-
1
-
-
0035856952
-
β cell death during progression to diabetes
-
Mathis D, Vence L, Benoist C. β cell death during progression to diabetes. Nature 2001; 414: 792-8.
-
(2001)
Nature
, vol.414
, pp. 792-798
-
-
Mathis, D.1
Vence, L.2
Benoist, C.3
-
3
-
-
0037219411
-
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
-
Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003; 52: 102-10.
-
(2003)
Diabetes
, vol.52
, pp. 102-110
-
-
Butler, A.E.1
Janson, J.2
Bonner-Weir, S.3
Ritzel, R.4
Rizza, R.A.5
Butler, P.C.6
-
4
-
-
0022827170
-
Mechanism of protein translocation across the endoplasmic reticulum membrane
-
Walter P, Lingappa VR. Mechanism of protein translocation across the endoplasmic reticulum membrane. Ann Rev Cell Biol 1986; 2: 499-516.
-
(1986)
Ann Rev Cell Biol
, vol.2
, pp. 499-516
-
-
Walter, P.1
Lingappa, V.R.2
-
5
-
-
0028170807
-
Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane
-
Walter P, Johnson AE. Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane. Ann Rev Cell Biol 1994; 10: 87-119.
-
(1994)
Ann Rev Cell Biol
, vol.10
, pp. 87-119
-
-
Walter, P.1
Johnson, A.E.2
-
6
-
-
0033566020
-
Glycoproteins: Glycan presentation and protein-fold stability
-
Wormald MR, Dwek RA. Glycoproteins: glycan presentation and protein-fold stability. Struct Fold Des 1999; 7: 155-60.
-
(1999)
Struct Fold Des
, vol.7
, pp. 155-160
-
-
Wormald, M.R.1
Dwek, R.A.2
-
7
-
-
0035424237
-
ER quality control: Towards an understanding at the molecular level
-
Ellgaard L, Helenius A. ER quality control: towards an understanding at the molecular level. Curr Opin Cell Biol 2001; 13: 431-7.
-
(2001)
Curr Opin Cell Biol
, vol.13
, pp. 431-437
-
-
Ellgaard, L.1
Helenius, A.2
-
8
-
-
0033521072
-
Setting the standards: Quality control in the secretory pathway
-
Ellgaard L, Molinari M, Helenius A. Setting the standards: quality control in the secretory pathway. Science 1999; 286: 1882-8.
-
(1999)
Science
, vol.286
, pp. 1882-1888
-
-
Ellgaard, L.1
Molinari, M.2
Helenius, A.3
-
9
-
-
0034689022
-
Conformational requirements for glycoprotein reglucosylation in the endoplasmic reticulum
-
Trombetta ES, Helenius A. Conformational requirements for glycoprotein reglucosylation in the endoplasmic reticulum. J Cell Biol 2000; 148: 1123-9.
-
(2000)
J Cell Biol
, vol.148
, pp. 1123-1129
-
-
Trombetta, E.S.1
Helenius, A.2
-
10
-
-
0000600344
-
Regulation and compartmentalization of lipid synthesis in yeast
-
Jones EW, Pringle JR, Broach JR, editors, New York: Cold Spring Harbor Laboratory Press, Plain view;
-
Paltauf F, Kohlwein SD, Henry SA. Regulation and compartmentalization of lipid synthesis in yeast. In: Jones EW, Pringle JR, Broach JR, editors. The molecular and cellular biology of the yeast Saccharomyces. New York: Cold Spring Harbor Laboratory Press, Plain view; 1992 p. 415-500.
-
(1992)
The molecular and cellular biology of the yeast Saccharomyces
, pp. 415-500
-
-
Paltauf, F.1
Kohlwein, S.D.2
Henry, S.A.3
-
11
-
-
0025516235
-
The endoplasmic reticulum and calcium storage
-
Koch GL. The endoplasmic reticulum and calcium storage. Bioessays 1990; 12: 527-31.
-
(1990)
Bioessays
, vol.12
, pp. 527-531
-
-
Koch, G.L.1
-
12
-
-
0036556684
-
The mammalian endoplasmic reticulum as a sensor for cellular stress
-
Ma Y, Hendershot LM. The mammalian endoplasmic reticulum as a sensor for cellular stress. Cell Stress Chaperones 2002; 7: 222-9.
