메뉴 건너뛰기




Volumn 7, Issue 6, 2004, Pages 659-664

Folate and brain function in the elderly

Author keywords

Alzheimer's disease; Dementia; Depression; Elderly; Folate; Folic acid; Homocysteine

Indexed keywords

ANTIDEPRESSANT AGENT; CYANOCOBALAMIN; FLAVINE ADENINE NUCLEOTIDE; FOLIC ACID DERIVATIVE; PYRIDOXAL 5 PHOSPHATE; TETRAHYDROFURAN;

EID: 14844291565     PISSN: 13631950     EISSN: None     Source Type: Journal    
DOI: 10.1097/00075197-200411000-00011     Document Type: Review
Times cited : (52)

References (48)
  • 1
    • 0034883149 scopus 로고    scopus 로고
    • B vitamins, homocysteine, and neurocognitive function
    • Rosenberg IH. B vitamins, homocysteine, and neurocognitive function. Nutr Rev 2001; 59:369-373.
    • (2001) Nutr Rev , vol.59 , pp. 369-373
    • Rosenberg, I.H.1
  • 3
    • 0034922510 scopus 로고    scopus 로고
    • CSF-folate levels are decreased in late-onset AD patients
    • Serot JM, Christmann D, Dubost T, et al. CSF-folate levels are decreased in late-onset AD patients. J Neural Transm 2001; 108:93-99.
    • (2001) J Neural Transm , vol.108 , pp. 93-99
    • Serot, J.M.1    Christmann, D.2    Dubost, T.3
  • 5
    • 0033621707 scopus 로고    scopus 로고
    • Serum vitamin B12, C, and folate concentrations in the New Mexico Elder Health Survey: Correlations with cognitive and affective functions
    • Lindeman RD, Romero LJ, Koehler KM, et al. Serum vitamin B12, C, and folate concentrations in the New Mexico Elder Health Survey: correlations with cognitive and affective functions. J Am Coll Nutr 2000; 19:68-76.
    • (2000) J Am Coll Nutr , vol.19 , pp. 68-76
    • Lindeman, R.D.1    Romero, L.J.2    Koehler, K.M.3
  • 6
    • 0033925828 scopus 로고    scopus 로고
    • Homocysteine, folate, methylation, and monoamine metabolism in depression
    • Bottiglieri T, Laundy M, Crellin R, et al. Homocysteine, folate, methylation, and monoamine metabolism in depression. J Neurol Neurosurg Psychiatry 2000; 69:228-232.
    • (2000) J Neurol Neurosurg Psychiatry , vol.69 , pp. 228-232
    • Bottiglieri, T.1    Laundy, M.2    Crellin, R.3
  • 7
    • 0002942853 scopus 로고
    • Biochemical role of folate in cellular metabolism
    • Bailey LB, editor. New York: Marcel Dekker, lnc
    • Wagner C. Biochemical role of folate in cellular metabolism. In: Bailey LB, editor. Folate in health and disease. New York: Marcel Dekker, lnc; 1995. pp. 23-42.
    • (1995) Folate in Health and Disease , pp. 23-42
    • Wagner, C.1
  • 8
    • 0034445732 scopus 로고    scopus 로고
    • Relationship between plasma homocysteine and vitamin status in the Framingham study population: Impact of folic acid fortification
    • Selhub J, Jacques PF, Bostom AG, et al. Relationship between plasma homocysteine and vitamin status in the Framingham study population: impact of folic acid fortification. Public Health Rev 2000; 28:117-145.
    • (2000) Public Health Rev , vol.28 , pp. 117-145
    • Selhub, J.1    Jacques, P.F.2    Bostom, A.G.3
  • 9
    • 0036713531 scopus 로고    scopus 로고
    • Folic acid intake from fortification in United States exceeds predictions
    • Choumenkovitch SF, Selhub J, Wilson PW, et al. Folic acid intake from fortification in United States exceeds predictions. J Nutr 2002; 132:2792-2798.
