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Volumn 13, Issue 2, 2004, Pages 215-223

Leptin, obesity and cardiovascular disease

Author keywords

Cardiovascular disease; Cardiovascular epidemiology; Leptin; Selective leptin resistance; Sympathetic nervous system

Indexed keywords

ANGIOTENSIN; INSULIN; LEPTIN;

EID: 1642305609     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-200403000-00010     Document Type: Review
Times cited : (148)

References (80)
  • 1
    • 15844409555 scopus 로고    scopus 로고
    • Role of leptin in fat regulation
    • Collins S, Kuhn CM, Petro AE, et al. Role of leptin in fat regulation [letter]. Nature 1996; 380:677.
    • (1996) Nature , vol.380 , pp. 677
    • Collins, S.1    Kuhn, C.M.2    Petro, A.E.3
  • 2
    • 0030876805 scopus 로고    scopus 로고
    • Receptor-mediated regional sympathetic nerve activation by leptin
    • Haynes WG, Morgan DA, Walsh SA, et al. Receptor-mediated regional sympathetic nerve activation by leptin. J Clin Invest 1997; 100:270-278.
    • (1997) J Clin Invest , vol.100 , pp. 270-278
    • Haynes, W.G.1    Morgan, D.A.2    Walsh, S.A.3
  • 3
    • 0030830662 scopus 로고    scopus 로고
    • Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats
    • Dunbar JC, Hu Y, Lu H. Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats. Diabetes 1997; 46:2040-2043.
    • (1997) Diabetes , vol.46 , pp. 2040-2043
    • Dunbar, J.C.1    Hu, Y.2    Lu, H.3
  • 4
    • 0031606279 scopus 로고    scopus 로고
    • Chronic leptin infusion increases arterial pressure
    • Shek EW, Brands MW, Hall JE. Chronic leptin infusion increases arterial pressure. Hypertension 1998; 31:409-414.
    • (1998) Hypertension , vol.31 , pp. 409-414
    • Shek, E.W.1    Brands, M.W.2    Hall, J.E.3
  • 5
    • 0035100787 scopus 로고    scopus 로고
    • Leptin acts in the central nervous system to produce dose-dependent changes in arterial pressure
    • Correia ML, Morgan DA, Sivitz WI, et al. Leptin acts in the central nervous system to produce dose-dependent changes in arterial pressure. Hypertension 2001; 37:936-942.
    • (2001) Hypertension , vol.37 , pp. 936-942
    • Correia, M.L.1    Morgan, D.A.2    Sivitz, W.I.3
  • 6
    • 0036179086 scopus 로고    scopus 로고
    • Chronic cardiovascular and renal actions of leptin: Role of adrenergic activity
    • Carlyle M, Jones OB, Kuo JJ, Hall JE. Chronic cardiovascular and renal actions of leptin: role of adrenergic activity. Hypertension 2002; 39:496-501.
    • (2002) Hypertension , vol.39 , pp. 496-501
    • Carlyle, M.1    Jones, O.B.2    Kuo, J.J.3    Hall, J.E.4
  • 7
    • 12944257370 scopus 로고    scopus 로고
    • Pathophysiological role of leptin in obesity-related hypertension
    • Aizawa-Abe M, Ogawa Y, Masuzaki H, et al. Pathophysiological role of leptin in obesity-related hypertension. J Clin Invest 2000; 105:1243-1252.
    • (2000) J Clin Invest , vol.105 , pp. 1243-1252
    • Aizawa-Abe, M.1    Ogawa, Y.2    Masuzaki, H.3
  • 8
    • 0032899719 scopus 로고    scopus 로고
    • Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic
    • Haynes WG, Morgan DA, Djalali A, et al. Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic. Hypertension 1999; 33:542-547.
    • (1999) Hypertension , vol.33 , pp. 542-547
    • Haynes, W.G.1    Morgan, D.A.2    Djalali, A.3
  • 9
    • 0035569847 scopus 로고    scopus 로고
    • Role of corticotrophin-releasing factor in effects of leptin on sympathetic nerve activity and arterial pressure
    • Correia ML, Morgan DA, Mitchell JL, et al. Role of corticotrophin- releasing factor in effects of leptin on sympathetic nerve activity and arterial pressure. Hypertension 2001; 38:384-388.
    • (2001) Hypertension , vol.38 , pp. 384-388
    • Correia, M.L.1    Morgan, D.A.2    Mitchell, J.L.3
  • 10
    • 0036668207 scopus 로고    scopus 로고
    • Differential modulation of leptin-induced sympathoexcitation by baroreflex activation
    • Hausberg M, Morgan DA, Chapleau MA, et al. Differential modulation of leptin-induced sympathoexcitation by baroreflex activation. J Hypertens 2002; 20:1633-1641. This interesting article demonstrates the dichotomy between the sympathetic actions of leptin on the thermogenic metabolism and cardio-renal homeostasis in rats. Thermogenic and cardio-renal sympathetic central nervous system networks responding to leptin might be completely distinct.