-
(2002)
Cell Stress Chaperones
, vol.7
, pp. 222-229
-
-
Ma, Y.1
Hendershot, L.M.2
-
14
-
-
0032101239
-
The unfolded protein response: An intracellular signaling pathway with many surprising features
-
Sidrauski C, Chapman R, Walter P. The unfolded protein response: an intracellular signaling pathway with many surprising features. Trends Cell Biol 1998; 8: 245-9.
-
(1998)
Trends Cell Biol
, vol.8
, pp. 245-249
-
-
Sidrauski, C.1
Chapman, R.2
Walter, P.3
-
15
-
-
0034644111
-
ER stress response: Getting the UPR hand on misfolded proteins
-
Hampton RY. ER stress response: getting the UPR hand on misfolded proteins. Curr Biol 2000; 10: R518-21.
-
(2000)
Curr Biol
, vol.10
-
-
Hampton, R.Y.1
-
16
-
-
0035966320
-
The unfolding tale of the unfolded protein response
-
Ma Y, Hendershot LM. The unfolding tale of the unfolded protein response. Cell 2001; 107: 827-30.
-
(2001)
Cell
, vol.107
, pp. 827-830
-
-
Ma, Y.1
Hendershot, L.M.2
-
17
-
-
4444232905
-
The unfolded protein response - a stress signaling pathway of the endoplasmic reticulum
-
Shen X, Zhang K, Kaufman RJ. The unfolded protein response - a stress signaling pathway of the endoplasmic reticulum. J Chem Neuroanat 2004; 28: 79-92.
-
(2004)
J Chem Neuroanat
, vol.28
, pp. 79-92
-
-
Shen, X.1
Zhang, K.2
Kaufman, R.J.3
-
18
-
-
0032432673
-
-
Kim PS, Arvan P. Endocrinopathies in the family of endoplasmic reticulum (ER) storage diseases: disorders of protein trafficking and the role of ER molecular chaperones. Endocr Rev 1998; 19: 173-202.
-
Kim PS, Arvan P. Endocrinopathies in the family of endoplasmic reticulum (ER) storage diseases: disorders of protein trafficking and the role of ER molecular chaperones. Endocr Rev 1998; 19: 173-202.
-
-
-
-
19
-
-
0037018773
-
Endoplasmic reticulum storage diseases
-
Rutishauser J, Spiess M. Endoplasmic reticulum storage diseases. Swiss Med Wkly 2002; 132: 211-22.
-
(2002)
Swiss Med Wkly
, vol.132
, pp. 211-222
-
-
Rutishauser, J.1
Spiess, M.2
-
20
-
-
0024404910
-
Increased synthesis of secreted proteins induces expression of glucose-regulated proteins in butyrate-treated Chinese hamster ovary cells
-
Dorner AJ, Wasley LC, Kaufman RJ. Increased synthesis of secreted proteins induces expression of glucose-regulated proteins in butyrate-treated Chinese hamster ovary cells. J Biol Chem 1989; 264: 20602-7.
-
(1989)
J Biol Chem
, vol.264
, pp. 20602-20607
-
-
Dorner, A.J.1
Wasley, L.C.2
Kaufman, R.J.3
-
21
-
-
0037140419
-
Induction of protein aggregation in an early secretory compartment by elevation of expression level
-
Schroder M, Schafer R, Friedl P. Induction of protein aggregation in an early secretory compartment by elevation of expression level. Biotechnol Bioeng 2002; 78: 131-40.
-
(2002)
Biotechnol Bioeng
, vol.78
, pp. 131-140
-
-
Schroder, M.1
Schafer, R.2
Friedl, P.3
-
22
-
-
34249296456
-
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1
-
Iwakoshi NN, Lee AH, Vallabhajosyula P, Otipoby KL, Rajewsky K, Glimcher LH. Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat Immunol 2003; 4: 310-11.
-
(2003)
Nat Immunol
, vol.4
, pp. 310-311
-
-
Iwakoshi, N.N.1
Lee, A.H.2
Vallabhajosyula, P.3
Otipoby, K.L.4
Rajewsky, K.5
Glimcher, L.H.6
-
23
-
-
26444442450
-
Endoplasmic reticulum stress: Cell life and death decisions
-
Xu C, Bailly-Maitre B, Reed JC. Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 2005; 115: 2656-64.
-
(2005)
J Clin Invest
, vol.115
, pp. 2656-2664
-
-
Xu, C.1
Bailly-Maitre, B.2
Reed, J.C.3
-
24
-
-
0034716887
-
Tripartite management of unfolded proteins in the endoplasmic reticulum
-
Mori K. Tripartite management of unfolded proteins in the endoplasmic reticulum. Cell 2000; 101: 451-4.