    • (2002) J Nutr , vol.132 , pp. 2792-2798
    • Choumenkovitch, S.F.1    Selhub, J.2    Wilson, P.W.3
  • 10
    • 0002115597 scopus 로고
    • Folate chemistry and metabolism
    • Bailey LB, editor. New York: Marcel Dekker, Inc
    • Shane B. Folate chemistry and metabolism. In: Bailey LB, editor. Folate in health and disease. New York: Marcel Dekker, Inc; 1995. pp. 1-22.
    • (1995) Folate in Health and Disease , pp. 1-22
    • Shane, B.1
  • 11
    • 0038045763 scopus 로고    scopus 로고
    • Prediction of treatment response in geriatric depression from baseline folate level: Interaction with an SSRI or a tricyclic antidepressant
    • Alpert M, Suva RR, Pouget ER. Prediction of treatment response in geriatric depression from baseline folate level: interaction with an SSRI or a tricyclic antidepressant. J Clin Psychopharmacol 2003; 23:309-313. Strong support for hypothesized relationship between folate and monoamines in depression.
    • (2003) J Clin Psychopharmacol , vol.23 , pp. 309-313
    • Alpert, M.1    Suva, R.R.2    Pouget, E.R.3
  • 12
    • 0033983288 scopus 로고    scopus 로고
    • B vitamins, homocysteine, and neurocognitive function in the elderly
    • Selhub J, Bagley LC, Miller J, Rosenberg IH. B vitamins, homocysteine, and neurocognitive function in the elderly. Am J Clin Nutr 2000; 71:6143-6203.
    • (2000) Am J Clin Nutr , vol.71 , pp. 6143-6203
    • Selhub, J.1    Bagley, L.C.2    Miller, J.3    Rosenberg, I.H.4
  • 13
    • 0031812410 scopus 로고    scopus 로고
    • The clinical interface of depression and dementia
    • Raskind MA. The clinical interface of depression and dementia. J Clin Psychiatry 1998; 59 (Suppl):9-12.
    • (1998) J Clin Psychiatry , vol.59 , Issue.SUPPL. , pp. 9-12
    • Raskind, M.A.1
  • 15
    • 0030614878 scopus 로고    scopus 로고
    • Folate, vitamin B12, and homocysteine in major depressive disorder
    • Fava M, Borus JS, Alpert JE, et al. Folate, vitamin B12, and homocysteine in major depressive disorder. Am J Psychiatry 1997; 154:426-428.
    • (1997) Am J Psychiatry , vol.154 , pp. 426-428
    • Fava, M.1    Borus, J.S.2    Alpert, J.E.3
  • 16
    • 0030299046 scopus 로고    scopus 로고
    • Folate, vitamin B12, and neuropsychiatric disorders
    • Bottiglieri T. Folate, vitamin B12, and neuropsychiatric disorders. Nutr Rev 1996; 54:382-390.
    • (1996) Nutr Rev , vol.54 , pp. 382-390
    • Bottiglieri, T.1
  • 17
    • 0037217507 scopus 로고    scopus 로고
    • Depression and folate status in the US population
    • Morris MS, Fava M, Jacques PF, et al. Depression and folate status in the US population. Psychother Psychosom 2003; 72:80-87. This paper convincingly demonstrates the importance of folate in depression independent of potentially confounding variables such as socio-economic status, ethnicity, and alcohol use.
    • (2003) Psychother Psychosom , vol.72 , pp. 80-87
    • Morris, M.S.1    Fava, M.2    Jacques, P.F.3
  • 18
    • 0141751882 scopus 로고    scopus 로고
    • Dietary folate and depressive symptoms are associated in middle-aged Finnish men
    • Tolmunen T, Voutilainen S, Hintikka J, et al. Dietary folate and depressive symptoms are associated in middle-aged Finnish men. J Nutr 2003; 133:3233-3236. This study provides additional evidence for association of low-folate status and depression.
