New developments in the understanding of immunology in silicosis

Current Opinion in Allergy and Clinical Immunology

Volumn 7, Issue 2, 2007, Pages 168-173

  Huaux, François ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Cytokines; Innate and adaptive immunity; Lung fibrosis; Silica

Indexed keywords

HEME OXYGENASE 1; INTERLEUKIN 10; INTERLEUKIN 9; SILICON DIOXIDE; TUMOR NECROSIS FACTOR ALPHA;

ADAPTIVE IMMUNITY; B LYMPHOCYTE; CANCER RISK; CD4+ T LYMPHOCYTE; CELL ACTIVATION; HUMAN; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOLOGY; INFLAMMATION; INHALATION; INNATE IMMUNITY; LUNG ALVEOLITIS; LUNG CANCER; LUNG DISEASE; LUNG FIBROSIS; LUNG INJURY; MACROPHAGE; MAST CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SILICOSIS; THROMBOSIS;

ANIMALS; HUMANS; MICE; OCCUPATIONAL DISEASES; OCCUPATIONAL EXPOSURE; RATS; SILICON DIOXIDE; SILICOSIS;

EID: 33947123566     PISSN: 15284050     EISSN: 14736322     Source Type: Journal    
DOI: 10.1097/ACI.0b013e32802bf8a5     Document Type: Review

References (47)