    • (2002) J Hypertens , vol.20 , pp. 1633-1641
    • Hausberg, M.1    Morgan, D.A.2    Chapleau, M.A.3
  • 11
    • 0036628739 scopus 로고    scopus 로고
    • Selective leptin resistance: A new concept in leptin physiology with cardiovascular implications
    • Mark AL, Correia ML, Rahmouni K, Haynes WG. Selective leptin resistance: a new concept in leptin physiology with cardiovascular implications. J Hypertens 2002; 20:1245-1250.
    • (2002) J Hypertens , vol.20 , pp. 1245-1250
    • Mark, A.L.1    Correia, M.L.2    Rahmouni, K.3    Haynes, W.G.4
  • 12
    • 0036066483 scopus 로고    scopus 로고
    • The concept of selective leptin resistance: Evidence from agouti yellow obese mice
    • Correia ML, Haynes WG, Rahmouni K, et al. The concept of selective leptin resistance: evidence from agouti yellow obese mice. Diabetes 2002; 51:439-442.
    • (2002) Diabetes , vol.51 , pp. 439-442
    • Correia, M.L.1    Haynes, W.G.2    Rahmouni, K.3
  • 13
    • 0036179425 scopus 로고    scopus 로고
    • Selective resistance to central neural administration of leptin in agouti obese mice
    • Rahmouni K, Haynes WG, Morgan DA, Mark AL. Selective resistance to central neural administration of leptin in agouti obese mice. Hypertension 2002; 39:486-490.
    • (2002) Hypertension , vol.39 , pp. 486-490
    • Rahmouni, K.1    Haynes, W.G.2    Morgan, D.A.3    Mark, A.L.4
  • 14
    • 1642272688 scopus 로고    scopus 로고
    • Selective leptin resistance during high fat diet in mice: Preservation sympathetic activation despite attenuation of metabolic responses
    • Morgan DA, Rahmouni K, Mark AL, et al. Selective leptin resistance during high fat diet in mice: preservation sympathetic activation despite attenuation of metabolic responses [abstract]. Hypertension 2001; 38:34.
    • (2001) Hypertension , vol.38 , pp. 34
    • Morgan, D.A.1    Rahmouni, K.2    Mark, A.L.3
  • 15
    • 1642319974 scopus 로고    scopus 로고
    • Renal-specific preservation of sympathoexcitatory effect of leptin in diet-induced obese mice
    • Rahmouni K, Morgan DA, Morgan GM, et al. Renal-specific preservation of sympathoexcitatory effect of leptin in diet-induced obese mice [abstract]. Hypertension 2003; 42:421.
    • (2003) Hypertension , vol.42 , pp. 421
    • Rahmouni, K.1    Morgan, D.A.2    Morgan, G.M.3
  • 16
    • 0038334588 scopus 로고    scopus 로고
    • Interactions between leptin and the human sympathetic nervous system
    • Eikelis N, Schlaich M, Aggarwal A, et al. Interactions between leptin and the human sympathetic nervous system. Hypertension 2003; 41:1072-1079. This correlation study suggests that leptinemia might be associated with increased renal sympathetic outflow in humans. The best evidence available of leptin sympathetic actions in humans derives from correlation studies because leptin has been rarely administered to human subjects.
    • (2003) Hypertension , vol.41 , pp. 1072-1079
    • Eikelis, N.1    Schlaich, M.2    Aggarwal, A.3
  • 17
    • 0034455966 scopus 로고    scopus 로고
    • Plasma leptin concentrations and cardiac autonomic nervous system in healthy subjects with different body weights
    • Paolisso G, Manzella D, Montano N, et al. Plasma leptin concentrations and cardiac autonomic nervous system in healthy subjects with different body weights. J Clin Endocrinol Metab 2000; 85:1810-1814.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 1810-1814
    • Paolisso, G.1    Manzella, D.2    Montano, N.3
  • 18
    • 0035017407 scopus 로고    scopus 로고
    • Leptin interacts with heart rate but not sympathetic nerve traffic in healthy male subjects
    • Narkiewicz K, Kato M, Phillips BG, et al. Leptin interacts with heart rate but not sympathetic nerve traffic in healthy male subjects. J Hypertens 2001; 19:1089-1094.
    • (2001) J Hypertens , vol.19 , pp. 1089-1094
    • Narkiewicz, K.1    Kato, M.2    Phillips, B.G.3
  • 19
    • 0242351760 scopus 로고    scopus 로고
    • Bound leptin and sympathetic outflow in nonobese men
    • Tank J, Jordan J, Diedrich A, et al. Bound leptin and sympathetic outflow in nonobese men. J Clin Endocrinol Metab 2003; 88:4955-4959.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 4955-4959
    • Tank, J.1    Jordan, J.2    Diedrich, A.3
  • 20
    • 0034005470 scopus 로고    scopus 로고
    • Free and protein bound leptin are distinct and independently controlled factors in energy regulation
    • Brabant G, Horn R, von zur Muhlen A, et al. Free and protein bound leptin are distinct and independently controlled factors in energy regulation. Diabetologia 2000; 43:438-442.