    • (2003) J Nutr , vol.133 , pp. 3233-3236
    • Tolmunen, T.1    Voutilainen, S.2    Hintikka, J.3
  • 19
    • 0030839990 scopus 로고    scopus 로고
    • Nutrition and depression: The role of folate
    • Alpert JE, Fava M. Nutrition and depression: the role of folate. Nutr Rev 1997; 55:145-149.
    • (1997) Nutr Rev , vol.55 , pp. 145-149
    • Alpert, J.E.1    Fava, M.2
  • 20
    • 0033625099 scopus 로고    scopus 로고
    • Vitamin B12 deficiency and depression in physically disabled older women: Epidemiologic evidence from the Women's Health and Aging Study
    • Penninx BWJH, Guralnik JM, Ferrucci L, et al. Vitamin B12 deficiency and depression in physically disabled older women: epidemiologic evidence from the Women's Health and Aging Study. Am J Psychiatry 2000; 157:715-721.
    • (2000) Am J Psychiatry , vol.157 , pp. 715-721
    • Penninx, B.W.J.H.1    Guralnik, J.M.2    Ferrucci, L.3
  • 21
    • 0036883967 scopus 로고    scopus 로고
    • Vitamin B12, folate, and homocysteine in depression: The Rotterdam Study
    • Tiemeier H, van Tuijl HR, Hofman A, et al. Vitamin B12, folate, and homocysteine in depression: the Rotterdam Study. Am J Psychiatry 2002; 159:2099-2101.
    • (2002) Am J Psychiatry , vol.159 , pp. 2099-2101
    • Tiemeier, H.1    Van Tuijl, H.R.2    Hofman, A.3
  • 22
    • 0036277585 scopus 로고    scopus 로고
    • Short-term folate, vitamin B12 or vitamin B6 supplementation slightly affects memory performance but not mood in women of various ages
    • Bryan J, Calvaresi E, Hughes D. Short-term folate, vitamin B12 or vitamin B6 supplementation slightly affects memory performance but not mood in women of various ages. J Nutr 2002; 132:1345-1356.
    • (2002) J Nutr , vol.132 , pp. 1345-1356
    • Bryan, J.1    Calvaresi, E.2    Hughes, D.3
  • 23
    • 0033858407 scopus 로고    scopus 로고
    • Enhancement of the antidepressant action of fluoxetine by folic acid: A randomized, placebo-controlled trial
    • Coppen A, Bailey JE. Enhancement of the antidepressant action of fluoxetine by folic acid: a randomized, placebo-controlled trial. J Affect Disord 2000; 60:121-130.
    • (2000) J Affect Disord , vol.60 , pp. 121-130
    • Coppen, A.1    Bailey, J.E.2
  • 24
    • 0027689454 scopus 로고
    • The use of diet and dietary components in the study of factors controlling affect in humans: A review
    • Young SN. The use of diet and dietary components in the study of factors controlling affect in humans: a review. J Psychiatry Neurosci 1993; 18:235-244.
    • (1993) J Psychiatry Neurosci , vol.18 , pp. 235-244
    • Young, S.N.1
  • 25
    • 0026720760 scopus 로고
    • Nutritional factors in physical and cognitive functions of elderly people
    • Rosenberg IH, Miller JW. Nutritional factors in physical and cognitive functions of elderly people. Am J Clin Nutr 1992; 55:1237S-1243S.
    • (1992) Am J Clin Nutr , vol.55
    • Rosenberg, I.H.1    Miller, J.W.2
  • 26
    • 0035050096 scopus 로고    scopus 로고
    • Hyperhomocysteinemia associated with poor recall in the third National Health and Nutrition Examination Survey
    • Morris MS, Jacques PF, Rosenberg IH, Selhub J. Hyperhomocysteinemia associated with poor recall in the third National Health and Nutrition Examination Survey. Am J Clin Nutr 2001; 73:927-933.
