N-acteyl cysteine alleviates oxidative damage to central nervous system of ApoE-deficient mice following folate and vitamin E-deficiency

Journal of Alzheimer's Disease

Volumn 7, Issue 2, 2005, Pages 135-138

  Tchantchou, Flaubert ^a   Graves, Michael ^a   Rogers, Eugene ^a   Ortiz, Daniela ^a   Shea, Thomas B ^a,b  

^a UNIVERSITY OF MASSACHUSETTS LOWELL   (United States)

^b University of Massachusetts Lowell   (United States)

Author keywords

Apolipoprotein E; Folate; Glutathione; N acteyl cysteine; Neurodegeneration; Oxidative stress; Vitamin E

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL; ANTIOXIDANT; APOLIPOPROTEIN E; FOLIC ACID; GLUTATHIONE SYNTHASE;

ALPHA TOCOPHEROL DEFICIENCY; ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DIET SUPPLEMENTATION; FOLIC ACID DEFICIENCY; HYPERLIPOPROTEINEMIA TYPE 3; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

EID: 17844394677     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2005-7206     Document Type: Article

References (41)

1. M.S. Parihar and T. Hemnani, Alzheimer's disease pathogenesis and therapeutic interventions, J Clin Neurosci 11 (2004), 456-467.
2. M.M. Mattson and T.B. Shea, Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders, Trends Neurosci 26 (2003), 137-146.
3. .B. Shea and E. Rogers, Homocysteine as a risk factor for Alzheimer's disease, New Eng J Med 346 (2002), 2007.
4. L.J. Whalley, J.M. Starr and I.J. Deary, Diet and dementia, J Br Menopause Soc 10 (2004), 113-117.
5. W.R. Markesbery and J.M. Carney, Oxidative alterations in Alzheimer's disease, Brain Path 9 (1999), 133-146.
6. X. Zhu, A.K. Raina, H.G. Lee, G. Casadesus, M.A. Smith and G. Perry, Oxidative stress signalling in Alzheimer's disease, Brain Res. 1000 (2004), 32-39.
7. C.A. Rottkamp, A. Nunomura, A.K. Raina, L.M. Sayre, G. Perry and M.A. Smith, Oxidative stress, antioxidants, and Alzheimer disease, Alzheimer Dis Assoc Disord. 14(Suppl 1) (2000), S62-S66.
8. K. Berman and H. Brodaty, Tocopherol (vitamin e) in Alzheimer's disease and other neurodegenerative disorders, CNS Drugs. 18 (2004), 807-825.
9. J. Growdon, Incorporating biomarkers into clinical drug trials in Alzheimer's disease, J Alz Dis 3 (2001), 287-292.
10. J. Vina, A. Lloret, R. Orti and D. Alonso, Molecular bases of the treatment of Alzheimer's disease with antioxidants: prevention of oxidative stress, Mol Aspects Med. 25 (2004), 117-123.
11. P.P. Zandi, I.C. Anthony, A.S. Khachaturian, S.V. Stone, D. Gustafson, J.T. Tschanz, M.C. Norton, K.A. Welsh-Bohmer and J.C. Breitner, Cache County Study Group, Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study, Arch Neurol. 61 (2004), 82-88.
12. M.C. Polidori, P. Mattioli, S. Aldred, R. Cecchetti, W. Stahl, H. Griffiths, U. Senin, H. Sies and P. Mecocci, Plasma antioxidant status, immunoglobulin g oxidation and lipid peroxidation in demented patients: relevance to Alzheimer disease and vascular dementia, Dement Geriatr Cogn Disord. 18 (2004), 265-270.
13. H. Liu, H. Wang, S. Shenvi, T.M. Hagen and R.M. Liu, Glutathione metabolism during aging and in Alzheimer disease, Ann N Y Acad Sci. 1019 (2004), 346-349.
14. M.A. Lovell, W.D. Ehmann, S.M. Butler and W.R. Markesbery, Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease, Neurol 45 (1995), 1594-1601.
15. C.B. Pocernich, M. La Fontaine and D.A. Butterfield, In-vivo glutathione elevation protects against hydroxyl free radical-induced protein oxidation in rat brain, Neurochem Int. 36 (2000), 185-191.
16. C.B. Pocernich, A.L. Cardin, C.L. Racine, C.M. Lauderback and D.A. Butterfield. Glutathione elevation and its protective role in acrolein-induced protein damage in synaptosomal membranes: relevance to brain lipid peroxidation in neurodegenerative disease, Neurochem Int. 39 (2001), 141-149.
17. J.B. Schultz, J. Linddenau, J. Seyfried and J. Dichgans, Glutathione, oxidative stress and neurodegeneration, Eur J Biochem 267 (2000), 4904-4911.
18. G.F. Weber, Final common pathways in neurodegenerative diseases: regulatory role of the glutathione cycle, Neurosci Biobehav Rev. 23 (1999), 1079-1086.
19. T.P. Dalton, Y. Chen, S.N. Schneider, D.W. Nebert and H.G. Shertzer, Genetically altered mice to evaluate glutathione homeostasis in health and disease, Free Radic Biol Med. 37 (2004), 1511-1126.
20. J. Choi, M.J. Forster, S.R. McDonald, S.T. Weintraub, C.A. Carroll and R.W. Gracy, Proteomic identification of specific oxidized proteins in ApoE-knockout mice: relevance to Alzheimer's disease, Free Radic Biol Med. 36 (2004), 1155-1162.
