The FYVE domain in Smad anchor for receptor activation (SARA) is sufficient for localization of SARA in early endosomes and regulates TGF-β/Smad signalling

Genes to Cells

Volumn 7, Issue 3, 2002, Pages 321-331

  Itoh, Fumiko ^a   Divecha, Nullin ^a   Brocks, Lenny ^a   Oomen, Lauran ^a   Janssen, Hans ^a   Calafat, Jero ^a   Itoh, Susumu ^a   Dijke, Peter Ten ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; LIPID; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOLIPID DERIVATIVE; POLYPHOSPHOINOSITIDE; PROTEIN SERINE KINASE; RECOMBINANT PROTEIN; SMAD PROTEIN; THREONINE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; WORTMANNIN; ZINC FINGER PROTEIN;

ANIMAL CELL; ARTICLE; BINDING ASSAY; CONTROLLED STUDY; CYTOSOL; ENDOSOME; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION INITIATION;

ANDROSTADIENES; CARRIER PROTEINS; DNA-BINDING PROTEINS; ENDOSOMES; HELA CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PHOSPHATIDYLINOSITOL PHOSPHATES; PROTEIN STRUCTURE, TERTIARY; RAB5 GTP-BINDING PROTEINS; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA;

EID: 0036201871     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2443.2002.00519.x     Document Type: Article

References (42)

1. TβRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling
2. Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth
3. Smads as transcriptional co-modulators
4. The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway
5. Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
6. TGF-β receptor signaling
7. Smads: Transcriptional activators of TGF-β responses
8. Peripheral membrane proteins: FYVE sticky fingers
9. Multivesicular body morphogenesis requires phosphatidylinositol 3-kinase activity
10. The pleckstrin homology domain of phospholipase C-δ1 binds with high affinity to phosphatidylinositol 4,5-bisphosphate in bilayer membranes
11. FYVE fingers bind PtdIns(3)P
12. Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells
13. Cellular functions of phosphatidylinositol 3-phosphate and FYVE domain proteins
14. The adaptor molecule Disabled-2 links the transforming growth factor β receptors to the Smad pathway
15. Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-β, activin, and bone morphogenetic protein-inducible enhancer
16. Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors
17. The FYVE domain of early endosome antigen 1 is required for both phosphatidylinositol 3-phosphate and rab5 binding. Critical role of this dual interaction for endosomal localization
18. Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain
19. MADR2 is a substrate of the TGFβ receptor and its phosphorylation is required for nuclear accumulation and signaling
20. TGF-β signal transduction
21. Transcriptional control by the TGF-β/Smad signaling system
22. Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA
23. Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-β family of receptor serine-threonine kinases
24. A functional PtdIns(3)P-binding motif
25. The L45 loop in type I receptors for TGF-b family members is a critical determinant in specifying Smad isoform activation
26. FYVE and coiled-coil domains determine the specific localization of Hrs to early endosomes
27. Hrs recruits clathrin to early endosomes
28. Function of Hrs in endocytic trafficking and signalling
29. The transforming growth factor-βs
30. Endofin, an endosomal FYVE domain protein
31. EEA1 links PI(3)K function to Rab5 regulation of endosome fusion
32. The role of phosphoinositides in membrane transport
33. Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-β signaling
34. FYVE-finger proteins-effectors of an inositol lipid
35. Endosomal localization of the autoantigen EEAI is mediated by Zinc-binding FYVE finger
36. Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis
37. SARA, a FYVE domain protein that recruits Smad2 to the TGFβ receptor
38. Endosomal localization and receptor dynamics determine tyrosine phosphorylation of hepatocyte growth factor-regulated tyrosine kinase substrate
39. TGFβ signals through a heteromeric protein kinase receptor complex
40. Structural basis of Smad2 recognition by the Smad anchor for receptor activation
41. Transforming growth factor-β receptor-associated protein 1 is a Smad4 chaperone
42. SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P