1. WHO. Silicosis. Fact Sheet no 238; 2000. http://www.who.int/mediacentre/ factsheets/fs238/en/. [Accessed 3 November 2006]
2. Rimal B, Greenberg AK, Rom WN. Basic pathogenetic mechanisms in silicosis: current understanding. Curr Opin Pulm Med 2005; 11:169-173. This is an excellent review on the mechanisms implicated in silicosis.
3. Fujimura N. Pathology and pathophysiology of pneumoconiosis. Curr Opin Pulm Med 2000; 6:140-144.
4. Zhai RH, Ge XM, Li HL, et al. Differences in cellular and inflammatory cytokine profiles in the bronchoalveolar lavage fluid in bagassosis and silicosis. Am J Ind Med 2004; 46:338-344.
5. Albrecht C, Knaapen AM, Becker A, et al. The crucial role of particle surface reactivity in respirable quartz-induced reactive oxygen/nitrogen species formation and APE/Ref-1 induction in rat lung. Respir Res 2005; 6:129.
6. Knaapen AM, Albrecht C, Becker A, et al. DNA damage in lung epithelial cells isolated from rats exposed to quartz: role of surface reactivity and neutrophilic inflammation. Carcinogenesis 2002; 23:1111-1120.
7. Zeidler PC, Hubbs A, Battelli L, Castranova V. Role of inducible nitric oxide synthase-derived nitric oxide in silica-induced pulmonary inflammation and fibrosis. J Toxicol Environ Health A 2004; 67:1001-1026.
8. Wang LY, Bowman L, Lu YJ, et al. Essential role of p53 in silica-induced apoptosis. Am J Physiol Lung Cell Mol Physiol 2005; 288:L488-L496.
9. Lalmanach G, Diot E, Godat E, et al. Cysteine cathepsins and caspases in silicosis. Biol Chem 2006; 387:863-870.
10. Gulumian M, Borm PJA, Vallyathan V, et al. Mechanistically identified suitable biomarkers of exposure, effect, and susceptibility for silicosis and coal-worker's pneumoconiosis: A comprehensive review. J Toxicol Environ Health B Crit Rev 2006; 9:357-395.
11. Borges VM, Falcao H, Leite-Junior JH, et al. Fas ligand triggers pulmonary silicosis. J Exp Med 2001; 194:155-164.
12. Srivastava KD, Rom WN, Jagirdar J, et al. Crucial role of interleukin-1beta and nitric oxide synthase in silica- induced inflammation and apoptosis in mice. Am J Respir Crit Care Med 2002; 165:527-533.
13. Lacasse Y, Martin S, Simard S, Desmeules M. Meta-analysis of silicosis and lung cancer. Scand J Work Environ Health 2005; 31:450-458.
14. International Agency for Research on Cancer (IARC). Monograph on the evaluation of the carcinogenic risk of chemicals to humans: Summaries & Evaluations. Volume 68. Lyon: IARC Press; 1997.
15. Cakmak GD, Schins RPF, Shi TM, et al. In vitro genotoxicity assessment of commercial quartz flours in comparison to standard DQ12 quartz. Int J Hyg Environ Health 2004; 207:105-113.
16. Schins RPF. Mechanisms of genotoxicity of particles and fibers. Inhal Toxicol 2002; 14:57-78.
17. Hamilton RF, Thakur SA, Mayfair JK, Holian A. MARCO mediates silica uptake and toxicity in alveolar macrophages from C57BL/6 mice. J Biol Chem 2006; 281:34218-34226. This elegant study demonstrated that innate receptors are essentials for the uptake of silica particles, activation and cell death signalling in macrophages.
18. Brown JM, Swindle EJ, Kushnir-Sukhov NM, et al. Silica Directed Mast Cell Activation is Enhanced by Scavenger Receptors. Am J Respir Cell Mol Biol 2006; Aug 10 [Epub ahead of print].
19. Arras M, Louahed J, Simoen V, et al. B lymphocytes are critical for lung fibrosis control and prostaglandin E2 regulation in IL-9 transgenic mice. Am J Respir Cell Mol Biol 2006; 34:573-580.
20. Yang HN, Bocchetta M, Kroczynska B, et al. TNF-alpha inhibits asbestos-induced cytotoxicity via a NF-kappa B-dependent pathway, a possible mechanism for asbestos-induced oncogenesis. Proc Natl Acad Sci USA 2006; 103:10397-10402.
21. Nemmar A, Nemery B, Hoet PHM, et al. Silica particles enhance peripheral thrombosis - Key role of lung macrophage-neutrophil cross-talk. Am J Respir Crit Care Med 2005; 171:872-879. This study provided the first demonstration that silica particles induce peripheral thrombosis in animals.
22. Misson P, van den Brule S, Barbarin V, et al. Markers of macrophage differentiation in experimental silicosis. J Leukoc Biol 2004; 76:926-932.
23. Mantovani A, Sica A, Sozzani S, et al. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 2004; 25:677-686.
24. Migliaccio CT, Hamilton RF, Holian A. Increase in a distinct pulmonary macrophage subset possessing an antigen-presenting cell phenotype and in vitro APC activity following silica exposure. Toxicol Appl Pharmacol 2005; 205:168-176.
25. Huaux F, Louahed J, Hudspith B, et al. Role of interleukin-10 (IL-10) in the lung response to silica in mice. Am J Respir Cell Mol Biol 1998; 18:51-59.
26. Beamer CA, Holian A. Scavenger receptor class A type I/II (CD204) null mice fail to develop fibrosis following silica exposure. Am J Physiol Lung Cell Mol Physiol 2005; 289:L186-L195.
27. Adamson IYR, Prieditis H, Bowden DH. Instillation of chemotactic factor to silica-injected lungs lowers interstitial particle content and reduces pulmonary fibrosis. Am J Pathol 1992; 141:319-326.
28. Barbarin V, Arras M, Misson P, et al. Characterization of the effect of interleukin-10 on silica-induced lung fibrosis in mice. Am J Respir Cell Mol Biol 2004; 31:78-85.
29. Barbarin V, Xing Z, Delos M, et al. Pulmonary overexpression of IL-10 augments lung fibrosis and Th2 responses induced by silica particles. Am J Physiol Lung Cell Mol Physiol 2005; 288:L841-L848.
30. Lee CG, Homer RJ, Cohn L, et al. Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13- dependent and -independent pathways. J Biol Chem 2002; 277:35466-35474.
31. Shull MM, Ormsby I, Kier AB, et al. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 1992; 359:693-699.
32. Border WA, Noble NA. Transforming growth factor beta in tissue fibrosis. N Engl J Med 1994; 331:1286-1292.
33. Barbarin V, Nihoul A, Misson P, et al. The role of pro- and anti-inflammatory responses in silica-induced lung fibrosis. Respir Res 2005; 6:112. This study showed that both inflammation and antiinflammation represent two distinct pathogenic routes in experimental silicosis.
34. Rom WN, Travis WD. Lymphocyte-macrophage alveolitis in nonsmoking individuals occupationally exposed to asbestos. Chest 1992; 101:779-786.
35. Ueki A, Yamaguchi M, Ueki H, et al. Polyclonal human T-cell activation by silicate in vitro. Immunology 1994; 82:332-335.
36. Suzuki N, Ohta K, Horiuchi T, et al. T lymphocytes and silica-induced pulmonary inflammation and fibrosis in mice. Thorax 1996; 51:1036-1042.
37. Arras M, Huaux F, Vink A, et al. Interleukin-9 reduces lung fibrosis and type 2 immune polarization induced by silica particles in a murine model. Am J Respir Cell Mol Biol 2001; 24:368-375.
38. Huaux F, Lardot C, Arras M, et al. Lung fibrosis induced by silica particles in NMRI mice is associated with an upregulation of the p40 subunit of interleukin-12 and Th-2 manifestations. Am J Respir Crit Care Med 1999; 20:561-572.
39. Chen Y, Chen J, Dong J, Liu WY. Antifibrotic effect of interferon gamma in silicosis model of rat. Toxicol Lett 2005; 155:353-360.
40. Misson P, Brombacher F, Delos M, et al. Type-2 immune response associated with silicosis is not instrumental in the development of the disease. Am J Physiol Lung Cell Mol Physiol 2006; Sep 22 [Epub ahead of print].
41. Davis GS, Pfeiffer LM, Hemenway DR. Interferon-gamma production by specific lung lymphocyte phenotypes in silicosis in mice. Am J Respir Cell Mol Biol 2000; 22:491-501.
42. Huaux F, Arras M, Tomasi D, et al. A profibrotic function of IL-12p40 in experimental pulmonary fibrosis. J Immunol 2002; 169:2653-2661.
43. van Zijverden M, van der Pijl A, Bol M, et al. Diesel exhaust, carbon black, and silica particles display distinct Th1/Th2 modulating activity. Toxicol Appl Pharmacol 2000; 168:131-139.
44. Brown JM, Pfau JC, Holian A. Immunoglobulin and lymphocyte responses following silica exposure in New Zealand mixed mice. Inhal Toxicol 2004; 16:133-139.
45. Davis GS, Holmes CE, Pfeiffer LM. Hemenway DR: Lymphocytes, lymphokines, and silicosis. J Environ Pathol Toxicol Oncol 2001; 20 (Suppl 1):53-65.
46. Desaki M, Sugawara I, Iwakura Y, et al. Role of interferon-gamma in the development of murine bronchus- associated lymphoid tissues induced by silica in vivo. Toxicol Appl Pharmacol 2002; 185:1-7.
47. Sato T, Takeno M, Honma K, et al. Heme oxygenase-1, a potential biomarker of chronic silicosis, attenuates silica-induced lung injury. Am J Respir Crit Care Med 2006; 174:906-914.