    • (2001) Am J Clin Nutr , vol.73 , pp. 927-933
    • Morris, M.S.1    Jacques, P.F.2    Rosenberg, I.H.3    Selhub, J.4
  • 27
    • 4344665176 scopus 로고    scopus 로고
    • A critical evaluation of the relationship between serum vitamin B12, folate and total homocysteine with cognitive impairment in the elderly
    • Ellinson M, Thomas J, Patterson A. A critical evaluation of the relationship between serum vitamin B12, folate and total homocysteine with cognitive impairment in the elderly. J Hum Nutr Dietet 2004; 17:371-383. Cochrane Dementia and Cognitive Improvement Group, Oxford review four studies examining B-vitamin status, homocysteine, mood, and cognition.
    • (2004) J Hum Nutr Dietet , vol.17 , pp. 371-383
    • Ellinson, M.1    Thomas, J.2    Patterson, A.3
  • 28
    • 0036560945 scopus 로고    scopus 로고
    • Folate, homocysteine, and neurological function
    • Morris MS. Folate, homocysteine, and neurological function. Nutr Clin Care 2002; 5:124-132.
    • (2002) Nutr Clin Care , vol.5 , pp. 124-132
    • Morris, M.S.1
  • 29
    • 0038387939 scopus 로고    scopus 로고
    • Homocysteine and Alzheimer's disease
    • Morris MS. Homocysteine and Alzheimer's disease. Lancet Neurol 2003; 2:425-428. Concise recent review of homocysteine and Alzheimer's disease - includes epidemiological data.
    • (2003) Lancet Neurol , vol.2 , pp. 425-428
    • Morris, M.S.1
  • 30
    • 3242887421 scopus 로고    scopus 로고
    • Plasma homocysteine concentration relates to the severity but not the duration of Alzheimer's disease
    • Nilsson K, Gustafson L, Hultberg B. Plasma homocysteine concentration relates to the severity but not the duration of Alzheimer's disease. Int J Geriatr Psychiatry 2004; 19:666-672.
    • (2004) Int J Geriatr Psychiatry , vol.19 , pp. 666-672
    • Nilsson, K.1    Gustafson, L.2    Hultberg, B.3
  • 31
    • 0037075257 scopus 로고    scopus 로고
    • Plasma homocysteine as a risk factor for dementia and Alzheimer's disease
    • Seshadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 2002; 346:476-483.
    • (2002) N Engl J Med , vol.346 , pp. 476-483
    • Seshadri, S.1    Beiser, A.2    Selhub, J.3
  • 32
    • 0141608651 scopus 로고    scopus 로고
    • Homocysteine and cognitive function in the Sacramento Area Latino Study on Aging
    • Miller JW, Green R, Ramos MI, et al. Homocysteine and cognitive function in the Sacramento Area Latino Study on Aging. Am J Clin Nutr 2003; 78:441-447.
    • (2003) Am J Clin Nutr , vol.78 , pp. 441-447
    • Miller, J.W.1    Green, R.2    Ramos, M.I.3
  • 33
    • 0038219536 scopus 로고    scopus 로고
    • Homocysteine: A marker for cognitive performance? A longitudinal follow-up study
    • Teunissen CE, Blom AH, Van Boxtel MP, et al. Homocysteine: a marker for cognitive performance? A longitudinal follow-up study. J Nutr Health Aging 2003; 7:153-159.
    • (2003) J Nutr Health Aging , vol.7 , pp. 153-159
    • Teunissen, C.E.1    Blom, A.H.2    Van Boxtel, M.P.3
  • 34
    • 3042784367 scopus 로고    scopus 로고
    • Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia
    • Quadri P, Fragiacomo C, Pezzati R, et al. Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia. Am J Clin Nutr 2004; 80:114-122. This study shows the relationship between folate and cognitive impairment, and suggests folate depletion may precede more severe impairment.