    • (2000) Diabetologia , vol.43 , pp. 438-442
    • Brabant, G.1    Horn, R.2    Von Zur Muhlen, A.3
  • 21
    • 0037907471 scopus 로고    scopus 로고
    • Pivotal role of nitric oxide in the control of blood pressure after leptin administration
    • Fruhbeck G. Pivotal role of nitric oxide in the control of blood pressure after leptin administration. Diabetes 1999; 48:903-908.
    • (1999) Diabetes , vol.48 , pp. 903-908
    • Fruhbeck, G.1
  • 22
    • 0033978467 scopus 로고    scopus 로고
    • Leptin induces direct vasodilation through distinct endothelial mechanisms
    • Lembo G, Vecchione C, Fratta L, et al. Leptin induces direct vasodilation through distinct endothelial mechanisms. Diabetes 2000; 49:293-297.
    • (2000) Diabetes , vol.49 , pp. 293-297
    • Lembo, G.1    Vecchione, C.2    Fratta, L.3
  • 23
    • 0035094738 scopus 로고    scopus 로고
    • Inhibition of NO synthesis enhances chronic cardiovascular and renal actions of leptin
    • Kuo JJ, Jones OB, Hall JE. Inhibition of NO synthesis enhances chronic cardiovascular and renal actions of leptin. Hypertension 2001; 37:670-676.
    • (2001) Hypertension , vol.37 , pp. 670-676
    • Kuo, J.J.1    Jones, O.B.2    Hall, J.E.3
  • 24
    • 0033672015 scopus 로고    scopus 로고
    • Reduction of obesity, as induced by leptin, reverses endothelial dysfunction in obese (Lep(ob)) mice
    • Winters B, Mo Z, Brooks-Asplund E, et al. Reduction of obesity, as induced by leptin, reverses endothelial dysfunction in obese (Lep(ob)) mice. J Appl Physiol 2000; 89:2382-2390.
    • (2000) J Appl Physiol , vol.89 , pp. 2382-2390
    • Winters, B.1    Mo, Z.2    Brooks-Asplund, E.3
  • 25
    • 0036091969 scopus 로고    scopus 로고
    • Leptin effect on endothelial nitric oxide is mediated through Akt-endothelial nitric oxide synthase phosphorylation pathway
    • Vecchione C, Maffei A, Colella S, et al. Leptin effect on endothelial nitric oxide is mediated through Akt-endothelial nitric oxide synthase phosphorylation pathway. Diabetes 2002; 51:168-173.
    • (2002) Diabetes , vol.51 , pp. 168-173
    • Vecchione, C.1    Maffei, A.2    Colella, S.3
  • 26
    • 0042767516 scopus 로고    scopus 로고
    • Cooperation between insulin and leptin in the modulation of vascular tone
    • Vecchione C, Aretini A, Maffei A, et al. Cooperation between insulin and leptin in the modulation of vascular tone. Hypertension 2003; 42:166-170. This interesting article demonstrates that insulin and leptin cooperate to increase nitric oxide release from the vascular endothelium. The cross-talk between leptin and insulin might have an important role in the metabolic syndrome.
    • (2003) Hypertension , vol.42 , pp. 166-170
    • Vecchione, C.1    Aretini, A.2    Maffei, A.3
  • 27
    • 0030737573 scopus 로고    scopus 로고
    • Effects of leptin on insulin sensitivity in normal rats
    • Sivitz WI, Walsh SA, Morgan DA, et al. Effects of leptin on insulin sensitivity in normal rats. Endocrinology 1997; 138:3395-3401.
    • (1997) Endocrinology , vol.138 , pp. 3395-3401
    • Sivitz, W.I.1    Walsh, S.A.2    Morgan, D.A.3
  • 28
    • 0035725056 scopus 로고    scopus 로고
    • Does leptin stimulate nitric oxide to oppose the effects of sympathetic activation?
    • Mitchell JL, Morgan DA, Correia ML, et al. Does leptin stimulate nitric oxide to oppose the effects of sympathetic activation? Hypertension 2001; 38:1081-1086.
    • (2001) Hypertension , vol.38 , pp. 1081-1086
    • Mitchell, J.L.1    Morgan, D.A.2    Correia, M.L.3
  • 29
    • 0034121709 scopus 로고    scopus 로고
    • Regional haemodynamic effects of recombinant murine or human leptin in conscious rats
    • Gardiner SM, Kemp PA, March JE, Bennett T. Regional haemodynamic effects of recombinant murine or human leptin in conscious rats. J Pharmacol 2000; 130:805-810.
    • (2000) J Pharmacol , vol.130 , pp. 805-810
    • Gardiner, S.M.1    Kemp, P.A.2    March, J.E.3    Bennett, T.4
  • 30
    • 0034957788 scopus 로고    scopus 로고
    • Does leptin cause functional peripheral sympatholysis?
    • Jalali A, Morgan DA, Sivitz WI, et al. Does leptin cause functional peripheral sympatholysis? Am J Hypertens 2001; 14:615-618.
    • (2001) Am J Hypertens , vol.14 , pp. 615-618
    • Jalali, A.1    Morgan, D.A.2    Sivitz, W.I.3
  • 31
    • 0036238115 scopus 로고    scopus 로고
    • Leptin causes vasodilation in humans
    • Nakagawa K, Higashi Y, Sasaki S, et al. Leptin causes vasodilation in humans. Hypertens Res 2002; 25:161-165.
