Insulin-like growth factor 1 inhibits extracellular signal-regulated kinase to promote neuronal survival via the phosphatidylinositol 3-kinase/protein kinase A/c-Raf pathway

Journal of Neuroscience

Volumn 25, Issue 11, 2005, Pages 2838-2852

  Subramaniam, Srinivasa ^a   Shahani, Neelam ^b   Strelau, Jens ^a   Laliberté, Christine ^c   Brandt, Roland ^b   Kaplan, David ^c,d   Unsicker, Klaus ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF OSNABRÜCK   (Germany)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

ERK; Neuronal death; PI3K; PKA; Raf S259A; Sindbis virus

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 8 BROMO CYCLIC AMP; CASPASE 3; CYCLIC AMP DEPENDENT PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; RAF PROTEIN; SERINE; SOMATOMEDIN C; WORTMANNIN;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL MEMBRANE; CELL SURVIVAL; CONTROLLED STUDY; DRUG INHIBITION; ENZYME ACTIVATION; ENZYME INHIBITION; NERVE REGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SINDBIS VIRUS; VIRUS EXPRESSION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANIMALS; ANIMALS, NEWBORN; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; CEREBELLUM; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME ACTIVATION; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GREEN FLUORESCENT PROTEINS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INDOLES; INSULIN-LIKE GROWTH FACTOR I; NEURONS; POTASSIUM CHLORIDE; PROTO-ONCOGENE PROTEINS C-RAF; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SERINE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

EID: 15244340082     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5060-04.2005     Document Type: Article

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