    • (2004) Am J Clin Nutr , vol.80 , pp. 114-122
    • Quadri, P.1    Fragiacomo, C.2    Pezzati, R.3
  • 35
    • 0038219533 scopus 로고    scopus 로고
    • Plasma total homocysteine levels, dietary vitamin B6 and folate intake in AD and healthy aging
    • Mizrahi EH, Jacobsen DW, Debanne SM, et al. Plasma total homocysteine levels, dietary vitamin B6 and folate intake in AD and healthy aging. J Nutr Health Aging 2003; 7:160-165.
    • (2003) J Nutr Health Aging , vol.7 , pp. 160-165
    • Mizrahi, E.H.1    Jacobsen, D.W.2    Debanne, S.M.3
  • 36
    • 11144356509 scopus 로고    scopus 로고
    • Correlations between cognitive, behavioural and psychological findings and levels of vitamin B12 and folate in patients with dementia
    • Engelborghs S, Vloeberghs E, Maertens K, et al. Correlations between cognitive, behavioural and psychological findings and levels of vitamin B12 and folate in patients with dementia, Int J Geriatr Psychiatry 2004; 19:365-370. Expands findings of low folate and severity of dementia in frontotemporal dementia patients.
    • (2004) Int J Geriatr Psychiatry , vol.19 , pp. 365-370
    • Engelborghs, S.1    Vloeberghs, E.2    Maertens, K.3
  • 37
    • 0034068273 scopus 로고    scopus 로고
    • Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: Findings from the Nun Study
    • Snowdon DA, Tully CL, Smith CD, et al. Serum folate and the severity of atrophy of the neocortex in Alzheimer disease: findings from the Nun Study. Am J Clin Nutr 2000; 71:993-998.
    • (2000) Am J Clin Nutr , vol.71 , pp. 993-998
    • Snowdon, D.A.1    Tully, C.L.2    Smith, C.D.3
  • 38
    • 0032921011 scopus 로고    scopus 로고
    • Low-dose folic acid supplementation decreases plasma homocysteine concentrations: A randomized trial
    • Brouwer IA, van Dusseldorp M, Thomas CM, et al. Low-dose folic acid supplementation decreases plasma homocysteine concentrations: a randomized trial. Am J Clin Nutr 1999; 69:99-104.
    • (1999) Am J Clin Nutr , vol.69 , pp. 99-104
    • Brouwer, I.A.1    Van Dusseldorp, M.2    Thomas, C.M.3
  • 39
    • 20244361897 scopus 로고    scopus 로고
    • A pilot study of vitamins to lower plasma homocysteine levels in Alzheimer disease
    • Aisen PS, Egelko S, Andrews H, et al. A pilot study of vitamins to lower plasma homocysteine levels in Alzheimer disease. Am J Geriatr Psychiatry 2003; 11:246-249. This pilot study is of particular importance in that the researchers are investigating the effects of B-vitamin supplementation in existing Alzheimer's patients and plan to follow up with cognitive scores.
    • (2003) Am J Geriatr Psychiatry , vol.11 , pp. 246-249
    • Aisen, P.S.1    Egelko, S.2    Andrews, H.3
  • 40
    • 0242680428 scopus 로고    scopus 로고
    • Folic acid supplementation in dementia: A preliminary report
    • Sommer BR, Hoff AL, Costa M. Folic acid supplementation in dementia: a preliminary report. J Geriatr Psychiatry Neurol 2003; 16:156-159.
    • (2003) J Geriatr Psychiatry Neurol , vol.16 , pp. 156-159
    • Sommer, B.R.1    Hoff, A.L.2    Costa, M.3
  • 41
    • 0034936213 scopus 로고    scopus 로고
    • Improvement of cognitive functions after cobalamin/folate supplementation in elderly patients with dementia and elevated plasma homocysteine
    • Nilsson K, Gustafson L, Hultberg B. Improvement of cognitive functions after cobalamin/folate supplementation in elderly patients with dementia and elevated plasma homocysteine. Int J Geriatr Psychiatry 2001; 16:609-614.