    • (2002) Hypertens Res , vol.25 , pp. 161-165
    • Nakagawa, K.1    Higashi, Y.2    Sasaki, S.3
  • 32
    • 0037301213 scopus 로고    scopus 로고
    • Leptin causes nitric-oxide independent coronary artery vasodilation in humans
    • Matsuda K, Teragawa H, Fukuda Y, et al. Leptin causes nitric-oxide independent coronary artery vasodilation in humans. Hypertens Res 2003; 26:147-152. This interesting article demonstrates the vasodilator action of high doses of leptin on human coronary arteries in vivo. Leptin-induced coronary vasodilation appears to be independent of nitric oxide release by the vascular endothelium.
    • (2003) Hypertens Res , vol.26 , pp. 147-152
    • Matsuda, K.1    Teragawa, H.2    Fukuda, Y.3
  • 33
    • 0030771886 scopus 로고    scopus 로고
    • Human leptin has natriuretic activity in the rat
    • Jackson EK, Li P. Human leptin has natriuretic activity in the rat. Am J Physiol Renal Physiol 1997; 272:F333-F338.
    • (1997) Am J Physiol Renal Physiol , vol.272
    • Jackson, E.K.1    Li, P.2
  • 35
    • 0033849818 scopus 로고    scopus 로고
    • Effects of renal denervation on the sodium excretory actions of leptin in hypertensive rats
    • Villarreal D, Reams G, Freeman RH. Effects of renal denervation on the sodium excretory actions of leptin in hypertensive rats. Kidney Int 2000; 58:989-994.
    • (2000) Kidney Int , vol.58 , pp. 989-994
    • Villarreal, D.1    Reams, G.2    Freeman, R.H.3
  • 36
    • 0037383112 scopus 로고    scopus 로고
    • Chronic cardiovascular and renal actions of leptin during hyperinsulinemia
    • Kuo JJ, Jones OB, Hall JE. Chronic cardiovascular and renal actions of leptin during hyperinsulinemia. Am J Physiol Regul lntegr Comp Physiol 2003; 284:R1037-R1042. This article shows that chronic leptin administration potentiates the pressor effect of chronic hyperinsulinemia in rats.
    • (2003) Am J Physiol Regul Lntegr Comp Physiol , vol.284
    • Kuo, J.J.1    Jones, O.B.2    Hall, J.E.3
  • 37
    • 0037382503 scopus 로고    scopus 로고
    • Sexual dimorphism in cafeteria diet-induced hypertension is associated with gender-related difference in renal leptin receptor down-regulation
    • Coatmellec-Taglioni G, Dausse JP, Giudicelli Y, Ribiere C. Sexual dimorphism in cafeteria diet-induced hypertension is associated with gender-related difference in renal leptin receptor down-regulation. J Pharmacol Exp Ther 2003; 305:362-367.
    • (2003) J Pharmacol Exp Ther , vol.305 , pp. 362-367
    • Coatmellec-Taglioni, G.1    Dausse, J.P.2    Giudicelli, Y.3    Ribiere, C.4
  • 38
    • 0036280459 scopus 로고    scopus 로고
    • Human leptin administered intraperitoneally stimulates natriuresis and decreases renal medullary Na+, K+-ATPase activity in the rat: Impaired effect in dietary-induced obesity
    • Beltowski J, Wjcicka G, Gorny D, Marciniak A. Human leptin administered intraperitoneally stimulates natriuresis and decreases renal medullary Na+, K+-ATPase activity in the rat: impaired effect in dietary-induced obesity. Med Sci Monit 2002; 8:BR221-BR229.
    • (2002) Med Sci Monit , vol.8
    • Beltowski, J.1    Wjcicka, G.2    Gorny, D.3    Marciniak, A.4
  • 39
    • 0036269954 scopus 로고    scopus 로고
    • Angiotensin II increases leptin secretion by 3T3-L1 and human adipocytes via a prostaglandin-independent mechanism
    • Kim S, Whelan J, Claycombe K, et al. Angiotensin II increases leptin secretion by 3T3-L1 and human adipocytes via a prostaglandin-independent mechanism. J Nutr 2002; 132:1135-1140.
    • (2002) J Nutr , vol.132 , pp. 1135-1140
    • Kim, S.1    Whelan, J.2    Claycombe, K.3
  • 40
    • 0346458801 scopus 로고    scopus 로고
    • Differential effects of local versus systemic angiotensin II in the regulation of leptin release from adipocytes
    • Cassis LA, English VL, Bharadwaj K, Boustany CM. Differential effects of local versus systemic angiotensin II in the regulation of leptin release from adipocytes. Endocrinology 2004; 145:169-174. This article demonstrates that adipocyte-derived angiotensin II increases leptin release.
    • (2004) Endocrinology , vol.145 , pp. 169-174
    • Cassis, L.A.1    English, V.L.2    Bharadwaj, K.3    Boustany, C.M.4
  • 41
    • 0031714508 scopus 로고    scopus 로고
    • Relationship between angiotensinogen, leptin and blood pressure levels in young normotensive men
    • Schorr U, Blaschke K, Turan S, et al. Relationship between angiotensinogen, leptin and blood pressure levels in young normotensive men. J Hypertens 1998; 16:1475-1480.
