Activation of the mammalian target of rapamycin complex 1 is both necessary and sufficient to stimulate eukaryotic initiation factor 2Bε mRNA translation and protein synthesis

International Journal of Biochemistry and Cell Biology

Volumn 40, Issue 11, 2008, Pages 2522-2533

  Kubica, Neil ^a   Crispino, Jamie L ^a   Gallagher, James W ^a   Kimball, Scot R ^a   Jefferson, Leonard S ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

eIF2B; mRNA translation; mTOR; Rheb

Indexed keywords

EUKARYOTIC INITIATION FACTOR 2BEPSILON; GUANINE NUCLEOTIDE EXCHANGE FACTOR; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MESSENGER RNA; RAPAMYCIN; RHEB PROTEIN; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; CYTOSTASIS; FIBROBLAST CULTURE; GENE OVEREXPRESSION; GENETIC CODE; NONHUMAN; POLYSOME; PROTEIN FUNCTION; PROTEIN SYNTHESIS; RAT; RNA INTERFERENCE; RNA TRANSLATION; SIGNAL TRANSDUCTION; TRANSLATION INITIATION;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELL PROLIFERATION; CELLS, CULTURED; EUKARYOTIC INITIATION FACTOR-2B; FIBROBLASTS; INSULIN-LIKE GROWTH FACTOR I; LEUCINE; MONOMERIC GTP-BINDING PROTEINS; NEUROPEPTIDES; POLYRIBOSOMES; PROTEIN BIOSYNTHESIS; RATS; RNA, MESSENGER; RNA, SMALL INTERFERING; SIROLIMUS; TRANSCRIPTION FACTORS;

EUKARYOTA; MAMMALIA;

EID: 48349096394     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2008.04.010     Document Type: Article

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