EID: 34247358272     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.02.049     Document Type: Article

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