    • (1998) J Hypertens , vol.16 , pp. 1475-1480
    • Schorr, U.1    Blaschke, K.2    Turan, S.3
  • 42
    • 0033839427 scopus 로고    scopus 로고
    • Relationship between plasma renin profile and leptinaemia in patients with essential hypertension
    • Adamczak M, Kokot F, Wiecek AW. Relationship between plasma renin profile and leptinaemia in patients with essential hypertension. J Hum Hypertens 2000; 14:503-509.
    • (2000) J Hum Hypertens , vol.14 , pp. 503-509
    • Adamczak, M.1    Kokot, F.2    Wiecek, A.W.3
  • 43
    • 0036185588 scopus 로고    scopus 로고
    • Sympathetic nervous system and the kidney in hypertension
    • DiBona GF. Sympathetic nervous system and the kidney in hypertension. Curr Opin Nephrol Hypertens 2002; 11:197-200.
    • (2002) Curr Opin Nephrol Hypertens , vol.11 , pp. 197-200
    • DiBona, G.F.1
  • 44
    • 0030699352 scopus 로고    scopus 로고
    • High plasma immunoreactive leptin level in essential hypertension
    • Agata J, Masuda A, Takada M, et al. High plasma immunoreactive leptin level in essential hypertension. Am J Hypertens 1997; 10:1171-1174.
    • (1997) Am J Hypertens , vol.10 , pp. 1171-1174
    • Agata, J.1    Masuda, A.2    Takada, M.3
  • 45
    • 0034578415 scopus 로고    scopus 로고
    • Elevated serum leptin concentrations in women with components of multiple risk factor clustering syndrome
    • Matsubara M, Chiba H, Maruoka S, Katayose S. Elevated serum leptin concentrations in women with components of multiple risk factor clustering syndrome. J Atheroscler Thromb 2000; 7:231-237.
    • (2000) J Atheroscler Thromb , vol.7 , pp. 231-237
    • Matsubara, M.1    Chiba, H.2    Maruoka, S.3    Katayose, S.4
  • 46
    • 0031775895 scopus 로고    scopus 로고
    • Hyperleptinemia as a component of a metabolic syndrome of cardiovascular risk
    • Leyva F, Godsland IF, Ghatei M, et al. Hyperleptinemia as a component of a metabolic syndrome of cardiovascular risk. Arterioscler Thromb Vasc Biol 1998; 18:928-933.
    • (1998) Arterioscler Thromb Vasc Biol , vol.18 , pp. 928-933
    • Leyva, F.1    Godsland, I.F.2    Ghatei, M.3
  • 47
    • 0032980313 scopus 로고    scopus 로고
    • Leptin and variables of body adiposity, energy balance, and insulin resistance in a population-based study. The Hoom Study
    • Ruige JB, Dekker JM, Blum WF, et al. Leptin and variables of body adiposity, energy balance, and insulin resistance in a population-based study. The Hoom Study. Diabetes Care 1999; 22:1097-1104.
    • (1999) Diabetes Care , vol.22 , pp. 1097-1104
    • Ruige, J.B.1    Dekker, J.M.2    Blum, W.F.3
  • 48
    • 0037735382 scopus 로고    scopus 로고
    • Plasma leptin and blood pressure in men: Graded association independent of body mass and fat pattern
    • Barba G, Russo O, Siani A, et al. Plasma leptin and blood pressure in men: graded association independent of body mass and fat pattern. Obes Res 2003; 11:160-166.
    • (2003) Obes Res , vol.11 , pp. 160-166
    • Barba, G.1    Russo, O.2    Siani, A.3
  • 49
    • 0036072768 scopus 로고    scopus 로고
    • Leptin gene polymorphism is associated with hypertension independent of obesity
    • Shintani M, Ikegami H, Fujisawa T, et al. Leptin gene polymorphism is associated with hypertension independent of obesity. J Clin Endocrinol Metab 2002; 87:2909-2912.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2909-2912
    • Shintani, M.1    Ikegami, H.2    Fujisawa, T.3
  • 50
    • 0033694380 scopus 로고    scopus 로고
    • Hypertension in obesity and the leptin receptor gene locus
    • Rosmond R, Chagnon YC, Holm G, et al. Hypertension in obesity and the leptin receptor gene locus. J Clin Endocrinol Metab 2000; 85:3126-3131.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 3126-3131
    • Rosmond, R.1    Chagnon, Y.C.2    Holm, G.3
  • 51
    • 0034548220 scopus 로고    scopus 로고
    • Elevated circulating leptin levels in arterial hypertension: Relationship to arteriovenous overflow and extraction of leptin
    • Lond
    • Henriksen JH, Holst JJ, Moller S, et al. Elevated circulating leptin levels in arterial hypertension: relationship to arteriovenous overflow and extraction of leptin. Clin Sci (Lond) 2000; 99:527-534.
