Identification of ciliary neurotrophic factor (CNTF) residues essential for leukemia inhibitory factor receptor binding and generation of CNTF receptor antagonists

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 17, 1996, Pages 9247-9252

  Di Marco, Annalise ^a   Gloaguen, Isabelle ^a   Graziani, Rita ^a   Paonessa, Giacomo ^a   Saggio, Isabella ^a,c   Hudson, Keith R ^b   Laufer, Ralph ^a  

^a IRBM   (Italy)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c CNRS   (France)

Author keywords

ciliary neurotrophic factor; gp130; leukemia inhibitory factor

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR RECEPTOR ANTAGONIST; CYTOKINE RECEPTOR; GLYCOPROTEIN GP 130; LEUKEMIA INHIBITORY FACTOR; MUTANT PROTEIN; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL LINE; DRUG ACTIVITY; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; INHIBITION KINETICS; MOUSE; MUTAGENESIS; NONHUMAN; PHARMACOLOGICAL BLOCKING; PHARMACOLOGICAL STIMULATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY;

AMINO ACID SEQUENCE; ANTIGENS, CD; CELL DIVISION; CELLS, CULTURED; CHOLINE O-ACETYLTRANSFERASE; CILIARY NEUROTROPHIC FACTOR; CYTOKINE RECEPTOR GP130; DNA MUTATIONAL ANALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; GROWTH INHIBITORS; HAPTOGLOBINS; HUMANS; INTERLEUKIN-6; LEUKEMIA INHIBITORY FACTOR; LEUKEMIA INHIBITORY FACTOR RECEPTOR ALPHA SUBUNIT; LYMPHOKINES; MEMBRANE GLYCOPROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; NERVE TISSUE PROTEINS; PROTEIN BINDING; RECEPTOR, CILIARY NEUROTROPHIC FACTOR; RECEPTORS, CYTOKINE; RECEPTORS, NERVE GROWTH FACTOR; RECEPTORS, OSM-LIF; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0029829270     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.17.9247     Document Type: Article

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