Endothelin-1 couples βPix to p66Shc: Role of βPix in cell proliferation through FOXO3a phosphorylation and p27kip1 down-regulation independently of Akt

Molecular Biology of the Cell

Volumn 19, Issue 6, 2008, Pages 2609-2619

  Chahdi, Ahmed ^a   Sorokin, Andrey ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ACTIN; ADAPTOR PROTEIN; ADAPTOR PROTEIN SHC66; BETA1 PAK INTERACTING EXCHANGE FACTOR; CYCLIN DEPENDENT KINASE INHIBITOR 1B; ENDOTHELIN 1; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; RAC1 PROTEIN; SERINE; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG; WORTMANNIN;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DIMERIZATION; DOWN REGULATION; ENZYME ACTIVATION; ENZYME KINETICS; ENZYME REGULATION; HUMAN; HUMAN CELL; MESANGIUM CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION;

ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DIMERIZATION; DOWN-REGULATION; ENDOTHELIN-1; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FORKHEAD TRANSCRIPTION FACTORS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; KINETICS; MICE; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SHC SIGNALING ADAPTOR PROTEINS; SIGNAL TRANSDUCTION;

EID: 48749118026     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E07-05-0424     Document Type: Article

References (45)

1. Ahn, S. J., Chung, K. W., Lee, R. A., Park, I. A., Lee, S. H., Park, D. E., and Noh, D. Y. (2003). Overexpression of βPix-a in human breast cancer tissues. Cancer Lett. 193, 99-107.
2. Alkarian, A., and Slingerland, J. (2004). Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancer. Breast Cancer Res. 6, 13-21.
3. Bae, J. Y. et al. (2005). BetaPix-a enhances the activity of phospholipase Cgamma1 by binding SH3 domain in breast cancer. J. Cell. Biochem. 94, 1010-1016.
4. Bonfini, L., Karlovich, C. A., Dasgupta, C., and Banerjee, U. (1992). The Son of sevenless gene product: a putative activator of Ras. Science 255, 603-606.
5. Brunet, A., Bonni, A., Zigmond, M., Lin, M., Juo, P., Hu, L., Anderson, M., Arden, K., Blenis, J., and Greenberg, M. (1999). Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96, 857-868.
6. Brunet, A., Park, J., Tran, H., Hu, L. S., Hemmings, B. A., and Greenberg, M. E. (2001). Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol. Cell. Biol. 21, 952-965.
7. 1Pix translocation and Cdc42 activation via protein kinase A-dependent pathway. J. Biol. Chem. 280, 578-584.
8. 1Pix guanine nucleotide exchange factor activity through 14-3-3β binding. Mol. Cell. Biol. 28, 1679-1687.
9. Daniels, R. H., Zenke, F. T., and Bokoch, G. M. (1999). alphaPix stimulates p21-activated kinase activity through exchange factor-dependent and -independent mechanisms. J. Biol. Chem. 274, 6047-6050.
10. De Ruiter, N. D., Burgering, B.M.T., and Bos, J. L. (2001). Regulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451. Mol. Cell. Biol. 21, 8225-8235.
11. Del Pozo, M. A., Price, L. S., Alderson, N. B., Ren, X. D., and Schwartz, M. A. (2000). Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK. EMBO J. 19, 2008-2014.
12. KIP1. Mol. Cell. Biol. 20, 9138-9148.
13. Eblen, S. T., Slack, J. K., Weber, M. J., and Catling, A. D. (2002). Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes. Mol. Cell. Biol. 22, 6023-6033.
14. Egan, S. E., Giddings, B. W., Brooks, M. W., Buday, L., Sizeland, A. M., and Weinberg, R. A. (1993). Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature 363, 45-51.
15. Foschi, M., Chari, S., Dunn, M. J., and Sorokin, A. (1997). Biphasic activation of p21ras by endothelin-1 sequentially activates the ERK cascade and phosphatidylinositol 3-kinase. EMBO J. 16, 6439-6451.
16. Foschi, M., Franchi, F., Han, J., La Villa, G., and Sorokin, A. (2001). Endothelin-1 induces serine phosphorylation of the adaptor protein p66Shc and its association with 14-3-3 protein in glomerular mesangial cells. J. Biol. Chem. 276, 26640-26647.
17. Frost, J. A., Steen, H., Shapiro, P., Lewis, T., Ahn, N., Shaw, P. E., and Cobb, M. H. (1997). Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. EMBO J. 16, 6426-6438.
18. Gu, H., Maeda, H., Moon, J. J., Lord, J. D., Yoakim, M., Nelson, B. H., and Neel, B. G. (2000). New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway. Mol. Cell. Biol. 20, 7109-7120.
19. Hu, M.C.T., Lee, D. F., Xia, W., Golfman, L. S., Yang, F. O., Yang, J. Y., Zou, Y., Bao, S., Hanada, N., Saso, H., Kobayashi, R., and Hung, M. C. (2004). IκB kinase promotes tumorigenesis through inhibition of Forkhead FOXO3a. Cell 117, 225-237.