    • (2000) Clin Sci , vol.99 , pp. 527-534
    • Henriksen, J.H.1    Holst, J.J.2    Moller, S.3
  • 52
    • 0033862646 scopus 로고    scopus 로고
    • Gender-dependent differences in plasma leptin in essential hypertension
    • Mallamaci F, Cuzzola F, Tripepi G, et al. Gender-dependent differences in plasma leptin in essential hypertension. Am J Hypertens 2000; 13:914-920.
    • (2000) Am J Hypertens , vol.13 , pp. 914-920
    • Mallamaci, F.1    Cuzzola, F.2    Tripepi, G.3
  • 53
    • 0036841320 scopus 로고    scopus 로고
    • Gender-specific correlates of leptin with hypertension-related phenotypes in African Americans
    • El-Gharbawy AH, Kotchen JM, Grim CE, et al. Gender-specific correlates of leptin with hypertension-related phenotypes in African Americans. Am J Hypertens 2002; 15:989-993.
    • (2002) Am J Hypertens , vol.15 , pp. 989-993
    • El-Gharbawy, A.H.1    Kotchen, J.M.2    Grim, C.E.3
  • 54
    • 0031866518 scopus 로고    scopus 로고
    • Genetic markers at the leptin (OB) locus are not significantly linked to hypertension in African Americans
    • Rutkowski MP, Klanke CA, Su YR, et al. Genetic markers at the leptin (OB) locus are not significantly linked to hypertension in African Americans. Hypertension 1998; 31:1230-1234.
    • (1998) Hypertension , vol.31 , pp. 1230-1234
    • Rutkowski, M.P.1    Klanke, C.A.2    Su, Y.R.3
  • 55
    • 0035122578 scopus 로고    scopus 로고
    • Leptin concentrations in relation to overall adiposity, fat distribution, and blood pressure in a rural Chinese population
    • Hu FB, Chen C, Wang B, et al. Leptin concentrations in relation to overall adiposity, fat distribution, and blood pressure in a rural Chinese population. Int J Obes Relat Metab Disord 2001; 25:121-125.
    • (2001) Int J Obes Relat Metab Disord , vol.25 , pp. 121-125
    • Hu, F.B.1    Chen, C.2    Wang, B.3
  • 56
    • 0034013813 scopus 로고    scopus 로고
    • No evidence for leptin as an independent associate of blood pressure in childhood and juvenile obesity
    • Sudi KM, Gallistl S, Weinhandl G, et al. No evidence for leptin as an independent associate of blood pressure in childhood and juvenile obesity. J Pediatr Endocrinol Metab 2000; 13:513-521.
    • (2000) J Pediatr Endocrinol Metab , vol.13 , pp. 513-521
    • Sudi, K.M.1    Gallistl, S.2    Weinhandl, G.3
  • 57
    • 0035109540 scopus 로고    scopus 로고
    • Obesity, leptin and blood pressure among children in Taiwan: The Taipei Children's Heart Study
    • Chu NF, Wang DJ, Shieh SM. Obesity, leptin and blood pressure among children in Taiwan: the Taipei Children's Heart Study. Am J Hypertens 2001; 14:135-140.
    • (2001) Am J Hypertens , vol.14 , pp. 135-140
    • Chu, N.F.1    Wang, D.J.2    Shieh, S.M.3
  • 58
    • 0032693812 scopus 로고    scopus 로고
    • Elevated plasma immunoreactive leptin levels preexist in healthy offspring of patients with essential hypertension
    • Makris TK, Stavroulakis GA, Krespi PG, et al. Elevated plasma immunoreactive leptin levels preexist in healthy offspring of patients with essential hypertension. Am Heart J 1999; 138:922-925.
    • (1999) Am Heart J , vol.138 , pp. 922-925
    • Makris, T.K.1    Stavroulakis, G.A.2    Krespi, P.G.3
  • 59
    • 0032707747 scopus 로고    scopus 로고
    • Plasma leptin level is associated with myocardial wall thickness in hypertensive insulin-resistant men
    • Paolisso G, Tagliamonte MR, Galderisi M, et al. Plasma leptin level is associated with myocardial wall thickness in hypertensive insulin-resistant men. Hypertension 1999; 34:1047-1052.
    • (1999) Hypertension , vol.34 , pp. 1047-1052
    • Paolisso, G.1    Tagliamonte, M.R.2    Galderisi, M.3
  • 60
    • 0041857804 scopus 로고    scopus 로고
    • The obesity-associated peptide leptin induces hypertrophy in neonatal rat ventricular myocytes
    • Rajapurohitam V, Gan XT, Kirshenbaum LA, Karmazyn M. The obesity-associated peptide leptin induces hypertrophy in neonatal rat ventricular myocytes. Circ Res 2003; 93:277-279. This article demonstrates that leptin has a direct hypertrophic effect on cultured neonatal rodent myocytes. However, neonatal myocyte trophic responses to leptin may be significantly different from adult myocardial cell responses.
