PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity

Oncogene

Volumn 23, Issue 40, 2004, Pages 6788-6797

  Gildea, John J ^a   Herlevsen, Mikael ^a   Harding, Michael A ^a   Gulding, Kathryn M ^a   Moskaluk, Christopher A ^a   Frierson, Henry F ^a   Theodorescu, Dan ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Bladder neoplasms; PTEN; Tumor invasion; Tumor motility; Tumor suppressor genes

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; LIPID PHOSPHATASE; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLADDER CANCER; CANCER INHIBITION; CANCER INVASION; CELL MOTILITY; CHEMOTAXIS; CLONOGENESIS; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME ACTIVITY; ENZYME DEFICIENCY; GENE CONSTRUCT; GENE EXPRESSION; GENETIC STABILITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; MICROSCOPIC ANATOMY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; TRANSGENE; TUMOR SUPPRESSOR GENE; WILD TYPE;

AMINO ACID SUBSTITUTION; CELL LINE, TUMOR; CLONING, MOLECULAR; HUMANS; NEOPLASM INVASIVENESS; PHOSPHATIDATE PHOSPHATASE; PHOSPHORIC MONOESTER HYDROLASES; PTEN PHOSPHOHYDROLASE; RECOMBINANT PROTEINS; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS; URINARY BLADDER NEOPLASMS;

ANIMALIA; MURINAE;

EID: 4644285846     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1207599     Document Type: Article

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