-
(2000)
Cell
, vol.101
, pp. 451-454
-
-
Mori, K.1
-
25
-
-
0038446405
-
The unfolded protein response
-
Liu CY, Kaufman RJ. The unfolded protein response. J Cell Sci 2003; 116: 1861-2.
-
(2003)
J Cell Sci
, vol.116
, pp. 1861-1862
-
-
Liu, C.Y.1
Kaufman, R.J.2
-
26
-
-
0027305620
-
A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus
-
Mori K, Ma W, Gething MJ, Sambrook J. A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus. Cell 1993; 74: 743-56.
-
(1993)
Cell
, vol.74
, pp. 743-756
-
-
Mori, K.1
Ma, W.2
Gething, M.J.3
Sambrook, J.4
-
27
-
-
0031755020
-
Identification and characterization of pancreatic eukaryotic initiation factor 2 α-subunit kinase, PEK, involved in translational control
-
Shi Y, Vattem KM, Sood R, An J, Liang J, Stramm L, et al. Identification and characterization of pancreatic eukaryotic initiation factor 2 α-subunit kinase, PEK, involved in translational control. Mol Cell Biol 1998; 18: 7499-509.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 7499-7509
-
-
Shi, Y.1
Vattem, K.M.2
Sood, R.3
An, J.4
Liang, J.5
Stramm, L.6
-
28
-
-
0035310752
-
Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response
-
Haze K, Okada T, Yoshida H, Yanagi H, Yura M, Mori K. Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response. Biochem J 2001; 355: 19-28.
-
(2001)
Biochem J
, vol.355
, pp. 19-28
-
-
Haze, K.1
Okada, T.2
Yoshida, H.3
Yanagi, H.4
Yura, M.5
Mori, K.6
-
29
-
-
0034637605
-
Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum
-
Liu CY, Schroder M, Kaufman RJ. Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum. J Biol Chem 2000; 275: 24881-5.
-
(2000)
J Biol Chem
, vol.275
, pp. 24881-24885
-
-
Liu, C.Y.1
Schroder, M.2
Kaufman, R.J.3
-
30
-
-
0033782015
-
Dynamic interaction of BiP and ER stress transducers in the unfolded protein response
-
Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D. Dynamic interaction of BiP and ER stress transducers in the unfolded protein response. Nat Cell Biol 2000; 2: 326-32.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 326-332
-
-
Bertolotti, A.1
Zhang, Y.2
Hendershot, L.M.3
Harding, H.P.4
Ron, D.5
-
31
-
-
0036069980
-
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals
-
Shen J, Chen X, Hendershot LM, Prywes R. ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev Cell 2002; 3: 99-111.
-
(2002)
Dev Cell
, vol.3
, pp. 99-111
-
-
Shen, J.1
Chen, X.2
Hendershot, L.M.3
Prywes, R.4
-
32
-
-
0029903049
-
Oligomerization and phosphorylation of the Irelp kinase during intracellular signaling from the endoplasmic reticulum to the nucleus
-
Shamu CE, Walter P. Oligomerization and phosphorylation of the Irelp kinase during intracellular signaling from the endoplasmic reticulum to the nucleus. EMBO J 1996; 15: 3028-39.
-
(1996)
EMBO J
, vol.15
, pp. 3028-3039
-
-
Shamu, C.E.1
Walter, P.2
-
33
-
-
0029892851
-
The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-phosphorylation of Ire1p (Ern1p) are required for kinase activation
-
Welihinda AA, Kaufman RJ. The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-phosphorylation of Ire1p (Ern1p) are required for kinase activation. J Biol Chem 1996; 271: 18181-7.
-
(1996)
J Biol Chem
, vol.271
, pp. 18181-18187
-
-
Welihinda, A.A.1
Kaufman, R.J.2
-
34
-
-
0030228708
-
Signaling from endoplasmic reticulum to nucleus: Transcription factor with a basic-leucine zipper motif is required for the unfolded protein response pathway
-
Mori K, Kawahara T, Yoshida H, Yanagi H, Yura T. Signaling from endoplasmic reticulum to nucleus: transcription factor with a basic-leucine zipper motif is required for the unfolded protein response pathway. Genes Cells 1996; 1: 803-17.
