8-(3-Chlorostyryl) caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonism

Journal of Biological Chemistry

Volumn 277, Issue 39, 2002, Pages 36040-36044

  Chen, Jiang Fan ^a,b,c,d   Steyn, Salome ^a,b,c   Staal, Roland ^a,b,c   Petzer, Jacobus P ^a,b,c   Xu, Kui ^a,b,c   Van Der Schyf, Cornelis J ^a,b,c   Castagnoli, Kay ^a,b,c   Sonsalla, Patricia K ^a,b,c   Castagnoli Jr , Neal ^a,b,c   Schwarzschild, Michael A ^a,b,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^c UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; DISEASES; METABOLISM; TOXICITY;

NEUROTOXICITY;

ENZYME INHIBITION;

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 2,3 DIHYDRO 1 METHYL 4 PHENYLPYRIDINIUM; 8 (3 CHLOROSTYRYL)CAFFEINE; ADENOSINE A2 RECEPTOR; AMINE OXIDASE (FLAVIN CONTAINING);

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG POTENCY; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; KNOCKOUT MOUSE; MALE; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; BRAIN; CAFFEINE; DOPAMINE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; KINETICS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MONOAMINE OXIDASE INHIBITORS; NEURONS; RECEPTOR, ADENOSINE A2A; RECEPTORS, PURINERGIC P1; TIME FACTORS;

ANIMALIA; GYMNOMYZA SAMOENSIS;

EID: 0037184039     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M206830200     Document Type: Article

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