21. C. Ramassamy, P. Krzywkowski, D. Averill, S. Lussier-Cacan, L. Throux, Y. Christen, J. Sch Davignon and J. Poirier, Impact of apolipoprotein E deficiency on oxidative insults and antioxidant levels in the brain, Mol Brain Res 86 (2002), 76-83.
22. T.B. Shea, E. Rogers, D. Ortiz andM.-S. Sheu, Apolipoprotein E deficiency promotes increased oxidative stress and compensatory increases in antioxidants in brain tissue, Free Rad Biol Med 33 (2002), 1115-1120.
23. I. Veinbergs, M. Mallory, Y. Sagara and E. Masliah, Vitamin E supplementation prevents spatial learning deficits and dendritic alterations in aged apolipoprotein E-deficient mice, Eur J Neurosci 12 (2000), 4541-4546.
24. T.B. Shea, E. Rogers, D. Ortiz and M.-S. Sheu, Apolipoprotein E deficiency promotes increased oxidative stress and compensatory increases in antioxidants in brain tissue, Free Rad Biol Med 33 (2002), 1115-1120.
25. S.M. Mihalick, D. Ortiz, R. Kumar, E. Rogers and T.B. Shea, Folate and vitamin E deficiency impair cognitive performance in mice subjected to oxidative stress: differential impact on normal mice and mice lacking apolipoprotein E, Neuromol Med 4 (2004), 197-202.
26. F. Tchantchou, M. Graves, D. Ashline, A. Morin, A. Pimenta, D. Ortiz, E. Rogers and T.B. Shea, Increased transcription and activity of glutathione synthase in response to deficiencies in folate, vitamin E and apolipoprotein E, J Neurosci Res 75(4) (2004), 508-155.
27. Dringen and R. Hamprecht, N-acetylcysteine, but not methionine or 2-oxothiazolidine-4-carboxylate, serves as cysteine donor for the synthesis of glutathione in cultured neurons derived from embryonal rat brain, Neurosci Lett 259 (1999), 79-82.
28. J.R. Mitchell, D.J. Jollow, W.Z. Potter, J.R. Gillette and B.B. Brodie, Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione, J Pharmacol Exp Ther 187 (1973), 211-217.
29. Y.C. Ou, C.C. White, C.M. Kresja, R.A. Once, T.J. Kavanagh and E.M. Faustman, The role of intracellular glutathione in methylmercury-induced toxicity in embryonic neuronal cells, Neurotox 20 (1999), 793-804.
30. G. Olivieri, G. Baysang, F. Meier, F. Muller-Spahn, H.B. Stahelin, M. Brockhaus and C. Brack, N-acetyl-L-cysteine protects SHSY5Y neuroblastoma cells from oxidative stress and cell cytotoxicity: effects on beta-amyloid secretion and tau phosphorylation, J Neurochem. 76 (2001), 224-233.
31. P. Ho, D. Ashline, S. Dhitavat, D. Ortiz, S.C. Collins, E. Rogers and T.B. Shea, Folate deprivation induces neurodegeneration: Roles of oxidative stress and increased homocysteine, Neurobiol Dis 14 (2003), 32-42.
32. S.A. Farr, H.F. Poon, D. Dogrukol-Ak, J. Drake, W.A. Banks, E. Eyerman, D.A. Butterfield and J.E. Morley, The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice, J Neurochem 84 (2003), 1173-1183.
33. E.J. Rogers, S. Mihalick, D. Ortiz and T.B. Shea, Apple juice prevents oxidative stress and impaired cognitive performance caused by genetic and dietary deficiencies in mice, J Nutr Health Aging 8 (2004), 92-97.
34. T.B. Shea, E. Rogers, D. Ashline, D. Ortiz, N. Duarte, T.A. Wilson, R.J. Nicolosi and M.-H. Sheu, Vitamin E deficiency does not induce compensatory antioxidant increases in central nervous system tissue of apolipoprotein E-deficient mice, J Alz Dis 3 (2002), 267-282.
35. M.-D. Linsley, F. Ekinci, D. Ortiz and T.B. Shea, Quantification of oxidative damage in situ using a modification of the thiobarbituic acid-reactive substances (TBARs) assay, J Neurosci Meth (2004), in press.
36. M. Khan, B. Sekhon, M. Jatana, S. Giri, A.G. Gilg, C. Sekhon, I. Singh and A.K. Singh, Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke, J Neurosci Res. 76(2004), 519-527.
37. B. Sekhon, C. Sekhon, M. Khan, S.J. Patel, I. Singh and A.K. Singh, N-Acetyl cysteine protects against injury in a rat model of focal cerebral ischemia, Brain Res. 971 (2003), 1-8.
38. S. Aydin, R. Ozaras, H. Uzun, A. Belce, E. Uslu, V. Tahan, T. Altug, E. Dumen and H. Senturk, N-acetylcysteine reduced the effect of ethanol on antioxidant system in rat plasma and brain tissue, Transplant. 11 (2002), 653-662.
39. T. Koppal, J. Drake and D.A. Butterfield, In vivo modulation of rodent glutathione and its role in peroxynitrite-induced neocortical synaptosomal membrane protein damage, Biochim Biophys Acta 1453 (1999), 407-411.
40. M.L. Sagrista, A.E. Garcia, M. Africa De Madariaga and M. Mora, Antioxidant and pro-oxidant effect of the thiolic compounds N-acetyl-L-cysteine and glutathione against free radical-induced lipid peroxidation, Free Radic Res. 36 (2002), 329-340.
41. K. Schuessel, S. Leutner, N.J. Cairns, W.E. Muller and A. Eckert, Impact of gender on upregulation of antioxidant defense mechanisms in Alzheimer's disease, J Neural Trans 111 (2004), 1167-1182.