-
(1996)
Genes Cells
, vol.1
, pp. 803-817
-
-
Mori, K.1
Kawahara, T.2
Yoshida, H.3
Yanagi, H.4
Yura, T.5
-
35
-
-
0027465942
-
The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum
-
Kohno K, Normington K, Sambrook J, Gething MJ, Mori K. The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum. Mol Cell Biol 1993; 13: 877-90.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 877-890
-
-
Kohno, K.1
Normington, K.2
Sambrook, J.3
Gething, M.J.4
Mori, K.5
-
36
-
-
0037011917
-
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
-
Calfon M, Zeng H, Urano F, Till JH, Hubbard SR, Harding HP, et al. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 2002; 415: 92-6.
-
(2002)
Nature
, vol.415
, pp. 92-96
-
-
Calfon, M.1
Zeng, H.2
Urano, F.3
Till, J.H.4
Hubbard, S.R.5
Harding, H.P.6
-
37
-
-
0029889755
-
The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE- like sequences containing an ACGT core
-
Clauss IM, Chu M, Zhao JL, Glimcher LH. The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE- like sequences containing an ACGT core. Nucl Acids Res 1996; 24: 1855-64.
-
(1996)
Nucl Acids Res
, vol.24
, pp. 1855-1864
-
-
Clauss, I.M.1
Chu, M.2
Zhao, J.L.3
Glimcher, L.H.4
-
38
-
-
0033780610
-
A regulatory link between ER-associated protein degradation and the unfolded protein response
-
Friedlander R, Jarosch E, Urban J, Volkwein C, Sommer T. A regulatory link between ER-associated protein degradation and the unfolded protein response. Nat Cell Biol 2000; 2: 379-84.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 379-384
-
-
Friedlander, R.1
Jarosch, E.2
Urban, J.3
Volkwein, C.4
Sommer, T.5
-
39
-
-
0034724520
-
Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation
-
Travers KJ, Patil CK, Wodicka L, Lockhart DJ, Weismann JS, Walter P. Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. Cell 2000; 101: 249-58.
-
(2000)
Cell
, vol.101
, pp. 249-258
-
-
Travers, K.J.1
Patil, C.K.2
Wodicka, L.3
Lockhart, D.J.4
Weismann, J.S.5
Walter, P.6
-
40
-
-
0142059951
-
XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
-
Lee AH, Iwakoshi NN, Glimcher LH. XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol 2003; 23 7448-59.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 7448-7459
-
-
Lee, A.H.1
Iwakoshi, N.N.2
Glimcher, L.H.3
-
41
-
-
0033590451
-
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
-
Harding HP, Zhang Y, Ron D. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 1999; 397: 271-4.
-
(1999)
Nature
, vol.397
, pp. 271-274
-
-
Harding, H.P.1
Zhang, Y.2
Ron, D.3
-
42
-
-
0141752795
-
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival
-
Cullinan SB, Zhang D, Hannink M, Arvisais E, Kaufman RJ, Diehl JA. Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol 2003; 23: 7198-209.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 7198-7209
-
-
Cullinan, S.B.1
Zhang, D.2
Hannink, M.3
Arvisais, E.4
Kaufman, R.J.5
Diehl, J.A.6
-
43
-
-
0033634654
-
Regulated translation initiation controls stress-induced gene expression in mammalian cells
-
Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, Ron D. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell 2000; 6: 1099-108.
-
(2000)
Mol Cell
, vol.6
, pp. 1099-1108
-
-
Harding, H.P.1
Novoa, I.2
Zhang, Y.3
Zeng, H.4
Wek, R.5
Ron, D.6
-
44
-
-
0037066741
-
The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi
-
Chen X, Shen J, Prywes R. The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi. J Biol Chem 2002; 277: 13045-52.
-
(2002)
J Biol Chem
, vol.277
, pp. 13045-13052
-
-
Chen, X.1
Shen, J.2
Prywes, R.3
-
45
-
-
1642442467
-
Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response
-
Hong M, Luo S, Baurneister P, Huang JM, Gogia RK, Lee AS. Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response. J Biol Chem 2004; 279: 11354-63.
-
(2004)
J Biol Chem
, vol.279
, pp. 11354-11363
-
-
Hong, M.1
Luo, S.2
Baurneister, P.3
Huang, J.M.4
Gogia, R.K.5
Lee, A.S.6
-
46
-
-
0032693671
-
Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress
-
Haze K, Yoshida H, Yanagi H, Yura T, Mori K. Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress. Mol Biol Cell 1999; 10: 3787-99.
