Regulation of PTEN binding to MAGI-2 by two putative phosphorylation sites at threonine 382 and 383

Cancer Research

Volumn 61, Issue 13, 2001, Pages 4985-4989

  Tolkacheva, Tatyana ^a   Boddapati, Manoranjan ^a   Sanfiz, Anthony ^a   Kimmelman, Alec C ^a   Chan, Andrew M L ^a   Tsuchida, Kunihiro ^b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN; PROTEIN MAGI 2; THREONINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CELL JUNCTION; CELL STRAIN 3T3; CODON; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY;

3T3 CELLS; ACTIVIN RECEPTORS, TYPE II; ANIMALS; CARRIER PROTEINS; GUANYLATE KINASE; HUMANS; INTERCELLULAR JUNCTIONS; MICE; MUTAGENESIS, SITE-DIRECTED; NUCLEOSIDE-PHOSPHATE KINASE; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEINS; PTEN PHOSPHOHYDROLASE; THREONINE; TUMOR SUPPRESSOR PROTEINS;

EID: 0035394373     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
2. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor β
3. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
4. Phosphatases and tumorigenesis
5. Signalling through the lipid products of phosphoinositide-3-OH kinase
6. The multiple roles of PTEN in tumor suppression
7. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
8. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
9. The lipid phosphatase activity of PTEN is critical for its tumor suppressor function
10. Crystal structure of the PTEN tumor suppressor: Implications for its phosphoinositide phosphatase activity and membrane association
11. Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding
12. Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2
13. Interaction of the tumor suppresser PTEN/MMAC with a PDZ domain of MAGI 3, a novel membrane-associated guanylate kinase
14. Inhibition of H-Ras transformation by the PTEN/MMACI/TEP1 tumor suppressor gene
15. Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases
16. Identification and characterization of a PDZ protein that interacts with activin type II receptors
17. Differential roles of Akt, Rac, and Ral in R-Ras-mediated cellular transformation, adhesion, and survival
18. Regulation of p53 stability
19. The ubiquitin system
20. Phosphorylation of the PTEN tail regulates protein stability and function
21. The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteosome-mediated degradation
22. The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region