    • (2001) Int J Geriatr Psychiatry , vol.16 , pp. 609-614
    • Nilsson, K.1    Gustafson, L.2    Hultberg, B.3
  • 42
    • 0035848341 scopus 로고    scopus 로고
    • Randomized trial of folic acid supplementation and serum homocysteine levels
    • Wald DS, Bishop L, Wald NJ, et al. Randomized trial of folic acid supplementation and serum homocysteine levels. Arch Intern Med 2001; 161:695-700.
    • (2001) Arch Intern Med , vol.161 , pp. 695-700
    • Wald, D.S.1    Bishop, L.2    Wald, N.J.3
  • 43
    • 14844301867 scopus 로고    scopus 로고
    • Homocysteine, cerebrovascular disease, cognitive function and aging
    • O'Brien J, Ames D, Gustafson L, et al., editors. London: Martin Dunitz
    • Tucker KL, Scott TM, Folstein M. Homocysteine, cerebrovascular disease, cognitive function and aging. In: O'Brien J, Ames D, Gustafson L, et al., editors. Cerebrovascular disease, cognitive impairment and dementia. 2nd ed. London: Martin Dunitz; 2004. pp. 181-193. Valuable contemporary review.
    • (2004) Cerebrovascular Disease, Cognitive Impairment and Dementia. 2nd Ed. , pp. 181-193
    • Tucker, K.L.1    Scott, T.M.2    Folstein, M.3
  • 44
    • 4243892309 scopus 로고
    • Folic acid, vitamin B12, and the nervous system: Historical aspects
    • Botez MI, Reynolds EH, editors. New York: Raven Press
    • Reynolds EH. Folic acid, vitamin B12, and the nervous system: historical aspects. In: Botez MI, Reynolds EH, editors. Folic acid in neurology, psychiatry, and internal medicine. New York: Raven Press; 1979. pp. 1-5.
    • (1979) Folic Acid in Neurology, Psychiatry, and Internal Medicine , pp. 1-5
    • Reynolds, E.H.1
  • 45
    • 0036237909 scopus 로고    scopus 로고
    • Benefits and risks of folic acid to the nervous system
    • Reynolds EH. Benefits and risks of folic acid to the nervous system. J Neurol Neurosurg Psychiatry 2002; 72:567-571.
    • (2002) J Neurol Neurosurg Psychiatry , vol.72 , pp. 567-571
    • Reynolds, E.H.1
  • 46
    • 0002399363 scopus 로고
    • Folate requirements and dietary recommendations
    • Bailey LB, editor. New York: Marcel Dekker, Inc
    • Bailey LB. Folate requirements and dietary recommendations. In: Bailey LB, editor. Folate in health and disease. New York: Marcel Dekker, Inc; 1995. pp. 123-151.
    • (1995) Folate in Health and Disease , pp. 123-151
    • Bailey, L.B.1
  • 47
    • 0001314003 scopus 로고
    • Food labeling: Health claims and label statements; folate and neural tube defects
    • Food and Drug Administration, DHHS. Food labeling: health claims and label statements; folate and neural tube defects. Fed Reg 1993; 58:53254-53295.
    • (1993) Fed Reg , vol.58 , pp. 53254-53295
  • 48
    • 0038549053 scopus 로고    scopus 로고
    • Folic acid supplements and fortification affect the risk for neural tube defects, vascular disease and cancer: Evolving science
    • Bailey LB. Folic acid supplements and fortification affect the risk for neural tube defects, vascular disease and cancer: evolving science. J Nutr 2003; 133:1961S-1968S.
    • (2003) J Nutr , vol.133
    • Bailey, L.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.