-
(1999)
Mol Biol Cell
, vol.10
, pp. 3787-3799
-
-
Haze, K.1
Yoshida, H.2
Yanagi, H.3
Yura, T.4
Mori, K.5
-
47
-
-
0033815971
-
ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the unfolded protein response
-
Yoshida H, Okada T, Haze K, Yanagi H, Yura T, Mori K. ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the unfolded protein response. Mol Cell Biol 2000; 20: 6755-67.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 6755-6767
-
-
Yoshida, H.1
Okada, T.2
Haze, K.3
Yanagi, H.4
Yura, T.5
Mori, K.6
-
48
-
-
1842509855
-
ATF6 modulates SREBP2-mediated lipogenesis
-
Zeng L, Lu M, Mori K, Luo S, Lee AS, Shyy JY. ATF6 modulates SREBP2-mediated lipogenesis. EMBO J 2004; 23: 950-8.
-
(2004)
EMBO J
, vol.23
, pp. 950-958
-
-
Zeng, L.1
Lu, M.2
Mori, K.3
Luo, S.4
Lee, A.S.5
Shyy, J.Y.6
-
49
-
-
0026546365
-
-
Ron D, Habener JF. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev 1992; 6: 439-53.
-
Ron D, Habener JF. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev 1992; 6: 439-53.
-
-
-
-
50
-
-
8944259440
-
Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153)
-
Wang ZX, Lawson B, Brewer JW, Zinszner H, Sanjay A, Mi LJ, et al. Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153). Mol Cell Biol 1996; 16: 4273-80.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4273-4280
-
-
Wang, Z.X.1
Lawson, B.2
Brewer, J.W.3
Zinszner, H.4
Sanjay, A.5
Mi, L.J.6
-
51
-
-
0032054744
-
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum
-
Zinszner H, Kuroda M, Wang X, Batchvarova N, Lightfoot RT, Reinotti H, et al. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev 1998; 12: 982-95.
-
(1998)
Genes Dev
, vol.12
, pp. 982-995
-
-
Zinszner, H.1
Kuroda, M.2
Wang, X.3
Batchvarova, N.4
Lightfoot, R.T.5
Reinotti, H.6
-
52
-
-
0034723235
-
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
-
Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Ron D. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 2000; 287: 664-6.
-
(2000)
Science
, vol.287
, pp. 664-666
-
-
Urano, F.1
Wang, X.2
Bertolotti, A.3
Zhang, Y.4
Chung, P.5
Ron, D.6
-
53
-
-
0034610743
-
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
-
Nakagawa T, Zhu H, Morishima. N, Li E, Xu J, Yuan J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 2000; 403: 98-103.
-
(2000)
Nature
, vol.403
, pp. 98-103
-
-
Nakagawa, T.1
Zhu, H.2
Morishima, N.3
Li, E.4
Xu, J.5
Yuan, J.6
-
54
-
-
0035823579
-
Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation
-
Rao RV, Hermel E, Castro-Obregon S, del Rio G, Ellerby LM, Bredesen DE. Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation. J Biol Chem 2001; 276: 33869-74.
-
(2001)
J Biol Chem
, vol.276
, pp. 33869-33874
-
-
Rao, R.V.1
Hermel, E.2
Castro-Obregon, S.3
del Rio, G.4
Ellerby, L.M.5
Bredesen, D.E.6
-
55
-
-
0030907296
-
-
Yoshioka M, Kayo T, Ikeda T, Koizumi A. A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/ 6 (Akita) mutant mice. Diabetes 1997; 46: 887-94.
-
Yoshioka M, Kayo T, Ikeda T, Koizumi A. A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/ 6 (Akita) mutant mice. Diabetes 1997; 46: 887-94.
-
-
-
-
56
-
-
0032918044
-
A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse
-
Wang J, Takeuchi T, Tanaka S, Kubo SK, Kayo T, Lu D, et al. A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse. J Clin Invest 1999; 103: 27-37.
-
(1999)
J Clin Invest
, vol.103
, pp. 27-37
-
-
Wang, J.1
Takeuchi, T.2
Tanaka, S.3
Kubo, S.K.4
Kayo, T.5
Lu, D.6
-
57
-
-
4744374044
-
High ER stress in beta-cells stimulates intracellular degradation of misfolded insulin
-
Allen JR, Nguyen LX, Sargent KE, Lipson KL, Hackett A, Urano F. High ER stress in beta-cells stimulates intracellular degradation of misfolded insulin. Biochem Biophys Res Commun 2004; 324: 166-70.
