The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid-imidazolide alters transforming growth factor β-dependent signaling and cell migration by affecting the cytoskeleton and the polarity complex

Journal of Biological Chemistry

Volumn 283, Issue 17, 2008, Pages 11700-11713

  To, Ciric ^a   Kulkarni, Sarang ^b   Pawson, Tony ^b   Honda, Tadashi ^c   Gribble, Gordon W ^c   Sporn, Michael B ^d   Wrana, Jeffrey L ^b   Di Guglielmo, Gianni M ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c Dartmouth College   (United States)

^d DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDS; BIOACTIVITY; CYTOLOGY; GROWTH (MATERIALS); PEPTIDES; PRESSURE EFFECTS;

BIOTINYLATED; CAPPING PROTEINS; CELL MIGRATIONS; CYTOSKELETON; ENDOSOMES; LEADING EDGES; MICROTUBULE; MICROTUBULE DYNAMICS; MICROTUBULE NETWORKS; MIGRATING CELLS; PERINUCLEAR REGIONS; PHOSPHATASE ACTIVITIES; POLARITY COMPLEXES; RECEPTOR TRAFFICKING; TRANSFORMING GROWTH FACTORS; TRITERPENOID;

CELL GROWTH;

2 CYANO 3,12 DIOXOOLEANA 1,9 DIEN 28 OIC ACID; 2 CYANO 3,12 DIOXOOLEANA 1,9 DIEN 28 OIC ACID IMIDAZOLIDE; EARLY ENDOSOME ANTIGEN 1; IMIDAZOLE DERIVATIVE; IQ MOTIF CONTAINING GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN 1; MICROTUBULE PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN; PROTEIN CLIP 170; PROTEIN KINASE C ZETA; PROTEIN PAR6; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; UNCLASSIFIED DRUG; 2-CYANO-3,12-DIOXOOLEAN-1,9-DIEN-28-OIC ACID; DRUG DERIVATIVE; OLEANOLIC ACID; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CELL POLARITY; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSKELETON; ENDOSOME; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; ACTIVE TRANSPORT; ANIMAL; BIOLOGICAL MODEL; CELL MOTION; CELL NUCLEUS; CELL STRAIN COS1; CERCOPITHECUS; FIBROBLAST; METABOLISM; MICROTUBULE; SIGNAL TRANSDUCTION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL MOVEMENT; CELL NUCLEUS; CERCOPITHECUS AETHIOPS; COS CELLS; CYTOSKELETON; FIBROBLASTS; IMIDAZOLES; MICROTUBULES; MODELS, BIOLOGICAL; OLEANOLIC ACID; RATS; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 45549096466     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M704064200     Document Type: Article

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