Crucial role of the C-terminus of PTEN in antagonizing NEDD4-1-mediated PTEN ubiquitination and degradation

Biochemical Journal

Volumn 414, Issue 2, 2008, Pages 221-229

  Wang, Xinjiang ^a   Shi, Yuji ^a   Wang, Junru ^a   Huang, Guochang ^a   Jiang, Xuejun ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Cancer mutation; Neural precursor cell expressed developmentally down regulated 4 1 (NEDD4 1); Phosphatase and tensin homologue deleted on chromosome 10 (PTEN); Protein degradation; Stability; Ubiquitination

Indexed keywords

AMINO ACIDS; ANIMAL CELL CULTURE; DEGRADATION; ENZYMES; MECHANISMS; TUMORS;

CANCER MUTATION; NEURAL-PRECURSOR-CELL-EXPRESSED DEVELOPMENTALLY DOWN-REGULATED 4-1 (NEDD4-1); PHOSPHATASE AND TENSIN HOMOLOGUE DELETED ON CHROMOSOME 10 (PTEN); PROTEIN DEGRADATION; STABILITY; UBIQUITINATION;

PORT TERMINALS;

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN E6; TRYPTOPHAN; UBIQUITIN PROTEIN LIGASE NEDD4;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CELL ASSAY; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; REGULATORY MECHANISM; SEQUENCE HOMOLOGY; UBIQUITINATION;

ANIMALS; CELL LINE; HUMANS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PTEN PHOSPHOHYDROLASE; RECOMBINANT PROTEINS; SPODOPTERA; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 49149117504     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20080674     Document Type: Article

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