-
(2004)
Biochem Biophys Res Commun
, vol.324
, pp. 166-170
-
-
Allen, J.R.1
Nguyen, L.X.2
Sargent, K.E.3
Lipson, K.L.4
Hackett, A.5
Urano, F.6
-
58
-
-
0035129172
-
Compensatory responses in mice carrying a null mutation for Ins1 or Ins2
-
Leroux L, Desbois P, Lamotte L, Duvillie B, Cordonnier N, Jackerott M, et al. Compensatory responses in mice carrying a null mutation for Ins1 or Ins2. Diabetes 2001; 50 (Suppl 1): S150-3.
-
(2001)
Diabetes
, vol.50
, Issue.SUPPL. 1
-
-
Leroux, L.1
Desbois, P.2
Lamotte, L.3
Duvillie, B.4
Cordonnier, N.5
Jackerott, M.6
-
59
-
-
0036175128
-
Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes
-
Oyadomari S, Koizumi A, Takeda K, Gotoh T, Akira S, Mori K. Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest 2002; 109: 525-32.
-
(2002)
J Clin Invest
, vol.109
, pp. 525-532
-
-
Oyadomari, S.1
Koizumi, A.2
Takeda, K.3
Gotoh, T.4
Akira, S.5
Mori, K.6
-
60
-
-
0034425698
-
EIF2AK3, encoding translation initiation factor 2-alpha kinase-3, in mutated in patients with Wolcott-Rallison syndrome
-
Delephine M, Nicolino M, Barrett T, Golamaully M, Lathrop GM, Julier C. EIF2AK3, encoding translation initiation factor 2-alpha kinase-3, in mutated in patients with Wolcott-Rallison syndrome. Nat Genet 2000; 25: 406-9.
-
(2000)
Nat Genet
, vol.25
, pp. 406-409
-
-
Delephine, M.1
Nicolino, M.2
Barrett, T.3
Golamaully, M.4
Lathrop, G.M.5
Julier, C.6
-
61
-
-
0034968330
-
Diabetes mellitus and exocrine pancreatic dysfunction in perk-1- mice reveals a role for translational control in survival of secretory cells
-
Harding HP, Zeng H, Zhang Y, Jungries R, Chung P, Plesken H, et al. Diabetes mellitus and exocrine pancreatic dysfunction in perk-1- mice reveals a role for translational control in survival of secretory cells. Mol Cell 2001; 7: 1153-63.
-
(2001)
Mol Cell
, vol.7
, pp. 1153-1163
-
-
Harding, H.P.1
Zeng, H.2
Zhang, Y.3
Jungries, R.4
Chung, P.5
Plesken, H.6
-
62
-
-
0033634641
-
Perk is essential for translational regulation and cell survival during the unfolded protein response
-
Harding HP, Zhang Y, Bertolotti A, Zeng H, Ron D. Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell 2000; 5: 897-904.
-
(2000)
Mol Cell
, vol.5
, pp. 897-904
-
-
Harding, H.P.1
Zhang, Y.2
Bertolotti, A.3
Zeng, H.4
Ron, D.5
-
63
-
-
0034163483
-
Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress
-
Sood R, Porter AC, Ma K, Quilliam LA, Wek RC. Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress. Biochem J 2000; 346: 281-93.
-
(2000)
Biochem J
, vol.346
, pp. 281-293
-
-
Sood, R.1
Porter, A.C.2
Ma, K.3
Quilliam, L.A.4
Wek, R.C.5
-
64
-
-
0034973982
-
Translational control is required for the unfolded protein response and in vivo glucose homeostasis
-
Scheuner D, Song B, McEwen E, Gillespie P, Saunders T, Kaufman RJ. Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol Cell 2001; 7: 1165-76.
-
(2001)
Mol Cell
, vol.7
, pp. 1165-1176
-
-
Scheuner, D.1
Song, B.2
McEwen, E.3
Gillespie, P.4
Saunders, T.5
Kaufman, R.J.6
-
65
-
-
0035800471
-
Protein synthesis: The perks of balancing glucose
-
Sonenberg N, Newgard CB. Protein synthesis: the perks of balancing glucose. Science 2001; 293: 818-9.
-
(2001)
Science
, vol.293
, pp. 818-819
-
-
Sonenberg, N.1
Newgard, C.B.2
-
66
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, Insulin action and type 2 diabetes
-
Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, et al. Endoplasmic reticulum stress links obesity, Insulin action and type 2 diabetes. Science 2004; 306: 457-61.
-
(2004)
Science
, vol.306
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
Lee, A.H.4
Iwakoshi, N.N.5
Ozdelen, E.6
-
67
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, Maeda K, et al. A central role for JNK in obesity and insulin resistance. Nature 2002; 420: 333-6.