20. Hu, Y., Wang, X., Zeng, L., Cai, D. Y., Sabapathy, K., Goff, S. P., Firpo, E. J., and Li, B. (2005). ERK phosphorylates p66shcA on Ser36 and subsequently regulates p27kip1 expression via the Akt-FOXO3a pathway: implication of p27kip1 in cell response to oxidative stress. Mol. Biol. Cell 16, 3705-3718.
21. Jackson, J. G., Yoneda, T., Clark, G. M., and Yee, D. (2000). Elevated levels of p66 Shc are found in breast cancer cell lines and primary tumors with high metastatic potential. Clin. Cancer Res. 6, 1135-1139.
22. Kim, S., Lee, S. H., and Park, D. (2001). Leucine zipper-mediated homodimerization of the p21-activated kinase-interacting factor, beta Pix. Implication for a role in cytoskeletal reorganization. J. Biol. Chem. 276, 10581-10584.
23. Kops, G. L., De Ruiter, N. D., De Vries-Smits, A. M., Powell, D. R., Bos, J. L., and Burgering, B. T. (1999). Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature 398, 630-634.
24. Lin, K., Hsin, H., Libina, N., and Kenyon, C. (2001). Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nature 28, 139-145.
25. Lim, C. S., Kim, S. H., Jung, J. G., Kim, J. K., Song, W. K. (2003). Regulation of SPIN90 phosphorylation and interaction with Nck by ERK and cell adhesion. J. Biol. Chem. 278, 52116-52123.
26. Manser, E., Loo, T. H., Koh, C. G., Zhao, Z. S., Chen, X. Q., Tan, L., Tan, I., Leung, T., and Lim, L. (1998). PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Mol. Cell 1, 183-192.
27. Mazumdar, A., and Kumar, R. (2003). Estrogen regulation of Pak1 and FKHR pathways in breast cancer cells. FEBS Lett. 535, 6-10.
28. kip1. Nature 404, 782-787.
29. Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L., and Pelicci, P. G. (1999). The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 402, 309-313.
30. Migliaccio, E., Mele, S., Salcini, A. E., Pelicci, G., Lai, K. M., Superti-Furga, G., Pawson, T., Di Fiore, P. P., Lanfrancone, L., and Pelicci, P. G. (1997). Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. EMBO J. 16, 706-716.
31. Mira, J. P., Benard, V., Groffen, J., Sanders, L. C., and Knaus, U. G. (2000). Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway. Proc. Natl. Acad. Sci. USA 97, 185-189.
32. Nakamura, N., Ramaswamy, S., Vazquez, F., Signoretti, S., Loda, M., and Sellers, W. R. (2000). Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. Mol. Cell. Biol. 20, 8969-8982.
33. Nemoto, S., and Finkel, T. (2002). Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science 295, 2450-2452.
34. Pacini, S. et al. (2004). p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells. Mol. Cell. Biol. 24, 1747-1757.
35. 2. Mol. Cell. Biol. 24, 4384-4394.
36. Pelicci, G., Lanfrancone, L., Grignani, F., McGlade, J., Cavallo, F., Forni, G., Pawson, T., and Pelicci, P. G. (1992). A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 10, 93-104.
37. Renshaw, M. W., Ren, X. D., and Schwartz, M. A. (1997). Growth factor activation of MAP kinase requires cell adhesion. EMBO J. 16, 5592-5599.
38. Sraer, J. D., Delarue, F., Hagege, J., Feunteun, J., Pinet, F., Nguyen, G., and Rondeau, E. (1996). Stable cell lines of T-SV40 immortalized human glomerular mesangial cells. Kidney Int. 49, 267-270.
39. Kip1 and Bim in response to IL-2. J. Immunol. 168, 5024-5031.
40. Stofega, M. R., Sanders, L. C., Gardiner, E. M., and Bokoch, G. M. (2004). Constitutive p21-activated kinase (PAK) activation in breast cancer cells as a result of mislocalization of PAK to focal adhesions. Mol. Biol. Cell 15, 2965-2977.
41. Sugimoto, T., Haneda, M., Sawano, H., Isshiki, K., Maeda, S., Koya, D., Inoki, K., Yasuda, H., Kashiwagi, A., and Kikkawa, R. 2001. Endothelin-1 induces cyclooxygenase-2 expression via nuclear factor of activated T-cell transcription factor in glomerular mesangial cells. J. Am. Soc. Nephrol. 12, 1359-1368.
42. Turner, C. E., Brown, M. C., Perrotta, J. A., Riedy, M. C., Nikolopoulos, S. N., McDonald, A. R., Bagrodia, S., Thomas, S., and Leventhal, P. S. (1999). Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: a role in cytoskeletal remodeling. J. Cell Biol. 145, 851-863.
43. Shc protein correlates with proliferation of human prostate cancer cells. Oncogene 24, 7203-7212.
44. Zhao, Z. S., Lim, J. P., Ng, N. Y., Lim, L., and Manser, E. (2005). The GIT-associated kinase Pak targets to the centrosome and regulates Aurora-A. Mol. Cell 20, 237-249.
45. Zhao, Z. S., Manser, E., Loo, T. H., and Lim, L. (2000). Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly. Mol. Cell. Biol. 20, 6354-6363.