    • (2003) Circ Res , vol.93 , pp. 277-279
    • Rajapurohitam, V.1    Gan, X.T.2    Kirshenbaum, L.A.3    Karmazyn, M.4
  • 61
    • 0042018759 scopus 로고    scopus 로고
    • Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice
    • Barouch LA, Berkowitz DE, Harrison RW, et al. Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. Circulation 2003; 108:754-759. This important article demonstrates that leptin possesses anti-hypertrophic effects in the hearts of adult mice. It is suggested that impaired leptin signaling may play an important role in the pathogenesis of left ventricular hypertrophy.
    • (2003) Circulation , vol.108 , pp. 754-759
    • Barouch, L.A.1    Berkowitz, D.E.2    Harrison, R.W.3
  • 62
    • 0033775092 scopus 로고    scopus 로고
    • Leptin attenuates cardiac contraction in rat ventricular myocytes: Role of NO
    • Nickola MW, Wold LE, Colligan PB, et al. Leptin attenuates cardiac contraction in rat ventricular myocytes: role of NO. Hypertension 2000; 36:501-505.
    • (2000) Hypertension , vol.36 , pp. 501-505
    • Nickola, M.W.1    Wold, L.E.2    Colligan, P.B.3
  • 63
    • 0036157726 scopus 로고    scopus 로고
    • Abrogated leptin-induced cardiac contractile response in ventricular myocytes under spontaneous hypertension: Role of JAK/STAT pathway
    • Wold LE, Relling DP, Duan J, et al. Abrogated leptin-induced cardiac contractile response in ventricular myocytes under spontaneous hypertension: role of JAK/STAT pathway. Hypertension 2002; 39:69-74.
    • (2002) Hypertension , vol.39 , pp. 69-74
    • Wold, L.E.1    Relling, D.P.2    Duan, J.3
  • 64
    • 0032862037 scopus 로고    scopus 로고
    • Leptin is associated with increased risk of myocardial infarction
    • Soderberg S, Ahren B, Jansson JH, et al. Leptin is associated with increased risk of myocardial infarction. J Intern Med 1999; 246:409-418.
    • (1999) J Intern Med , vol.246 , pp. 409-418
    • Soderberg, S.1    Ahren, B.2    Jansson, J.H.3
  • 65
    • 0037242940 scopus 로고    scopus 로고
    • High leptin levels are associated with stroke
    • Soderberg S, Stegmayr B, Ahlbeck-Glader C, et al. High leptin levels are associated with stroke. Cerebrovasc Dis 2003; 15:63-69. This article reports a case-control study suggesting that leptin might be associated with stroke.
    • (2003) Cerebrovasc Dis , vol.15 , pp. 63-69
    • Soderberg, S.1    Stegmayr, B.2    Ahlbeck-Glader, C.3
  • 66
    • 0035909997 scopus 로고    scopus 로고
    • Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS)
    • Wallace AM, McMahon AD, Packard CJ, et al. Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS). Circulation 2001; 104:3052-3056.
    • (2001) Circulation , vol.104 , pp. 3052-3056
    • Wallace, A.M.1    McMahon, A.D.2    Packard, C.J.3
  • 67
    • 0035206659 scopus 로고    scopus 로고
    • Leptin stimulates rat aortic smooth muscle cell proliferation and migration
    • Oda A, Taniguchi T, Yokoyama M. Leptin stimulates rat aortic smooth muscle cell proliferation and migration. Kobe J Med Sci 2001; 47:141-150.
    • (2001) Kobe J Med Sci , vol.47 , pp. 141-150
    • Oda, A.1    Taniguchi, T.2    Yokoyama, M.3
  • 68
    • 0035844031 scopus 로고    scopus 로고
    • Leptin enhances the calcification of vascular cells: Artery wall as a target of leptin
    • Parhami F, Tintut Y, Ballard A, et al. Leptin enhances the calcification of vascular cells: artery wall as a target of leptin. Circ Res 2001; 88:954-960.
    • (2001) Circ Res , vol.88 , pp. 954-960
    • Parhami, F.1    Tintut, Y.2    Ballard, A.3
  • 69
    • 0242721942 scopus 로고    scopus 로고
    • Neointimal formation after endovascular arterial injury is markedly attenuated in db/db mice
    • Stephenson K, Tunstead J, Tsai A, et al. Neointimal formation after endovascular arterial injury is markedly attenuated in db/db mice. Arterioscler Thromb Vasc Biol 2003; 23:2027-2033. This article shows that impaired leptin signaling in leptin-receptor-deficient db/db mice substantially reduces (by 90%) neointimal formation after endovascular experimental lesion, suggesting a role of leptin in the restenosis process.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 2027-2033
    • Stephenson, K.1    Tunstead, J.2    Tsai, A.3
  • 70
    • 0035816639 scopus 로고    scopus 로고
    • Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A
    • Yamagishi SI, Edelstein D, Du XL, et al. Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A. J Biol Chem 2001; 276:25096-25100.