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
Gorgun, C.Z.4
Uysal, K.T.5
Maeda, K.6
-
68
-
-
17344362695
-
A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optical atrophy (Wolfram syndrome)
-
Inoue H, Tanizawa Y, Wasson J, Behn P, Kalidas K, Bernal-Mizrachi E, et al. A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optical atrophy (Wolfram syndrome). Nat Genet 1998; 20: 143-8.
-
(1998)
Nat Genet
, vol.20
, pp. 143-148
-
-
Inoue, H.1
Tanizawa, Y.2
Wasson, J.3
Behn, P.4
Kalidas, K.5
Bernal-Mizrachi, E.6
-
69
-
-
28244435870
-
WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic β-cells
-
Fonseca SG, Fukuma M, Lipson KL, Nguyen LX, Allen JR, Urano F. WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic β-cells. J Biol Chem 2005; 280: 39609-15.
-
(2005)
J Biol Chem
, vol.280
, pp. 39609-39615
-
-
Fonseca, S.G.1
Fukuma, M.2
Lipson, K.L.3
Nguyen, L.X.4
Allen, J.R.5
Urano, F.6
-
70
-
-
33745202552
-
WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells
-
Yamada T, Ishihara H, Tamura A, Takahashi R, Yamaguchi S, Takei D, et al. WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells. Hum Mol Genet 2006; 15: 1600-9.
-
(2006)
Hum Mol Genet
, vol.15
, pp. 1600-1609
-
-
Yamada, T.1
Ishihara, H.2
Tamura, A.3
Takahashi, R.4
Yamaguchi, S.5
Takei, D.6
-
71
-
-
34249317835
-
Hexosamines, insulin resistance, and the complications of diabetes: Current status
-
Buse MG. Hexosamines, insulin resistance, and the complications of diabetes: current status. Am J Physiol Endocrinol Metab 2006; 291: E1274-80.
-
(2006)
Am J Physiol Endocrinol Metab
, vol.291
-
-
Buse, M.G.1
-
72
-
-
33644767028
-
Glucosamine-induced endoplasmic reticulum dysfunction is associated with accelerated atherosclerosis in a hyperglycemic mouse model
-
Werstuck GH, Khan MI, Femia G, Kim AJ, Tedesco V, Trigatti B, et al. Glucosamine-induced endoplasmic reticulum dysfunction is associated with accelerated atherosclerosis in a hyperglycemic mouse model. Diabetes 2006; 55: 93-101.
-
(2006)
Diabetes
, vol.55
, pp. 93-101
-
-
Werstuck, G.H.1
Khan, M.I.2
Femia, G.3
Kim, A.J.4
Tedesco, V.5
Trigatti, B.6
-
73
-
-
34249275069
-
Convergence of ER stress and hexosamine pathways in the pathogenesis of insulin resistance in L6 skeletal muscle cells
-
Balasubramanyam M, Srinivasan V, Tatu U, Mohan V, Convergence of ER stress and hexosamine pathways in the pathogenesis of insulin resistance in L6 skeletal muscle cells. Diabetes 2006; 55 (Suppl 1): A563.
-
(2006)
Diabetes
, vol.55
, Issue.SUPPL. 1
-
-
Balasubramanyam, M.1
Srinivasan, V.2
Tatu, U.3
Mohan, V.4
-
74
-
-
33745962325
-
Nitric oxide and endoplasmic reticulum stress
-
Gotoh T, Mori M. Nitric oxide and endoplasmic reticulum stress. Arterioscler Thromb Vasc Biol 2006; 26: 1439-46.
-
(2006)
Arterioscler Thromb Vasc Biol
, vol.26
, pp. 1439-1446
-
-
Gotoh, T.1
Mori, M.2
-
75
-
-
0035845568
-
Nitric oxide-induced apoptosis in pancreatic β-cells is mediated by the endoplasmic reticulum stress pathway
-
Oyadomari S, Takeda K, Takiguchi M, Gotoh T, Matsumoto M, Wada I, et al. Nitric oxide-induced apoptosis in pancreatic β-cells is mediated by the endoplasmic reticulum stress pathway. Proc Natl Acad Sci USA 2001; 98: 10845-50.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10845-10850
-
-
Oyadomari, S.1
Takeda, K.2
Takiguchi, M.3
Gotoh, T.4
Matsumoto, M.5
Wada, I.6
-
76
-
-
0037023726
-
Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP
-
Gotoh T, Oyadomari S, Mori K, Mori M. Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP. J Biol Chem 2002; 277: 12343-50.
