Peroxisome Proliferator-Activated Receptor-γ-Independent Repression of Collagenase Gene Expression by 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic Acid and Prostaglandin 15-Deoxy-Δ(12,14) J2: A Role for Smad Signaling

Molecular Pharmacology

Volumn 65, Issue 2, 2004, Pages 309-318

  Mix, Kimberlee S ^a   Coon, Charles I ^a   Rosen, Evan D ^b   Suh, Nanjoo ^a   Sporn, Michael B ^a   Brinckerhoff, Constance E ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXY 12,14 PROSTAGLANDIN J2; 15 DEOXY DELTA12,14 PROSTAGLANDIN J2; 15-DEOXY-12,14-PROSTAGLANDIN J2; 2 CHLORO 5 NITROBENZANILIDE; 2 CYANO 3,12 DIOXOOLEANA 1,9 DIEN 28 OIC ACID; 2-CYANO-3,12-DIOXOOLEAN-1,9-DIEN-28-OIC ACID; CELL RECEPTOR; COLLAGENASE; COLLAGENASE 3; COLLAGENASE INHIBITOR; DNA BINDING PROTEIN; DRUG DERIVATIVE; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE; MESSENGER RNA; OLEANOLIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA ANTAGONIST; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; PROPIONIC ACID DERIVATIVE; PROSTAGLANDIN D2; RECEPTOR BLOCKING AGENT; SMAD PROTEIN; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; TRITERPENOID; UNCLASSIFIED DRUG;

ANIMAL; ANIMAL CELL; ARTHRITIS; ARTICLE; BIOSYNTHESIS; CELL LINE; COMPARATIVE STUDY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME REPRESSION; EXTRACELLULAR MATRIX; FIBROBLAST; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE REPRESSION; GENETICS; HUMAN; MOUSE; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; CELL LINE; CELL LINE, TUMOR; COLLAGENASES; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME REPRESSION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MICE; OLEANOLIC ACID; PROSTAGLANDIN D2; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 1642457200     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.65.2.309     Document Type: Article

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