Identification and optimization of novel 1,3,4-oxadiazole EP1 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 16, 2007, Pages 4450-4455

  Hall, Adrian ^a   Brown, Susan H ^a   Chowdhury, Anita ^a   Giblin, Gerard M P ^a   Gibson, Mairi ^a   Healy, Mark P ^a   Livermore, David G ^a   McArthur Wilson, Richard J ^a   Naylor, Alan ^a   Rawlings, D Anthony ^a   Roman, Shilina ^a   Ward, Emma ^a   Willay, Caroline ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Amide isostere; EP1 antagonist; Oxadiazole

Indexed keywords

1,3,4 OXADIAZOLE DERIVATIVE; OXADIAZOLE DERIVATIVE; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E1; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; IN VITRO STUDY; MICROSOME; NONHUMAN; RAT; RECEPTOR BLOCKING; SUBSTITUTION REACTION;

MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXADIAZOLES; PROTEIN BINDING; RECEPTORS, PROSTAGLANDIN E; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34447335366     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.06.014     Document Type: Article

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