-
(2002)
J Biol Chem
, vol.277
, pp. 12343-12350
-
-
Gotoh, T.1
Oyadomari, S.2
Mori, K.3
Mori, M.4
-
77
-
-
33644790277
-
Peroxynitrite causes endoplasmic reticulum stress and apoptosis in human vascular endothelium: Implications in atherogenesis
-
Dickhout JG, Hossain GS, Pozza LM, Zhou J, Lhotak S, Austin RC. Peroxynitrite causes endoplasmic reticulum stress and apoptosis in human vascular endothelium: implications in atherogenesis. Arterioscler Thromb Vasc Biol 2005; 25: 2623-9.
-
(2005)
Arterioscler Thromb Vasc Biol
, vol.25
, pp. 2623-2629
-
-
Dickhout, J.G.1
Hossain, G.S.2
Pozza, L.M.3
Zhou, J.4
Lhotak, S.5
Austin, R.C.6
-
78
-
-
9244231766
-
Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: Role of nuclear factor-kappaB and endoplasmic reticulum stress
-
Kharroubi I, Ladriere L, Cardozo AK, Dogusan Z, Cnop M, Eizirik DL. Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress. Endocrinology 2004; 145: 5087-96.
-
(2004)
Endocrinology
, vol.145
, pp. 5087-5096
-
-
Kharroubi, I.1
Ladriere, L.2
Cardozo, A.K.3
Dogusan, Z.4
Cnop, M.5
Eizirik, D.L.6
-
79
-
-
19944432792
-
Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells
-
Cardozo AK, Ortis F, Storling J, Feng YM, Rasschaert J, Tonnesen M, et al. Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells. Diabetes 2005; 54: 452-61.
-
(2005)
Diabetes
, vol.54
, pp. 452-461
-
-
Cardozo, A.K.1
Ortis, F.2
Storling, J.3
Feng, Y.M.4
Rasschaert, J.5
Tonnesen, M.6
-
80
-
-
33845575826
-
Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death
-
Borradaile NM, Han X, Harp JD, Gale SE, Ory DS, Schaffer JE. Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death. J Lipid Res 2006; 47: 2726-37.
-
(2006)
J Lipid Res
, vol.47
, pp. 2726-2737
-
-
Borradaile, N.M.1
Han, X.2
Harp, J.D.3
Gale, S.E.4
Ory, D.S.5
Schaffer, J.E.6
-
81
-
-
26444524411
-
Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor
-
Devries-Seimon T, Li Y, Yao PM, Stone E, Wang Y, Davis RJ, et al. Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor. J Cell Biol 2005; 171: 61-73.
-
(2005)
J Cell Biol
, vol.171
, pp. 61-73
-
-
Devries-Seimon, T.1
Li, Y.2
Yao, P.M.3
Stone, E.4
Wang, Y.5
Davis, R.J.6
-
82
-
-
14644397903
-
The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes
-
Ozawa K, Miyazaki M, Matsuhisa M, Takano K, Nakatani Y, Hatazaki M, et al. The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes. Diabetes 2005; 54: 657-63.
-
(2005)
Diabetes
, vol.54
, pp. 657-663
-
-
Ozawa, K.1
Miyazaki, M.2
Matsuhisa, M.3
Takano, K.4
Nakatani, Y.5
Hatazaki, M.6
-
83
-
-
0037058574
-
Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK
-
Yan W, Frank CL, Korth MJ, Sopher BL, Novoa I, Ron D. Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK. Proc Natl Acad Sci USA 2002; 99: 15920-5.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 15920-15925
-
-
Yan, W.1
Frank, C.L.2
Korth, M.J.3
Sopher, B.L.4
Novoa, I.5
Ron, D.6
-
84
-
-
20144386666
-
Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK
-
Ladiges WC, Knoblaugh SE, Morton JF, Korth MJ, Sopher BL, Baskin CR, et al. Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK. Diabetes 2005; 54: 1074-81.
-
(2005)
Diabetes
, vol.54
, pp. 1074-1081
-
-
Ladiges, W.C.1
Knoblaugh, S.E.2
Morton, J.F.3
Korth, M.J.4
Sopher, B.L.5
Baskin, C.R.6
-
85
-
-
33748069813
-
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
-
Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 2006; 313: 1137-40.
-
(2006)
Science
, vol.313
, pp. 1137-1140
-
-
Ozcan, U.1
Yilmaz, E.2
Ozcan, L.3
Furuhashi, M.4
Vaillancourt, E.5
Smith, R.O.6
|