    • (2001) J Biol Chem , vol.276 , pp. 25096-25100
    • Yamagishi, S.I.1    Edelstein, D.2    Du, X.L.3
  • 71
    • 0042696057 scopus 로고    scopus 로고
    • Leptin decreases plasma paraoxonase 1 (PON1) activity and induces oxidative stress: The possible novel mechanism for proatherogenic effect of chronic hyperleptinemia
    • Beltowski J, Wojcicka G, Jamroz A. Leptin decreases plasma paraoxonase 1 (PON1) activity and induces oxidative stress: the possible novel mechanism for proatherogenic effect of chronic hyperleptinemia. Atherosclerosis 2003; 170:21-29. This important article shows that leptin-dependent reductions of PON1 are followed by increased oxidative stress in rats. Chronic increases in leptin-induced oxidative stress could potentially contribute to atherogenesis.
    • (2003) Atherosclerosis , vol.170 , pp. 21-29
    • Beltowski, J.1    Wojcicka, G.2    Jamroz, A.3
  • 72
    • 0043268732 scopus 로고    scopus 로고
    • Leptin increases lipoprotein lipase secretion by macrophages: Involvement of oxidative stress and protein kinase C
    • Maingrette F, Renier G. Leptin increases lipoprotein lipase secretion by macrophages: involvement of oxidative stress and protein kinase C. Diabetes 2003; 52:2121-2128.
    • (2003) Diabetes , vol.52 , pp. 2121-2128
    • Maingrette, F.1    Renier, G.2
  • 73
    • 0034016962 scopus 로고    scopus 로고
    • Endothelial dysfunction as a possible link between C-reactive protein levels and cardiovascular disease
    • Lond
    • Cleland SJ, Sattar N, Petrie JR, et al. Endothelial dysfunction as a possible link between C-reactive protein levels and cardiovascular disease. Clin Sci (Lond) 2000; 98:531-535.
    • (2000) Clin Sci , vol.98 , pp. 531-535
    • Cleland, S.J.1    Sattar, N.2    Petrie, J.R.3
  • 74
    • 0031965266 scopus 로고    scopus 로고
    • Leptin regulates proinflammatory immune responses
    • Loffreda S, Yang SQ, Lin HZ, et al. Leptin regulates proinflammatory immune responses. FASEB J 1998; 12:57-65.
    • (1998) FASEB J , vol.12 , pp. 57-65
    • Loffreda, S.1    Yang, S.Q.2    Lin, H.Z.3
  • 75
    • 0141459376 scopus 로고    scopus 로고
    • C-reactive protein in young, apparently healthy men: Associations with serum leptin, QTc interval, and high-density lipoprotein-cholesterol
    • Kazumi T, Kawaguchi A, Hirano T, Yoshino G. C-reactive protein in young, apparently healthy men: associations with serum leptin, QTc interval, and high-density lipoprotein-cholesterol. Metabolism 2003; 52:1113-1116.
    • (2003) Metabolism , vol.52 , pp. 1113-1116
    • Kazumi, T.1    Kawaguchi, A.2    Hirano, T.3    Yoshino, G.4
  • 76
    • 0037044397 scopus 로고    scopus 로고
    • Influence of leptin on arterial distensibility: A novel link between obesity and cardiovascular disease?
    • Singhal A, Farooqi IS, Cole TJ, et al. Influence of leptin on arterial distensibility: a novel link between obesity and cardiovascular disease? Circulation 2002; 106:1919-1924.
    • (2002) Circulation , vol.106 , pp. 1919-1924
    • Singhal, A.1    Farooqi, I.S.2    Cole, T.J.3
  • 77
    • 0035179087 scopus 로고    scopus 로고
    • Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity
    • Konstantinides S, Schafer K, Koschnick S, Loskutoff DJ. Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. J Clin Invest 2001; 108:1533-1540.
    • (2001) J Clin Invest , vol.108 , pp. 1533-1540
    • Konstantinides, S.1    Schafer, K.2    Koschnick, S.3    Loskutoff, D.J.4
  • 78
    • 0037012483 scopus 로고    scopus 로고
    • Effect of leptin on arterial thrombosis following vascular injury in mice
    • Bodary PF, Westrick RJ, Wickenheiser KJ, et al. Effect of leptin on arterial thrombosis following vascular injury in mice. JAMA 2002; 287:1706-1709.
    • (2002) JAMA , vol.287 , pp. 1706-1709
    • Bodary, P.F.1    Westrick, R.J.2    Wickenheiser, K.J.3
  • 79
    • 0034122291 scopus 로고    scopus 로고
    • Effect of leptin in platelet and endothelial cells. Obesity and arterial thrombosis
    • Maruyama I, Nakata M, Yamaji K. Effect of leptin in platelet and endothelial cells. Obesity and arterial thrombosis. Ann N Y Acad Sci 2000; 902:315-319.
    • (2000) Ann N Y Acad Sci , vol.902 , pp. 315-319
    • Maruyama, I.1    Nakata, M.2    Yamaji, K.3
  • 80
    • 0032930738 scopus 로고    scopus 로고
    • Plasma leptin levels are associated with abnormal fibrinolysis in men and postmenopausal women
    • Soderberg S, Olsson T, Eliasson M, et al. Plasma leptin levels are associated with abnormal fibrinolysis in men and postmenopausal women. J Intern Med 1999; 245:533-543.
    • (1999) J Intern Med , vol.245 , pp. 533-543
    • Soderberg, S.1    Olsson, T.2    Eliasson, M.3


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